HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 [Homo sapiens] - Gene

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Summary

Official Symbol: HNRNPA2B1provided by HGNC
Official Full Name: heterogeneous nuclear ribonucleoprotein A2/B1provided by HGNC
Primary source: HGNC:5033
See related: Ensembl:ENSG00000122566; HPRD:02526; MIM:600124; Vega:OTTHUMG00000023471
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; HNRPA2B1; FLJ22720; DKFZp779B0244
Summary: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 7p15

Sequence :: Chromosome: 7; NC_000007.13 (26229556..26240413, complement)

See HNRNPA2B1 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Patient serum IgA was reactve against human recombinant hnRNP-A2/B1 in Behcet (83.3%), systemic lupus erythematosus (13.3%), rheumatoid arthritis (26.7%), Takayasu's arteritis (30%), and no IgA nephropathy patients, vs healthy controls (20%).
Title: Identification of HnRNP-A2/B1 as a target antigen of anti-endothelial cell IgA antibody in Behçet's disease.
Data show that hnRNPA1/A2, HuR and DAZAP1 splicing factors and DHX36 RNA helicase bind to the ISE, with hnRNPA1 acting negatively and DAZAP1 positively on splicing selection.
Title: Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing.
The impact of VHL genetic alterations on the expression of several pVHL protein targets in paired normal and tumor tissue, was evaluated.
Title: VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.
High HNRPA2B1 expression is associated with pancreatic cancer progression.
Title: Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer.
In addition to the core protein, hnRNP A2 also associated with Japanese encephalitis virus nonstructural protein 5 and with the 5'-untranslated region of the negative-sense Japanese encephalitis virus RNA.
Title: Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA.
The expression and distribution of hnRNP A2/B1 can affect the differentiation of SK-N-SH cells, as well as its co-localization with related oncogenes and tumor suppressor genes
Title: The localization of hnRNP A2/B1 in nuclear matrix and the aberrant expression during the RA-induced differentiation of human neuroblastoma SK-N-SH cells.
hnRNP-A2/B1 affected tumor cell differentiation through interaction with oncogenes and tumor-suppressor genes, and it was overexpressed in human gastric cancer.
Title: Aberrant expression and localization of hnRNP-A2/B1 is a common event in human gastric adenocarcinoma.
hnRNP A2/B1 and osteopontin expression was variable in CCRCCs and had no association with VHL genetic status.
Title: VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.
Increased expression and cytoplasmic localization of hnRNP A2/B1 is associated with the development of hepatocellular carcinoma.
Title: Up-regulation and subcellular localization of hnRNP A2/B1 in the development of hepatocellular carcinoma.
A conserved nonsense-mediated mRNA decay event within HNRNPA2B1 that appears to mediate autoregulation of HNRNPA2B1 expression levels, was identified upon UPF1 knockdown .
Title: Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.

Submit: New GeneRIF Correction See all (38)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P22626	P68400	CSNK2A1	HPRD	PubMed
P22626	P14866	HNRNPL	HPRD	PubMed
P22626	P08621	SNRNP70	HPRD	PubMed
P22626	Q8WXA9	SREK1	HPRD	PubMed
P22626	Q9UNY4	TTF2	HPRD	PubMed
P22626	P40337	VHL	HPRD	PubMed
P22626	Q9UBW7	ZMYM2	HPRD	PubMed
BioGRID:109422	BioGRID:107358	CD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:107459	CDK9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:107463	CDKN2A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:107841	CSNK2A1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:109422	BioGRID:107843	CSNK2B	BioGRID	PubMed	Reconstituted Complex
BioGRID:109422	BioGRID:971788	EBNA-LP	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:109422	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:109318	HDGF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:109420	HNRNPA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:109428	HNRNPH1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:109432	HNRNPL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109422	BioGRID:128436	KHDRBS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:111809	MAP4K2	BioGRID	PubMed	Two-hybrid
BioGRID:109422	BioGRID:121122	MEPCE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:110411	MGMT	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:109407	NR4A1	BioGRID	PubMed	Two-hybrid
BioGRID:109422	BioGRID:111657	PSMA3	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
	NP_006734.1	RBM3	BIND	PubMed	hnRNPA2 interacts with RBM3.
BioGRID:109422	BioGRID:112490	SMN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:126754	SREK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:117071	SRRM2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:113003	TOP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
	NP_063755.1	VACVgp128	BIND	PubMed	H5R interacts with hnRNPA2.
	NP_063780.1	VACVgp153	BIND	PubMed	A2L interacts with hnRNPA2.
BioGRID:109422	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:109422	BioGRID:121317	YAE1D1	BioGRID	PubMed	Two-hybrid
BioGRID:109422	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109422	BioGRID:113534	ZMYM2	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
RNA binding	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
single-stranded telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
RNA splicing	TAS Traceable Author Statement more info
RNA transport	IDA Inferred from Direct Assay more info	PubMed
gene expression	TAS Traceable Author Statement more info
mRNA processing	IDA Inferred from Direct Assay more info	PubMed
nuclear mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
nuclear mRNA splicing, via spliceosome	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
catalytic step 2 spliceosome	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
heterogeneous nuclear ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: heterogeneous nuclear ribonucleoproteins A2/B1

Names: heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; nuclear ribonucleoprotein particle A2 protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029680.1 RefSeqGene

Range

5001..15858

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002137.3 → NP_002128.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2

Status: REVIEWED

Description

Transcript Variant: This variant (A2) lacks 36 bases at the beginning of the coding region compared to variant B1. The N-terminus of isoform A2 is thus different from isoform B1. This isoform (A2) is the predominant protein.

Source sequence(s)

AC004520, DB244417, M29065

Consensus CDS

CCDS5397.1

UniProtKB/Swiss-Prot

P22626

Related

ENSP00000349101, OTTHUMP00000122512, ENST00000356674, OTTHUMT00000214110

Conserved Domains (1) summary

cd00590
Location:10 – 83
Blast Score: 177

RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
NM_031243.2 → NP_112533.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform B1

Status: REVIEWED

Description

Transcript Variant: This variant (B1) contains an additional 36 bases compared to variant A2. This additional region affects only the beginning of the coding region. The N-terminus of isoform B1 is thus different from isoform A2.

Source sequence(s)

AC004520, DB244417, M29064

Consensus CDS

CCDS43557.1

UniProtKB/Swiss-Prot

P22626

Related

ENSP00000346694, OTTHUMP00000122511, ENST00000354667, OTTHUMT00000214109

Conserved Domains (1) summary

cd00590
Location:23 – 95
Blast Score: 177

RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

26229556..26240413, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

26111470..26122327, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

26280706..26291563, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC004520.2 (130058..132356)	None
genomic	AC010677.4	None
genomic	CH236948.1 (3455412..3464314)	None
genomic	CH471073.1	EAW93834.1
		EAW93835.1
		EAW93836.1
		EAW93837.1
		EAW93838.1
		EAW93839.1
		EAW93840.1
		EAW93841.1
genomic	D28877.1	BAA06031.1
		BAA06032.1
genomic	U09121.1	AAB60650.1
genomic	U09123.1	AAB60650.1
mRNA	AK026373.1	None
mRNA	AK129839.1	None
mRNA	AK289429.1	BAF82118.1
mRNA	BC000506.2	AAH00506.3
mRNA	BC045724.1	None
mRNA	BX537494.1	None
mRNA	BX538099.1	None
mRNA	BX641084.1	None
mRNA	DB244417.1	None
mRNA	M29064.1	AAA60271.1
mRNA	M29065.1	AAA36574.1