CXCL12 chemokine (C-X-C motif) ligand 12 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CXCL12provided by HGNC
Official Full Name: chemokine (C-X-C motif) ligand 12provided by HGNC
Primary source: HGNC:10672
See related: Ensembl:ENSG00000107562; HPRD:02904; MIM:600835; Vega:OTTHUMG00000018054
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
Summary: This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Genomic context

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Location :: 10q11.1

Sequence :: Chromosome: 10; NC_000010.10 (44865605..44880545, complement)

See CXCL12 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that melanocytes may have a unique mechanism of migration via SDF1/CXCR7 signaling that is different from that of other cell types.
Title: CXCR7 mediates SDF1-induced melanocyte migration.
SDF-1-3'A confers increased susceptibility to breast cancer and that the E-selectin S128R CC genotype may be related to poorer prognosis.
Title: The impact of the stromal cell-derived factor-1-3'A and E-selectin S128R polymorphisms on breast cancer.
These results indicate that endogenous SDF-1 expression by AML cells plays a role in the autonomous growth of the cells.
Title: Endogenous stromal cell-derived factor-1 (CXCL12) supports autonomous growth of acute myeloid leukemia cells.
SDF-1alpha or MIF affects the metastasis-related behaviors of CXCR4-expressing colon cancer cells.
Title: Stromal cell-derived factor-1α and macrophage migration-inhibitory factor induce metastatic behavior in CXCR4-expressing colon cancer cells.
High expression of SDF-1 is associated with renal cell carcinoma.
Title: High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma.
we discuss the manner in which CXCR4 signaling can regulate the development of different structures in the central and peripheral nervous systems--{REVIEW}
Title: CXCL12 signaling in the development of the nervous system.
The expression of SDF-1 and CXCR7 were positively correlated with lymph node metastasis in papillary thyroid carcinoma.
Title: Expression of stromal cell-derived factor 1 and CXCR7 in papillary thyroid carcinoma.
SDF-1 and CXCR4 protein are highly expressed in laryngocarcinoma and in metastatic lymph node tissue. Expression is correlated with lymph node metastasis, clinical stage and pathological grading.
Title: [The expression and significance of SDF-1/CXCR4 biological axis in laryngeal squamous cell carcinoma and lymph node metastasize].
The HMGB1-CXCL12 heterocomplex constitutes a specific target that may hold promise for the treatment of several pathologies.
Title: HMGB1 and leukocyte migration during trauma and sterile inflammation.
Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12
Title: Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12.

Submit: New GeneRIF Correction See all (621)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Congenital human immunodeficiency virus

MIM: 609423

Genetic Testing Registry

NHGRI GWAS Catalog

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.

Genomewide association analysis of coronary artery disease.

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	CXCL12 and HIV-1 gp120 modulate the excitability of Cajal-Retzius cells in opposite directions	PubMed
	env	HIV-1 gp120 abnormally interferes with SDF-1-mediated T cell chemotaxis and cell migration in resting CD4+ T Cells	PubMed
	env	CXCL12 variant proteins exhibits the various levels of inhibition of HIV-1 X4 Env-mediated fusion. The strongest and weakest inhibition activities among the variant proteins in the X4 Env fusion assay are CXCL12gamma and CXCL12delta, respectively	PubMed
	env	The ability of HIV-1 gp120 to inhibit SDF-1a-induced chemotaxis is mediated by the CD4 receptor and Lck signaling	PubMed
	env	The entry of T cell-tropic HIV-1 isolates into cells is blocked by SDF-1, which interacts with the HIV-1 gp120 coreceptor CXCR4	PubMed
	env	HIV-1 gp120 from a T-cell-tropic virus causes CD4-dependent antagonism of CXCR4 response to SDF-1alpha, whereas gp120 from macrophage-tropic viruses causes CD4-dependent antagonism of CCR5 response to MIP-1alpha	PubMed
	env	RANTES, stromal derived factor-1alpha (SDF-1alpha), macrophage-derived chemokine (MDC), and their combination attenuate HIV-1 gp120-induced food and water intake decrease in rats	PubMed
	env	Apoptosis of CD8+ T cells is mediated by the interaction between TNF-alpha bound to the membrane of macrophages (mbTNF) and a receptor on CD8+ T cells (TNF-receptor II, or TNFRII), which is upregulated by treatment with recombinant HIV-1 gp120 or SDF-1	PubMed
	env	The death rate of CD8+ T cells by apoptosis, which is induced by HIV-1 gp120 from CXCR4-tropic HIV strains or by the ligand of the chemokine receptor CXCR4 (SDF-1), increased markedly during HIV infection of peripheral blood mononuclear cells	PubMed
	env	A synthetic peptide domain of the V3 region of HIV-1 gp120 activates the FPRL1 receptor in monocytes and neutrophils and causes reduced response to several chemokines that use multiple cell receptors, including SDF-1alpha and RANTES	PubMed
	env	Chemokines such as fractalkine, macrophage-derived chemokine (MDC), RANTES, and SDF-1alpha are able to block gp120-induced apoptosis of hippocampal neurons; both fractalkine and MDC activate ERK-1/2, while SDF-1alpha activates CREB	PubMed
	env	SDF-1alpha reverses gp120-induced downregulation of CD79b in CD40- and IL-4-activated purified HIV-1 seronegative human peripheral blood B cells	PubMed
	env	CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 proteins inhibit B cell chemotaxis toward CXCL12, CCL20, and CCL21, and gp120-induced p38 MAPK activation is triggered by CCL21 and CCL20	PubMed
	env	The fusion of insulin-like growth factor I (IGF I) with stromal cell-derived factor I or alpha1 proteinase inhibitor has the capacity to compete with the binding of HIV-1 gp120 to CD4 receptor	PubMed
Gag, Pr55	gag	Expression of HIV-1 Gag attenuates SDF-1-mediated downregulation of CXCR4. The effect of Gag is dependent on a TSG101 interacting motif within the C-terminal p6 region of Gag	PubMed
Nef, p27	nef	Disruption of the proline-rich region of HIV-1 Nef inhibits T-cell migration to SDF-1 alpha, suggesting Nef occupies a position in the CXCR4-mediated signaling pathway that is upstream of an SH3-dependent pathway	PubMed
	nef	An intracellular signaling pathway mediated by the binding of SDF-1alpha and CXCR4 is inhibited by Nef in both Jurkat T cells and primary peripheral CD4+ T lymphocytes	PubMed
Tat, p14	tat	HIV-1 Tat tethered to the surface of syndecan-1 expression B-lymphoid cells or of peripheral blood monocytes promotes their transendothelial migration in vitro in response to CXCL12 or CCL5, respectively	PubMed
	tat	HIV-1 Tat increases CXCL12-induced internalization of CXCR4, and the Tat-mediated CXCR4 internalization requires activity of protein kinase C (zeta)	PubMed
	tat	HIV-1 Tat interacts with SDF-1alpha to induce apoptosis in Tat-treated erythroid cells	PubMed
	tat	HIV-1 Tat can inhibit CXCR4-mediated functions by interfering with the chemotactic activity of SDF-1/CXCL12, an effect mediated by Tat amino acids 25-31	PubMed
	tat	HIV-1 Tat induces SDF-1alpha expression in neurons and Tat-mediated neurite outgrowth is blocked by anti-SDF-1alpha antibody, suggesting a role for SDF-1alpha in the neuronal response to HIV in brains of AIDS patients	PubMed
	tat	SDF-1 is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed
	tat	SDF-1alpha stimulates the ability of HIV-1 Tat to transactivate the HIV-1 LTR promoter	PubMed
	tat	HIV-1 Tat competes with SDF-1alpha for binding to CXCR4	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_954637.1	NP_003458.1	CXCR4	BIND	PubMed	CXCR4 interacts with SDF-1-alpha. This interaction was modeled on a demonstrated interaction between human CXCR4 and SDF-1-alpha from an unspecified species.
P48061	P01730	CD4	HPRD	PubMed
P48061	P08311	CTSG	HPRD	PubMed
P48061	P48061	CXCL12	HPRD	PubMed
P48061	P61073	CXCR4	HPRD	PubMed
P48061	P27487	DPP4	HPRD	PubMed
P48061	P08246	ELANE	HPRD	PubMed
P48061	P02751	FN1	HPRD	PubMed
P48061	P08253	MMP2	HPRD	PubMed
BioGRID:112288	BioGRID:112288	CXCL12	BioGRID	PubMed	Co-crystal Structure
BioGRID:112288	BioGRID:113607	CXCR4	BioGRID	PubMed	Co-crystal Structure
BioGRID:112288	BioGRID:115143	DAZAP2	BioGRID	PubMed	Two-hybrid
BioGRID:112288	BioGRID:108621	FN1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112288	BioGRID:111219	PF4	BioGRID	PubMed	Reconstituted Complex
BioGRID:112288	BioGRID:107844	VCAN	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
CXCR4-mediated signaling events, organism-specific biosystem
CXCR4-mediated signaling events
Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
HIF-1-alpha transcription factor network, organism-specific biosystem
HIF-1-alpha transcription factor network
Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
Intestinal immune network for IgA production, conserved biosystem (from KEGG)
Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Leukocyte transendothelial migration, conserved biosystem (from KEGG)
Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-4-mediated signaling events, organism-specific biosystem
Syndecan-4-mediated signaling events

General gene information

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Markers

D10S2188 (e-PCR)
- UniSTS:38915

G30000 (e-PCR)
- UniSTS:77584

D10S1350E (e-PCR)
- UniSTS:151362

G17474 (e-PCR)
- UniSTS:2886

SGC33589 (e-PCR)
- UniSTS:81058

RH44690 (e-PCR)
- UniSTS:26280

SGC33789 (e-PCR)
- UniSTS:54469

RH44662 (e-PCR)
- UniSTS:62715

Genotypes

See CXCL12 SNP Geneview Report
See CXCL12 SNP Genotype Report
See CXCL12 SNP Variation Viewer Report

Homology

Homologs of the CXCL12 gene: The CXCL12 gene is conserved in chimpanzee, Rhesus monkey, dog, and cow.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
CXCR chemokine receptor binding	IDA Inferred from Direct Assay more info
chemokine activity	IEA Inferred from Electronic Annotation more info
growth factor activity	IEA Inferred from Electronic Annotation more info
receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
T cell proliferation	IEA Inferred from Electronic Annotation more info
ameboidal cell migration	IEA Inferred from Electronic Annotation more info
blood circulation	TAS Traceable Author Statement more info	PubMed
brain development	IEA Inferred from Electronic Annotation more info
cell adhesion	TAS Traceable Author Statement more info	PubMed
cellular calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed
chemokine-mediated signaling pathway	IDA Inferred from Direct Assay more info
chemotaxis	TAS Traceable Author Statement more info	PubMed
germ cell development	IEA Inferred from Electronic Annotation more info
germ cell migration	IEA Inferred from Electronic Annotation more info
immune response	IEA Inferred from Electronic Annotation more info
induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info
motor neuron axon guidance	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info
negative regulation of leukocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
patterning of blood vessels	IEA Inferred from Electronic Annotation more info
positive regulation of monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
regulation of actin polymerization or depolymerization	TAS Traceable Author Statement more info	PubMed
response to virus	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stromal cell-derived factor 1

Names: stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016861.1 RefSeqGene

Range

5001..19945

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000609.6 → NP_000600.1 stromal cell-derived factor 1 isoform beta precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon, and differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform beta) is longer and has a distinct C-terminus compared to isoform alpha.

Source sequence(s)

AK292628, AL137026, L36033

Consensus CDS

CCDS44373.1

UniProtKB/Swiss-Prot

P48061

Related

ENSP00000363551, OTTHUMP00000019492, ENST00000374429, OTTHUMT00000047738

Conserved Domains (1) summary

cd00273
Location:27 – 88
Blast Score: 129

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
NM_001033886.2 → NP_001029058.1 stromal cell-derived factor 1 isoform gamma precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate exon, and differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform gamma) is longer and has a distinct C-terminus compared to isoform alpha.

Source sequence(s)

AL137026, AY644456, BC031072, DQ345518

Consensus CDS

CCDS31186.1

UniProtKB/Swiss-Prot

P48061

Related

ENSP00000363548, OTTHUMP00000216979, ENST00000374426, OTTHUMT00000358150

Conserved Domains (1) summary

cd00273
Location:27 – 88
Blast Score: 129

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
NM_001178134.1 → NP_001171605.1 stromal cell-derived factor 1 isoform delta precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate segment, which results in a frameshift, compared to variant 1. The resulting protein (isoform delta) is longer and has a distinct C-terminus compared to isoform alpha.

Source sequence(s)

AI092156, DA266752, DQ345517

Consensus CDS

CCDS53527.1

UniProtKB/Swiss-Prot

P48061

Related

ENSP00000379140, OTTHUMP00000216980, ENST00000395794, OTTHUMT00000358151

Conserved Domains (1) summary

cd00273
Location:27 – 88
Blast Score: 135

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
NM_001277990.1 → NP_001264919.1 stromal cell-derived factor 1 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site and an alternate 3'-terminal exon, compared to variant 1. The resulting protein (isoform 5) is longer and has a distinct C-terminus compared to isoform alpha.

Source sequence(s)

AK292628, AL137026, AU120056, L36033

UniProtKB/TrEMBL

H7BYN8
NM_199168.3 → NP_954637.1 stromal cell-derived factor 1 isoform alpha precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the shortest protein (isoform alpha).

Source sequence(s)

AI092156, AL137026, BC031072, BC039893

Consensus CDS

CCDS7207.1

UniProtKB/Swiss-Prot

P48061

Related

ENSP00000339913, OTTHUMP00000019491, ENST00000343575, OTTHUMT00000047737

Conserved Domains (1) summary

cd00273
Location:27 – 88
Blast Score: 128

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p10 Primary Assembly

Range

44865605..44880545, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

41391949..41406899, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018921.1 Alternate CHM1_1.0

Range

44981955..44996867, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01050018.1 (77020..91970)	None
genomic	AL137026.21 (161318..176262)	None
genomic	AMYH01002295.1 (426460..441372)	None
genomic	AY802782.1	AAV49999.1
genomic	CH471160.1	EAW86618.1
		EAW86619.1
		EAW86620.1
		EAW86621.1
genomic	CS131913.1	CAJ21099.1
genomic	CS131917.1	CAJ21100.1
mRNA	AI092156.1	None
mRNA	AJ227905.1	None
mRNA	AK090482.1	BAC03463.1
mRNA	AK124641.1	None
mRNA	AK292628.1	BAF85317.1
mRNA	AK311814.1	BAG34757.1
mRNA	AL713778.1	CAD28539.1
mRNA	AU120056.1	None
mRNA	AW014388.1	None
mRNA	AY644456.1	AAT76437.1
mRNA	AY874118.1	AAW82036.1
mRNA	BC031072.1	None
mRNA	BC039893.1	AAH39893.1
mRNA	BX647204.1	None
mRNA	CD172464.1	None
mRNA	CR450283.1	CAG29279.1
mRNA	DA266752.1	None
mRNA	DQ345517.1	ABC69270.1
mRNA	DQ345518.1	ABC69271.1
mRNA	DQ345519.1	ABC69272.1
mRNA	DQ345520.1	ABC69273.1
mRNA	L36033.1	AAB39332.1
mRNA	L36034.1	AAB39333.1
mRNA	U16752.1	AAA97434.1