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EXOC6 exocyst complex component 6 [ Homo sapiens (human) ]

Gene ID: 54536, updated on 26-Jun-2015
Official Symbol
EXOC6provided by HGNC
Official Full Name
exocyst complex component 6provided by HGNC
Primary source
HGNC:HGNC:23196
See related
Ensembl:ENSG00000138190; HPRD:10216; MIM:609672; Vega:OTTHUMG00000018767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC15; EXOC6A; SEC15L; Sec15p; SEC15L1; SEC15L3
Summary
The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs
See EXOC6 in Epigenomics, MapViewer
Location:
10q23.33
Exon count:
24
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (92834713..93059494)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94590887..94819251)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2, subunit 2 beta pseudogene 3 Neighboring gene hematopoietically expressed homeobox Neighboring gene uncharacterized LOC105378435 Neighboring gene cytochrome P450, family 26, subfamily C, polypeptide 1 Neighboring gene cytochrome P450, family 26, subfamily A, polypeptide 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 6 (EXOC6) is a Nef-binding protein in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ1125, FLJ11251, MGC33397, DKFZp761I2124

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
organelle organization TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle docking involved in exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
exocyst IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
exocyst complex component 6
Names
exocyst complex component 6
SEC15-like 1
SEC15-like protein 1
SEC15-like protein 3
exocyst complex component Sec15A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013848.2NP_001013870.1  exocyst complex component 6 isoform b

    See identical proteins and their annotated locations for NP_001013870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (b) contains a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK128190, AL392103, BC028395, BM979273, DB060830
    Consensus CDS
    CCDS31247.1
    UniProtKB/TrEMBL
    B3KXY5
    UniProtKB/Swiss-Prot
    Q8TAG9
    Related
    ENSP00000360607, ENST00000371552
    Conserved Domains (1) summary
    pfam04091
    Location:450726
    Sec15; Exocyst complex subunit Sec15-like
  2. NM_019053.4NP_061926.3  exocyst complex component 6 isoform a

    See identical proteins and their annotated locations for NP_061926.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AK128190, AL392103, BC028395, BM979273, DA187840
    Consensus CDS
    CCDS7424.2
    UniProtKB/TrEMBL
    B3KXY5
    UniProtKB/Swiss-Prot
    Q8TAG9
    Related
    ENSP00000260762, OTTHUMP00000020105, ENST00000260762, OTTHUMT00000049410
    Conserved Domains (1) summary
    pfam04091
    Location:455731
    Sec15; Exocyst complex subunit Sec15-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    92834713..93059494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717896.2XP_006717959.1  

    Conserved Domains (1) summary
    pfam04091
    Location:450736
    Sec15; Exocyst complex subunit Sec15-like
  2. XM_011539874.1XP_011538176.1  

    Conserved Domains (1) summary
    pfam04091
    Location:450735
    Sec15; Exocyst complex subunit Sec15-like
  3. XM_011539875.1XP_011538177.1  

    Conserved Domains (1) summary
    pfam04091
    Location:427713
    Sec15; Exocyst complex subunit Sec15-like
  4. XM_005269913.1XP_005269970.1  

    Conserved Domains (1) summary
    pfam04091
    Location:455741
    Sec15; Exocyst complex subunit Sec15-like
  5. XM_005269915.1XP_005269972.1  

    See identical proteins and their annotated locations for XP_005269972.1

    Conserved Domains (1) summary
    pfam04091
    Location:455730
    Sec15; Exocyst complex subunit Sec15-like
  6. XM_006717899.1XP_006717962.1  

    Conserved Domains (1) summary
    pfam04091
    Location:432718
    Sec15; Exocyst complex subunit Sec15-like
  7. XM_006717901.1XP_006717964.1  

    Related
    ENSP00000396206, ENST00000443748
    Conserved Domains (1) summary
    pfam04091
    Location:432708
    Sec15; Exocyst complex subunit Sec15-like

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    94877294..95101961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)