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EXOC6 exocyst complex component 6 [ Homo sapiens (human) ]

Gene ID: 54536, updated on 26-May-2016
Official Symbol
EXOC6provided by HGNC
Official Full Name
exocyst complex component 6provided by HGNC
Primary source
HGNC:HGNC:23196
See related
Ensembl:ENSG00000138190 HPRD:10216; MIM:609672; Vega:OTTHUMG00000018767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC15; EXOC6A; SEC15L; Sec15p; SEC15L1; SEC15L3
Summary
The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]
Orthologs
Location:
10q23.33
Exon count:
24
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (92834713..93059494)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94590887..94819251)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 3 Neighboring gene hematopoietically expressed homeobox Neighboring gene uncharacterized LOC105378435 Neighboring gene cytochrome P450 family 26 subfamily C member 1 Neighboring gene cytochrome P450 family 26 subfamily A member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 6 (EXOC6) is a Nef-binding protein in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • Assembly of the primary cilium, organism-specific biosystem (from REACTOME)
    Assembly of the primary cilium, organism-specific biosystemThe primary cilium is one of two main types of cilia present on the surface of many eukaryotic cells (reviewed in Flieghauf et al, 2007). Unlike the motile cilia, which are generally present in large...
  • Cargo trafficking to the periciliary membrane, organism-specific biosystem (from REACTOME)
    Cargo trafficking to the periciliary membrane, organism-specific biosystemThe primary cilium is a sensory organelle that is required for the transduction of numerous external signals such as growth factors, hormones and morphogens, and an intact primary cilium is needed fo...
  • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
    Insulin Pathway, organism-specific biosystem
    Insulin Pathway
  • Insulin processing, organism-specific biosystem (from REACTOME)
    Insulin processing, organism-specific biosystemThe generation of insulin-containing secretory granules from proinsulin in the lumen of the endoplasmic reticulum (ER) can be described in 4 steps: formation of intramolecular disulfide bonds, format...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
    Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • VxPx cargo-targeting to cilium, organism-specific biosystem (from REACTOME)
    VxPx cargo-targeting to cilium, organism-specific biosystemA number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ1125, FLJ11251, MGC33397, DKFZp761I2124

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle docking involved in exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
exocyst IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
exocyst complex component 6
Names
SEC15-like 1
SEC15-like protein 3
exocyst complex component Sec15A
rsec15-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013848.3NP_001013870.1  exocyst complex component 6 isoform b

    See identical proteins and their annotated locations for NP_001013870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform c.
    Source sequence(s)
    AK128190, AK300285, AL832501, BC028395, BU674151
    Consensus CDS
    CCDS31247.1
    UniProtKB/Swiss-Prot
    Q8TAG9
    UniProtKB/TrEMBL
    B3KXY5, B7Z6G5
    Related
    ENSP00000360607, ENST00000371552
    Conserved Domains (1) summary
    pfam04091
    Location:450726
    Sec15; Exocyst complex subunit Sec15-like
  2. NM_001319194.1NP_001306123.1  exocyst complex component 6 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AK300285, AL832501, BC028395, BU674151
    UniProtKB/Swiss-Prot
    Q8TAG9
    UniProtKB/TrEMBL
    B7Z6G5
    Conserved Domains (1) summary
    pfam04091
    Location:471747
    Sec15; Exocyst complex subunit Sec15-like
  3. NM_001319195.1NP_001306124.1  exocyst complex component 6 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform c.
    Source sequence(s)
    AL832501, BC028395, BU674151, DA333847
    UniProtKB/Swiss-Prot
    Q8TAG9
    Conserved Domains (1) summary
    pfam04091
    Location:455730
    Sec15; Exocyst complex subunit Sec15-like
  4. NM_001319200.1NP_001306129.1  exocyst complex component 6 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also lacks four internal exons resulting in the loss of two in-frame segments in the central coding region, compared to variant 3. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform c.
    Source sequence(s)
    BC028395, BU674151, DA333847, EF571007
    UniProtKB/Swiss-Prot
    Q8TAG9
    UniProtKB/TrEMBL
    A5YP36, E7EW84
    Conserved Domains (1) summary
    pfam04091
    Location:352628
    Sec15; Exocyst complex subunit Sec15-like
  5. NM_019053.5NP_061926.3  exocyst complex component 6 isoform a

    See identical proteins and their annotated locations for NP_061926.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 3. The encoded isoform (a) has a distinct and shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AK315544, AL832501, BC028395, BU674151, DA333847
    Consensus CDS
    CCDS7424.2
    UniProtKB/Swiss-Prot
    Q8TAG9
    UniProtKB/TrEMBL
    B2RDH5
    Related
    ENSP00000260762, OTTHUMP00000020105, ENST00000260762, OTTHUMT00000049410
    Conserved Domains (1) summary
    pfam04091
    Location:455731
    Sec15; Exocyst complex subunit Sec15-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    92834713..93059494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717896.2XP_006717959.1  

    Conserved Domains (1) summary
    pfam04091
    Location:450736
    Sec15; Exocyst complex subunit Sec15-like
  2. XM_011539874.1XP_011538176.1  

    Conserved Domains (1) summary
    pfam04091
    Location:450735
    Sec15; Exocyst complex subunit Sec15-like
  3. XM_011539875.1XP_011538177.1  

    Conserved Domains (1) summary
    pfam04091
    Location:427713
    Sec15; Exocyst complex subunit Sec15-like
  4. XM_005269913.1XP_005269970.1  

    Conserved Domains (1) summary
    pfam04091
    Location:455741
    Sec15; Exocyst complex subunit Sec15-like
  5. XM_005269915.1XP_005269972.1  

    Conserved Domains (1) summary
    pfam04091
    Location:455730
    Sec15; Exocyst complex subunit Sec15-like
  6. XM_006717899.1XP_006717962.1  

    Conserved Domains (1) summary
    pfam04091
    Location:432718
    Sec15; Exocyst complex subunit Sec15-like
  7. XM_006717901.1XP_006717964.1  

    Related
    ENSP00000396206, ENST00000443748
    Conserved Domains (1) summary
    pfam04091
    Location:432708
    Sec15; Exocyst complex subunit Sec15-like

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    94877294..95101961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)