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PRDX6 peroxiredoxin 6 [ Homo sapiens (human) ]

Gene ID: 9588, updated on 8-May-2016
Official Symbol
PRDX6provided by HGNC
Official Full Name
peroxiredoxin 6provided by HGNC
Primary source
HGNC:HGNC:16753
See related
Ensembl:ENSG00000117592 HPRD:03817; MIM:602316; Vega:OTTHUMG00000034804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m
Summary
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (173477347..173488807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173446486..173457946)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506023 Neighboring gene centrosomal protein 57kDa pseudogene Neighboring gene uncharacterized LOC101928673 Neighboring gene solute carrier family 9 member C2 (putative) Neighboring gene uncharacterized LOC730159 Neighboring gene uncharacterized LOC105371619 Neighboring gene ankyrin repeat domain 45

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0106, MGC46173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to reactive oxygen species TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic, membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
peroxiredoxin-6
Names
1-Cys PRX
1-Cys peroxiredoxin
24 kDa protein
acidic calcium-independent phospholipase A2
antioxidant protein 2
epididymis secretory sperm binding protein Li 128m
liver 2D page spot 40
non-selenium glutathione peroxidase
red blood cells page spot 12
NP_004896.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004905.2NP_004896.1  peroxiredoxin-6

    See identical proteins and their annotated locations for NP_004896.1

    Status: REVIEWED

    Source sequence(s)
    BC035857
    Consensus CDS
    CCDS1307.1
    UniProtKB/Swiss-Prot
    P30041
    UniProtKB/TrEMBL
    V9HWC7
    Related
    ENSP00000342026, OTTHUMP00000032693, ENST00000340385, OTTHUMT00000084222
    Conserved Domains (2) summary
    COG0450
    Location:5200
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03016
    Location:7222
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    173477347..173488807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    174868919..174880398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)