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IFNA1 interferon, alpha 1 [ Homo sapiens (human) ]

Gene ID: 3439, updated on 7-Jul-2014
Official Symbol
IFNA1provided by HGNC
Official Full Name
interferon, alpha 1provided by HGNC
Primary source
HGNC:5417
See related
Ensembl:ENSG00000197919; HPRD:00974; MIM:147660; Vega:OTTHUMG00000019673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFL; IFN; IFNA@; IFNA13; IFN-ALPHA; IFN-alphaD
Summary
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]
See IFNA1 in Epigenomics, MapViewer
Location:
9p22
Exon count :
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (21440454..21441316)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21440453..21441315)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene interferon, alpha 8 Neighboring gene interferon, omega 1 pseudogene 2 Neighboring gene MIR31 host gene (non-protein coding) Neighboring gene interferon, omega 1 pseudogene 19 Neighboring gene interferon, epsilon

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Env, gp160, envelope glycoprotein env IFN-alpha treated effector clones (gp120+CD8+ HPB-ALL/HIV) simultaneously downregulate CD8 expression and upregulate expression of both major histocompatibility antigen complex class I (MHC-I) and HIV-1 gp120/gp160 PubMed
Envelope surface glycoprotein gp120 env HIV-1 gp120-mediated inhibition of IFN-alpha production involves CD4 and BDCA2 in plasmacytoid dendritic cells PubMed
env HIV-1 gp120 inhibits CpG-A-induced secretion of IFN-alpha and IFN-beta proteins in PBMCs PubMed
env TLR-9-induced IFN-alpha production is inhibited by both monomeric and trimeric HIV-1 gp120 in plasmacytoid dendritic cells (pDC) PubMed
env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
env Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120 PubMed
env Treatment of cells with IFN reduces HIV-1 gp120 incorporation, as well as HIV-1 envelope-mediated incorporation of ICAM-1, into virions resulting in viruses that exhibit a significantly decreased ability to become bound to CD4+ target cells PubMed
env Interaction of HIV-1 gp120 with cell-associated CD4 leads to the induction of IFN alpha; preincubation of cells with anti-CD4 or the presence of soluble CD4 during incubation inhibits IFN alpha induction PubMed
env Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN) PubMed
env HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2 PubMed
env HIV-1 gp120-specific cell mediated cytotoxicity (CMC) is enhanced by IL-2 or the combination of IL-2 and IFN-alpha PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
Gag, Pr55 gag HIV-1 Gag virus-like particles induce production of IFN-alpha in human monocyte-derived dendritic cells, which leads to upregulated expression of APOBEC3G/F and increased incorporation of APOBEC3G/F into nascent virions PubMed
gag Interferon alpha inhibits the release of HIV-1 Gag/capsid proteins from infected cells by inducing changes in posttranslational modifications of Gag proteins PubMed
Tat, p14 tat HIV-1 Tat upregulates the production of cytokines, including TNF-alpha, IL-6, IL-10, IL-12, IFN-alpha1, and IFN-gamma, in human monocyte derived-dendritic cells PubMed
tat HIV-1 Tat inhibits CpG-A-induced secretion of IFN-alpha and IFN-beta proteins in PBMCs PubMed
tat HIV-1 Tat upregulates IFN-alpha secretion by macrophages, an effect that augments MIP-1alpha and MIP-1beta secretion and induces immunosuppression of uninfected T cells PubMed
tat HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication PubMed
tat IFN treatment significantly reduces HIV-1 mRNA levels from a Tat defective provirus, suggesting Tat can overcome the inhibitory effects of IFN on HIV-1 replication PubMed
Vif, p23 vif IFN-alpha enhances APOBEC3G expression and inhibits suppression of APOBEC3G by HIV-1 Vif PubMed
Vpr, p15 vpr Synthetic HIV-1 Vpr substantially inhibits type I IFN-alpha production by pDCs without inducing apoptosis in pDCs PubMed
vpr Exposure of rat or human cultured dorsal root ganglion neurons to Vpr rapidly increases cytosolic Ca2+ and expression of IFN-alpha and MX-1 are also increased in vpr-transgenic animals compared to control animals PubMed
Vpu, p16 vpu IFN-alpha and IFN-beta increase SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism PubMed
vpu IFNalpha/ribavirin treatment in vivo induces APOBEC3G, APOBEC3F, and BST-2 expression and results in hyper-mutations in viral genome and A11G/S61A mutations in HIV-1 Vpu. These two mutations in Vpu enhance the interaction between BST-2 and Vpu PubMed
vpu IFN alpha induces retention of viral particles on the surface of fibroblasts, T cells, or primary lymphocytes infected with HIV-1 lacking the Vpu protein. HIV-1 Vpu counteracts the IFNalpha-induced retention of virus particles PubMed
pol gag-pol Infection of IFN-alpha-treated primary macrophages, dendritic cells, and activated PBLs by HIV-2 and SIVmac is inhibited more potently than HIV-1 and the differential inhibition by IFN-alpha is caused by defects of vDNA accumulation by RT activity PubMed
gag-pol IFN-alpha interferes with the initiation of HIV-1 reverse transcription resulting in a significant reduction in the relative levels of HIV-1 proviral DNA PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description
Preferred Names
interferon alpha-1/13
Names
interferon alpha-1/13
leIF D
IFN-alpha 1b
IFN-alpha-1/13
interferon-alpha1
interferon alpha-D
interferon alpha 1b

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024013.2NP_076918.1  interferon alpha-1/13 precursor

    See proteins identical to NP_076918.1

    Status: REVIEWED

    Source sequence(s)
    V00537, V00538
    Consensus CDS
    CCDS6508.1
    UniProtKB/TrEMBL
    L0N195
    UniProtKB/Swiss-Prot
    P01562
    Related
    ENSP00000276927, OTTHUMP00000021142, ENST00000276927, OTTHUMT00000051902
    Conserved Domains (1) summary
    cd00095
    Location:26178
    Blast Score: 589
    IFab; Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    21440454..21441316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    21403853..21404715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    21440274..21441136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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