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    HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 [ Homo sapiens ]

    Gene ID: 3178, updated on 20-May-2012

    Summary

    Official Symbol
    HNRNPA1provided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A1provided by HGNC
    Primary source
    HGNC:5031
    See related
    Ensembl:ENSG00000135486; HPRD:01242; MIM:164017; Vega:OTTHUMG00000169702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPA1; HNRPA1L3; hnRNP A1; hnRNP-A1; MGC102835
    Summary
    This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    12q13.1
    Sequence :
    Chromosome: 12; NC_000012.11 (54674488..54679030)
    See HNRNPA1 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene single-strand-selective monofunctional uracil-DNA glycosylase 1 Neighboring gene microRNA 3198-2 Neighboring gene chromobox homolog 5 Neighboring gene nuclear factor (erythroid-derived 2), 45kDa Neighboring gene coatomer protein complex, subunit zeta 1 Neighboring gene microRNA 148b

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev hnRNP A1 binds to cis-acting repressive (CRS) sequences in HIV-1 RNA suggesting a role for this binding in influencing Rev function PubMed
    rev hnRNP A1 modulates Rev expression by controlling HIV-1 mRNA splicing PubMed
    rev hnRNP A1 binds to an instability (INS) element in the p17gag gene of HIV-1 RNA causing synergistic stimulation of Rev-dependent nuclear export of unspliced HIV-1 mRNA PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P09651 O95870 ABHD16A    HPRD  PubMed  
    P09651 P39748 FEN1    HPRD  PubMed  
    P09651 P25963 NFKBIA    HPRD  PubMed  
    P09651 Q86U42 PABPN1    HPRD  PubMed  
    P09651 Q92561 PHYHIP    HPRD  PubMed  
    P09651 Q99873 PRMT1    HPRD  PubMed  
    P09651 P48634 PRRC2A    HPRD  PubMed  
    P09651 P46778 RPL21    HPRD  PubMed  
    P09651 Q15424 SAFB    HPRD  PubMed  
    P09651 Q8WXA9 SREK1    HPRD  PubMed  
    P09651 Q9UMX1 SUFU    HPRD  PubMed  
    P09651 Q92973 TNPO1    HPRD  PubMed  
    P09651 Q9UNY4 TTF2    HPRD  PubMed  
    P09651 Q8IZH2 XRN1    HPRD  PubMed  
    BioGRID:109420 BioGRID:121677 ARHGAP23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:128219 ARID2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:107274 CAPN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:107343 CCNT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:107489 CENPC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115776 DDX17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:108528 FEN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109420 BioGRID:120817 FRMD4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109212 GTF2A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109216 GTF2E2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109420 HNRNPA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109420 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109423 HNRNPAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109424 HNRNPC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109428 HNRNPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109431 HNRNPK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109432 HNRNPL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:110751 HNRNPM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115530 HNRNPR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:128685 HNRNPUL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115308 HNRPDL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109558 HSP90AB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109538 HSPA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109545 HSPA9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115886 IGF2BP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115888 IGF2BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115887 IGF2BP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109821 ILF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109822 ILF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:128436 KHDRBS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:114139 KHSRP    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109420 BioGRID:116966 KIAA0368    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:119619 LARP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:131127 LOC341333    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:136689 LOC440563    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:110484 MOV10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:119410 MRPL37    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:116731 MRPS27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:110859 NFKBIA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109420 BioGRID:117076 NNT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115783 NOP56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:109165 NR3C1    BioGRID  PubMed Two-hybrid 
    BioGRID:109420 BioGRID:117939 PABPC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:114296 PABPC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:111367 PLOD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:114467 PLOD3    BioGRID  PubMed Affinity Capture-MS 
    NP_002735.3 PRKCZ    BIND  PubMed PKC-zeta phosphorylates and interacts with hnRNPA1. This interaction was modeled on a demonstrated interaction between PKC-zeta and hnRNPA1, both from unspecified species. 
    BioGRID:109420 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:109420 BioGRID:121140 PRMT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:113646 PRRC2A    BioGRID  PubMed Two-hybrid 
    BioGRID:109420 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    NM_002823.2 PTMA    BIND  PubMed HNRPA1 (hnRNP A1) interacts with PTMA (ProT-alpha) mRNA. 
    BioGRID:109420 BioGRID:111772 PURA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:114952 RBM39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:118134 RBMX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:112020 ROCK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:117487 RPAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:116708 RRP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:112201 SAFB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109420 BioGRID:941018 SAP25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:112609 SRP72    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115755 SYNCRIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:120194 SYTL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:117003 TARDBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109420 BioGRID:128238 UBR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:116896 UBR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:119543 YTHDF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109420 BioGRID:119667 ZFR    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Pathways from BioSystems

    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded RNA binding IC
    Inferred by Curator
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA export from nucleus IC
    Inferred by Curator
    more info
    PubMed 
    RNA splicing TAS
    Traceable Author Statement
    more info
     
    alternative nuclear mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear export IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    nuclear mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heterogeneous nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein A1
    Names
    heterogeneous nuclear ribonucleoprotein A1
    hnRNP A1-like 3
    hnRNP core protein A1
    helix-destabilizing protein
    hnRNP core protein A1-like 3
    single-strand RNA-binding protein
    single-strand DNA-binding protein UP1
    nuclear ribonucleoprotein particle A1 protein
    heterogeneous nuclear ribonucleoprotein B2 protein
    heterogeneous nuclear ribonucleoprotein A1B protein
    heterogeneous nuclear ribonucleoprotein core protein A1
    Putative heterogeneous nuclear ribonucleoprotein A1-like 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002136.2NP_002127.1  heterogeneous nuclear ribonucleoprotein A1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the coding region, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment, compared to isoform 2. This variant is the predominant transcript.
      Source sequence(s)
      BC052296, CD705336
      Consensus CDS
      CCDS41793.1
      UniProtKB/Swiss-Prot
      P09651
      Related
      ENSP00000448617, OTTHUMP00000241883, ENST00000546500, OTTHUMT00000405474
      Conserved Domains (1) summary
      cd00590
      Location:1588
      Blast Score: 197
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
    2. NM_031157.2NP_112420.1  heterogeneous nuclear ribonucleoprotein A1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon in the coding region, compared to variant 1, resulting in a longer protein (isoform 2) that has a unique internal segment, compared to isoform 1.
      Source sequence(s)
      BQ277208, BU501222, BX425482, CF541085
      Consensus CDS
      CCDS44909.1
      UniProtKB/Swiss-Prot
      P09651
      Related
      ENSP00000341826, OTTHUMP00000241887, ENST00000340913, OTTHUMT00000405480
      Conserved Domains (1) summary
      cd00590
      Location:1588
      Blast Score: 195
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      54674488..54679030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      51713759..51718301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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