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    FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) [ Homo sapiens (human) ]

    Gene ID: 2212, updated on 19-May-2013
    Official Symbol
    FCGR2Aprovided by HGNC
    Official Full Name
    Fc fragment of IgG, low affinity IIa, receptor (CD32)provided by HGNC
    Primary source
    HGNC:3616
    Locus tag
    RP11-5K23.6
    See related
    Ensembl:ENSG00000143226; HPRD:00906; MIM:146790; Vega:OTTHUMG00000034469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1
    Summary
    This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
    Location :
    1q23
    Sequence :
    Chromosome: 1; NC_000001.10 (161475205..161489360)
    See FCGR2A in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine 14 (anticodon CAG) Neighboring gene transfer RNA glycine 25 (anticodon GCC) Neighboring gene transfer RNA aspartic acid 20 (anticodon GUC) pseudogene Neighboring gene transfer RNA glycine 31 (anticodon GCC)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. [New evidence in the susceptibility to dengue infection associated to HH polymorphism of FcgammaRIIa receptor]. García Menéndez CG, et al. Rev Cubana Med Trop, 2011 Sep-Dec. PMID 23444610.
    2. Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition. Takahashi M, et al. J Biol Chem, 2013 Mar 15. PMID 23372157.
    3. Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRγ deficiency. Zhang T, et al. J Immunol, 2013 Feb 15. PMID 23345329.
    4. Bruton's tyrosine kinase mediates FcγRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils. Krupa A, et al. Am J Respir Cell Mol Biol, 2013 Feb. PMID 23239500.
    5. A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors. Corrales-Aguilar E, et al. J Immunol Methods, 2013 Jan 31. PMID 23023090.

    See all (341) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. engagement of CD300C led to Fc receptor gamma-dependent activation of mast cells and monocytes
      Title: Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.
    2. Data indicate a tool for measuring antibodies triggering activation of FcgammaRIIIA, FcgammaRIIA or FcgammaRI receptors.
      Title: A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors.
    3. it seems that those individuals with polymorphism in FCgammaRIIa-H/H receptor would tend to non-elimination of IgG antibodies through this receptor
      Title: [New evidence in the susceptibility to dengue infection associated to HH polymorphism of FcgammaRIIa receptor].
    4. In a population of patients with invasive pneumococcal diseases, the frequency of the variant FcgammaRIIa-R131 does not differ from other critically ill patients. The FcgammaRIIa-R/R131 genotype was independently associated with increased survival.
      Title: Protective effects of FCGR2A polymorphism in invasive pneumococcal diseases.
    5. Unlike classical memory cells that use gene-rearranged antigen-specific receptors, g-NK cells use a germline-encoded Fc receptor (FcR)gamma that recognizes antibodies bound to target cells.
      Title: Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRγ deficiency.
    6. study reveals the existence of Btk-dependent molecular cooperation between FcgammaRIIa and TLR4 signaling cascades in LPS-"primed" human neutrophils
      Title: Bruton's tyrosine kinase mediates FcγRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils.
    7. Patients with unstable angina pectoris show an increased frequency of the Fc gamma RIIa R131 allele.
      Title: Patients with unstable angina pectoris show an increased frequency of the Fc gamma RIIa R131 allele.
    8. Forty-eight genetic variations were found including 12 novel ones. Beside the well-known functional 497A>G (H166R) polymorphism, 818T>C (L273P) was detected at 0.005 frequency.
      Title: Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.
    9. FcgammaRIIA engagement of tissue soluble immune complexes generates neutrophil extracellular traps, a proinflammatory process linked to autoimmunity.
      Title: Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo.
    10. FCGR2A polymorphism is not associated with response to therapy in follicular lymphoma.
      Title: Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms.
    Submit: New GeneRIF Correction See all (178)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Nef, p27 nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P12318 P51451 BLK    HPRD  PubMed  
    P12318 P02741 CRP    HPRD  PubMed  
    P12318 P06241 FYN    HPRD  PubMed  
    P12318 Q9HCN6 GP6    HPRD  PubMed  
    P12318 P08631 HCK    HPRD  PubMed  
    P12318 O43561 LAT    HPRD  PubMed  
    P12318 P17931 LGALS3    HPRD  PubMed  
    P12318 P07948 LYN    HPRD  PubMed  
    P12318 P27986 PIK3R1    HPRD  PubMed  
    P12318 P29353 SHC1    HPRD  PubMed  
    P12318 P43405 SYK    HPRD  PubMed  
    BioGRID:108506 BioGRID:107315 CBL    BioGRID  PubMed Co-fractionation 
    BioGRID:108506 BioGRID:107800 CRYAB    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:108506 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108506 BioGRID:117971 LAT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108506 BioGRID:110149 LGALS3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108506 BioGRID:110245 LYN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108506 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108506 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108506 BioGRID:112615 TRIM21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108506 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    • FCGR activation, organism-specific biosystem (from REACTOME)
      FCGR activation, organism-specific biosystemCross-linking of FCGRs with IgG coated immune complexes results in tyrosine phosphorylation of the immuno tyrosine activation motif (ITAMs) of the rececptor by membrane-bound tyrosine kinases of the ...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
    • Role of phospholipids in phagocytosis, organism-specific biosystem (from REACTOME)
      Role of phospholipids in phagocytosis, organism-specific biosystemPhospholipases play an integral role in phagocytosis by generating essential second messengers. An early step in phagocytic signaling is the association of PIP2 and IP3 with the phagocytic cup. These...
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC23887, MGC30032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    IgG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor II-a
    Names
    low affinity immunoglobulin gamma Fc region receptor II-a
    fcRII-a
    fc-gamma-RIIa
    fc-gamma RII-a
    igG Fc receptor II-a
    Immunoglobulin G Fc receptor II

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012066.1 RefSeqGene

      Range
      5001..19156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136219.1 → NP_001129691.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK315225, AL590385
      Consensus CDS
      CCDS44264.1
      UniProtKB/Swiss-Prot
      P12318
      Related
      ENSP00000271450, OTTHUMP00000032376, ENST00000271450, OTTHUMT00000083318
      Conserved Domains (2) summary
      cd05752
      Location:41 – 119
      Blast Score: 308
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123 – 205
      Blast Score: 388
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    2. NM_021642.3 → NP_067674.2  low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL590385, BC019931
      Consensus CDS
      CCDS30922.1
      UniProtKB/Swiss-Prot
      P12318
      Conserved Domains (2) summary
      cd05752
      Location:40 – 118
      Blast Score: 308
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:122 – 204
      Blast Score: 388
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      161475205..161489360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      132800353..132814372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      168025858..168040008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic A21604.1 CAA01563.1
    genomic ABBA01047318.1 (21962..34729) None
    genomic ABBA01047319.1 None
    genomic AL590385.23 (62074..76229) None
    genomic AMYH01001458.1 (57339..71489) None
    mRNA AF416711.1 AAL78867.1
    mRNA AI250177.1 None
    mRNA AK225438.1 None
    mRNA AK225601.1 None
    mRNA AK226059.1 None
    mRNA AK298657.1 BAH12840.1
    mRNA AK298734.1 BAH12860.1
    mRNA AK315225.1 BAG37654.1
    mRNA BC019931.1 AAH19931.1
    mRNA BC020823.1 AAH20823.1
    mRNA J03619.1 AAA35932.1
    mRNA M28697.1 AAA36050.1
    mRNA M31932.1 AAA35827.1
    mRNA X62572.1 None
    mRNA Y00644.1 CAA68672.1
    other-genetic DQ892037.2 ABM82963.1
    other-genetic DQ895228.2 ABM86154.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12318.4 GenPept UniProtKB/Swiss-Prot:P12318

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
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      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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