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    CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) [ Homo sapiens ]

    Gene ID: 1234, updated on 20-May-2012
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    Summary

    Official Symbol
    CCR5provided by HGNC
    Official Full Name
    chemokine (C-C motif) receptor 5 (gene/pseudogene)provided by HGNC
    Primary source
    HGNC:1606
    See related
    Ensembl:ENSG00000160791; HPRD:03223; MIM:601373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; FLJ78003
    Summary
    This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    3p21.31
    Sequence :
    Chromosome: 3; NC_000003.11 (46411633..46417697)
    See CCR5 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase core protein II pseudogene Neighboring gene chemokine (C-C motif) receptor 2 Neighboring gene chemokine (C-C motif) receptor-like 2 Neighboring gene lactotransferrin

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A new assay for CCR5del32 mutation: genotyping through the number of fragments amplified. Wang Q, et al. J Biomed Nanotechnol, 2011 Dec. PMID 22416573.
    2. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. O'Boyle G, et al. Proc Natl Acad Sci U S A, 2012 Mar 20. PMID 22392992.
    3. [CCR5-Δ32 allele involvement in the clinical evolution of HIV1+ patients in Yucatán, Mexico]. Valadez-González N, et al. Salud Publica Mex, 2011 Nov-Dec. PMID 22282138.
    4. HIV Type 1 Coreceptor Tropism, CCR5 Genotype, and Integrase Inhibitor Resistance Profiles in Vietnam: Implications for the Introduction of New Antiretroviral Regimens. Luu QP, et al. AIDS Res Hum Retroviruses, 2012 Mar 9. PMID 22264071.
    5. Chemokine receptor 2-V64I and chemokine receptor 5-Delta32 polymorphisms and clinical risk factors of delayed graft function and acute rejection in kidney transplantation. Azmandian J, et al. Iran J Kidney Dis, 2012 Jan. PMID 22218121.

    See all (913) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data indicate that IFN2b treatment upregulates the expression of CCR5, RANTES, MIP-1alpha and MIP-1beta on monocytes/macrophages.
      Title: Dysregulated CC receptor/ligand in monocytes/macrophages from tongue squamous cell carcinoma patients is partially rectified by interferon α-2b.
    2. Results failed to suggest CCR2-V64I or CCR5-Delta32 gene polymorphisms as risk factors for acute rejection and delayed graft function in kidney transplantation.
      Title: Chemokine receptor 2-V64I and chemokine receptor 5-Delta32 polymorphisms and clinical risk factors of delayed graft function and acute rejection in kidney transplantation.
    3. CXCR3 agonist induces receptor cross-phosphorylation within CXCR3-CCR5 heterodimers on the surface of activated T cells
      Title: Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation.
    4. Notch1 regulates chemotaxis and proliferation by controlling the CC-chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia.
      Title: Notch1 regulates chemotaxis and proliferation by controlling the CC-chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia.
    5. The data supported a role for CCR5, CXCR3, and CXCR6 in the selective recruitment of T cells into renal cell carcinoma tissue and, together with CCR6, in the recruitment of regulatory T cells.
      Title: T lymphocyte recruitment into renal cell carcinoma tissue: a role for chemokine receptors CXCR3, CXCR6, CCR5, and CCR6.
    6. The present study demonstrated a new primer extension assay for genetic analysis of the CCR5del32 mutation: each genotype is determined by a specific number of fragments amplified.
      Title: A new assay for CCR5del32 mutation: genotyping through the number of fragments amplified.
    7. Both IL28B rs1297860 and CCR5Delta32 allelic variants are independent genetic determinants of spontaneous HCV clearance.
      Title: The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation.
    8. CCR5-conjugated cell-derived liposomes demonstrate specific targeting and cytotoxic effect towards glycoprotein (gp)120-expressing HIV model cells.
      Title: Cell derived liposomes expressing CCR5 as a new targeted drug-delivery system for HIV infected cells.
    9. Our results show a potential influence of the CCR5Delta32 deletion on the risk of cardiovascular disease among patients with rheumatoid arthritis
      Title: CCR5Δ32 variant and cardiovascular disease in patients with rheumatoid arthritis: a cohort study.
    10. Genotype wt/Delta32 was observed in all non-progressing HIV+ patients, supporting its role in this group's disease development and clinical evolution.
      Title: [CCR5-Δ32 allele involvement in the clinical evolution of HIV1+ patients in Yucatán, Mexico].
    Submit: New GeneRIF Correction See all (405)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Diabetes mellitus, insulin-dependent, 22

    Hepatitis C virus, resistance to

    HIV infection, susceptibility/resistance to

    Multiple common variants for celiac disease influencing immune gene expression.

    West nile virus, susceptibility to

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 and gp41-mediated virus-cell fusion is more dependent on viral core maturation for viruses bearing CXCR4-tropic gp120 than for those bearing CCR5-tropic gp120 PubMed
    env The coreceptor-binding site in HIV-1 gp120 is centered around an anti-parallel beta-sheet structure "bridging sheet domain"; mutations in and adjacent to this domain have greater impact on CXCR4-mediated fusion than on CCR5-mediated fusion PubMed
    env The V3 domain of HIV-1 gp120 induces associations between CD4 and CCR5 receptors in cholesterol-rich microenvironments PubMed
    env HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES PubMed
    env HIV-1 gp120-induced neuronal cell death involves p38 mitogen-activated protein kinase; both HIV-1 coreceptors, CCR5 and CXCR4, can mediate HIV-1 gp120-induced neurotoxicity PubMed
    env Stimulation of human monocyte-derived macrophages with HIV-1 gp120 results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2, which leads to production of TNF-alpha PubMed
    env HIV-1 gp120-induced Ca(2+) fluxing is CD4 dependent and coreceptor specific, and is mediated by the CCR5 and CXCR4 coreceptors PubMed
    env HIV-1 gp120 from a T-cell-tropic virus causes CD4-dependent antagonism of CXCR4 response to SDF-1alpha, whereas gp120 from macrophage-tropic viruses causes CD4-dependent antagonism of CCR5 response to MIP-1alpha PubMed
    env In addition to the V3 loop of HIV-1 gp120, some conserved amino acid residues (117-123, 207, 419-422, and 438-441) are also involved in CCR5 chemokine receptor binding PubMed
    env The amino-terminal residues (amino acids 1-25) and three extracellular loops (amino acids 88-102, 168-194, 261-277) of the CCR5 coreceptor are highly involved in its binding to gp120 from macrophage-tropic HIV-1 strains and in CCR5-mediated HIV-1 entry PubMed
    env A peptide fragment corresponding to the loop between the fifth and sixth transmembrane regions of the CCR5 receptor (amino acids 222-240) can inhibit HIV-1 infection of MT-4 cells, suggesting this region of CCR5 is involved with HIV-1 gp120 binding PubMed
    env A synthetic peptide corresponding to amino acid residues 414-434 of HIV-1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R PubMed
    env Chemokines such as MCP-3 and MCP-2 that can compete with high affinity for MIP-1beta binding to CCR5 can also compete for monomeric HIV-1 gp120 binding to CCR5, although with variable potencies PubMed
    env An adapted primary HIV-1 isolate, ADA, is able to replicate in CD4-negative cells expressing human CCR5; the gp120 glycoprotein of the adapted virus binds CCR5 directly, without prior interaction with CD4 PubMed
    env The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells PubMed
    env N-formyl-methionyl-leucylphenyl-alanine binding to formyl peptide receptor (FPR) results in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1 gp120-mediated fusion and infection of cells expressing CD4, CCR5, and FPR PubMed
    env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed
    env Anti-CCR5 monoclonal antibodies efficiently prevent HIV-1 infection by inducing receptor dimerization, but not by interfering with HIV-1 gp120 binding to CCR5 PubMed
    env Antibodies to specific epitopes of the CCR5 or CXCR4 chemokine receptors inhibit the entry of M-tropic, T-tropic, or dual-tropic HIV-1 into target cells by blocking the interaction of the receptors with the HIV-1 gp120/CD4 complex PubMed
    env AGP inhibits the binding of the HIV-1 gp120 consensus V3 domain (V3Cs) and macrophage inflammatory protein-1beta (MIP-1beta) to CCR5 on human monocyte-derived macrophages (MDM) PubMed
    env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
    env V1, V2, and V3 domains and N-linked glycosylation sites of HIV-1 gp120 confer coreceptor tropism; loss of an N-linked glycosylation site within V3 has a major influence on the virus switching from CCR5 to CXCR4 tropism in a V3 charge-dependent manner PubMed
    env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
    env HIV-1 gp120 interactions with CXCR4 and CCR5 lead to the cross-desensitization of CCR6 and CCR7; this gp120-induced inhibition is strictly dependent on CXCR4 or CCR5 and lipid rafts but not on CD4 or V(H)3-expressing BCR PubMed
    env Engagement of the CCR5 and CXCR4 receptors by HIV-1 gp120 induces tyrosine phosphorylation of the protein tyrosine kinase Pyk2 PubMed
    env The specific amino acids 298-329 in the V3 loop of HIV-1 gp120 that determine cellular tropism also regulate chemokine coreceptor (CCR5 or CXCR4) preference for cell entry by the virus PubMed
    env HIV-1-induced cell fusion is mediated by multiple regions within both the viral gp120 protein and the CCR5 coreceptor; dual-tropic virus isolates are less tolerant to changes in CCR5 than macrophage-tropic strains that have more restricted coreceptor use PubMed
    env Antibodies to specific epitopes of HIV-1 gp120 block the interaction of CCR5 with the gp120/CD4 complex, suggesting that a CD4-mediated conformational change in gp120 is required for subsequent binding to CCR5 PubMed
    env The HIV-1 envelope protein gp120 from macrophage-tropic HIV and SIV induces a signal through CCR5 on CD4+ T cells and macrophages, and this gp120-mediated signal transduction induces chemotaxis of T cells PubMed
    env The binding of HIV-1 gp120 to CCR5 and entry of macrophage-tropic HIV-1 isolates into cells is blocked by CCR5 antagonists or the chemokine RANTES, which interacts with CCR5 PubMed
    env The CCR5 chemokine receptor is required for the entry of macrophage-tropic HIV-1 into target cells; the HIV-1 gp120-CD4 complex binds CCR5, which inhibits the binding of the natural CCR5 ligands macrophage inflammatory protein (MIP)-1alpha and MIP-1beta PubMed
    Envelope transmembrane glycoprotein gp41 env RANTES, MIP-1beta, and anti-CD4 antibodies inhibit CCR5-dependent cell-cell fusion mediated by HIV-1 gp120 and gp41 from macrophage-tropic isolates PubMed
    env HIV-1 gp120 and gp41 form a transitional complex with the CD4 receptor and CCR5/CXCR4 coreceptors during virus-cell and cell-cell membrane fusion PubMed
    env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
    env HIV-1 gp41 activates innate host immune cells through FPRL1, and the activation of FPRL1 by gp41 further induces the phosphorylation of the chemokine receptor CCR5 PubMed
    Nef nef SH3 (PxxP motif) and PACS (E4) interaction surfaces as well as the myristoylation site (G2) in HIV-1 Nef are required for Nef-mediated downregulation of CCR5 PubMed
    nef HIV-1 Nef downregulates cell-surface levels of CCR5 in CHO cells expressing human CCR5; the Nef-induced downregulation of CCR5 is as efficient as the downregulation induced by the natural beta-chemokine ligand RANTES PubMed
    Tat tat Results from the treatment of microglia with HIV-1 Tat suggest downregulation of CCR5 mRNA expression by HIV-1 Tat, however this was deemed to not be significant PubMed
    tat HIV-1 Tat upregulates CCR5 expression on monocytes/macrophages but not on lymphocytes, indicating a role for Tat in HIV-1 pathogenesis and in promoting the infection of monocytes/macrophages. PubMed
    tat HIV-1 Tat is associated with upregulation of CCR5 and MIP-1alpha expression in nodular lesions found in HIV encephalopathy and progressive multifocal leukoencephalopathy (PML), indicating a role for Tat in HIV-1 pathogenesis PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P51681 P25098 ADRBK1    HPRD  PubMed  
    P51681 P35626 ADRBK2    HPRD  PubMed  
    P51681 P02771 AFP    HPRD  PubMed  
    P51681 O75915 ARL6IP5    HPRD  PubMed  
    P51681 P49407 ARRB1    HPRD  PubMed  
    P51681 P51671 CCL11    HPRD  PubMed  
    P51681 Q99616 CCL13    HPRD  PubMed  
    P51681 Q16627 CCL14    HPRD  PubMed  
    P51681 O15467 CCL16    HPRD  PubMed  
    P51681 P13500 CCL2    HPRD  PubMed  
    P51681 P10147 CCL3    HPRD  PubMed  
    P51681 P16619 CCL3L1    HPRD  PubMed  
    P51681 Chemokine ligand 3 like centromeric CCL3L3    HPRD  PubMed  
    P51681 Chemokine, CC motif, ligand 4 CCL4    HPRD  PubMed  
    P51681 P13501 CCL5    HPRD  PubMed  
    P51681 P80098 CCL7    HPRD  PubMed  
    P51681 P80075 CCL8    HPRD  PubMed  
    P51681 P41597 CCR2    HPRD  PubMed  
    P51681 P51681 CCR5    HPRD  PubMed  
    P51681 P01730 CD4    HPRD  PubMed  
    P51681 P61073 CXCR4    HPRD  PubMed  
    P51681 P50570 DNM2    HPRD  PubMed  
    P51681 P63096 GNAI1    HPRD  PubMed  
    P51681 P04899 GNAI2    HPRD  PubMed  
    P51681 P08754 GNAI3    HPRD  PubMed  
    P51681 P09471 GNAO1    HPRD  PubMed  
    P51681 P50148 GNAQ    HPRD  PubMed  
    P51681 P23458 JAK1    HPRD  PubMed  
    P51681 O60674 JAK2    HPRD  PubMed  
    P51681 P06239 LCK    HPRD  PubMed  
    P51681 P02763 ORM1    HPRD  PubMed  
    P51681 O60831 PRAF2    HPRD  PubMed  
    P51681 P28066 PSMA5    HPRD  PubMed  
    P51681 Q05397 PTK2    HPRD  PubMed  
    P51681 Q14289 PTK2B    HPRD  PubMed  
    P51681 P42224 STAT1    HPRD  PubMed  
    P51681 P40763 STAT3    HPRD  PubMed  
    P51681 P42229 STAT5A    HPRD  PubMed  
    P51681 P42681 TXK    HPRD  PubMed  
    BioGRID:107639 BioGRID:106682 AFP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107639 BioGRID:106901 ARRB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107639 BioGRID:112252 CCL3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107639 BioGRID:112253 CCL3L1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107639 BioGRID:112255 CCL5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107639 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107639 BioGRID:113607 CXCR4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107639 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107639 BioGRID:111314 PIK3R2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107639 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107639 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107639 BioGRID:112654 STAT5B    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Binding and entry of HIV virion, organism-specific biosystem (from REACTOME)
      Binding and entry of HIV virion, organism-specific biosystemHIV enters cells by fusion at the cell surface, that results in a productive infection. The envelope (Env) protein of HIV mediates entry. Env is composed of a surface subunit, gp120, and a transmemb...
    • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
      Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Early Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Early Phase of HIV Life Cycle, organism-specific biosystemIn the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-C chemokine binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    C-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    C-C chemokine receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chemokine (C-C motif) ligand 5 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    chemokine receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    coreceptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    phosphatidylinositol phospholipase C activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    MAPK cascade IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    dendritic cell chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    elevation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    entry into host cell TAS
    Traceable Author Statement
    more info
    		  
    immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    initiation of viral infection TAS
    Traceable Author Statement
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to cholesterol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    signaling IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    C-C chemokine receptor type 5
    Names
    C-C chemokine receptor type 5
    chemr13
    HIV-1 fusion coreceptor
    chemokine receptor CCR5
    C-C motif chemokine receptor 5 A159A
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012637.1 RefSeqGene

      Range
      5001..11065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000579.3 → NP_000570.1  C-C chemokine receptor type 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AC098613, BC038398, DA818906, U54994
      Consensus CDS
      CCDS2739.1
      UniProtKB/Swiss-Prot
      P51681
      UniProtKB/TrEMBL
      Q38L21
      Related
      ENSP00000343985, ENST00000343801
      Conserved Domains (1) summary
      PHA03087
      Location:36 – 304
      Blast Score: 397
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

    2. NM_001100168.1 → NP_001093638.1  C-C chemokine receptor type 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR compared to variant A. Both variants encode the same protein.
      Source sequence(s)
      AC098613, BC038398, DA818906, U54994
      Consensus CDS
      CCDS2739.1
      UniProtKB/Swiss-Prot
      P51681
      UniProtKB/TrEMBL
      Q38L21
      Conserved Domains (1) summary
      PHA03087
      Location:36 – 304
      Blast Score: 397
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      46411633..46417697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      46455276..46461340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB182984.1 BAD83805.1
    genomic AB182988.1 BAD83807.1
    genomic AB182990.1 BAD83808.1
    genomic AC098613.2 (26670..32727) None
    genomic AF009962.1 AAC23944.1
    genomic AF031237.1 AAB94735.1
    genomic AF052244.1 AAF65577.1
    genomic AF052539.1 AAD18131.1
    genomic AF056020.1 AAF65579.1
    genomic AF161909.1 AAD47666.1
    genomic AF161910.1 AAD47667.1
    genomic AF161911.1 AAD47668.1
    genomic AF161912.1 AAD47669.1
    genomic AF161913.1 AAD47670.1
    genomic AF161914.1 AAD47671.1
    genomic AF161915.1 AAD47672.1
    genomic AF161916.1 AAD47673.1
    genomic AF161917.1 AAD47674.1
    genomic AF161918.1 AAD47675.1
    genomic AF161919.1 AAD47676.1
    genomic AF161920.1 AAD47677.1
    genomic AF161921.1 AAD47678.1
    genomic AX256200.1 CAC94550.1
    genomic AX705068.1 CAD88097.1
    genomic AY221093.1 AAO65971.1
    genomic AY463213.1 AAS19312.1
    genomic AY463214.1 AAS19313.1
    genomic AY463215.1 AAS19314.1
    genomic AY744141.1 AAW62445.1
    genomic AY874119.1 AAW82037.1
    genomic AY874120.1 AAW82038.1
    genomic AY874121.1 AAW82039.1
    genomic CH471055.1 EAW64763.1
      EAW64764.1
    genomic DQ217934.1 ABB01004.1
    genomic EF408698.1 ABQ95606.1
    genomic EF408699.1 ABQ95607.1
    genomic EF408700.1 ABQ95608.1
    genomic FB584189.1 CAR96699.1
    genomic GQ917109.1 ACX50405.1
    genomic HC295434.1 CBJ06541.1
    genomic JQ291182.1 AEZ06624.1
    genomic JQ291183.1 AEZ06625.1
    genomic JQ291184.1 AEZ06626.1
    genomic JQ291185.1 AEZ06627.1
    genomic JQ291186.1 AEZ06628.1
    genomic JQ291187.1 AEZ06629.1
    genomic JQ291188.1 AEZ06630.1
    genomic JQ291190.1 AEZ06632.1
    genomic JQ291191.1 AEZ06633.1
    genomic JQ291192.1 AEZ06634.1
    genomic JQ291193.1 AEZ06635.1
    genomic JQ291194.1 AEZ06636.1
    genomic JQ291195.1 AEZ06637.1
    genomic JQ291196.1 AEZ06638.1
    genomic JQ291197.1 AEZ06639.1
    genomic JQ291198.1 AEZ06640.1
    genomic JQ291199.1 AEZ06641.1
    genomic JQ291200.1 AEZ06642.1
    genomic JQ291201.1 AEZ06643.1
    genomic JQ291202.1 AEZ06644.1
    genomic JQ291203.1 AEZ06645.1
    genomic JQ291204.1 AEZ06646.1
    genomic JQ291205.1 AEZ06647.1
    genomic JQ291206.1 AEZ06648.1
    genomic JQ291207.1 AEZ06649.1
    genomic JQ291208.1 AEZ06650.1
    genomic JQ291209.1 AEZ06651.1
    genomic JQ291210.1 AEZ06652.1
    genomic JQ291211.1 AEZ06653.1
    genomic JQ291212.1 AEZ06654.1
    genomic JQ291213.1 AEZ06655.1
    genomic JQ291214.1 AEZ06656.1
    genomic JQ291215.1 AEZ06657.1
    genomic JQ291216.1 AEZ06658.1
    genomic JQ291217.1 AEZ06659.1
    genomic JQ291218.1 AEZ06660.1
    genomic JQ291219.1 AEZ06661.1
    genomic JQ291220.1 AEZ06662.1
    genomic JQ291221.1 AEZ06663.1
    genomic JQ291222.1 AEZ06664.1
    genomic JQ291223.1 AEZ06665.1
    genomic JQ291224.1 AEZ06666.1
    genomic U83326.1 AAC51797.1
    genomic U95626.1 AAB57793.1
    genomic X91492.1 CAA62796.1
    mRNA AF011500.1 AAB65700.1
    mRNA AF011501.1 AAB65701.1
    mRNA AF011502.1 AAB65702.1
    mRNA AF011503.1 AAB65703.1
    mRNA AF011504.1 AAB65704.1
    mRNA AF011505.1 AAB65705.1
    mRNA AF011506.1 AAB65706.1
    mRNA AF011507.1 AAB65707.1
    mRNA AF011508.1 AAB65708.1
    mRNA AF011509.1 AAB65709.1
    mRNA AF011510.1 AAB65710.1
    mRNA AF011511.1 AAB65711.1
    mRNA AF011512.1 AAB65712.1
    mRNA AF011513.1 AAB65713.1
    mRNA AF011514.1 AAB65714.1
    mRNA AF011515.1 AAB65715.1
    mRNA AF011516.1 AAB65716.1
    mRNA AF011517.1 AAB65717.1
    mRNA AF011518.1 AAB65718.1
    mRNA AF011519.1 AAB65719.1
    mRNA AF011520.1 AAB65720.1
    mRNA AF011521.1 AAB65721.1
    mRNA AF011522.1 AAB65722.1
    mRNA AF011523.1 AAB65723.1
    mRNA AF011524.1 AAB65724.1
    mRNA AF011525.1 AAB65725.1
    mRNA AF011526.1 AAB65726.1
    mRNA AF011527.1 AAB65727.1
    mRNA AF011528.1 AAB65728.1
    mRNA AF011529.1 AAB65729.1
    mRNA AF011530.1 AAB65730.1
    mRNA AF011531.1 AAB65731.1
    mRNA AF011532.1 AAB65732.1
    mRNA AF011533.1 AAB65733.1
    mRNA AF011534.1 AAB65734.1
    mRNA AF011535.1 AAB65735.1
    mRNA AF011536.1 AAB65736.1
    mRNA AF011537.1 AAB65737.1
    mRNA AK292132.1 BAF84821.1
    mRNA BC038398.1 AAH38398.1
    mRNA DA818906.1 None
    mRNA U54994.1 AAC50598.1
    mRNA U57840.1 AAB17071.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A502 GenPept UniProtKB/TrEMBL:A0A502
    O14694 GenPept UniProtKB/TrEMBL:O14694
    P51681.1 GenPept UniProtKB/Swiss-Prot:P51681
    Q38L21 GenPept UniProtKB/TrEMBL:Q38L21
    Q3L3Q6 GenPept UniProtKB/TrEMBL:Q3L3Q6
    Q5EKM8 GenPept UniProtKB/TrEMBL:Q5EKM8
    Q5EKM9 GenPept UniProtKB/TrEMBL:Q5EKM9
    Q5EKN0 GenPept UniProtKB/TrEMBL:Q5EKN0
    Q5KSY4 GenPept UniProtKB/TrEMBL:Q5KSY4
    Q5KSY5 GenPept UniProtKB/TrEMBL:Q5KSY5
    Q5QIN9 GenPept UniProtKB/TrEMBL:Q5QIN9
    Q5QIP0 GenPept UniProtKB/TrEMBL:Q5QIP0
    Q5QIP1 GenPept UniProtKB/TrEMBL:Q5QIP1
    Q9P1T4 GenPept UniProtKB/TrEMBL:Q9P1T4
    Q9P1T8 GenPept UniProtKB/TrEMBL:Q9P1T8
    Q9UBJ7 GenPept UniProtKB/TrEMBL:Q9UBJ7
    Q9UBT9 GenPept UniProtKB/TrEMBL:Q9UBT9
    Q9UN23 GenPept UniProtKB/TrEMBL:Q9UN23
    Q9UN24 GenPept UniProtKB/TrEMBL:Q9UN24
    Q9UN25 GenPept UniProtKB/TrEMBL:Q9UN25
    Q9UN26 GenPept UniProtKB/TrEMBL:Q9UN26
    Q9UN27 GenPept UniProtKB/TrEMBL:Q9UN27
    Q9UN28 GenPept UniProtKB/TrEMBL:Q9UN28
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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