HSPA2 heat shock 70kDa protein 2 [Homo sapiens] - Gene

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Summary

Official Symbol: HSPA2provided by HGNC
Official Full Name: heat shock 70kDa protein 2provided by HGNC
Primary source: HGNC:5235
See related: Ensembl:ENSG00000126803; HPRD:07174; MIM:140560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSP70-2; HSP70-3

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Genomic context

Location :: 14q24.1

Sequence :: Chromosome: 14; NC_000014.8 (65007186..65009955)

See HSPA2 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results clearly show that certain human tissues constitutively express varying levels of HSPA2 protein in a highly differentiated way.
Title: Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study.
GDF15, HSPA2, TMEFF2, and VIM were identified as epigenetic biomarkers for Bladder cancer.
Title: Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients.
results indicate that the there may be no association of the HSP70-2 gene polymorphism with ankylosing spondylitis in Chinese Han population
Title: [The heat shock protein 70-2 gene +1267(A/G) polymorphism and susceptibility to ankylosing spondylitis in Chinese Han population].
The HspA2, like Hsp70 protein, can be involved in protecting nucleoli and centrosomes integrity in cancer cells subjected to heat shock and, possibly, other cellular stressors.
Title: The HspA2 protein localizes in nucleoli and centrosomes of heat shocked cancer cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: HLA-association of serum levels of natural antibodies.
Delineation of the minimal promoter is a basic step toward identifying the cis and trans elements involved in the regulation of the HSPA2 gene expression, especially in cancer cells.
Title: The structural and functional analysis of the human HSPA2 gene promoter region.
This is the first report on HSPA2 gene expression in ejaculated spermatozoa from adolescents and its relationship with varicocele pathology.
Title: Expression of the HSPA2 gene in ejaculated spermatozoa from adolescents with and without varicocele.
The HspA2 gene was down-regulated in sperm from infertile men with idiopathic oligoteratozoospermia, suggesting that such anomalies of gene expression might be associated with pathogenesis in some subtypes of male infertility.
Title: Oligozoospermia and heat-shock protein expression in ejaculated spermatozoa.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity	PubMed
	env	The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein	PubMed
Pr55(Gag)	gag	Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins	PubMed
	gag	Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag	PubMed
Tat	tat	Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation	PubMed
Vpr	vpr	HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha	PubMed
matrix	gag	Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P54652	P06493	CDK1	HPRD	PubMed
P54652	Q01844	EWSR1	HPRD	PubMed
P54652	HSPBP1	HSPBP1	HPRD	PubMed
P54652	Q99759	MAP3K3	HPRD	PubMed
P54652	P50222	MEOX2	HPRD	PubMed
BioGRID:109538	BioGRID:113911	BAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109538	BioGRID:107459	CDK9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109538	BioGRID:109420	HNRNPA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109538	BioGRID:117168	HSPBP1	BioGRID	PubMed	Two-hybrid
BioGRID:109538	BioGRID:121122	MEPCE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109538	BioGRID:115761	NCOA2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109538	BioGRID:106652	PARP1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:109538	BioGRID:115350	PARP2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:109538	BioGRID:111657	PSMA3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109538	BioGRID:122136	RFWD2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109538	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109538	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
glycolipid binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
unfolded protein binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
male meiosis	TAS Traceable Author Statement more info	PubMed
male meiosis I	IEA Inferred from Electronic Annotation more info
positive regulation of cyclin-dependent protein kinase activity involved in G2/M	IEA Inferred from Electronic Annotation more info
positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
response to stress	IEA Inferred from Electronic Annotation more info
response to unfolded protein	TAS Traceable Author Statement more info	PubMed
spermatid development	IEA Inferred from Electronic Annotation more info
synaptonemal complex disassembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
male germ cell nucleus	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info
synaptonemal complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: heat shock-related 70 kDa protein 2

Names: heat shock-related 70 kDa protein 2; heat shock 70kD protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021979.3 → NP_068814.2 heat shock-related 70 kDa protein 2

Status: VALIDATED

Source sequence(s)

BC001752, BC036107, BG772858, BI461827, CD300159, CN356507, DB042367

Consensus CDS

CCDS9766.1

UniProtKB/Swiss-Prot

P54652

Related

ENSP00000247207, ENST00000247207

Conserved Domains (1) summary

PTZ00009
Location:2 – 615
Blast Score: 2694

PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

65007186..65009955

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

45179854..45182623

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL049869.6 (136646..143978)	None
genomic	CH471061.1	EAW80864.1
		EAW80865.1
genomic	DQ489378.1	ABE96830.1
genomic	L26336.1	AAA52698.1
mRNA	AK097824.1	BAG53534.1
mRNA	BC001752.1	AAH01752.1
mRNA	BC034365.1	None
mRNA	BC036107.1	AAH36107.1
mRNA	BG772858.1	None
mRNA	BI461827.1	None
mRNA	BT009815.1	AAP88817.1
mRNA	CD300159.1	None
mRNA	CN356507.1	None
mRNA	DB042367.1	None
other-genetic	DQ892538.2	ABM83464.1
other-genetic	DQ895749.2	ABM86675.1