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CCL3 chemokine (C-C motif) ligand 3 [ Homo sapiens (human) ]

Gene ID: 6348, updated on 19-Nov-2014
Official Symbol
CCL3provided by HGNC
Official Full Name
chemokine (C-C motif) ligand 3provided by HGNC
Primary source
HGNC:HGNC:10627
See related
Ensembl:ENSG00000277632; HPRD:01656; MIM:182283; Vega:OTTHUMG00000188413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
Summary
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
See CCL3 in Epigenomics, MapViewer
Location:
17q12
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (36088256..36090160, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34415602..34417506, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) ligand 23 Neighboring gene uncharacterized LOC102724850 Neighboring gene chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) Neighboring gene uncharacterized LOC101927369 Neighboring gene golgi membrane protein 1 pseudogene Neighboring gene chemokine (C-C motif) ligand 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces the release of cytokines MIP-1 alpha, MIP-1 beta, IL-6, IL10, and TNF-alpha in immature dentritic cells PubMed
env The CCR5 chemokine receptor is required for the entry of macrophage-tropic HIV-1 into target cells; the HIV-1 gp120-CD4 complex binds CCR5, which inhibits the binding of the natural CCR5 ligands macrophage inflammatory protein (MIP)-1alpha and MIP-1beta PubMed
env HIV-1 gp120 binding causes increased expression of CCL3 in T cells PubMed
env Exposure of macrophages to purified CCR5- or CXCR4-tropic HIV-1 envelope glycoprotein gp120 induces secretion of high levels of macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, RANTES, and tumor necrosis factor alpha PubMed
env NK cells exposed to CXCR4-tropic HIV-1 gp120 produce lower levels of CC chemokines RANTES, MIP-1alpha, and MIP-1beta compared with that produced from untreated NK cells PubMed
env HIV-1 gp120 from a T-cell-tropic virus causes CD4-dependent antagonism of CXCR4 response to SDF-1alpha, whereas gp120 from macrophage-tropic viruses causes CD4-dependent antagonism of CCR5 response to MIP-1alpha PubMed
env The neuroprotective action of VIP on gp120-induced neuronal cell death is attenuated by co-treatment with anti-MIP-1alpha, suggesting that the neuroprotective action of VIP is linked in part to its release of MIP-1alpha PubMed
env The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells PubMed
env N-formyl-methionyl-leucylphenyl-alanine binding to formyl peptide receptor (FPR) results in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1 gp120-mediated fusion and infection of cells expressing CD4, CCR5, and FPR PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of MIP-1alpha in peptide-treated PBMCs PubMed
env HIV-1 gp41 stimulates microglial cell production of cytokines (TNF-alpha, IL-1beta, and IL-6) and chemokines (RANTES and MIP-1alpha) PubMed
Nef nef HIV-1 Nef impairs the mobility of primary CD4+ lymphocytes and inhibits chemotaxis of primary T cells to CCL3 PubMed
nef The expression of HIV-1 Nef in primary human monocyte-derived macrophages (MDM) increases the concentration of MIP-1alpha PubMed
nef HIV-1 Nef expression by immature human and macaque dendritic cells (DCs) upregulates IL-6, IL-12, TNF-alpha, CXCL8, CCL3, and CCL4 release, but without upregulating co-stimulatory and other molecules characteristic of mature DCs PubMed
Pr55(Gag) gag HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release GM-CSF and MIP-1alpha in a dose-and time-dependent manner PubMed
Tat tat HIV-1 and the viral protein Tat modulate the expression of chemokine (C-C motif) ligand 3 (CCL3; MIP-1-alpha) in immature dendritic cells and monocyte-derived macrophages PubMed
tat HIV-1 Tat upregulates MIP-1alpha expression in microglia, MDDC, and T and B cell lines, an effect that suggests Tat plays an important role in the pathogenesis of HIV encephalitis and AIDS associated progressive multifocal leukoencephalopathy (PML) PubMed
tat HIV-1 Tat enhances the NFkappaB activity and promotes the transcriptional activation of MIP-1alpha by interacting with IkappaB-alpha and p65 RelA PubMed
tat Wild-type Tat but not Cys-22 and oxidized Tat induces CD1A-expressing monocyte-derived dendritic cells (MDDC) maturation and increases the production of cytokines TNF-alpha, IL-12, MIP-1alpha, and MIP-1beta PubMed
tat HIV-1 Tat downregulates MIP-1alpha expression in Jurkat T-cells by inducing MNP-1 PubMed
Vpr vpr HIV-1 Vpr downregulates the expression of beta chemokines in primary lymphocytes and macrophage, including MIP-1 alpha, MIP-1 beta, and RANTES PubMed
matrix gag HIV-1 Matrix is able to reduce MIP-1alpha secretion from IL-15-stimulated monocyte cells PubMed

Go to the HIV-1, Human Interaction Database

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    IL12-mediated signaling events, organism-specific biosystem
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  • Salmonella infection, organism-specific biosystem (from KEGG)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CCR1 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
CCR5 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium-dependent protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEP
Inferred from Expression Pattern
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
behavior IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell activation IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interferon-gamma IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
eosinophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
eosinophil degranulation IDA
Inferred from Direct Assay
more info
PubMed 
exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
granulocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
lymphocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
monocyte chemotaxis IC
Inferred by Curator
more info
PubMed 
monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation by host of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium ion import TAS
Traceable Author Statement
more info
PubMed 
positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of natural killer cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase B signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sensory perception of pain IDA
Inferred from Direct Assay
more info
PubMed 
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
response to cholesterol IDA
Inferred from Direct Assay
more info
PubMed 
response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
signaling IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
C-C motif chemokine 3
Names
C-C motif chemokine 3
SIS-beta
PAT 464.1
G0/G1 switch regulatory protein 19-1
macrophage inflammatory protein 1-alpha
tonsillar lymphocyte LD78 alpha protein
small inducible cytokine A3 (homologous to mouse Mip-1a)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027730.1 

    Range
    5001..6905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002983.2NP_002974.1  C-C motif chemokine 3 precursor

    See proteins identical to NP_002974.1

    Status: REVIEWED

    Source sequence(s)
    BX103455, M23452
    Consensus CDS
    CCDS11307.1
    UniProtKB/TrEMBL
    A0N0R1
    UniProtKB/Swiss-Prot
    P10147
    Related
    ENSP00000477908, OTTHUMP00000276534, ENST00000613922, OTTHUMT00000477142
    Conserved Domains (1) summary
    cd00272
    Location:3389
    Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    30600149..30602053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    36088256..36090160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 

    Range
    323130..325034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_2

Genomic

  1. NT_187661.1 

    Range
    42353..138418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725571.1XP_006725634.1  

    Conserved Domains (1) summary
    cd00272
    Location:163219
    Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    34479827..34481731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)