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    FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) [ Homo sapiens ]

    Gene ID: 2212, updated on 19-May-2012
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    Summary

    Official Symbol
    FCGR2Aprovided by HGNC
    Official Full Name
    Fc fragment of IgG, low affinity IIa, receptor (CD32)provided by HGNC
    Primary source
    HGNC:3616
    Locus tag
    RP11-5K23.6
    See related
    Ensembl:ENSG00000143226; HPRD:00906; MIM:146790; Vega:OTTHUMG00000034469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; MGC23887; MGC30032
    Summary
    This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
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    Genomic context

    Location :
    1q23
    Sequence :
    Chromosome: 1; NC_000001.10 (161475205..161489360)
    See FCGR2A in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase M2 polypeptide pseudogene 2 Neighboring gene uncharacterized LOC100505703 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene transfer RNA aspartic acid 20 (anticodon GUC) pseudogene Neighboring gene heat shock 70kDa protein 6 (HSP70B')

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Genetic polymorphism of Fcγ-receptors IIa, IIIa and IIIb in South Indian patients with generalized aggressive periodontitis. Hans VM, et al. J Oral Sci, 2011 Dec. PMID 22167032.
    2. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Khor CC, et al. Nat Genet, 2011 Nov 13. PMID 22081228.
    3. Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding. Ueyama T, et al. J Biol Chem, 2011 Nov 25. PMID 21956105.
    4. Differences in endocytosis mediated by FcγRIIA and FcγRIIB2. Zhang CY, et al. Mol Immunol, 2011 Oct. PMID 21945020.
    5. Structural basis for Fc gammaRIIa recognition of human IgG and formation of inflammatory signaling complexes. Ramsland PA, et al. J Immunol, 2011 Sep 15. PMID 21856937.

    See all (312) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. R allele, may be risk factor for generalized aggressive periodontitis in the population of South India.
      Title: Genetic polymorphism of Fcγ-receptors IIa, IIIa and IIIb in South Indian patients with generalized aggressive periodontitis.
    2. Results here demonstrate that variation in the FcgammaR gene alters susceptibility to repeated episodes of SMA and mortality, as well as functional changes in IFN-gamma production.
      Title: Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.
    3. Our data suggest that FCGR2A variants play a role in the pathogenesis of ulcerative colitis in Koreans.
      Title: Association of FCGR2A, JAK2 or HNF4A variants with ulcerative colitis in Koreans.
    4. FCGR2A is a susceptibility gene to SLE in Chinese with an odds ratio of 1.094 and population attributable risk proportion of 0.031.
      Title: Is FCGR2A a susceptibility gene to systemic lupus erythematosus in Chinese?
    5. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
      Title: Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
    6. cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis
      Title: Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.
    7. Data show no statistically significant differences in OS and PFS according to genotypes of FcgammaRIIA and FcgammaRIIIA.
      Title: FcγRIIA and FcγRIIIA polymorphisms do not influence survival and response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone immunochemotherapy in patients with diffuse large B-cell lymphoma.
    8. FcgammaRIIB2 mediates internalization of immune complexes at a faster rate than FcgammaRIIA, and facilitates the endocytosis of FcgammaRIIA upon co-engagement of both receptors
      Title: Differences in endocytosis mediated by FcγRIIA and FcγRIIB2.
    9. A model is presented whereby a dimer of FcgammaRIIa-HR binds Ag-Ab complexes in an arrangement that possibly occurs on the cell membrane as part of a larger signaling assembly.
      Title: Structural basis for Fc gammaRIIa recognition of human IgG and formation of inflammatory signaling complexes.
    10. no association between this FcgammaRIIA-H/R131 polymorphism and susceptibility or resistance to ATL, neither influencing the development of different clinical forms of this illness.
      Title: Allelic polymorphism of human FcγRIIA-H/R131 receptor in American tegumentary leishmaniasis.
    Submit: New GeneRIF Correction See all (153)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.

    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

    Lupus nephritis, susceptibility to

    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P12318 P51451 BLK    HPRD  PubMed  
    P12318 P02741 CRP    HPRD  PubMed  
    P12318 P06241 FYN    HPRD  PubMed  
    P12318 Q9HCN6 GP6    HPRD  PubMed  
    P12318 P08631 HCK    HPRD  PubMed  
    P12318 O43561 LAT    HPRD  PubMed  
    P12318 P17931 LGALS3    HPRD  PubMed  
    P12318 P07948 LYN    HPRD  PubMed  
    P12318 P27986 PIK3R1    HPRD  PubMed  
    P12318 P29353 SHC1    HPRD  PubMed  
    P12318 P43405 SYK    HPRD  PubMed  
    BioGRID:108506 BioGRID:107315 CBL    BioGRID  PubMed Co-fractionation 
    BioGRID:108506 BioGRID:117971 LAT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108506 BioGRID:110149 LGALS3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108506 BioGRID:110245 LYN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108506 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108506 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108506 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    IgG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor II-a
    Names
    low affinity immunoglobulin gamma Fc region receptor II-a
    fcRII-a
    fc-gamma-RIIa
    fc-gamma RII-a
    igG Fc receptor II-a
    Immunoglobulin G Fc receptor II
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012066.1 RefSeqGene

      Range
      5001..19156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136219.1 → NP_001129691.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK315225, AL590385
      Consensus CDS
      CCDS44264.1
      UniProtKB/Swiss-Prot
      P12318
      Related
      ENSP00000271450, OTTHUMP00000032376, ENST00000271450, OTTHUMT00000083318
      Conserved Domains (2) summary
      cd05752
      Location:41 – 119
      Blast Score: 308
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123 – 205
      Blast Score: 388
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    2. NM_021642.3 → NP_067674.2  low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL590385, BC019931
      Consensus CDS
      CCDS30922.1
      UniProtKB/Swiss-Prot
      P12318
      Related
      ENSP00000356949, OTTHUMP00000032377, ENST00000367972, OTTHUMT00000083319
      Conserved Domains (2) summary
      cd05752
      Location:40 – 118
      Blast Score: 308
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:122 – 204
      Blast Score: 388
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      161475205..161489360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      132800353..132814372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic A21604.1 CAA01563.1
    genomic AL590385.23 CAI16118.1
      CAI16119.1
    mRNA AF416711.1 AAL78867.1
    mRNA AI250177.1 None
    mRNA AK225438.1 None
    mRNA AK225601.1 None
    mRNA AK226059.1 None
    mRNA AK298657.1 BAH12840.1
    mRNA AK298734.1 BAH12860.1
    mRNA AK315225.1 BAG37654.1
    mRNA BC019931.1 AAH19931.1
    mRNA BC020823.1 AAH20823.1
    mRNA J03619.1 AAA35932.1
    mRNA M28697.1 AAA36050.1
    mRNA M31932.1 AAA35827.1
    mRNA X62572.1 None
    mRNA Y00644.1 CAA68672.1
    other-genetic DQ892037.2 ABM82963.1
    other-genetic DQ895228.2 ABM86154.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12318.4 GenPept UniProtKB/Swiss-Prot:P12318
    Q8TEX8 GenPept UniProtKB/TrEMBL:Q8TEX8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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