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    KPNB1 karyopherin (importin) beta 1 [ Homo sapiens ]

    Gene ID: 3837, updated on 12-May-2012
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    Summary

    Official Symbol
    KPNB1provided by HGNC
    Official Full Name
    karyopherin (importin) beta 1provided by HGNC
    Primary source
    HGNC:6400
    See related
    Ensembl:ENSG00000108424; HPRD:04114; MIM:602738; Vega:OTTHUMG00000036957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMB1; IPO1; IPOB; Impnb; NTF97; MGC2155; MGC2156; MGC2157
    Summary
    Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17q21.32
    Sequence :
    Chromosome: 17; NC_000017.10 (45727275..45761004)
    See KPNB1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L45 pseudogene 2 Neighboring gene aminopeptidase puromycin sensitive Neighboring gene TBK1 binding protein 1 Neighboring gene T-box 21

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. Andersen SD, et al. DNA Repair (Amst), 2012 Mar 1. PMID 22222486.
    2. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    3. A cohesin-RAD21 interactome. Panigrahi AK, et al. Biochem J, 2012 Mar 15. PMID 22145905.
    4. Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity. Watt PJ, et al. PLoS One, 2011. PMID 22125623.
    5. Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells. Kojima Y, et al. J Biol Chem, 2011 Dec 16. PMID 22020938.

    See all (160) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Findings suggest that the deregulated activity of E2F in cancer cells causes increased activation of the Kpnbeta1 and Kpnalpha2 promoters, leading to elevated levels of these proteins, and ultimately impacting the cancer phenotype.
      Title: Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.
    2. Findings suggest that the importin beta1-mediated nuclear localization of DR5 limits the DR5/TRAIL-induced cell death of human tumor cells and thus can be a novel target to improve cancer therapy with recombinant TRAIL and anti-DR5 antibodies.
      Title: Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells.
    3. study defines importin-alpha/importin-beta1/Ran as the molecular mechanism by which STAT3 traffics to the nucleus
      Title: Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1.
    4. [review] The cellular functions of Ran are mediated by RanGTP interactions with nuclear transport receptors related to importin beta and depend on the existence of chromosome-centered RanGTP gradient.
      Title: The role of RanGTP gradient in vertebrate oocyte maturation.
    5. The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells.
      Title: Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme.
    6. Importin beta interacts with the NFAT-tubulin alpha complex rather than NFAT or tubulin alpha alone, resulting in cotranslocation of NFAT and tubulin alpha into the nucleus.
      Title: Cutting edge: tubulin α functions as an adaptor in NFAT-importin β interaction.
    7. Results demonstrate that PP2A-B55alpha and importin-beta1 cooperate in the regulation of postmitotic assembly mechanisms in human cells.
      Title: Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.
    8. [review] Recognition and shuttling of calcineurin into the nucleus by importin-beta requires the nuclear localization sequence of the region spanning amino acids 172-183 of calcineurin A beta.
      Title: Inhibition of the calcineurin-NFAT signalling cascade in the treatment of heart failure.
    9. replacement of the cap-binding complex by eukaryotic translation initiation factor 4E is promoted by importin beta (IMPbeta)
      Title: Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta.
    10. Crm1, Kpnbeta1 and Kpnalpha2 are overexpressed in cervical cancer and inhibiting the expression of Crm1 and Kpnbeta1, not Kpnalpha2, induces cancer cell death
      Title: The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.
    Submit: New GeneRIF Correction See all (24)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev importin beta specifically binds to the Rev nuclear localization signal (NLS, amino acids 35-50) and mediates the nuclear import of Rev PubMed
    rev importin beta can inhibit the interaction of HIV-1 Rev with HIV-1 RRE RNA PubMed
    Tat tat The binding of HIV-1 Tat with importin beta is inhibited by RanGTP PubMed
    tat Importin beta binds to the HIV-1 Tat protein nuclear localization signal (NLS; amino acids 49-57) and mediates the nuclear import of Tat through a novel import pathway PubMed
    Vpr vpr HIV-1 Vpr co-localizes with karyopherin beta and regulates karyopherin beta-mediated docking of the HIV-1 preintegration complex at the nuclear envelope, however multiple reports indicate the two proteins do not directly interact PubMed
    integrase gag-pol Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import PubMed
    gag-pol Karyopherin beta binds to complexes between HIV-1 integrase (integrase/GST fusion protein) and karyopherin alpha, but not to integrase alone PubMed
    gag-pol Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways PubMed
    matrix gag Karyopherin beta mediates the nuclear import of HIV-1 preintegration complexes through karyopherin alpha, which binds directly to nuclear localization signals in HIV-1 Matrix PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002256.2 NP_002405.1 CD99    BIND  PubMed CD99 interacts with KPNB1. 
    NP_002256.2 NP_006316.1 RAN    BIND  PubMed Interaction between KPNB1 (PDB ID: 1IBR_B) and RAN (PDB ID: 1IBR_A). 
    NP_002256.2 NP_000337.1 SOX9    BIND  PubMed KPNB1 (importin beta) interacts with SOX9. 
    NP_002256.2 NP_057854.1 rev    BIND  PubMed Rev interacts with Imp-beta. 
    NP_002256.2 NP_057853.1 tat    BIND  PubMed Tat interacts with Imp-beta. 
    NP_002256.2     BIND  PubMed KPNB1 (Importin-beta) interacts with Ran-GTP. This interaction was modelled on a demonstrated interaction between human KPNB1 and canine Ran-GTP. 
    Q14974 P14209 CD99    HPRD  PubMed  
    Q14974 Q12873 CHD3    HPRD  PubMed  
    Q14974 P55060 CSE1L    HPRD  PubMed  
    Q14974 P48729 CSNK1A1    HPRD  PubMed  
    Q14974 Q15717 ELAVL1    HPRD  PubMed  
    Q14974 P11362 FGFR1    HPRD  PubMed  
    Q14974 P07305 H1F0    HPRD  PubMed  
    Q14974 P17936 IGFBP3    HPRD  PubMed  
    Q14974 P24593 IGFBP5    HPRD  PubMed  
    Q14974 O95373 IPO7    HPRD  PubMed  
    Q14974 O15397 IPO8    HPRD  PubMed  
    Q14974 P52292 KPNA2    HPRD  PubMed  
    Q14974 O00505 KPNA3    HPRD  PubMed  
    Q14974 O60684 KPNA6    HPRD  PubMed  
    Q14974 Q14974 KPNB1    HPRD  PubMed  
    Q14974 Q99698 LYST    HPRD  PubMed  
    Q14974 P23511 NFYA    HPRD  PubMed  
    Q14974 P49790 NUP153    HPRD  PubMed  
    Q14974 Q9UKX7 NUP50    HPRD  PubMed  
    Q14974 P37198 NUP62    HPRD  PubMed  
    Q14974 P52948 NUP98    HPRD  PubMed  
    Q14974 Q8N2W9 PIAS4    HPRD  PubMed  
    Q14974 P51178 PLCD1    HPRD  PubMed  
    Q14974 O94806 PRKD3    HPRD  PubMed  
    Q14974 P12272 PTHLH    HPRD  PubMed  
    Q14974 P06454 PTMA    HPRD  PubMed  
    Q14974 P21246 PTN    HPRD  PubMed  
    Q14974 P17706 PTPN2    HPRD  PubMed  
    Q14974 P62826 RAN    HPRD  PubMed  
    Q14974 P49792 RANBP2    HPRD  PubMed  
    Q14974 P46777 RPL5    HPRD  PubMed  
    Q14974 Q06455 RUNX1T1    HPRD  PubMed  
    Q14974 Q15796 SMAD2    HPRD  PubMed  
    Q14974 P84022 SMAD3    HPRD  PubMed  
    Q14974 Q16637 SMN2    HPRD  PubMed  
    Q14974 O75940 SMNDC1    HPRD  PubMed  
    Q14974 O95149 SNUPN    HPRD  PubMed  
    Q14974 P48436 SOX9    HPRD  PubMed  
    Q14974 Q12772 SREBF2    HPRD  PubMed  
    Q14974 P54274 TERF1    HPRD  PubMed  
    Q14974 P04637 TP53    HPRD  PubMed  
    Q14974 O95071 UBR5    HPRD  PubMed  
    BioGRID:110035 BioGRID:106823 AIRE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:106764 AMFR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:120548 C20orf20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:114028 CUL4B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:122559 DERL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:114602 EXO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:116573 FAN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:108551 FGFR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:109261 HIST1H1C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:109314 HTT    BioGRID  PubMed Two-hybrid 
    BioGRID:110035 BioGRID:109833 ING1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110035 BioGRID:115782 IPO7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:115781 IPO8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:110034 KPNA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:110036 KPNA2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:110037 KPNA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:110038 KPNA4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:117163 KPNA6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:110035 KPNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:200952 Kifc5b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:200654 Kpnb1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:107552 LYST    BioGRID  PubMed Two-hybrid 
    BioGRID:110035 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:116794 MESDC2    BioGRID  PubMed Two-hybrid 
    BioGRID:110035 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:110438 MLH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:115001 MORF4L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:201430 Mki67    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:110845 NFATC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:110846 NFATC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:113843 NRIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:121386 NUP107    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:115297 NUP153    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:115982 NUP50    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:119759 NUP54    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:117165 NUP62    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:110982 NUP98    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:115499 NUTF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:203509 Nhp2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:116119 PAPOLA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:111404 PMS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:111716 PTHLH    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:110035 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:111837 RAN    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:111838 RANBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:111839 RANBP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:107529 RCC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:107310 RUNX1T1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:202582 Ranbp2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:216710 Rmi1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:120934 SELS    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:115384 SNUPN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:116734 SPG20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:112599 SREBF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:112614 SRY    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:112872 TERF1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:110035 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110035 BioGRID:116624 TPX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110035 BioGRID:113603 TUBA1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110035 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110035 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of DNA fragmentation factor, organism-specific biosystem (from REACTOME)
      Activation of DNA fragmentation factor, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved, in part, through the activity of apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) (reviewed ...
    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis induced DNA fragmentation, organism-specific biosystem (from REACTOME)
      Apoptosis induced DNA fragmentation, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
      Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by TCPTP, organism-specific biosystem
      Signaling events mediated by TCPTP
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystem (from REACTOME)
      Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystemAn unusual characteristic of the influenza virus life cycle is its dependence on the nucleus. Trafficking of the viral genome into and out of the nucleus is a tightly regulated process with all viral...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nuclear localization sequence binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA fragmentation involved in apoptotic nuclear change TAS
    Traceable Author Statement
    more info
    		  
    NLS-bearing substrate import into nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein import into nucleus, translocation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ribosomal protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    viral genome transport in host cell TAS
    Traceable Author Statement
    more info
    		  
    viral infectious cycle TAS
    Traceable Author Statement
    more info
    		  
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear pore TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    importin subunit beta-1
    Names
    importin subunit beta-1
    PTAC97
    importin 1
    importin 90
    importin-90
    nuclear factor p97
    importin beta-1 subunit
    karyopherin subunit beta-1
    pore targeting complex 97 kDa subunit
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002265.4 → NP_002256.2  importin subunit beta-1

      Status: REVIEWED

      Source sequence(s)
      BE046507, L38951
      Consensus CDS
      CCDS11513.1
      UniProtKB/Swiss-Prot
      Q14974
      Related
      ENSP00000290158, OTTHUMP00000035030, ENST00000290158, OTTHUMT00000089755
      Conserved Domains (3) summary
      cd00020
      Location:365 – 477
      Blast Score: 131
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      COG5215
      Location:2 – 871
      Blast Score: 1506
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      cl04271
      Location:21 – 101
      Blast Score: 139
      IBN_N; Importin-beta N-terminal domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      45727275..45761004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      41096335..41130080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC015674.12 (113355..147078) None
    genomic AC025682.6 None
    genomic CH471109.2 EAW94807.1
      EAW94808.1
      EAW94809.1
      EAW94810.1
    genomic CS531808.1 CAM84939.1
    genomic L39793.1 AAA82869.1
    mRNA AK299145.1 BAH12957.1
    mRNA AK301463.1 BAH13488.1
    mRNA AK314780.1 BAG37316.1
    mRNA AK316421.1 BAH14792.1
    mRNA BC003572.1 AAH03572.1
    mRNA BC024045.1 AAH24045.1
    mRNA BC036703.2 AAH36703.1
    mRNA BE046507.1 None
    mRNA BT009797.1 AAP88799.1
    mRNA L38951.1 AAC41763.1
    mRNA L39924.1 None
    other-genetic DQ892863.2 ABM83789.1
    other-genetic DQ896112.2 ABM87111.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14974.2 GenPept UniProtKB/Swiss-Prot:Q14974
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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