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    MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens ]

    Gene ID: 2475, updated on 20-May-2012
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    Summary

    Official Symbol
    MTORprovided by HGNC
    Official Full Name
    mechanistic target of rapamycin (serine/threonine kinase)provided by HGNC
    Primary source
    HGNC:3942
    See related
    Ensembl:ENSG00000198793; HPRD:03134; MIM:601231; Vega:OTTHUMG00000002001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRAP; FRAP1; FRAP2; RAFT1; RAPT1; FLJ44809
    Summary
    The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
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    Genomic context

    Location :
    1p36.2
    Sequence :
    Chromosome: 1; NC_000001.10 (11166588..11322608, complement)
    See MTOR in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene exosome component 10 Neighboring gene uncharacterized LOC100652764 Neighboring gene spermidine synthase Neighboring gene angiopoietin-like 7 Neighboring gene ribosomal protein L39 pseudogene 6 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene patched domain containing 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Pulmonary cysts of Birt-Hogg-Dubé syndrome: a clinicopathologic and immunohistochemical study of 9 families. Furuya M, et al. Am J Surg Pathol, 2012 Apr. PMID 22441547.
    2. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. Settembre C, et al. EMBO J, 2012 Feb 17. PMID 22343943.
    3. Overexpression of the μ-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis. Lennon FE, et al. Anesthesiology, 2012 Apr. PMID 22343475.
    4. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Muranen T, et al. Cancer Cell, 2012 Feb 14. PMID 22340595.
    5. Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway. Chen W, et al. Cancer Res, 2012 Mar 15. PMID 22287548.

    See all (644) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. DA6034 has the ability to heal scratch wounds, which may result from an increase in gastric epithelial cell migration mediated by PI3K-Akt-dependent activation of the mTOR pathway.
      Title: DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway.
    2. The results defined the TSC2-mTOR pathway as a key determinant in the differentiation of monocytes into M2 phenotype tumor-associated macrophages that promote angiogenesis.
      Title: Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway.
    3. Birt-Hogg-Dube syndrome-associated pulmonary cyst may be considered a hamartoma-like cystic alveolar formation associated with deranged mTOR signaling.
      Title: Pulmonary cysts of Birt-Hogg-Dubé syndrome: a clinicopathologic and immunohistochemical study of 9 families.
    4. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
      Title: Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
    5. Akt/mTOR might be effective targets to overcome the resistance to IGF-1R mAbs in head and neck squamous cell carcinoma and non-small cell lung carcinomas.
      Title: Akt/mTOR counteract the antitumor activities of cixutumumab, an anti-insulin-like growth factor I receptor monoclonal antibody.
    6. Report schedule-dependent inhibition of T-cell lymphoma cells by cotreatment with the mTOR inhibitor everolimus and anticancer agents.
      Title: Schedule-dependent inhibition of T-cell lymphoma cells by cotreatment with the mTOR inhibitor everolimus and anticancer drugs.
    7. Activation status of mTOR in T-lymphocytes influences not only lymphocyte activation and signal transduction but also regulates autoimmunity, immune tolerance, T cell subsets, and cell differentiation. [REVIEW]
      Title: mTOR signaling and metabolic regulation of T cells: new potential therapeutic targets in autoimmune diseases.
    8. mTOR pathway controls IL-12/IL-10 modulation by L. donovani in monocyte-dervied macrophages.
      Title: mTOR signaling pathway regulates the IL-12/IL-10 axis in Leishmania donovani infection.
    9. Aberrant expressions of p-AKT1 and p-MTOR in intrahepatic cholangiocarcinoma were associated with a favorable prognosis, possibly in a PTEN-independent manner.
      Title: The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas.
    10. When nutrients are present, phosphorylation of TFEB by mTORC1 inhibits TFEB activity.
      Title: A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
    Submit: New GeneRIF Correction See all (548)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Syncytia arising from the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 complex causes phosphorylation of p53, which is mediated by the upregulation of mammalian target of FKBP12-rapamycin-associated protein (FRAP) PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004949.1 NP_000792.1 FKBP1A    BIND  PubMed mTOR interacts with FKBP12 bound to rapamycin. This interaction was modeled on a demonstrated interaction between human mTOR and mouse FKBP12. 
    NP_004949.1 NP_005605.1 RHEB    BIND  PubMed FRAP1 (mTOR) interacts with Rheb. 
    NP_004949.1 AAS79796.1 RICTOR    BIND  PubMed mTOR phosphorylates mAVO3 within the mTORC2 complex. 
    NP_004949.1 XP_380173.2 RICTOR    BIND  PubMed mTOR interacts with rictor. 
    NP_004949.1 NP_065812.1 RPTOR    BIND  PubMed mTOR interacts with raptor. 
    P42345 P31749 AKT1    HPRD  PubMed  
    P42345 Q96B36 AKT1S1    HPRD  PubMed  
    P42345 P30622 CLIP1    HPRD  PubMed  
    P42345 O00303 EIF3F    HPRD  PubMed  
    P42345 Q13541 EIF4EBP1    HPRD  PubMed  
    P42345 P62942 FKBP1A    HPRD  PubMed  
    P42345 Q9NQX3 GPHN    HPRD  PubMed  
    P42345 P35568 IRS1    HPRD  PubMed  
    P42345 G protein beta subunit like MLST8    HPRD  PubMed  
    P42345 P42345 MTOR    HPRD  PubMed  
    P42345 O15530 PDPK1    HPRD  PubMed  
    P42345 O14939 PLD2    HPRD  PubMed  
    P42345 Q13131 PRKAA1    HPRD  PubMed  
    P42345 Q15382 RHEB    HPRD  PubMed  
    P42345 Ras homolog enriched in brain like 1 RHEBL1    HPRD  PubMed  
    P42345 Rictor RICTOR    HPRD  PubMed  
    P42345 Q15418 RPS6KA1    HPRD  PubMed  
    P42345 P23443 RPS6KB1    HPRD  PubMed  
    P42345 Q9UBS0 RPS6KB2    HPRD  PubMed  
    P42345 P40763 STAT3    HPRD  PubMed  
    P42345 O14746 TERT    HPRD  PubMed  
    P42345 Q9UMX0 UBQLN1    HPRD  PubMed  
    P42345 P27348 YWHAQ    HPRD  PubMed  
    BioGRID:108757 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:106710 AKT1    BioGRID  PubMed Biochemical Activity; Protein-peptide; Reconstituted Complex 
    BioGRID:108757 BioGRID:122489 C7orf25    BioGRID  PubMed Two-hybrid 
    BioGRID:108757 BioGRID:116312 CDC37    BioGRID  PubMed Two-hybrid 
    BioGRID:108757 BioGRID:111222 CFP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108757 BioGRID:112163 CLIP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108757 BioGRID:122304 DEPTOR    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108757 BioGRID:114211 EIF3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:114212 EIF3C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:114214 EIF3F    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108757 BioGRID:108293 EIF4EBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108757 BioGRID:120581 FBXW7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:108570 FKBP1A    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:108757 BioGRID:108935 GDI2P1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:115537 GPHN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108757 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:108757 BioGRID:109874 IRS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:110221 LRPAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:122551 MAPKAP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108757 BioGRID:122113 MLST8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108757 BioGRID:108757 MTOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:111075 PA2G4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108757 BioGRID:111189 PDK1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:108757 BioGRID:111354 PLD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:111512 PPP2R2A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108757 BioGRID:111549 PRKAA1    BioGRID  PubMed Protein-peptide 
    BioGRID:108757 BioGRID:111564 PRKCA    BioGRID  PubMed Biochemical Activity 
    BioGRID:108757 BioGRID:111566 PRKCD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:120755 PRR5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:111841 RAP1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:111941 RHEB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108757 BioGRID:128962 RICTOR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108757 BioGRID:114752 RPL23    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:112067 RPL23A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:112073 RPL26    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:112045 RPL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:112108 RPS6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:112112 RPS6KB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108757 BioGRID:121582 RPTOR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:108757 BioGRID:202889 Rheb    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108757 BioGRID:215408 Rps6kb1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:110812 SEPT2    BioGRID  PubMed Two-hybrid 
    BioGRID:108757 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108757 BioGRID:247196 Stat3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:115223 TELO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:112874 TERT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:115030 TTI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108757 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108757 BioGRID:119007 UBQLN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108757 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108757 BioGRID:276043 tti1    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the MTOR gene: The MTOR gene is conserved in dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , S.pombe, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • AMPK signaling, organism-specific biosystem (from WikiPathways)
      AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
    • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
      CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
    • CD28 dependent PI3K/Akt signaling, organism-specific biosystem (from REACTOME)
      CD28 dependent PI3K/Akt signaling, organism-specific biosystemPI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors (CD28), cytokine receptors and chemokine receptors. However, the specific role...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • CXCR3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR3-mediated signaling events, organism-specific biosystem
      CXCR3-mediated signaling events
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Class I PI3K signaling events mediated by Akt, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events mediated by Akt, organism-specific biosystem
      Class I PI3K signaling events mediated by Akt
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • EGFR-dependent Endothelin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      EGFR-dependent Endothelin signaling events, organism-specific biosystem
      EGFR-dependent Endothelin signaling events
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
    • ErbB2/ErbB3 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB2/ErbB3 signaling events, organism-specific biosystem
      ErbB2/ErbB3 signaling events
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events, organism-specific biosystem (from REACTOME)
      IRS-related events, organism-specific biosystemIRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned unde...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      LKB1 signaling events, organism-specific biosystem
      LKB1 signaling events
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • PI-3K cascade, organism-specific biosystem (from REACTOME)
      PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K Cascade, organism-specific biosystem (from REACTOME)
      PI3K Cascade, organism-specific biosystem
      PI3K Cascade
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs). Following ligand binding and autophosphorylation, RTKs recruit the 85 kDa regulatory subunit of PI3K (PI...
    • PKB-mediated events, organism-specific biosystem (from REACTOME)
      PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Telomerase, organism-specific biosystem
      Regulation of Telomerase
    • Release of eIF4E, organism-specific biosystem (from REACTOME)
      Release of eIF4E, organism-specific biosystemRaptor recruits mTOR to non-phosphorylated 4E-BP1 bound to eIF4E and positively modulates phosphorylation of 4E-BP1 by mTOR. 4E-BP1 is further phosphorylated on multiple sites by other unknown kinase...
    • S6K1-mediated signalling, organism-specific biosystem (from REACTOME)
      S6K1-mediated signalling, organism-specific biosystem
      S6K1-mediated signalling
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystem
      mTOR signaling pathway
    • mTOR signalling, organism-specific biosystem (from REACTOME)
      mTOR signalling, organism-specific biosystem
      mTOR signalling
    • mTORC1-mediated signalling, organism-specific biosystem (from REACTOME)
      mTORC1-mediated signalling, organism-specific biosystem
      mTORC1-mediated signalling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase III type 1 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    RNA polymerase III type 2 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    RNA polymerase III type 3 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    TFIIIC-class transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		  
    kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    TOR signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cellular response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of NFAT protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
    		  
    phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein kinase B signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase III promoter IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of Rac GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of carbohydrate utilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of response to food IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to nutrient NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    ruffle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    TORC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    TORC1 complex IMP
    Inferred from Mutant Phenotype
    more info
    		  
    TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    lysosome IDA
    Inferred from Direct Assay
    more info
    		  
    mTOR-FKBP12-rapamycin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol 3-kinase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    serine/threonine-protein kinase mTOR
    Names
    serine/threonine-protein kinase mTOR
    rapamycin target protein 1
    mammalian target of rapamycin
    rapamycin and FKBP12 target 1
    FKBP-rapamycin associated protein
    rapamycin associated protein FRAP2
    FKBP12-rapamycin complex-associated protein 1
    FK506 binding protein 12-rapamycin associated protein 1
    FK506 binding protein 12-rapamycin associated protein 2
    FK506-binding protein 12-rapamycin complex-associated protein 1
    NP_004949.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004958.3 → NP_004949.1  serine/threonine-protein kinase mTOR

      Status: REVIEWED

      Source sequence(s)
      AA725390, AB209995, BC117166, BP250183, DC403129, L34075, U88966
      Consensus CDS
      CCDS127.1
      UniProtKB/Swiss-Prot
      P42345
      Related
      ENSP00000354558, OTTHUMP00000001983, ENST00000361445, OTTHUMT00000005558
      Conserved Domains (7) summary
      COG5032
      Location:363 – 1805
      Blast Score: 1042
      TEL1; Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication, recombination, and repair / Intracellular ...
      cd05169
      Location:2153 – 2431
      Blast Score: 1453
      PIKKc_TOR; TOR (Target of rapamycin), catalytic domain; The TOR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside ...
      pfam08771
      Location:2015 – 2114
      Blast Score: 479
      Rapamycin_bind; Rapamycin binding domain
      smart00146
      Location:2184 – 2433
      Blast Score: 748
      PI3Kc; Phosphoinositide 3-kinase, catalytic domain
      pfam02259
      Location:1865 – 1908
      Blast Score: 128
      FAT; FAT domain
      pfam02260
      Location:2519 – 2549
      Blast Score: 169
      FATC; FATC domain
      pfam11865
      Location:854 – 1024
      Blast Score: 521
      DUF3385; Domain of unknown function (DUF3385)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      11166588..11322608, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      10317883..10473910, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF152840.1 None
    genomic AJ300188.1 CAC15570.1
    genomic AL049653.7 CAI22145.1
    genomic AL109811.40 CAI22101.1
      CAI22105.1
      CAI22108.1
    genomic AL359082.16 CAC42395.1
    genomic AL391561.20 CAI17227.1
      CAI17228.1
    genomic CH471130.1 EAW71681.1
      EAW71682.1
      EAW71683.1
    mRNA AA725390.1 None
    mRNA AB209995.1 BAE06077.1
    mRNA AK126762.1 BAG54371.1
    mRNA AK302863.1 BAG64047.1
    mRNA AK304273.1 BAG65134.1
    mRNA BC117166.1 AAI17167.1
    mRNA BP250183.1 None
    mRNA DC403129.1 None
    mRNA L34075.1 AAA58486.1
    mRNA L35478.1 AAC41713.1
    mRNA U88966.1 AAC39933.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42345.1 GenPept UniProtKB/Swiss-Prot:P42345
    Q96QW8 GenPept UniProtKB/TrEMBL:Q96QW8
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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