Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [ Homo sapiens (human) ]

    Gene ID: 4775, updated on 14-May-2013
    Official Symbol
    NFATC3provided by HGNC
    Official Full Name
    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3provided by HGNC
    Primary source
    HGNC:7777
    See related
    Ensembl:ENSG00000072736; HPRD:04077; MIM:602698; Vega:OTTHUMG00000137555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NFAT4; NFATX
    Summary
    The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]
    Location :
    16q22.2
    Sequence :
    Chromosome: 16; NC_000016.9 (68119269..68263162)
    See NFATC3 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100131303 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 Neighboring gene dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene phospholipase A2, group XV Neighboring gene solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 Neighboring gene solute carrier family 7, member 6 opposite strand

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Dynamic response diversity of NFAT isoforms in individual living cells. Yissachar N, et al. Mol Cell, 2013 Jan 24. PMID 23219532.
    2. Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons. Ulrich JD, et al. J Biol Chem, 2012 Nov 2. PMID 22977251.
    3. Aβ-induced Ca(2+) influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals. Jin SM, et al. Biochem Biophys Res Commun, 2012 Aug 31. PMID 22846573.
    4. Cooperative roles of NF-κB and NFAT4 in polyomavirus JC regulation at the KB control element. Wollebo HS, et al. Virology, 2012 Oct 10. PMID 22749879.
    5. Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1. Gonzalez-Hernandez MJ, et al. J Virol, 2012 Aug. PMID 22593154.

    See all (48) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The closely related transcription factors NFAT1 and NFAT4 possess distinct nuclear localization dynamics in response to cell stimulation.
      Title: Dynamic response diversity of NFAT isoforms in individual living cells.
    2. Data indicate that NFATc3 undergoes rapid dephosphorylation and nuclear translocation that are essentially complete within 20 min, although NFATc4 remains phosphorylated and localized to the cytosol.
      Title: Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.
    3. Abeta-activated NFAT4 proteins were associated with astrocytic BACE1 gene expression via direct interaction with the BACE1 promoter region.
      Title: Aβ-induced Ca(2+) influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals.
    4. The authors report that NFAT4 and NF-kappaB interact at the KB element to co-operatively activate both human polyomavirus JC early and late transcription and viral DNA replication.
      Title: Cooperative roles of NF-κB and NFAT4 in polyomavirus JC regulation at the KB control element.
    5. NFATc3 is specifically required for IL2 and cyclooxygenase-2 (COX2) gene expression in T cells and for T-cell proliferation and NFATc3 regulates COX2 in endothelial cells
      Title: NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    8. CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway
      Title: CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.
    9. NFAT and MyoD cooperation regulates myogenin expression and myogenesis
      Title: Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis.
    10. transactivation activity and role in inducing differentiation of CD4(+)CD8(+) T cells
      Title: A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells.
    Submit: New GeneRIF Correction See all (14)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation PubMed
    env Using either anti-CD4 monoclonal antibodies or HIV-1 gp120 binding to CD4 reveals a common epitope-specific activation of both the HIV-1 LTR and of the transcription factors NF-kappa B and NF-AT PubMed
    Tat, p14 tat The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes PubMed
    tat Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2 PubMed
    tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT PubMed
    tat HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR PubMed
    tat HIV-1 Tat enhances IL-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif PubMed
    Vpr, p15 vpr HIV-1 Vpr upregulates NFAT-directed gene expression PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    Q12968 P48729 CSNK1A1    HPRD  PubMed  
    Q12968 P01100 FOS    HPRD  PubMed  
    Q12968 P45984 MAPK9    HPRD  PubMed  
    Q12968 Q15361 TTF1    HPRD  PubMed  
    BioGRID:110848 BioGRID:107456 CDK6    BioGRID  PubMed Biochemical Activity 
    BioGRID:110848 BioGRID:111585 MAPK8    BioGRID  PubMed Two-hybrid 
    BioGRID:110848 BioGRID:111587 MAPK9    BioGRID  PubMed Two-hybrid 
    BioGRID:110848 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110848 BioGRID:116982 SIRT3    BioGRID  PubMed Positive Genetic 
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
      Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem
      Calcium signaling in the CD4+ TCR pathway
    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Heart Development, organism-specific biosystem (from WikiPathways)
      Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
      Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
      Validated transcriptional targets of AP1 family members Fra1 and Fra2
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Markers

    Genotypes

    Potential readthrough

    Included gene: DUS2L

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cellular respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    patterning of blood vessels IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    nuclear factor of activated T-cells, cytoplasmic 3
    Names
    nuclear factor of activated T-cells, cytoplasmic 3
    NF-ATc3
    T cell transcription factor NFAT4
    nuclear factor of activated T-cells c3 isoform IE-Xa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029147.1 RefSeqGene

      Range
      5001..148894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004555.3 → NP_004546.1  nuclear factor of activated T-cells, cytoplasmic 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional segment in the coding region, which causes a frameshift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC020978, BU849493, CA418693, L41067
      Consensus CDS
      CCDS10862.1
      UniProtKB/TrEMBL
      B5B2S0
      UniProtKB/Swiss-Prot
      Q12968
      Related
      ENSP00000331324, OTTHUMP00000174862, ENST00000329524, OTTHUMT00000268891
      Conserved Domains (2) summary
      cd01178
      Location:599 – 699
      Blast Score: 440
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      cd07881
      Location:421 – 594
      Blast Score: 960
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

    2. NM_173163.2 → NP_775186.1  nuclear factor of activated T-cells, cytoplasmic 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional segment in the coding region, which causes a frameshift, compared to variant 1. The resulting isoform (3) contains a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC020978, BU849493, CA418693, L41067, U85429
      Consensus CDS
      CCDS10861.1
      UniProtKB/Swiss-Prot
      Q12968
      Related
      ENSP00000264008, OTTHUMP00000174860, ENST00000349223, OTTHUMT00000268889
      Conserved Domains (2) summary
      cd01178
      Location:599 – 699
      Blast Score: 441
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      cd07881
      Location:421 – 594
      Blast Score: 961
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

    3. NM_173165.2 → NP_775188.1  nuclear factor of activated T-cells, cytoplasmic 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC020978, BC001050, BU849493, CA418693
      Consensus CDS
      CCDS10860.1
      UniProtKB/TrEMBL
      B5B2S1
      UniProtKB/Swiss-Prot
      Q12968
      Related
      ENSP00000300659, OTTHUMP00000174861, ENST00000346183, OTTHUMT00000268890
      Conserved Domains (2) summary
      cd01178
      Location:599 – 699
      Blast Score: 441
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      cd07881
      Location:421 – 594
      Blast Score: 959
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p10 Primary Assembly

      Range
      68119269..68263162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      53992420..54136266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018927.1 Alternate CHM1_1.0

      Range
      69125503..69269648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173164.1: Suppressed sequence

      Description
      NM_173164.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01025477.1 (18054..72049) None
    genomic ABBA01025478.1 None
    genomic ABBA01025479.1 None
    genomic ABBA01025480.1 None
    genomic ABBA01025481.1 None
    genomic AC020978.10 (111815..140936) None
    genomic AC130462.3 (76946..191594) None
    genomic AMYH01007755.1 (128..27050) None
    genomic AMYH01007756.1 None
    genomic CH471092.1 EAW83210.1
      EAW83211.1
      EAW83212.1
      EAW83213.1
    mRNA AB209824.1 BAD93061.1
    mRNA AK057574.1 None
    mRNA AK290370.1 BAF83059.1
    mRNA BC001050.2 AAH01050.1
    mRNA BE350846.1 None
    mRNA BU849493.1 None
    mRNA CA418693.1 None
    mRNA EU887605.1 ACG55625.1
    mRNA EU887606.1 ACG55626.1
    mRNA EU887607.1 ACG55627.1
    mRNA EU887608.1 ACG55628.1
    mRNA EU887609.1 ACG55629.1
    mRNA EU887610.1 ACG55630.1
    mRNA EU887611.1 ACG55631.1
    mRNA EU887612.1 ACG55632.1
    mRNA EU887613.1 ACG55633.1
    mRNA EU887614.1 ACG55634.1
    mRNA EU887615.1 ACG55635.1
    mRNA EU887616.1 ACG55636.1
    mRNA EU887617.1 ACG55637.1
    mRNA EU887618.1 ACG55638.1
    mRNA EU887619.1 ACG55639.1
    mRNA EU887620.1 ACG55640.1
    mRNA EU887621.1 ACG55641.1
    mRNA EU887622.1 ACG55642.1
    mRNA EU887623.1 ACG55643.1
    mRNA EU887624.1 ACG55644.1
    mRNA EU887625.1 ACG55645.1
    mRNA L41067.1 AAA79174.1
    mRNA U14510.1 AAA86308.1
    mRNA U85428.1 AAB46595.1
    mRNA U85429.1 AAB46596.1
    mRNA U85430.1 AAB46597.1
    other-genetic DQ895384.2 ABM86310.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12968.1 GenPept UniProtKB/Swiss-Prot:Q12968

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...