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    FASLG Fas ligand (TNF superfamily, member 6) [ Homo sapiens ]

    Gene ID: 356, updated on 19-May-2012
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    Summary

    Official Symbol
    FASLGprovided by HGNC
    Official Full Name
    Fas ligand (TNF superfamily, member 6)provided by HGNC
    Primary source
    HGNC:11936
    See related
    Ensembl:ENSG00000117560; HPRD:00610; MIM:134638; Vega:OTTHUMG00000034841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1
    Summary
    The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1q23
    Sequence :
    Chromosome: 1; NC_000001.10 (172628185..172636013)
    See FASLG in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 105 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C Neighboring gene chromosome 1 open reading frame 9 Neighboring gene solute carrier family 25, member 38 pseudogene 1 Neighboring gene tumor necrosis factor (ligand) superfamily, member 18

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Underlying mechanisms of cAMP- and glucocorticoid-mediated inhibition of FasL expression in activation-induced cell death. Liberman AC, et al. Mol Immunol, 2012 Apr. PMID 22341864.
    2. Circulating CD95-ligand as a potential prognostic marker for recurrence in patients with synchronous colorectal liver metastases. Hoogwater FJ, et al. Anticancer Res, 2011 Dec. PMID 22199323.
    3. High expression of Fas ligand on cord blood dendritic cells: a possible immunoregulatory mechanism after cord blood transplantation. Naderi N, et al. Transplant Proc, 2011 Dec. PMID 22172872.
    4. Functional polymorphisms in FAS/FASL system contribute to the risk of occurrence but not progression of gastric cardiac adenocarcinoma. Zhang W, et al. Hepatogastroenterology, 2012 Jan-Feb. PMID 21940365.
    5. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis. Yao SQ, et al. Apoptosis, 2011 Dec. PMID 21910009.

    See all (449) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Functional polymorphisms in the apoptotic pathway genes FAS and FASL may significantly contribute to the occurrence of gastric cardia adenocarcinoma.
      Title: Functional polymorphisms in FAS/FASL system contribute to the risk of occurrence but not progression of gastric cardiac adenocarcinoma.
    2. Our results suggest that the chromatinization status of the FasL promoter may function as a molecular switch, controlling cAMP and glucocorticoid responsiveness in t-cells
      Title: Underlying mechanisms of cAMP- and glucocorticoid-mediated inhibition of FasL expression in activation-induced cell death.
    3. Report high expression of Fas ligand on cord blood dendritic cells which may reduce severity of graft-versus-host disease after cord blood transplantation.
      Title: High expression of Fas ligand on cord blood dendritic cells: a possible immunoregulatory mechanism after cord blood transplantation.
    4. SOD coenzyme can effectively regulate Fas/FasL signal transduction and block apoptosis of alveolar macrophages from pneumoconiosis patients.
      Title: [Regulation role of superoxide dismutase coenzyme on Fas/FasL signal transduction and apoptosis in alveolar macrophages of pneumoconiosis patients].
    5. This study determines if Fas/FasL regulates E. coli-induced human monocyte line U937 cell apoptosis.
      Title: Escherichia coli induces apoptosis in human monocytic U937 cells through the Fas/FasL signaling pathway.
    6. CD95-ligand may have a role in recurrence in patients with synchronous colorectal liver metastases
      Title: Circulating CD95-ligand as a potential prognostic marker for recurrence in patients with synchronous colorectal liver metastases.
    7. Fas and FasL mediated alveolar macrophage apoptosis in human silicosis.
      Title: Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis.
    8. Up-regulation of FasL expression and decrease of TIL apoptosis in Epstein-Barr virus-associated gastric carcinoma may facilitate the escape of tumor cells from the host immunosurveillance.
      Title: Correlation of Fas/FasL expression to cell apoptosis in Epstein-Barr virus-associated gastric carcinoma.
    9. The activation of Fas/FasL pathway may play an important role in the K562 cell apoptosis induced by diallyl disulfide.
      Title: [Mechanism of Fas/FasL signal transduction pathway in K562 cell apoptosis induced by diallyl disulfide].
    10. FAS-1377, FAS-670 and FASL-844 polymorphisms are not susceptible factors of silicosis.
      Title: [Polymorphisms of FAS and FASL genes and susceptibility of silicosis].
    Submit: New GeneRIF Correction See all (334)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Multiple common variants for celiac disease influencing immune gene expression.

    Systemic lupus erythematosus, susceptibility

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Binding of HIV-1 gp120 to CD4 downregulates Bcl-2 protein in CD4+ T lymphocytes and facilitates Fas/Fas-ligand triggered apoptosis; addition of IL-2 rescues CD4+ T cells from CD4/gp120-induced Bcl-2 downmodulation and apoptosis induction PubMed
    env At high concentrations, HIV-1 gp120 enhances expression of Fas and FasL and promotes apoptosis in human mesangial cells (HMC) PubMed
    env Preincubation of T cells with HIV-1 gp120 accelerates the apoptosis observed during CD2-pathway stimulation of the T cells; this process is mediated by Fas/Fas ligand interaction and related to an increased induction of Fas ligand mRNA by gp120 PubMed
    env Depletion of CD4 and CD8 T cells by HIV-1 gp120 is mediated by Fas ligand PubMed
    env Apoptosis induced by HIV-1 gp120/CD4 cross-linking in Th1 clones is inhibited by anti-CD95 or anti-CD95L neutralizing monoclonal antibodies, as well as by a specific interleukin-1 beta converting enzyme (ICE) inhibitor PubMed
    Nef nef HIV-1 Nef upregulates Fas ligand expression in gene-transfected hepatic cells from rat liver allografts PubMed
    nef Upregulation of Fas ligand by HIV-1 Nef is mediated through a direct interaction of Nef with the T cell Receptor zeta chain and binding of Nef to the Nef-associated kinase (NAK/p62) PubMed
    nef The PxxP domain of HIV-1 Nef is required for upregulation of Fas ligand transcription and p38 MAPK activation by Nef PubMed
    nef Experiments using a dominant-negative isoform of p38 MAPK, p38 siRNA, and inhibitors of p38 activation indicate that p38 is required for HIV-1 Nef-induced Fas ligand upregulation PubMed
    nef Increased expression of Fas ligand was observed in CD4(+) and CD8(+) T cells from Transgenic (Tg) mice expressing HIV-1 Nef compared to that of non-Tg mice PubMed
    nef HIV-1 Nef sensitizes CD4+ T lymphoid cells to apoptosis by upregulating the expression of both Fas and Fas ligand, an effect that requires the PxxP motif (amino acids 72-75) in the core region of Nef PubMed
    Tat tat HIV-1 Tat has a synergistic effect on Cryptosporidium parvum-induced cholangiocyte apoptosis via a paracrine-mediated, FasL-dependent mechanism PubMed
    tat HIV-1 Tat upregulates FasL expression by enhancing Egr-dependent and NF-kappaB mediated transactivation of the FasL promoter PubMed
    tat HIV-1 Tat sensitizes T cells to CD95 mediated apoptosis through the upregulation of CD95 ligand and caspase 8 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000001.8 NP_000390.2 EGR2    BIND  PubMed EGR2 interacts with p-FasL (FasL promoter). 
    NC_000001.8 NP_004421.2 EGR3    BIND  PubMed EGR3 interacts with p-FasL (FasL promoter). 
    NP_000630.1 AAK49824.1 FNBP1    BIND  PubMed CD95L interacts with FBP17. 
    NP_000630.1 NP_002077.1 GRB2    BIND  PubMed CD95L interacts with Grb2. 
    NP_000630.1 NP_009160.1 PACSIN2    BIND  PubMed CD95L interacts with PACSIN2. 
    P48023 O00213 APBB1    HPRD  PubMed  
    P48023 Q9UER7 DAXX    HPRD  PubMed  
    P48023 P11532 DMD    HPRD  PubMed  
    P48023 P15311 EZR    HPRD  PubMed  
    P48023 Q13158 FADD    HPRD  PubMed  
    P48023 P25445 FAS    HPRD  PubMed  
    P48023 P02751 FN1    HPRD  PubMed  
    P48023 Q96RU3 FNBP1    HPRD  PubMed  
    P48023 P06241 FYN    HPRD  PubMed  
    P48023 Q13588 GRAP    HPRD  PubMed  
    P48023 O75791 GRAP2    HPRD  PubMed  
    P48023 P62993 GRB2    HPRD  PubMed  
    P48023 P06239 LCK    HPRD  PubMed  
    P48023 Q03164 MLL    HPRD  PubMed  
    P48023 P09237 MMP7    HPRD  PubMed  
    P48023 P14598 NCF1    HPRD  PubMed  
    P48023 P16333 NCK1    HPRD  PubMed  
    P48023 Q9UNF0 PACSIN2    HPRD  PubMed  
    P48023 O75340 PDCD6    HPRD  PubMed  
    P48023 P27986 PIK3R1    HPRD  PubMed  
    P48023 Q13526 PIN1    HPRD  PubMed  
    P48023 O75400 PRPF40A    HPRD  PubMed  
    P48023 O43586 PSTPIP1    HPRD  PubMed  
    P48023 Q12923 PTPN13    HPRD  PubMed  
    P48023 P12931 SRC    HPRD  PubMed  
    P48023 P63165 SUMO1    HPRD  PubMed  
    P48023 O95407 TNFRSF6B    HPRD  PubMed  
    BioGRID:106852 BioGRID:106889 ARHGDIA    BioGRID  PubMed Co-purification 
    BioGRID:106852 BioGRID:107106 BID    BioGRID  PubMed Co-purification 
    BioGRID:106852 BioGRID:107293 CASP10    BioGRID  PubMed Co-purification 
    BioGRID:106852 BioGRID:107291 CASP8    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:106852 BioGRID:113271 EZR    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:106852 BioGRID:114302 FADD    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:106852 BioGRID:106851 FAS    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:106852 BioGRID:108559 FGR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:108621 FN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:116686 FNBP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106852 BioGRID:108810 FYN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:115973 GRAP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:114799 GRAP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106852 BioGRID:110124 LCK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:110245 LYN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:111585 MAPK8    BioGRID  PubMed Co-purification 
    BioGRID:106852 BioGRID:110459 MMP7    BioGRID  PubMed Biochemical Activity 
    BioGRID:106852 BioGRID:110584 MSN    BioGRID  PubMed Co-purification 
    BioGRID:106852 BioGRID:110770 NCK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:116413 PACSIN2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106852 BioGRID:111747 PTPN13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106852 BioGRID:106880 RHOA    BioGRID  PubMed Co-purification 
    BioGRID:106852 BioGRID:113188 SUMO1    BioGRID  PubMed Two-hybrid 
    BioGRID:106852 BioGRID:114323 TNFRSF10B    BioGRID  PubMed Co-purification 
    BioGRID:106852 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:106852 BioGRID:114301 TNFRSF6B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106852 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of Pro-Caspase 8, organism-specific biosystem (from REACTOME)
      Activation of Pro-Caspase 8, organism-specific biosystemPro-caspase-8 is known to be activated by various factors in response to a variety of external and internal stimuli. These include FAS, TRAIL, and TNF.
    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
      Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
      Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem
      Calcium signaling in the CD4+ TCR pathway
    • Caspase-8 is formed from procaspase-8, organism-specific biosystem (from REACTOME)
      Caspase-8 is formed from procaspase-8, organism-specific biosystemCaspase-8 is formed from the precursor protein pro-Caspase-8 as a cleavage product.
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • Extrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Extrinsic Pathway for Apoptosis, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • FasL/ CD95L signaling, organism-specific biosystem (from REACTOME)
      FasL/ CD95L signaling, organism-specific biosystemThe Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the t...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL2 signaling events mediated by STAT5, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by STAT5, organism-specific biosystem
      IL2 signaling events mediated by STAT5
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    activation of pro-apoptotic gene products TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosomal lumen acidification IEA
    Inferred from Electronic Annotation
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by extracellular signals IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    induction of apoptosis by extracellular signals TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of necroptosis by extracellular signals IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    induction of necroptosis of activated-T cells IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    inflammatory cell apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    necrotic cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB cascade IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of neuron apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    retinal cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic membrane-bounded vesicle lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    tumor necrosis factor ligand superfamily member 6
    Names
    tumor necrosis factor ligand superfamily member 6
    APTL
    CD95 ligand
    fas antigen ligand
    apoptosis antigen ligand
    apoptosis (APO-1) antigen ligand 1
    tumor necrosis factor (ligand) superfamily, member 6
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007269.1 RefSeqGene

      Range
      5001..12829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_58

    mRNA and Protein(s)

    1. NM_000639.1 → NP_000630.1  tumor necrosis factor ligand superfamily member 6

      Status: REVIEWED

      Source sequence(s)
      X89102
      Consensus CDS
      CCDS1304.1
      UniProtKB/Swiss-Prot
      P48023
      UniProtKB/TrEMBL
      Q53ZZ1
      Related
      ENSP00000356694, OTTHUMP00000032708, ENST00000367721, OTTHUMT00000084276
      Conserved Domains (1) summary
      cd00184
      Location:146 – 279
      Blast Score: 338
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      172628185..172636013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      143852795..143860622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB013303.1 BAA32542.1
    genomic CH471067.1 EAW90935.1
      EAW90936.1
    genomic EF064739.1 ABK41922.1
    genomic GN083421.1 CAX86839.1
    genomic HI179174.1 CBX53895.1
    genomic JA362609.1 CCA94585.1
    genomic Z96050.1 CAB09424.1
    mRNA AF288573.1 AAG60017.1
    mRNA AK314874.1 BAG37389.1
    mRNA AY225406.1 AAO43991.1
    mRNA AY858799.1 AAX49569.1
    mRNA BC017502.1 AAH17502.1
    mRNA D38122.1 BAA07320.1
    mRNA U08137.1 AAC50071.1
    mRNA U11821.1 AAC50124.1
    mRNA X89102.1 CAA61474.1
    other-genetic DQ893466.2 ABM84392.1
    other-genetic DQ896147.2 ABM87146.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48023.1 GenPept UniProtKB/Swiss-Prot:P48023
    Q0VHD7 GenPept UniProtKB/TrEMBL:Q0VHD7
    Q53ZZ1 GenPept UniProtKB/TrEMBL:Q53ZZ1
    Help top of page

    Additional Links

    Additional Links

    • Epigenomics
    • MIM 134638
    • FASLGbase: Mutation registry for Autoimmune lymphoproliferative syndrome, type 1B (ALPS1B) (previously known as TNFSF6base) FASLGbase/
    • PharmGKB PA56
    • GeneTests for MIM: 134638
    • CCHMC - Human Genetics Mutation Database FASLG
    • Resource of Asian Primary Immunodeficiency Diseases (RAPID) AGID_57
    • UCSC UCSC
    • UniGene Hs.2007

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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