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    BMX BMX non-receptor tyrosine kinase [ Homo sapiens ]

    Gene ID: 660, updated on 11-May-2012
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    Summary

    Official Symbol
    BMXprovided by HGNC
    Official Full Name
    BMX non-receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:1079
    See related
    Ensembl:ENSG00000102010; HPRD:02111; MIM:300101; Vega:OTTHUMG00000021180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ETK; PSCTK2; PSCTK3
    Summary
    This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]
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    Genomic context

    Location :
    Xp22.2
    Sequence :
    Chromosome: X; NC_000023.10 (15518900..15574652)
    See BMX in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene PIR-FIGF readthrough Neighboring gene c-fos induced growth factor (vascular endothelial growth factor D) Neighboring gene pirin (iron-binding nuclear protein) Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Neighboring gene uncharacterized LOC100506630

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Guryanova OA, et al. Cancer Cell, 2011 Apr 12. PMID 21481791.
    3. The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner. Gottar-Guillier M, et al. J Immunol, 2011 May 15. PMID 21471444.
    4. Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy. Guo S, et al. PLoS One, 2011 Mar 7. PMID 21408190.
    5. Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells from apoptosis induced by radiation. Zhang Z, et al. Cancer Biol Ther, 2011 Apr 1. PMID 21339702.

    See all (47) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Etk/BMX may play a role in protection of NPC cells from apoptosis.
      Title: Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells from apoptosis induced by radiation.
    2. study concludes that BMX is an essential component of inflammatory cytokine signaling and that catalytic, as well as noncatalytic functions of BMX are involved
      Title: The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner.
    3. Deregulation of ETK may attribute to the elevated activity of STAT3 and AKT frequently detected in bladder cancer.
      Title: Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy.
    4. BMX is associated with multi-drug resistance of K562/HHT cell line.
      Title: [Changes of gene expression profile in homoharringtonine-induced leukemia multi-drug resistant cell line K562/HHT].
    5. Constitutively active STAT3 rescued the effects of BMX downregulation, supporting that BMX signals through STAT3 in glioblastoma stem cells (GSCs).
      Title: Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
    6. possible role in regulation of vesicle trafficking
      Title: Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking.
    7. Investigate Bmx mediates VEGF-dependent lymphangiogenic signaling.
      Title: Functional analyses of the bone marrow kinase in the X chromosome in vascular endothelial growth factor-induced lymphangiogenesis.
    8. by preventing binding of Etk/Bmx to PAR(1) -C-tail, hPar1 oncogenic properties are abrogated
      Title: Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
    10. high expression of Etk occurs in 74.6% of SCLC cases, but only in 40% of NSCLC cases, and there is marked difference in the expression levels of Bcl-2, Bcl-X(L) and p53 between Etk-positive and Etk-negative SCLC cases
      Title: Non-receptor tyrosine kinase Etk is involved in the apoptosis of small cell lung cancer cells.
    Submit: New GeneRIF Correction See all (24)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001712.1     BIND  PubMed BMX interacts with PtdIns(3,4,5)P3. 
    P51813 Q06187 BTK    HPRD  PubMed  
    P51813 P42574 CASP3    HPRD  PubMed  
    P51813 Q03135 CAV1    HPRD  PubMed  
    P51813 Q08881 ITK    HPRD  PubMed  
    P51813 P35968 KDR    HPRD  PubMed  
    P51813 Q13153 PAK1    HPRD  PubMed  
    P51813 Q05397 PTK2    HPRD  PubMed  
    P51813 Q16825 PTPN21    HPRD  PubMed  
    P51813 P62834 RAP1A    HPRD  PubMed  
    P51813 Q96T51 RUFY1    HPRD  PubMed  
    P51813 Q8WXA3 RUFY2    HPRD  PubMed  
    P51813 P12931 SRC    HPRD  PubMed  
    P51813 P42224 STAT1    HPRD  PubMed  
    P51813 P40763 STAT3    HPRD  PubMed  
    P51813 P42229 STAT5A    HPRD  PubMed  
    P51813 P42680 TEC    HPRD  PubMed  
    P51813 P20333 TNFRSF1B    HPRD  PubMed  
    BioGRID:107128 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107128 BioGRID:107305 CAV1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107128 BioGRID:111095 PAK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107128 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107128 BioGRID:116280 PTPN21    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107128 BioGRID:123193 RUFY1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:107128 BioGRID:120809 RUFY2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107128 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107128 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107128 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
      Angiopoietin receptor Tie2-mediated signaling
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by focal adhesion kinase, organism-specific biosystem
      Signaling events mediated by focal adhesion kinase

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    mesoderm development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    cytoplasmic tyrosine-protein kinase BMX
    Names
    cytoplasmic tyrosine-protein kinase BMX
    NTK38 tyrosine kinase
    Etk/Bmx cytosolic tyrosine kinase
    epithelial and endothelial tyrosine kinase
    bone marrow tyrosine kinase gene in chromosome X protein
    NP_001712.1
    NP_975010.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013227.1 RefSeqGene

      Range
      5001..60753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001721.6 → NP_001712.1  cytoplasmic tyrosine-protein kinase BMX

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF045459, BC016652, BQ226991
      Consensus CDS
      CCDS14168.1
      UniProtKB/Swiss-Prot
      P51813
      Related
      ENSP00000340082, OTTHUMP00000022964, ENST00000342014, OTTHUMT00000055873
      Conserved Domains (5) summary
      cl02465
      Location:113 – 148
      Blast Score: 172
      BTK; BTK motif
      cd05113
      Location:412 – 667
      Blast Score: 1328
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd01238
      Location:6 – 109
      Blast Score: 374
      PH_Tec; Tec pleckstrin homology (PH) domain
      cd10399
      Location:290 – 394
      Blast Score: 542
      SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx
      pfam07714
      Location:417 – 666
      Blast Score: 1030
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_203281.2 → NP_975010.1  cytoplasmic tyrosine-protein kinase BMX

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript.
      Source sequence(s)
      AF045459, BC016652, BP236451, X83107
      Consensus CDS
      CCDS14168.1
      UniProtKB/Swiss-Prot
      P51813
      Related
      ENSP00000308774, OTTHUMP00000022966, ENST00000348343, OTTHUMT00000055878
      Conserved Domains (5) summary
      cl02465
      Location:113 – 148
      Blast Score: 172
      BTK; BTK motif
      cd05113
      Location:412 – 667
      Blast Score: 1328
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd01238
      Location:6 – 109
      Blast Score: 374
      PH_Tec; Tec pleckstrin homology (PH) domain
      cd10399
      Location:290 – 394
      Blast Score: 542
      SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx
      pfam07714
      Location:417 – 666
      Blast Score: 1030
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      15518900..15574652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      13280437..13329298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC097625.11 (80213..135913) None
    genomic CH471074.1 EAW98889.1
      EAW98890.1
    mRNA AF045459.1 AAC08966.1
    mRNA AK291824.1 BAF84513.1
    mRNA AK313568.1 BAG36341.1
    mRNA BC016652.2 AAH16652.1
    mRNA BP236451.1 None
    mRNA BQ226991.1 None
    mRNA CB998198.1 None
    mRNA U08341.1 AAA17744.1
    mRNA X83107.1 CAA58169.1
    other-genetic DQ891059.2 ABM81985.1
    other-genetic DQ896814.2 ABM87813.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51813.1 GenPept UniProtKB/Swiss-Prot:P51813
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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