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    VCL vinculin [ Homo sapiens (human) ]

    Gene ID: 7414, updated on 15-Jun-2013
    Official Symbol
    VCLprovided by HGNC
    Official Full Name
    vinculinprovided by HGNC
    Primary source
    HGNC:12665
    Locus tag
    RP11-178G16.3
    See related
    Ensembl:ENSG00000035403; HPRD:01900; MIM:193065; Vega:OTTHUMG00000018498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MV; MVCL; CMD1W; CMH15
    Summary
    Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
    Location :
    10q22.2
    Sequence :
    Chromosome: 10; NC_000010.10 (75757872..75879918)
    See VCL in Epigenomics

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene chromosome 10 open reading frame 55 Neighboring gene plasminogen activator, urokinase Neighboring gene adaptor-related protein complex 3, mu 1 subunit Neighboring gene adenosine kinase Neighboring gene translocase of inner mitochondrial membrane 9 homolog (yeast) pseudogene 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Vinculin and metavinculin: oligomerization and interactions with F-actin. Thompson PM, et al. FEBS Lett, 2013 Apr 17. PMID 23466368.
    2. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. Yu CC, et al. PLoS One, 2013. PMID 23383273.
    3. Metavinculin: New insights into functional properties of a muscle adhesion protein. Thoss F, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159629.
    4. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. Vigodner M, et al. Hum Reprod, 2013 Jan. PMID 23077236.
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.

    See all (134) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies indicate that that vinculin not only bundles actin filaments but can also cap these filaments and promote actin polymerization.
      Title: Vinculin and metavinculin: oligomerization and interactions with F-actin.
    2. these data suggest that metavinculin enrichment in attachment sites of muscle cells leads to higher mechanical stability of adhesion complexes allowing for greater shear force resistance.
      Title: Metavinculin: New insights into functional properties of a muscle adhesion protein.
    3. Western blotting demonstrated that vinculin was predominantly expressed in the pancreatic cancer tissues compared with non-cancerous tissues; findings indicate that vinculin may be a clinically useful biomarker of pancreatic cancer
      Title: Proteomic differential display identifies upregulated vinculin as a possible biomarker of pancreatic cancer.
    4. These binding assays show that raver1 forms a ternary complex with metavinculin and vinculin mRNA.
      Title: The metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA.
    5. The metavinculin promoted severing of actin filaments, most efficiently at substoichiometric concentrations.
      Title: The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments.
    6. binding studies suggest that vinculin must be in an activated state to bind to alpha-catenin and that this interaction is stabilized by the formation of a ternary alpha-catenin-vinculin-F-actin complex, which can be formed via the F-actin binding domain
      Title: The cytoskeletal protein α-catenin unfurls upon binding to vinculin.
    7. Results implicate Vinculin-dependent VE-cadherin mechanosensing in endothelial processes such as leukocyte extravasation and angiogenesis.
      Title: Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.
    8. Data show that SGK1 regulates cell migration via vinculin dephosphorylation, a mechanism that is controlled by membrane androgen receptor function.
      Title: Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.
    9. alpha-catenin employs a novel mechanism to activate vinculin and may explain how vinculin is differentially recruited and/or activated in cell-cell and cell-matrix adhesions.
      Title: α-Catenin uses a novel mechanism to activate vinculin.
    10. sca4 activates vinculin and interacts with the actin cytoskeleton; vinculin has roles in Rickettsia pathogenesis
      Title: The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
    Submit: New GeneRIF Correction See all (47)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Dilated cardiomyopathy 1W

    Summary from GeneReviews: Dilated Cardiomyopathy Overview Go to GeneReviews

    Disease Characteristics
    Nonsyndromic isolated dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and systolic dysfunction, a reduction in the myocardial force of contraction. DCM usually presents with any one of the following: Heart failure with symptoms of congestion (edema, orthopnea, paroxysmal dyspnea) and/or reduced cardiac output (fatigue, dyspnea on exertion). Arrhythmias and/or conduction system disease. Thromboembolic disease (from left ventricular mural thrombus) including stroke .
    Diagnosis Testing
    Genetic forms of DCM must be distinguished from other identifiable causes. After exclusion of all identifiable non-genetic causes, DCM is traditionally referred to as idiopathic dilated cardiomyopathy. When two or more closely related family members meet a formal diagnostic standard for idiopathic dilated cardiomyopathy, the diagnosis of familial dilated cardiomyopathy (FDC) is made. The genetic forms of DCM are diagnosed by family history and molecular genetic testing.
    Genetic Counseling
    Genetic DCM can be inherited in an autosomal dominant, autosomal recessive, or X-linked manner. Maternal mitochondrial inheritance has also been reported; however, mitochondrial forms of DCM, although highly variable in presentation (including mild adult-onset forms), are usually syndromic and thus outside the scope of this review. Genetic counseling and risk assessment depend on determination of the specific DCM subtype in an individual.
    References

    Primary dilated cardiomyopathy

    Summary from GeneReviews: Dilated Cardiomyopathy Overview Go to GeneReviews

    Disease Characteristics
    Nonsyndromic isolated dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and systolic dysfunction, a reduction in the myocardial force of contraction. DCM usually presents with any one of the following: Heart failure with symptoms of congestion (edema, orthopnea, paroxysmal dyspnea) and/or reduced cardiac output (fatigue, dyspnea on exertion). Arrhythmias and/or conduction system disease. Thromboembolic disease (from left ventricular mural thrombus) including stroke .
    Diagnosis Testing
    Genetic forms of DCM must be distinguished from other identifiable causes. After exclusion of all identifiable non-genetic causes, DCM is traditionally referred to as idiopathic dilated cardiomyopathy. When two or more closely related family members meet a formal diagnostic standard for idiopathic dilated cardiomyopathy, the diagnosis of familial dilated cardiomyopathy (FDC) is made. The genetic forms of DCM are diagnosed by family history and molecular genetic testing.
    Genetic Counseling
    Genetic DCM can be inherited in an autosomal dominant, autosomal recessive, or X-linked manner. Maternal mitochondrial inheritance has also been reported; however, mitochondrial forms of DCM, although highly variable in presentation (including mild adult-onset forms), are usually syndromic and thus outside the scope of this review. Genetic counseling and risk assessment depend on determination of the specific DCM subtype in an individual.
    References
    Protein Gene Interaction Pubs
    Nef, p27 nef HIV-1 Nef induces polarization of vinculin, a molecule important for dendritic cell (DC) adhesion, motility, and maturation, at one pole of DCs corresponding to the substrate-adhering portion or leading edge of the cell PubMed
    matrix gag HIV-1 MA colocalizes with 2 integrin CD18, aM and aX integrins (CD11b and CD11c) in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P18206 Q9NYB9 ABI2    HPRD  PubMed  
    P18206 P68133 ACTA1    HPRD  PubMed  
    P18206 P12814 ACTN1    HPRD  PubMed  
    P18206 Chromosome 19 open reading frame 57 C19orf57    HPRD  PubMed  
    P18206 P12830 CDH1    HPRD  PubMed  
    P18206 Q00610 CLTC    HPRD  PubMed  
    P18206 Q9UQ03 CORO2B    HPRD  PubMed  
    P18206 P35221 CTNNA1    HPRD  PubMed  
    P18206 P06396 GSN    HPRD  PubMed  
    P18206 Q86VF7 NRAP    HPRD  PubMed  
    P18206 P98161 PKD1    HPRD  PubMed  
    P18206 P17252 PRKCA    HPRD  PubMed  
    P18206 O75400 PRPF40A    HPRD  PubMed  
    P18206 Q06323 PSME1    HPRD  PubMed  
    P18206 Q05397 PTK2    HPRD  PubMed  
    P18206 P49023 PXN    HPRD  PubMed  
    P18206 Q8IY67 RAVER1    HPRD  PubMed  
    P18206 P16581 SELE    HPRD  PubMed  
    P18206 Q9BX66 SORBS1    HPRD  PubMed  
    P18206 Arg binding protein 2 SORBS2    HPRD  PubMed  
    P18206 P12931 SRC    HPRD  PubMed  
    P18206 Q9Y490 TLN1    HPRD  PubMed  
    P18206 Q15654 TRIP6    HPRD  PubMed  
    P18206 P50552 VASP    HPRD  PubMed  
    BioGRID:113257 BioGRID:115454 ABI2    BioGRID  PubMed Two-hybrid 
    BioGRID:113257 BioGRID:106932 ASNS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:107007 ATP6V1A    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:114934 BCAR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113257 BioGRID:122590 C19orf57    BioGRID  PubMed Two-hybrid 
    BioGRID:113257 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113257 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:107623 CLTC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113257 BioGRID:115663 CORO2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113257 BioGRID:107876 CTNNA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113257 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113257 BioGRID:107883 CTPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:216476 Cep350    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:107975 DAG1    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:113257 BioGRID:118787 DCPS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:123242 DNAJC5    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:108221 ECHS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:108298 EIF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:116704 ERP44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:116175 FERMT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:108814 G6PD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:122295 GINS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:109035 GNAI3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:109189 GSN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113257 BioGRID:109192 GSS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:109545 HSPA9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:119222 ISOC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:109894 ITGB1    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:110584 MSN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:110951 NRAP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113257 BioGRID:116400 PDCD10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:111186 PDHA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:114966 PDIA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:111221 PFAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:111258 PGM5    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:111497 PPP1R2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:111528 PPP5C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:120792 PRPF40A    BioGRID  PubMed Two-hybrid 
    BioGRID:113257 BioGRID:111692 PSME1    BioGRID  PubMed Two-hybrid 
    BioGRID:113257 BioGRID:111787 PXN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113257 BioGRID:111845 RAP1GDS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:214910 Raver1    BioGRID  PubMed Two-hybrid 
    BioGRID:113257 BioGRID:121536 SCAF4    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:120288 SDHAF2    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:112520 SNRPF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:115831 SORBS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113257 BioGRID:114047 SORBS2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113257 BioGRID:118869 SSU72    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:114011 STK24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:112707 SVIL    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:107575 TBCB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:112899 TGFB1I1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113257 BioGRID:113020 TPI1    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:113056 TRIP6    BioGRID  PubMed Two-hybrid 
    BioGRID:113257 BioGRID:113603 TUBA1A    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:113257 BioGRID:115654 TUBB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:114755 TXNL1    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:114503 UBA3    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:121034 UBFD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:128238 UBR1    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:119577 UFC1    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:123542 URM1    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:114173 USO1    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:114650 VAPB    BioGRID  PubMed Co-fractionation 
    BioGRID:113257 BioGRID:113251 VASP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113257 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:113348 XPO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113257 BioGRID:124907 ZC3HAV1L    BioGRID  PubMed Co-fractionation 
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by focal adhesion kinase, organism-specific biosystem
      Signaling events mediated by focal adhesion kinase
    • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
      Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rho GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    alpha-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    beta-catenin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cadherin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    dystroglycan binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    adherens junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		  
    apical junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    		  
    cellular component movement TAS
    Traceable Author Statement
    more info
    		 PubMed 
    epithelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		  
    lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		  
    muscle contraction TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    platelet degranulation TAS
    Traceable Author Statement
    more info
    		  
    protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    		  
    cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell-substrate junction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    costamere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    costamere ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    fascia adherens IEA
    Inferred from Electronic Annotation
    more info
    		  
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    vinculin
    Names
    vinculin
    metavinculin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008868.1 RefSeqGene

      Range
      5001..127047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_383

    mRNA and Protein(s)

    1. NM_003373.3 → NP_003364.1  vinculin isoform VCL

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 3' coding exon, as compared to variant 1. It encodes a shorter isoform (VCL), which is the major talin-binding protein in platelets.
      Source sequence(s)
      AI290052, AK126978, AL708715, AL832130, BC013847, BC039174, BX537994
      Consensus CDS
      CCDS7340.1
      UniProtKB/TrEMBL
      B3KXA2
      UniProtKB/Swiss-Prot
      P18206
      Related
      ENSP00000361841, OTTHUMP00000019861, ENST00000372755, OTTHUMT00000048751
      Conserved Domains (1) summary
      pfam01044
      Location:375 – 1066
      Blast Score: 1519
      Vinculin; Vinculin family

    2. NM_014000.2 → NP_054706.1  vinculin isoform meta-VCL

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs from variant 2 in having an additional exon in the 3' coding region. It thus encodes a longer isoform (meta-VCL).
      Source sequence(s)
      AA368699, AI290052, AK126978, AL700886, AL708715, AL832130, BC013847, BC039174
      Consensus CDS
      CCDS7341.1
      UniProtKB/TrEMBL
      B3KXA2
      UniProtKB/Swiss-Prot
      P18206
      Related
      ENSP00000211998, ENST00000211998
      Conserved Domains (1) summary
      pfam01044
      Location:3 – 360
      Blast Score: 1121
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p10 Primary Assembly

      Range
      75757872..75879918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      69753196..69875221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018921.1 Alternate CHM1_1.0

      Range
      76130982..76253029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01020295.1 (35613..68080) None
    genomic ABBA01020296.1 None
    genomic ABBA01020297.1 None
    genomic AL596247.22 (147013..228097) None
    genomic AL731576.9 (2000..42961) None
    genomic AMYH01002834.1 (34952..156999) None
    genomic CH471083.1 EAW54547.1
      EAW54548.1
      EAW54549.1
      EAW54550.1
      EAW54551.1
    genomic L04933.1 AAA61271.1
    genomic S87180.1 AAB21656.1
    genomic S87223.1 AAB21657.1
    mRNA AA368699.1 None
    mRNA AI290052.1 None
    mRNA AK126978.1 BAG54414.1
    mRNA AK296509.1 BAG59141.1
    mRNA AK300280.1 BAG62039.1
    mRNA AK304823.1 BAG65571.1
    mRNA AL700886.1 None
    mRNA AL708715.1 None
    mRNA AL832130.1 None
    mRNA BC013847.1 None
    mRNA BC039174.1 AAH39174.1
    mRNA BX537994.1 CAD97952.1
    mRNA M33308.1 AAA61283.1
    other-genetic DQ894680.2 ABM85606.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18206.4 GenPept UniProtKB/Swiss-Prot:P18206

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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