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    LCK lymphocyte-specific protein tyrosine kinase [ Homo sapiens ]

    Gene ID: 3932, updated on 19-May-2012
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    Summary

    Official Symbol
    LCKprovided by HGNC
    Official Full Name
    lymphocyte-specific protein tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:6524
    Locus tag
    RP4-675E8.4
    See related
    Ensembl:ENSG00000182866; HPRD:01080; MIM:153390; Vega:OTTHUMG00000007463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LSK; YT16; p56lck; pp58lck
    Summary
    This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p34.3
    Sequence :
    Chromosome: 1; NC_000001.10 (32716840..32751766)
    See LCK in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 9-like, pseudogene Neighboring gene family with sequence similarity 167, member B Neighboring gene histone deacetylase 1 Neighboring gene MARCKS-like 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A negatively charged domain of LAT mediates its interaction with the active form of Lck. Kabouridis PS, et al. Mol Membr Biol, 2011 Oct-Nov. PMID 22034845.
    2. DHHC2 is a protein S-acyltransferase for Lck. Zeidman R, et al. Mol Membr Biol, 2011 Oct-Nov. PMID 22034844.
    3. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. Mori T, et al. Cell Cycle, 2011 Oct 1. PMID 21952639.
    4. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Schoenborn JR, et al. Sci Signal, 2011 Sep 13. PMID 21917715.
    5. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.

    See all (367) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the segment comprising residues 112-126 of human LAT is required for its interaction with Lck.
      Title: A negatively charged domain of LAT mediates its interaction with the active form of Lck.
    2. DHHC2 localizes primarily to the endoplasmic reticulum and Golgi apparatus suggesting that it is involved in S-acylation of newly-synthesized or recycling Lck involved in T cell signalling.
      Title: DHHC2 is a protein S-acyltransferase for Lck.
    3. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.
      Title: Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.
    4. These results showed that MG132-induced apoptosis was caused by ER stress and subsequent activation of mitochondria-dependent caspase cascade; the presence of p56(lck) enhances MG132-induced apoptosis by augmenting ER stress-mediated apoptotic events.
      Title: Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells.
    5. Data show that MAL regulates membrane order and the distribution of microtubule and transport vesicle docking machinery at the IS and, by doing so, ensures correct protein sorting of Lck and LAT to the cSMAC.
      Title: MAL protein controls protein sorting at the supramolecular activation cluster of human T lymphocytes.
    6. Deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a in T cells were found to be associated with cholesterol-dependent-dismantling of HLA-DR rafts in macrophages in leprosy progression.
      Title: Disruption of HLA-DR raft, deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a towards T cell hyporesponsiveness in leprosy.
    7. Preactivated Lck is both necessary and sufficient for T cell activation but remains uncoupled from the T cell receptor in the absence of antigen.
      Title: The role of L(u)ck in T cell triggering.
    8. Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.
      Title: Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.
    9. Results indicate for the first time that LAT promotes TCR signal initiation and suggest that this adaptor may contribute to maintain active Lck in proximity of their substrates.
      Title: T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.
    10. Lck protects cells from glucocorticoid-induced apoptosis and its inhibition enhances sensitivity to dexamethasone.
      Title: Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
    Submit: New GeneRIF Correction See all (99)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    SCID due to LCK deficiency

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Interaction of HIV-1 gp120 with CD4 leads to increased levels of phosphorylation of the src-family Lck and Fyn protein tyrosine kinases and enhancement of their activities PubMed
    env CD4-p56Lck interaction is required for HIV-1 gp120-induced nuclear translocation of NF-kappaB in HeLa cells PubMed
    env HIV-1 gp120 inhibits CD3-induced Lck activation and cellular tyrosine phosphorylation, particularly of phosphoinositide-specific phospholipase C-gamma-1 PubMed
    env p56lck-positive cells are markedly more susceptible to syncytium formation than p56lck-negative cells, implying a regulatory role for p56lck in the syncytium formation mediated by HIV-1 gp120 envelope interaction with CD4 PubMed
    env HIV-1 gp120 induces the dissociation of p56lck from CD4 and the downregulation of CD4 from the cellular surface PubMed
    env Binding of HIV-1 gp120 to CD4 molecules results in the association of Lck and Raf-1, which is abolished by preincubation of the virus with soluble CD4 PubMed
    env The protein tyrosine kinase p56lck plays an active role in transmitting an HIV-1 gp120-mediated signal that increases the oxidative state of cells and as a consequence amplifies TNF-mediated NF-kappa B DNA binding PubMed
    env Activation of the CD4-p56lck receptor signal transduction pathway by HIV-1 gp120 does not increase prostaglandin formation PubMed
    env Binding of HIV-1 gp120 to CD4 induces p56lck activation and zeta-chain (TCR) associated protein kinase 70kDa desensitization independent of TCR tyrosine phosphorylation PubMed
    env HIV-1 gp120 induces an increase in tyrosine phosphorylation of two proteins, p56lck and phosphatidylinositol 3-kinase (PI 3-kinase) p85 alpha, that are physically complexed to the CD4 molecule PubMed
    Envelope surface glycoprotein gp160, precursor env Interaction of HIV-1 gp160 with CD4 increases p56lck autophosphorylation and kinase activity PubMed
    env HIV-1 gp160 downregulates lymphocyte function-associated antigen-1 (LFA-1)-dependent adhesion between CD4+ T cells and B cells; this downregulation is shown to be p56lck-dependent PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp120 and gp41-induced cell killing is accompanied by tyrosine phosphorylation and activation of the CD4-associated p56(Lck) kinase, and by activation of a second member of the scr family of protein tyrosine kinases, p59(fyn) kinase PubMed
    Nef nef Assays with phage-displayed Nef from HIV-1 NL4-3 have been used to identify a series of guanidine alkaloid-based inhibitors of Nef interactions with p53, actin, and p56(lck) PubMed
    nef HIV-1 Nef increases the association of the src family tyrosine kinase, Lck, and TCRzeta with rafts in human T cells, suggesting Nef primes resting T cells for activation by upregulating the levels of signaling molecules within rafts PubMed
    nef Amino acid residues 402-419 of the cytoplasmic tail of CD4 are required for association with Lck and also for the downregulation of CD4 induced by HIV-1 Nef, suggesting a potential interaction between Nef and Lck PubMed
    nef HIV-1 Nef interferes with the activation of Lck and as a consequence of signaling via the IL-2 receptor PubMed
    nef HIV-1 and SIV Nef can bind Lck SH2 domains, and their N-terminal 50 amino acid residues are sufficient for Src kinase binding and activation PubMed
    nef A highly conserved proline-rich repeat sequence in Nef between amino acids 69-78 directly binds to the SH2 and SH3 domains of Lck PubMed
    nef Cooperation of the Lck SH2 and SH3 domains is required for HIV-1 Nef binding to Lck to a level similar to Nef binding to the Hck SH3 domain PubMed
    nef HIV-1 Nef enhances the phosphorylation of c-Cbl in CD4+ T cells, an effect that requires the Src tyrosine kinase Lck PubMed
    nef HIV-1 Nef efficiently interacts with Lck by coimmunoprecipitation and in vitro kinase assays; this interaction is reduced by an R71T mutation in the proline-rich motif of Nef PubMed
    Tat tat HIV-1 Tat activates p56lck in Jurkat cells leading to the degradation of IkappaBalpha and activation of NFkappaB, AP-1, JNK, MAPKK, caspases, and apoptosis PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005347.2 CD8B    BIND  PubMed CD8-Beta interacts with Lck. 
    NP_005347.2 DNM2    BIND  PubMed An unspecified isoform of Dyn2 interacts with Lck. This interaction was modeled on a demonstrated interaction between human Dyn2 and Lck from an unspecified species. 
    NP_005347.2 NP_751927.1 HCVgp1    BIND  PubMed NS5A interacts with Lck. 
    NP_005347.2 NP_006550.1 KHDRBS1    BIND  PubMed Lck interacts with Sam68. 
    NP_005347.2 NP_065390.1 NFKBIA    BIND  PubMed LCK interacts with and phosphorylates NFKBIA (I-kappa-B-alpha). This interaction was modeled on a demonstrated interaction between LCK from an unspecified species and human NFKBIA. 
    P06239 P24666 ACP1    HPRD  PubMed  
    P06239 Q13444 ADAM15    HPRD  PubMed  
    P06239 P30530 AXL    HPRD  PubMed  
    P06239 P56945 BCAR1    HPRD  PubMed  
    P06239 P22681 CBL    HPRD  PubMed  
    P06239 P51681 CCR5    HPRD  PubMed  
    P06239 P06729 CD2    HPRD  PubMed  
    P06239 P20963 CD247    HPRD  PubMed  
    P06239 P10747 CD28    HPRD  PubMed  
    P06239 P28907 CD38    HPRD  PubMed  
    P06239 P07766 CD3E    HPRD  PubMed  
    P06239 P01730 CD4    HPRD  PubMed  
    P06239 P16070 CD44    HPRD  PubMed  
    P06239 P09326 CD48    HPRD  PubMed  
    P06239 P06127 CD5    HPRD  PubMed  
    P06239 P08174 CD55    HPRD  PubMed  
    P06239 P11912 CD79A    HPRD  PubMed  
    P06239 P40259 CD79B    HPRD  PubMed  
    P06239 P01732 CD8A    HPRD  PubMed  
    P06239 P30307 CDC25C    HPRD  PubMed  
    P06239 P60953 CDC42    HPRD  PubMed  
    P06239 P32927 CSF2RB    HPRD  PubMed  
    P06239 Q99062 CSF3R    HPRD  PubMed  
    P06239 P41240 CSK    HPRD  PubMed  
    P06239 P16410 CTLA4    HPRD  PubMed  
    P06239 Q9UQB3 CTNND2    HPRD  PubMed  
    P06239 Q9UN19 DAPP1    HPRD  PubMed  
    P06239 DEF6 DEF6    HPRD  PubMed  
    P06239 Q12959 DLG1    HPRD  PubMed  
    P06239 Q99704 DOK1    HPRD  PubMed  
    P06239 O60496 DOK2    HPRD  PubMed  
    P06239 Q7L591 DOK3    HPRD  PubMed  
    P06239 P03372 ESR1    HPRD  PubMed  
    P06239 P15311 EZR    HPRD  PubMed  
    P06239 P25445 FAS    HPRD  PubMed  
    P06239 P48023 FASLG    HPRD  PubMed  
    P06239 P08637 FCGR3A    HPRD  PubMed  
    P06239 Q9UQC2 GAB2    HPRD  PubMed  
    P06239 Q13588 GRAP    HPRD  PubMed  
    P06239 P07900 HSP90AA1    HPRD  PubMed  
    P06239 P17181 IFNAR1    HPRD  PubMed  
    P06239 P14784 IL2RB    HPRD  PubMed  
    P06239 Q08881 ITK    HPRD  PubMed  
    P06239 P52333 JAK3    HPRD  PubMed  
    P06239 Q07666 KHDRBS1    HPRD  PubMed  
    P06239 P43628 KIR2DL3    HPRD  PubMed  
    P06239 P10721 KIT    HPRD  PubMed  
    P06239 O43561 LAT    HPRD  PubMed  
    P06239 Q8IWV1 LAX1    HPRD  PubMed  
    P06239 P06239 LCK    HPRD  PubMed  
    P06239 Q13094 LCP2    HPRD  PubMed  
    P06239 Q9H400 LIME1    HPRD  PubMed  
    P06239 P28482 MAPK1    HPRD  PubMed  
    P06239 P27361 MAPK3    HPRD  PubMed  
    P06239 Q9H204 MED28    HPRD  PubMed  
    P06239 P11836 MS4A1    HPRD  PubMed  
    P06239 P15941 MUC1    HPRD  PubMed  
    P06239 Q14511 NEDD9    HPRD  PubMed  
    P06239 P25963 NFKBIA    HPRD  PubMed  
    P06239 P46531 NOTCH1    HPRD  PubMed  
    P06239 P04150 NR3C1    HPRD  PubMed  
    P06239 Q9NWQ8 PAG1    HPRD  PubMed  
    P06239 Q13177 PAK2    HPRD  PubMed  
    P06239 P16284 PECAM1    HPRD  PubMed  
    P06239 P42336 PIK3CA    HPRD  PubMed  
    P06239 P27986 PIK3R1    HPRD  PubMed  
    P06239 P19174 PLCG1    HPRD  PubMed  
    P06239 P16885 PLCG2    HPRD  PubMed  
    P06239 O14939 PLD2    HPRD  PubMed  
    P06239 P17612 PRKACA    HPRD  PubMed  
    P06239 P17252 PRKCA    HPRD  PubMed  
    P06239 Q05655 PRKCD    HPRD  PubMed  
    P06239 Q04759 PRKCQ    HPRD  PubMed  
    P06239 Q05397 PTK2    HPRD  PubMed  
    P06239 Q14289 PTK2B    HPRD  PubMed  
    P06239 Q06124 PTPN11    HPRD  PubMed  
    P06239 Q9Y2R2 PTPN22    HPRD  PubMed  
    P06239 P29350 PTPN6    HPRD  PubMed  
    P06239 P08575 PTPRC    HPRD  PubMed  
    P06239 P10586 PTPRF    HPRD  PubMed  
    P06239 Protein tyrosine phosphatase receptor type H PTPRH    HPRD  PubMed  
    P06239 P49023 PXN    HPRD  PubMed  
    P06239 P04049 RAF1    HPRD  PubMed  
    P06239 P20936 RASA1    HPRD  PubMed  
    P06239 Q9UQQ2 SH2B3    HPRD  PubMed  
    P06239 O60880 SH2D1A    HPRD  PubMed  
    P06239 Q9NP31 SH2D2A    HPRD  PubMed  
    P06239 P78314 SH3BP2    HPRD  PubMed  
    P06239 P29353 SHC1    HPRD  PubMed  
    P06239 Q9Y3P8 SIT1    HPRD  PubMed  
    P06239 Q86WV1 SKAP1    HPRD  PubMed  
    P06239 Q13501 SQSTM1    HPRD  PubMed  
    P06239 P42224 STAT1    HPRD  PubMed  
    P06239 P40763 STAT3    HPRD  PubMed  
    P06239 P42229 STAT5A    HPRD  PubMed  
    P06239 P43405 SYK    HPRD  PubMed  
    P06239 P04216 THY1    HPRD  PubMed  
    P06239 Q6PIZ9 TRAT1    HPRD  PubMed  
    P06239 Q9HBA0 TRPV4    HPRD  PubMed  
    P06239 P50607 TUB    HPRD  PubMed  
    P06239 Q13432 UNC119    HPRD  PubMed  
    P06239 P15498 VAV1    HPRD  PubMed  
    P06239 P43403 ZAP70    HPRD  PubMed  
    P06239 Thy1 cotranscribed     HPRD  PubMed  
    BioGRID:110124 BioGRID:106616 ADAM10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:114287 ADAM15    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:120424 ARHGAP17    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:107036 AXL    BioGRID  PubMed Far Western 
    BioGRID:110124 BioGRID:114934 BCAR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:107352 CD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110124 BioGRID:107398 CD44    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:110124 BioGRID:107400 CD48    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:107843 CSNK2B    BioGRID  PubMed Two-hybrid 
    BioGRID:110124 BioGRID:107875 CTLA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:107881 CTNND1    BioGRID  PubMed Biochemical Activity 
    BioGRID:110124 BioGRID:198596 Cd3e    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:108083 DLG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:106851 FAS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:106852 FASLG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:114089 IKBKG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:115900 KHDRBS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:110015 KIT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:201120 Lck    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110124 BioGRID:107369 MS4A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:110816 NEDD9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:112884 NR2F2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110124 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:120931 PAG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:111201 PECAM1    BioGRID  PubMed Biochemical Activity 
    BioGRID:110124 BioGRID:111315 PI4KA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:111308 PIK3CA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:111313 PIK3R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:111574 PRKCQ    BioGRID  PubMed Two-hybrid 
    BioGRID:110124 BioGRID:108480 PTK2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:111742 PTPN6    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:110124 BioGRID:111752 PTPRC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:111787 PXN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:111856 RASA1    BioGRID  PubMed Biochemical Activity 
    BioGRID:110124 BioGRID:115336 SH2B3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:118088 SIT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:114184 SKAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:114397 SQSTM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:112926 THY1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:119154 TRAT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110124 BioGRID:121883 TRPV4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:113185 UBE3A    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110124 BioGRID:125434 UHRF2    BioGRID  PubMed Far Western 
    BioGRID:110124 BioGRID:114548 UNC119    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110124 BioGRID:113367 ZAP70    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110124 BioGRID:1205545 nef    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
      Alpha-synuclein signaling, organism-specific biosystem
      Alpha-synuclein signaling
    • Atypical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
      Atypical NF-kappaB pathway, organism-specific biosystem
      Atypical NF-kappaB pathway
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
      CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
    • CD28 dependent PI3K/Akt signaling, organism-specific biosystem (from REACTOME)
      CD28 dependent PI3K/Akt signaling, organism-specific biosystemPI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors (CD28), cytokine receptors and chemokine receptors. However, the specific role...
    • CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
      CD28 dependent Vav1 pathway, organism-specific biosystemCD28 binds to several intracellular proteins including PI3 kinase, Grb-2, Gads and ITK. Grb-2 specifically co-operates with Vav-1 in the up-regulation of NFAT/AP-1 transcription. CD28 costimulation r...
    • CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
      CTLA4 inhibitory signaling, organism-specific biosystemCTLA4 is one of the best studied inhibitory receptors of the CD28 superfamily. CTLA4 inhibits Tcell activation by reducing IL2 production and IL2 expression, and by arresting T cells at the G1 phase ...
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events, organism-specific biosystem
      Class I PI3K signaling events
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHA forward signaling, organism-specific biosystem
      EPHA forward signaling
    • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
      Ephrin B reverse signaling, organism-specific biosystem
      Ephrin B reverse signaling
    • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
      GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • Glypican 1 network, organism-specific biosystem (from Pathway Interaction Database)
      Glypican 1 network, organism-specific biosystem
      Glypican 1 network
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • IL2 signaling events mediated by STAT5, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by STAT5, organism-specific biosystem
      IL2 signaling events mediated by STAT5
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Nef Mediated CD4 Down-regulation, organism-specific biosystem (from REACTOME)
      Nef Mediated CD4 Down-regulation, organism-specific biosystemThe presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD4. CD4 has its own internalization motif, though this motif is normally concealed by CD4 inte...
    • Nef and signal transduction, organism-specific biosystem (from REACTOME)
      Nef and signal transduction, organism-specific biosystemNef interferes with cellular signal transduction pathways in a number of ways. Nef is associated with lipid rafts through its amino-terminal myristoylation and a proline-rich SH3-binding domain. Thes...
    • Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystem (from REACTOME)
      Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystemThe maximal virulence of HIV-1 requires Nef, a virally encoded peripheral membrane protein. Nef binds to the adaptor protein (AP) complexes of coated vesicles, inducing an expansion of the endosomal ...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-beta signaling pathway, organism-specific biosystem
      PDGFR-beta signaling pathway
    • PECAM1 interactions, organism-specific biosystem (from REACTOME)
      PECAM1 interactions, organism-specific biosystemPECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activ...
    • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
      Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Regulation of KIT signaling, organism-specific biosystem (from REACTOME)
      Regulation of KIT signaling, organism-specific biosystemSCF induced proliferation is negatively regulated by various proteins including SHP1, PKC, CBL, SOCS1, SOCS6 and LNK.
    • Regulation of p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of p38-alpha and p38-beta, organism-specific biosystem
      Regulation of p38-alpha and p38-beta
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystem (from REACTOME)
      The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystemThe HIV-1 Nef protein is a 27-kDa myristoylated protein that is abundantly produced during the early phase of viral replication cycle. It is highly conserved in all primate lentiviruses, suggesting t...
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
      Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    CD4 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    CD8 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    SH2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    glycoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol 3-kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular zinc ion homeostasis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    cellular zinc ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    induction of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    peptidyl-tyrosine dephosphorylation TAS
    Traceable Author Statement
    more info
    		  
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of T cell receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of tyrosine phosphorylation of Stat5 protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of defense response to virus by virus TAS
    Traceable Author Statement
    more info
    		  
    regulation of lymphocyte activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to drug IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    pericentriolar material ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    tyrosine-protein kinase Lck
    Names
    tyrosine-protein kinase Lck
    leukocyte C-terminal Src kinase
    p56(LSTRA) protein-tyrosine kinase
    t cell-specific protein-tyrosine kinase
    proto-oncogene tyrosine-protein kinase LCK
    lymphocyte cell-specific protein-tyrosine kinase
    T-lymphocyte specific protein tyrosine kinase p56lck
    NP_001036236.1
    NP_005347.3
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023387.1 RefSeqGene

      Range
      5001..39927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042771.1 → NP_001036236.1  tyrosine-protein kinase Lck precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is transcribed from the proximal type I promoter. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA747421, AF228313, DB122062, DB129997
      Consensus CDS
      CCDS359.1
      UniProtKB/Swiss-Prot
      P06239
      Related
      ENSP00000328213, OTTHUMP00000008740, ENST00000333070, OTTHUMT00000019805
      Conserved Domains (4) summary
      cd00174
      Location:66 – 118
      Blast Score: 138
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05067
      Location:238 – 497
      Blast Score: 1457
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
      cd10362
      Location:123 – 223
      Blast Score: 551
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      pfam07714
      Location:245 – 494
      Blast Score: 1053
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_005356.3 → NP_005347.3  tyrosine-protein kinase Lck precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is transcribed from the distal type II promoter and contains a distinct 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA747421, AF228313, DA007906, X13529
      Consensus CDS
      CCDS359.1
      UniProtKB/Swiss-Prot
      P06239
      Related
      ENSP00000337825, OTTHUMP00000008640, ENST00000336890, OTTHUMT00000019616
      Conserved Domains (4) summary
      cd00174
      Location:66 – 118
      Blast Score: 138
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05067
      Location:238 – 497
      Blast Score: 1457
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
      cd10362
      Location:123 – 223
      Blast Score: 551
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      pfam07714
      Location:245 – 494
      Blast Score: 1053
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      32716840..32751766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      30833080..30867241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL109945.15 (2000..2215) None
    genomic AL121991.50 CAI22320.1
      CAI22321.1
    genomic BN000073.1 CAD55807.1
    genomic CH471059.2 EAX07542.1
      EAX07543.1
      EAX07544.1
      EAX07545.1
      EAX07546.1
    genomic M21510.1 AAA59501.1
    genomic M26692.1 AAA59503.1
    genomic M26693.1 None
    genomic M36824.1 None
    genomic X14055.1 CAA32211.1
    mRNA AA747421.1 None
    mRNA AF228313.1 AAF34794.1
    mRNA AJ865079.1 CAI23831.1
    mRNA AK098027.1 BAG53565.1
    mRNA AK303073.1 BAG64189.1
    mRNA BC013200.1 AAH13200.1
    mRNA DA007906.1 None
    mRNA DB122062.1 None
    mRNA DB129997.1 None
    mRNA M36881.1 AAA59502.1
    mRNA U07236.1 AAA18225.1
    mRNA U23852.1 AAC50287.1
    mRNA X04476.1 CAA28165.1
    mRNA X05027.1 CAA28691.1
    mRNA X06369.1 CAA29667.1
    mRNA X13529.1 CAA31884.1
    other-genetic DQ891675.2 ABM82601.1
    other-genetic DQ894861.2 ABM85787.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06239.6 GenPept UniProtKB/Swiss-Prot:P06239
    Q573B4 GenPept UniProtKB/TrEMBL:Q573B4
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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