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VSIG4 V-set and immunoglobulin domain containing 4 [ Homo sapiens (human) ]

Gene ID: 11326, updated on 8-May-2016
Official Symbol
VSIG4provided by HGNC
Official Full Name
V-set and immunoglobulin domain containing 4provided by HGNC
Primary source
HGNC:HGNC:17032
See related
Ensembl:ENSG00000155659 HPRD:02286; MIM:300353; Vega:OTTHUMG00000021727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRIg; Z39IG
Summary
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Orthologs
Location:
Xq12
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (66021738..66040125, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (65241580..65259967, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein, X-linked-like 3 pseudogene Neighboring gene microRNA 223 Neighboring gene ataxin 7 like 3 pseudogene Neighboring gene eukaryotic translation initiation factor 4B pseudogene 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of V-set and immunoglobulin domain containing 4 (VSIG4) in peptide-treated PBMCs PubMed
Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein V-set and immunoglobulin domain containing 4 (VSIG4) in cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
V-set and immunoglobulin domain-containing protein 4
Names
Ig superfamily protein
complement receptor of the immunoglobulin superfamily
protein Z39Ig

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021306.1 RefSeqGene

    Range
    5001..23388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001100431.1NP_001093901.1  V-set and immunoglobulin domain-containing protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001093901.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as CRIg(S), lacks an alternate in-frame segment compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AL552873, BX482258, CA310184, CA405669
    Consensus CDS
    CCDS48132.1
    UniProtKB/Swiss-Prot
    Q9Y279
    Related
    ENSP00000394143, OTTHUMP00000023441, ENST00000412866, OTTHUMT00000056988
    Conserved Domains (2) summary
    smart00410
    Location:26116
    IG_like; Immunoglobulin like
    cl11960
    Location:35136
    Ig; Immunoglobulin domain
  2. NM_001184830.1NP_001171759.1  V-set and immunoglobulin domain-containing protein 4 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001171759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (4) has a shorter C-terminus, compared to isoform 4.
    Source sequence(s)
    AJ132502, AK297050, AY358341, BX482258
    Consensus CDS
    CCDS55435.1
    UniProtKB/Swiss-Prot
    Q9Y279
    Related
    ENSP00000411581, ENST00000455586
    Conserved Domains (4) summary
    cd00096
    Location:161223
    Ig; Immunoglobulin domain
    smart00408
    Location:157218
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:26116
    IG_like; Immunoglobulin like
    cl11960
    Location:35136
    Ig; Immunoglobulin domain
  3. NM_001184831.1NP_001171760.1  V-set and immunoglobulin domain-containing protein 4 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AJ132502, AK298389, AL034397, AY358341, BX482258
    UniProtKB/Swiss-Prot
    Q9Y279
    Conserved Domains (2) summary
    smart00410
    Location:26116
    IG_like; Immunoglobulin like
    cl11960
    Location:35136
    Ig; Immunoglobulin domain
  4. NM_001257403.1NP_001244332.1  V-set and immunoglobulin domain-containing protein 4 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ132502, AL542949, AL553835, BX482258
    UniProtKB/Swiss-Prot
    Q9Y279
    Conserved Domains (4) summary
    cd00096
    Location:161223
    Ig; Immunoglobulin domain
    smart00408
    Location:157218
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:26116
    IG_like; Immunoglobulin like
    cl11960
    Location:35136
    Ig; Immunoglobulin domain
  5. NM_007268.2NP_009199.1  V-set and immunoglobulin domain-containing protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_009199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is also called CRIg(L). It encodes the longest isoform (1).
    Source sequence(s)
    AJ132502, BP292528, BX482258
    Consensus CDS
    CCDS14383.1
    UniProtKB/Swiss-Prot
    Q9Y279
    Related
    ENSP00000363869, OTTHUMP00000023439, ENST00000374737, OTTHUMT00000056986
    Conserved Domains (4) summary
    cd00096
    Location:161223
    Ig; Immunoglobulin domain
    smart00408
    Location:157218
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:26116
    IG_like; Immunoglobulin like
    cl11960
    Location:35136
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    66021738..66040125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    65134610..65152555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)