CEBPG CCAAT/enhancer binding protein (C/EBP), gamma [Homo sapiens] - Gene

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Summary

Official Symbol: CEBPGprovided by HGNC
Official Full Name: CCAAT/enhancer binding protein (C/EBP), gammaprovided by HGNC
Primary source: HGNC:1837
See related: Ensembl:ENSG00000153879; HPRD:00738; MIM:138972
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPE1BP; IG/EBP-1
Summary: The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]

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Genomic context

Location :: 19q13.11

Sequence :: Chromosome: 19; NC_000019.9 (33864609..33873592)

See CEBPG in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
CEBPG regulates ERCC5 expression and this regulation is modified by E2F1/YY1 interactions.
Title: CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions.
Ig/EBP (C/EBPgamma)is constitutively multiubiquitinated & then degraded by the proteasome. Ubiquitination and degradation are suppressed by forming dimers through the leucine zipper domains.
Title: C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.
CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals
Title: CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P53567	P15336	ATF2	HPRD	PubMed
P53567	P18848	ATF4	HPRD	PubMed
P53567	Q9Y2D1	ATF5	HPRD	PubMed
P53567	P17676	CEBPB	HPRD	PubMed
P53567	P49716	CEBPD	HPRD	PubMed
P53567	P53567	CEBPG	HPRD	PubMed
P53567	cAMP responsive element binding protein 3 like 3	CREB3L3	HPRD	PubMed
P53567	P35638	DDIT3	HPRD	PubMed
P53567	P01100	FOS	HPRD	PubMed
P53567	P13984	GTF2F2	HPRD	PubMed
P53567	P55198	MLLT6	HPRD	PubMed
P53567	GRINL1A downstream protein Gdown1	POLR2M	HPRD	PubMed
BioGRID:107483	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107483	BioGRID:107480	CEBPB	BioGRID	PubMed	Reconstituted Complex
BioGRID:107483	BioGRID:108016	DDIT3	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107483	BioGRID:110448	MLLT6	BioGRID	PubMed	Two-hybrid
BioGRID:107483	BioGRID:123498	POLR2M	BioGRID	PubMed	Two-hybrid
BioGRID:107483	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
enucleate erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
immune response	ISS Inferred from Sequence or Structural Similarity more info
liver development	ISS Inferred from Sequence or Structural Similarity more info
mRNA metabolic process	IEA Inferred from Electronic Annotation more info
natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of sequence-specific DNA binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of DNA binding	TAS Traceable Author Statement more info	PubMed
positive regulation of DNA repair	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of interferon-gamma biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Preferred Names: CCAAT/enhancer-binding protein gamma

Names: CCAAT/enhancer-binding protein gamma; c/EBP gamma

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252296.1 → NP_001239225.1 CCAAT/enhancer-binding protein gamma

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC008744, BC013128, CN353219

UniProtKB/Swiss-Prot

P53567

Conserved Domains (1) summary

cl02576
Location:61 – 114
Blast Score: 140

bZIP_1; bZIP transcription factor
NM_001806.3 → NP_001797.1 CCAAT/enhancer-binding protein gamma

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC008744, BC007582, BC013128

Consensus CDS

CCDS12432.1

UniProtKB/Swiss-Prot

P53567

Related

ENSP00000284000, ENST00000284000

Conserved Domains (1) summary

cl02576
Location:61 – 114
Blast Score: 140

bZIP_1; bZIP transcription factor

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

33864609..33873592

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

30365245..30374228

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC008744.6 (70708..79691)	None
mRNA	AK313634.1	BAG36393.1
mRNA	BC007582.1	AAH07582.1
mRNA	BC013128.1	AAH13128.1
mRNA	BT019819.1	AAV38622.1
mRNA	BT019820.1	AAV38623.1
mRNA	CB993585.1	None
mRNA	CN353219.1	None
mRNA	U20240.1	AAC50201.1
other-genetic	DQ896455.2	ABM87454.1
other-genetic	EU176442.1	ABW03893.1