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MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [ Homo sapiens (human) ]

Gene ID: 4313, updated on 14-Apr-2014
Official Symbol
MMP2provided by HGNC
Official Full Name
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)provided by HGNC
Primary source
HGNC:7166
See related
Ensembl:ENSG00000087245; HPRD:00386; MIM:120360; Vega:OTTHUMG00000133202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLG4; MONA; CLG4A; TBE-1; MMP-II
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Location :
16q13-q21
Sequence :
Chromosome: 16; NC_000016.10 (55479169..55506674)
See MMP2 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 56 Neighboring gene uncharacterized LOC102723429 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain, small subunit 2 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
env Matrix metalloproteinases MMP2 and MMP9 participate in the maturation process of cleavage and activation of IL-1beta based on the intracerebroventricular injection of the HIV-1 envelope glycoprotein gp120 PubMed
Envelope transmembrane glycoprotein gp41 env Treatment of human glial and neuronal cells with an HIV-1 gp41 peptide (amino acids 583-599) markedly increases the activity of matrix metalloproteinase 2 (MMP-2) PubMed
Nef, p27 nef Overexpression of HIV-1 Nef and ALK effect gelatinase activation in astrocytic glioma cells PubMed
Tat, p14 tat HIV-1 Tat from AIDS patients with HIV-associated dementia upregulates MMP-2 and MMP-7 release and activation, leading to neurotoxicity PubMed
tat HIV-1 Tat and methamphetamine enhance the release of MMP-1, MMP-2, and uPA from human brain cells PubMed
tat HIV-1 Tat and bFGF synergize to upregulate MMP-2 (type-IV collagenase) secretion and activation in endothelial cells and also synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice as a result of enhanced MMP-2 expression PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel maturation IEA
Inferred from Electronic Annotation
more info
 
bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
collagen catabolic process TAS
Traceable Author Statement
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
intramembranous ossification IEA
Inferred from Electronic Annotation
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
sarcomere IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
72 kDa type IV collagenase
Names
72 kDa type IV collagenase
MMP-2
gelatinase A
72 kDa gelatinase
collagenase type IV-A
neutrophil gelatinase
matrix metalloproteinase-2
matrix metalloproteinase-II
NP_001121363.1
NP_004521.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008989.1 RefSeqGene

    Range
    5001..32506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127891.1NP_001121363.1  72 kDa type IV collagenase isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC007336, AK310314, AK312711, AL046162, CA446916, DB059054, J03210
    Consensus CDS
    CCDS45487.1
    UniProtKB/Swiss-Prot
    P08253
    Conserved Domains (5) summary
    cd00062
    Location:293340
    Blast Score: 220
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00094
    Location:416610
    Blast Score: 615
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:68396
    Blast Score: 509
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:68396
    Blast Score: 524
    Peptidase_M10; Matrixin
    pfam01471
    Location:247
    Blast Score: 106
    PG_binding_1; Putative peptidoglycan binding domain
  2. NM_004530.4NP_004521.1  72 kDa type IV collagenase isoform a preproprotein

    See proteins identical to NP_004521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK310314, AK312711, AL046162, AU279927, CA446916, DB154582, J03210
    Consensus CDS
    CCDS10752.1
    UniProtKB/Swiss-Prot
    P08253
    Related
    ENSP00000219070, OTTHUMP00000164261, ENST00000219070, OTTHUMT00000256913
    Conserved Domains (5) summary
    cd00062
    Location:343390
    Blast Score: 223
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00094
    Location:466660
    Blast Score: 624
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:118446
    Blast Score: 514
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:118446
    Blast Score: 528
    Peptidase_M10; Matrixin
    pfam01471
    Location:5297
    Blast Score: 106
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38 Primary Assembly

    Range
    55479169..55506674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 Alternate HuRef

    Range
    41400533..41427983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    56920344..56947845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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