MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: MMP2provided by HGNC
Official Full Name: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)provided by HGNC
Primary source: HGNC:7166
See related: Ensembl:ENSG00000087245; HPRD:00386; MIM:120360; Vega:OTTHUMG00000133202
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLG4; MONA; CLG4A; TBE-1; MMP-II
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 16q13-q21

Sequence :: Chromosome: 16; NC_000016.9 (55513081..55540586)

See MMP2 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMP-2 over-expression is a poor prognostic factor for survival in patients with colorectal cancer.
Title: Letter to the editor: a meta-analysis of MMP-2 expression on the survival of patients with colorectal cancer.
SphK1 promoting the secretion of MMP-2/9 and uPA via activation of ERK1/2 and suppression of p38 MAPK pathways maybe the molecular mechanisms for its regulation of the malignant behavior of colon cancer cell.
Title: Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.
Temocaprilat bound to the MMP-2 active centre.
Title: Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport.
No correlation was found between pinopodes development stage and MMP2 expressions in endometrium
Title: No correlation between pinopode formation and LIF and MMP2 expression in endometrium during implantation window.
gene polymorphism is associated with advanced-stage endometriosis in Korean women
Title: Association between MMP-2 and TIMP-2 gene polymorphisms and advanced-stage endometriosis in Korean women.
Simvastatin and rosuvastatin significantly and dose-dependently reduced RAS protein, MMP-2/9 and NF-kappaB-p65 expression in tumor cells.
Title: Effects of simvastatin and rosuvastatin on RAS protein, matrix metalloproteinases and NF-κB in lung cancer and in normal pulmonary tissues.
Hypomethylating drug 5-azadC and histone deacetylase inhibitor trichostatin A induced modulations in higher order chromatin organization and in MMP-9 and MMP-2 expression in human HT1080 fibrosarcoma cells.
Title: Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells.
Abnormal expression of MMP-2 and TIMP-1 might play roles in the development of renal fibrosis in chronic antibody-mediated renal graft rejection.
Title: Expression of MMP-2 and TIMP-1 in renal tissue of patients with chronic active antibody-mediated renal graft rejection.
SIRT1 is an important regulator of MMP2 expression, activity, and prostate cancer cell invasion.
Title: SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells.
Abnormal expressions of MMP-2 and TIMP-1 can promote the development of renal fibrosis in chronic active antibody-mediated renal graft rejection.
Title: [Expression of MMP-2 and TIMP-1 in renal tissues of patients with chronic active antibody-mediated renal graft rejection].

Submit: New GeneRIF Correction See all (889)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes	PubMed
	env	Matrix metalloproteinases MMP2 and MMP9 participate in the maturation process of cleavage and activation of IL-1beta based on the intracerebroventricular injection of the HIV-1 envelope glycoprotein gp120	PubMed
Envelope transmembrane glycoprotein gp41	env	Treatment of human glial and neuronal cells with an HIV-1 gp41 peptide (amino acids 583-599) markedly increases the activity of matrix metalloproteinase 2 (MMP-2)	PubMed
Nef, p27	nef	Overexpression of HIV-1 Nef and ALK effect gelatinase activation in astrocytic glioma cells	PubMed
Tat, p14	tat	HIV-1 Tat from AIDS patients with HIV-associated dementia upregulates MMP-2 and MMP-7 release and activation, leading to neurotoxicity	PubMed
	tat	HIV-1 Tat and methamphetamine enhance the release of MMP-1, MMP-2, and uPA from human brain cells	PubMed
	tat	HIV-1 Tat and bFGF synergize to upregulate MMP-2 (type-IV collagenase) secretion and activation in endothelial cells and also synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice as a result of enhanced MMP-2 expression	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P08253	P01023	A2M	HPRD	PubMed
P08253	P16112	ACAN	HPRD	PubMed
P08253	P56817	BACE1	HPRD	PubMed
P08253	Q96GW7	BCAN	HPRD	PubMed
P08253	P80098	CCL7	HPRD	PubMed
P08253	O95832	CLDN1	HPRD	PubMed
P08253	P39060	COL18A1	HPRD	PubMed
P08253	P02452	COL1A1	HPRD	PubMed
P08253	P12111	COL6A3	HPRD	PubMed
P08253	Q02388	COL7A1	HPRD	PubMed
P08253	P48061	CXCL12	HPRD	PubMed
P08253	P07585	DCN	HPRD	PubMed
P08253	P29323	EPHB2	HPRD	PubMed
P08253	P11362	FGFR1	HPRD	PubMed
P08253	P10915	HAPLN1	HPRD	PubMed
P08253	P07900	HSP90AA1	HPRD	PubMed
P08253	P17936	IGFBP3	HPRD	PubMed
P08253	P01584	IL1B	HPRD	PubMed
P08253	P06756	ITGAV	HPRD	PubMed
P08253	Q15726	KISS1	HPRD	PubMed
P08253	P80188	LCN2	HPRD	PubMed
P08253	P17931	LGALS3	HPRD	PubMed
P08253	P50281	MMP14	HPRD	PubMed
P08253	Q9ULZ9	MMP17	HPRD	PubMed
P08253	Q9NPA2	MMP25	HPRD	PubMed
P08253	P20742	PZP	HPRD	PubMed
P08253	Q08629	SPOCK1	HPRD	PubMed
P08253	P01137	TGFB1	HPRD	PubMed
P08253	P07996	THBS1	HPRD	PubMed
P08253	P35442	THBS2	HPRD	PubMed
P08253	P01033	TIMP1	HPRD	PubMed
P08253	P16035	TIMP2	HPRD	PubMed
P08253	P35625	TIMP3	HPRD	PubMed
P08253	Q99727	TIMP4	HPRD	PubMed
BioGRID:110457	BioGRID:106524	A2M	BioGRID	PubMed	Reconstituted Complex
BioGRID:110457	BioGRID:121964	BCAN	BioGRID	PubMed	Biochemical Activity
BioGRID:110457	BioGRID:120937	CAND1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110457	BioGRID:112257	CCL7	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:110457	BioGRID:107674	COL1A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110457	BioGRID:109891	ITGAV	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:110457	BioGRID:109894	ITGB1	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:110457	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110457	BioGRID:110126	LCN2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110457	BioGRID:125385	OSBPL10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110457	BioGRID:111796	PZP	BioGRID	PubMed	Reconstituted Complex
BioGRID:110457	BioGRID:112898	TGFB1	BioGRID	PubMed	Biochemical Activity
BioGRID:110457	BioGRID:112915	THBS1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110457	BioGRID:112916	THBS2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110457	BioGRID:112933	TIMP2	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex; Two-hybrid
BioGRID:110457	BioGRID:112934	TIMP3	BioGRID	PubMed	Reconstituted Complex
BioGRID:110457	BioGRID:112935	TIMP4	BioGRID	PubMed	Reconstituted Complex
BioGRID:110457	BioGRID:128522	USP12	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
ATF-2 transcription factor network, organism-specific biosystem
ATF-2 transcription factor network
Activation of Matrix Metalloproteinases, organism-specific biosystem (from REACTOME)
Activation of Matrix Metalloproteinases, organism-specific biosystemThe matrix metalloproteinases (MMPs), previously known as matrixins, are classically known to be involved in the turnover of extracellular matrix (ECM) components. However, recent high throughput pro...
Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
Angiopoietin receptor Tie2-mediated signaling
Bladder cancer, organism-specific biosystem (from KEGG)
Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Bladder cancer, conserved biosystem (from KEGG)
Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Degradation of collagen, organism-specific biosystem (from REACTOME)
Degradation of collagen, organism-specific biosystemCollagen fibril diameter and spatial organisation are dependent on the species, tissue type and stage of development (Parry 1988). The lengths of collagen fibrils in mature tissues are largely unknow...
Degradation of collagen, organism-specific biosystem (from REACTOME)
Degradation of collagen, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
Degradation of the extracellular matrix, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
Direct p53 effectors, organism-specific biosystem
Direct p53 effectors
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Extracellular matrix organization, organism-specific biosystem (from REACTOME)
Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin, fibronectin and laminin embedded in a viscoelastic gel of ani...
Extracellular matrix organization, organism-specific biosystem (from REACTOME)
Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
FOXM1 transcription factor network, organism-specific biosystem
FOXM1 transcription factor network
GnRH signaling pathway, organism-specific biosystem (from KEGG)
GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
GnRH signaling pathway, conserved biosystem (from KEGG)
GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
LPA receptor mediated events, organism-specific biosystem
LPA receptor mediated events
Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Leukocyte transendothelial migration, conserved biosystem (from KEGG)
Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Matrix Metalloproteinases, organism-specific biosystem (from WikiPathways)
Matrix Metalloproteinases, organism-specific biosystemMatrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzi...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
Osteopontin-mediated events, organism-specific biosystem
Osteopontin-mediated events
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Plasma membrane estrogen receptor signaling, organism-specific biosystem
Plasma membrane estrogen receptor signaling
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem (from REACTOME)
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystemThe family of Insulin like Growth Factor Binding Proteins (IGFBPs) share 50% amino acid identity with conserved N terminal and C terminal regions responsible for binding Insulin like Growth Factors I...
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-2-mediated signaling events, organism-specific biosystem
Syndecan-2-mediated signaling events
Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
Validated transcriptional targets of AP1 family members Fra1 and Fra2
amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
amb2 Integrin signaling, organism-specific biosystem
amb2 Integrin signaling

General gene information

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Markers

PMC179881P2 (e-PCR)
- UniSTS:271663

D16S2904 (e-PCR)
- UniSTS:153474

G62045 (e-PCR)
- UniSTS:139144

STS-M55593 (e-PCR)
- UniSTS:66965

STS-W44530 (e-PCR)
- UniSTS:19916

WI-18839 (e-PCR)
- UniSTS:9943

RH69324 (e-PCR)
- UniSTS:30687

MMP2_210 (e-PCR)
- UniSTS:277493

Mmp2 (e-PCR), detects polymorphism
- UniSTS:495865

Genotypes

See MMP2 SNP Geneview Report
See MMP2 SNP Genotype Report
See MMP2 SNP Variation Viewer Report

Homology

Homologs of the MMP2 gene: The MMP2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
serine-type endopeptidase activity	TAS Traceable Author Statement more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
blood vessel maturation	IEA Inferred from Electronic Annotation more info
bone trabecula formation	IEA Inferred from Electronic Annotation more info
cellular protein metabolic process	TAS Traceable Author Statement more info
cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
collagen catabolic process	TAS Traceable Author Statement more info
embryo implantation	IEA Inferred from Electronic Annotation more info
extracellular matrix disassembly	TAS Traceable Author Statement more info
extracellular matrix organization	TAS Traceable Author Statement more info
face morphogenesis	IEA Inferred from Electronic Annotation more info
intramembranous ossification	IEA Inferred from Electronic Annotation more info
proteolysis	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info
sarcomere	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 72 kDa type IV collagenase

Names: 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II

NP_001121363.1

EC 3.4.24.24

NP_004521.1

EC 3.4.24.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008989.1 RefSeqGene

Range

5001..32506

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001127891.1 → NP_001121363.1 72 kDa type IV collagenase isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC007336, AK310314, AK312711, AL046162, CA446916, DB059054, J03210

Consensus CDS

CCDS45487.1

UniProtKB/Swiss-Prot

P08253

Conserved Domains (5) summary

cd00062
Location:293 – 340
Blast Score: 202

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00094
Location:417 – 610
Blast Score: 545

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:68 – 166
Blast Score: 391

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:331 – 396
Blast Score: 262

Peptidase_M10; Matrixin

pfam01471
Location:2 – 47
Blast Score: 106

PG_binding_1; Putative peptidoglycan binding domain
NM_004530.4 → NP_004521.1 72 kDa type IV collagenase isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK310314, AK312711, AL046162, AU279927, CA446916, DB154582, J03210

Consensus CDS

CCDS10752.1

UniProtKB/Swiss-Prot

P08253

Related

ENSP00000219070, OTTHUMP00000164261, ENST00000219070, OTTHUMT00000256913

Conserved Domains (5) summary

cd00062
Location:343 – 390
Blast Score: 205

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00094
Location:467 – 660
Blast Score: 549

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:118 – 216
Blast Score: 392

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:381 – 446
Blast Score: 263

Peptidase_M10; Matrixin

pfam01471
Location:48 – 97
Blast Score: 106

PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p10 Primary Assembly

Range

55513081..55540586

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

41400533..41427983

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018927.1 Alternate CHM1_1.0

Range

56526935..56554437

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01066524.1 (55280..55765)	None
genomic	ABBA01066525.1	None
genomic	AC007336.6 (94629..122144)	None
genomic	AJ298926.1	None
genomic	AMYH01007681.1 (35..27537)	None
genomic	AY738117.1	AAU10089.1
genomic	CH471092.1	EAW82824.1
		EAW82825.1
		EAW82826.1
		EAW82827.1
		EAW82828.1
genomic	FB571114.1	CAR95108.1
genomic	FB668245.1	CAS92766.1
genomic	M33789.1	AAA52027.1
genomic	M55582.1	AAA52028.1
genomic	M55583.1	AAA52028.1
genomic	M55584.1	AAA52028.1
genomic	M55585.1	AAA52028.1
genomic	M55586.1	AAA52028.1
genomic	M55587.1	AAA52028.1
genomic	M55588.1	AAA52028.1
genomic	M55589.1	AAA52028.1
genomic	M55590.1	AAA52028.1
genomic	M55591.1	AAA52028.1
genomic	M55592.1	AAA52028.1
genomic	M55593.1	AAA52028.1
genomic	M58552.1	AAA52028.1
genomic	U96098.1	None
mRNA	AK301536.1	BAG63035.1
mRNA	AK310314.1	None
mRNA	AK312711.1	BAG35588.1
mRNA	AL046162.1	None
mRNA	AL542407.3	None
mRNA	AL832088.1	None
mRNA	AU279927.1	None
mRNA	BC002576.2	AAH02576.1
mRNA	BQ004983.1	None
mRNA	CA446916.1	None
mRNA	DA993141.1	None
mRNA	DB059054.1	None
mRNA	DB154582.1	None
mRNA	DQ385623.1	ABD38929.1
mRNA	J03210.1	AAA35701.1
mRNA	X58968.1	None
other-genetic	DQ891952.2	ABM82878.1
other-genetic	DQ895138.2	ABM86064.1