DPT dermatopontin [Homo sapiens] - Gene

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Summary

Official Symbol: DPTprovided by HGNC
Official Full Name: dermatopontinprovided by HGNC
Primary source: HGNC:3011
See related: Ensembl:ENSG00000143196; HPRD:00510; MIM:125597; Vega:OTTHUMG00000034554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRAMP
Summary: Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1q12-q23

Sequence :: Chromosome: 1; NC_000001.10 (168664695..168698442, complement)

See DPT in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DPT has an accelerating role in fibroblast cell adhesion to the provisional matrix in the initial stage of wound healing.
Title: Dermatopontin interacts with fibronectin, promotes fibronectin fibril formation, and enhances cell adhesion.
suggests that dermatopontin can play various roles in different tissues and might be a molecule related to carcinogenesis and the progression of HCC via possible interaction with TGF-beta1 and other potential mechanisms
Title: Dermatopontin is expressed in human liver and is downregulated in hepatocellular carcinoma.
Observational study of gene-disease association. (HuGE Navigator)
Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
roles of dermatopontin and histamine receptor H1 genes as downstream targets for the VDR were confirmed by gel electromotility shift and chromatin immunoprecipitation assays that showed the presence of VDR complex binding sequences
Title: Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef-induced upregulation of tyrosine-rich acidic matrix protein (TRAMP) is found in Nef expressing HeLa cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Q07507	P46379	BAG6	HPRD	PubMed
Q07507	P07585	DCN	HPRD	PubMed
Q07507	P28300	LOX	HPRD	PubMed
Q07507	P01137	TGFB1	HPRD	PubMed
BioGRID:108139	BioGRID:113647	BAG6	BioGRID	PubMed	Two-hybrid

Process	Evidence Code	Pubs
cell adhesion	IEA Inferred from Electronic Annotation more info
collagen fibril organization	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
colocalizes_with extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: dermatopontin

Names: dermatopontin; tyrosine-rich acidic matrix protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001937.4 → NP_001928.2 dermatopontin precursor

Status: VALIDATED

Source sequence(s)

AI699890, BC033736, BP257325

Consensus CDS

CCDS1275.1

UniProtKB/Swiss-Prot

Q07507

Related

ENSP00000356791, OTTHUMP00000032500, ENST00000367817, OTTHUMT00000083618

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

168664695..168698442, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

139910794..139944541, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL049798.7	CAB46693.1
genomic	CH471067.1	EAW90830.1
mRNA	AF086330.1	None
mRNA	AI699890.1	None
mRNA	AL049455.1	None
mRNA	BC033736.1	AAH33736.1
mRNA	BP257325.1	None
mRNA	Z22865.1	CAA80487.1
other-genetic	DQ892055.2	ABM82981.1
other-genetic	DQ895249.2	ABM86175.1