MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: MMP9provided by HGNC
Official Full Name: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)provided by HGNC
Primary source: HGNC:7176
See related: Ensembl:ENSG00000100985; HPRD:00387; MIM:120361; Vega:OTTHUMG00000033044
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GELB; CLG4B; MMP-9; MANDP2
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 20q11.2-q13.1

Sequence :: Chromosome: 20; NC_000020.10 (44637547..44645200)

See MMP9 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results support the use of MMP-9 and TIMP-1 as early biomarkers for the presence and extent of perinatal brain injury in human term newborns.
Title: Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia-ischemia: a potential marker of neonatal encephalopathy.
High matrix metallopeptidase 9 is associated with relapse in colorectal cancer.
Title: Matrix metalloproteinase-9 is associated with relapse and prognosis of patients with colorectal cancer.
MMP-9, MMP-13 and TIMP-1 expression may serve as a prognostic marker for early tumor invasiveness. Moreover, up-regulation of TIMP-1 in tumor and/or surrounding stromal cells may indicate an increased risk for BCC recurrence.
Title: Expression of matrix metalloproteinase-1, -9, -13, and tissue inhibitor of metalloproteinases-1 in basal cell carcinomas of the eyelid.
Methotrexate chemotherapy transiently alters bone marrow cellularity and composition and the reduced cellularity may be associated with increased MMP-9 expression.
Title: Deregulation of the CXCL12/CXCR4 axis in methotrexate chemotherapy-induced damage and recovery of the bone marrow microenvironment.
we conclude that the analysed genetic variants in MMP2 are not major contributors to aneurysmal subarachnoid haemorrhage
Title: No evidence for an association between genetic variation at the MMP2 and MMP9 loci and aneurysmal subarachnoid haemorrhage.
investigated the influence of matrix metalloproteinase (MMP)-9 genetic variations on gene- and protein expression in stable coronary artery disease patients; the investigated MMP-9 polymorphisms influenced gene- and protein expression differently and t...
Title: Genetic variation, gene-expression and circulating levels of matrix metalloproteinase-9 in patients with stable coronary artery disease.
the expression of KLF5 and MMP-9 may be involved in cartilage degeneration, contributing to human osteoarthritis
Title: Clinicopathological correlation of Krüppel-like factor 5 and matrix metalloproteinase-9 expression and cartilage degeneration in human osteoarthritis.
High levels of MMP-7 in tumor cells and high levels of MMP-9 in tumor associated stroma were independent positive prognostic factors in NSCLC patients.
Title: Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: correlation with a favorable clinical outcome.
Zoledronic acid can inhibit the in vitro proliferation and invasion of HNE1 cell through suppressing the secretion of VEGF and suppressing MMP2 and MMP9 activity.
Title: [Inhibitory effects of zoledronic acid on cell proliferation and invasion in human nasopharyngeal carcinoma cell line HNE1].
H-Ras activates MMP9 culminating in the development of diabetic retinopathy that leads to the capillary cell apoptosis in the retinal microvasculature obtained from human donors.
Title: Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9.

Submit: New GeneRIF Correction See all (1206)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Lumbar disc herniation, susceptibility to

MIM: 603932

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	T- and M-tropic HIV-1 gp120 proteins are able to induce the secretion of matrix metalloproteinase 9 (MMP-9) by T cells or glioma cells; MMP-9 is an extracellular metalloproteinase present in cerebrospinal fluid of patients with HIV-1	PubMed
Nef	nef	MMP-9 activity in the cerebrospinal fluid (CSF) samples from rats is induced by injecting the rats intracisternally with recombinant HIV-1 Nef protein, but not after injection of heat-treated Nef, HIV-1 gp120, HIV-1 gp160 or PBS	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of MMP-9 in monocytes in an IL-1beta, TNF-alpha, and tyrosine phosphatase dependent manner	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
P14780	P15514	AREG	HPRD	PubMed
P14780	P35070	BTC	HPRD	PubMed
P14780	P16070	CD44	HPRD	PubMed
P14780	P02452	COL1A1	HPRD	PubMed
P14780	P08123	COL1A2	HPRD	PubMed
P14780	P02462	COL4A1	HPRD	PubMed
P14780	P08572	COL4A2	HPRD	PubMed
P14780	Q01955	COL4A3	HPRD	PubMed
P14780	P53420	COL4A4	HPRD	PubMed
P14780	P29400	COL4A5	HPRD	PubMed
P14780	Q14031	COL4A6	HPRD	PubMed
P14780	P09341	CXCL1	HPRD	PubMed
P14780	P42830	CXCL5	HPRD	PubMed
P14780	P29323	EPHB2	HPRD	PubMed
P14780	P02751	FN1	HPRD	PubMed
P14780	P10915	HAPLN1	HPRD	PubMed
P14780	P10145	IL8	HPRD	PubMed
P14780	Q15726	KISS1	HPRD	PubMed
P14780	P80188	LCN2	HPRD	PubMed
P14780	P09238	MMP10	HPRD	PubMed
P14780	Q9NRE1	MMP26	HPRD	PubMed
P14780	P09237	MMP7	HPRD	PubMed
P14780	P14780	MMP9	HPRD	PubMed
P14780	P00747	PLG	HPRD	PubMed
P14780	P07478	PRSS2	HPRD	PubMed
P14780	P20742	PZP	HPRD	PubMed
P14780	O95980	RECK	HPRD	PubMed
P14780	P10646	TFPI	HPRD	PubMed
P14780	P07996	THBS1	HPRD	PubMed
P14780	P35442	THBS2	HPRD	PubMed
P14780	P35625	TIMP3	HPRD	PubMed
BioGRID:110461	BioGRID:112276	CXCL5	BioGRID	PubMed	Biochemical Activity
BioGRID:110461	BioGRID:112274	CXCL6	BioGRID	PubMed	Biochemical Activity
BioGRID:110461	BioGRID:112898	TGFB1	BioGRID	PubMed	Biochemical Activity
BioGRID:110461	BioGRID:112915	THBS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110461	BioGRID:112916	THBS2	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
collagen binding	TAS Traceable Author Statement more info	PubMed
fibronectin binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
peptidase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
anatomical structure regression	IEA Inferred from Electronic Annotation more info
cell growth	IEA Inferred from Electronic Annotation more info
cellular response to cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
cellular response to low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
collagen catabolic process	IEA Inferred from Electronic Annotation more info
extracellular matrix organization	IEA Inferred from Electronic Annotation more info
macrophage differentiation	TAS Traceable Author Statement more info	PubMed
metabolic process	IEA Inferred from Electronic Annotation more info
ossification	IEA Inferred from Electronic Annotation more info
positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of keratinocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
proteolysis	IDA Inferred from Direct Assay more info	PubMed
response to drug	IEA Inferred from Electronic Annotation more info
response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to heat	IEA Inferred from Electronic Annotation more info
response to hyperoxia	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
response to nicotine	IEA Inferred from Electronic Annotation more info
response to nutrient	IEA Inferred from Electronic Annotation more info
response to oxidative stress	IEA Inferred from Electronic Annotation more info
response to radiation	IEA Inferred from Electronic Annotation more info
response to retinoic acid	IEA Inferred from Electronic Annotation more info
response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
skeletal system development	IEA Inferred from Electronic Annotation more info
tissue remodeling	IEA Inferred from Electronic Annotation more info
transformation of host cell by virus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
protein complex	IEA Inferred from Electronic Annotation more info
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: matrix metalloproteinase-9

Names: matrix metalloproteinase-9; 92 kDa gelatinase; type V collagenase; macrophage gelatinase; 92 kDa type IV collagenase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

NP_004985.2

EC 3.4.24.35

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011468.1 RefSeqGene

Range

5001..12654

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004994.2 → NP_004985.2 matrix metalloproteinase-9 preproprotein

Status: REVIEWED

Source sequence(s)

AW468235, BC006093, CN288579, J05070

Consensus CDS

CCDS13390.1

UniProtKB/Swiss-Prot

P14780

Related

ENSP00000361405, OTTHUMP00000031674, ENST00000372330, OTTHUMT00000080337

Conserved Domains (4) summary

cd00062
Location:282 – 329
Blast Score: 199

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00094
Location:514 – 704
Blast Score: 481

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:115 – 213
Blast Score: 357

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

cl00064
Location:379 – 444
Blast Score: 232

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

44637547..44645200

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

41378970..41386505

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF148064.1	AAD37404.1
genomic	AF538844.1	AAM97934.1
genomic	AL162458.10	CAC10459.1
genomic	AX011001.1	CAC07541.1
genomic	CH471077.2	EAW75776.1
genomic	D10051.1	BAA20967.1
genomic	DQ194553.1	ABA03169.1
genomic	M68351.1	None
genomic	M68355.1	None
mRNA	AK298246.1	BAH12743.1
mRNA	AK301446.1	BAH13483.1
mRNA	AK302530.1	BAH13736.1
mRNA	AK303080.1	BAH13895.1
mRNA	AK313137.1	BAG35956.1
mRNA	AK316145.1	BAH14516.1
mRNA	AW468235.1	None
mRNA	BC006093.1	AAH06093.1
mRNA	CN288579.1	None
mRNA	HQ874462.1	AEA49029.1
mRNA	J05070.1	AAA51539.1
other-genetic	DQ896791.2	ABM87790.1
other-genetic	EU176415.1	ABW03866.1