FOS FBJ murine osteosarcoma viral oncogene homolog [ Homo sapiens ]

Gene ID: 2353, updated on 19-May-2012

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Summary

Official Symbol: FOSprovided by HGNC
Official Full Name: FBJ murine osteosarcoma viral oncogene homologprovided by HGNC
Primary source: HGNC:3796
See related: Ensembl:ENSG00000170345; HPRD:01275; MIM:164810; Vega:OTTHUMG00000171774
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p55; AP-1; C-FOS
Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 14q24.3

Sequence :: Chromosome: 14; NC_000014.8 (75745481..75748937)

See FOS in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an intricate network of energetically-coupled residues within the basic regions of the Jun-Fos heterodimeric transcription factor accounts for its allosteric binding to DNA
Title: Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA.
Results suggest that IL-3 plays an inhibitory role in osteoclast differentiation by regulating c-Fos and Id1, and also exerts anti-bone erosion effects.
Title: Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-Fos and Id protein expression.
c-Fos transcript levels in blood leukocytes could be considered as a cumulative biomarker of smoking in coronary artery disease.
Title: Smoking and FOS expression from blood leukocyte transcripts in patients with coronary artery disease.
EVI1 is a multipurpose transcription factor that synergizes with FOS in invasive tumors.
Title: Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors.
High C-fos is associated with rectal cancer.
Title: Molecular changes consistent with increased proliferation and invasion are common in rectal cancer.
Data show that HPV16E6-dependent c-fos oncogenic protein expression contributes to AP-1 complex formation under oxidative stress in SiHa cells.
Title: HPV16E6-dependent c-fos expression contributes to AP-1 complex formation in SiHa cells.
c-Fos acts as a positive regulator of HCV propagation and may contribute to HCV-associated pathogenesis.
Title: c-Fos regulates hepatitis C virus propagation.
AP-1-dependent up-regulation of the P2 promoter, SLE T cells fail to further increase their basal CREM levels upon T cell activation due to a decreased content of the AP-1 family member c-Fos
Title: A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus.
Elevated expression of c-fos in CNS might be one of key mechanisms in etiology of irritable bowel syndrome.
Title: Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment.
Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells
Title: Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.

Submit: New GeneRIF Correction See all (134)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway	PubMed
	env	HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites	PubMed
	env	Binding of heat-inactivated HIV-1 (iHIV-1) or HIV-1 gp120 to infected resting PBMCs is sufficient to activate NF-kappa B and AP-1, to induce cell surface expression of CD25, and to commit cells to produce virus	PubMed
	env	HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 induces activation of transcription factor, activated protein-1 (AP-1), comprised of Fos and Jun proteins, in CD4 positive T cell lines	PubMed
Nef	nef	HIV-1 Nef expression in human (THP-1) monocyte-macrophages induces both DNA binding and transcriptional activities of the activator protein-1 (AP-1) transcription factor, c-fos and c-jun; this induction requires the proline-rich PxxP motif of Nef	PubMed
	nef	HIV-1 Nef inhibits the recruitment of AP-1 DNA binding activity by downregulating the transcription of c-fos in mitogen-stimulated human T cells	PubMed
Tat	tat	HIV-1 Tat upregulates c-Fos expression and c-Fos protein has been shown to be essential for optimal transactivation of the HIV-1 LTR promoter by Tat	PubMed
	tat	HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR	PubMed
	tat	HIV-1 Tat contributes to the super-induction of IL-2 promoter activity through transcription factors such as NF-kappaB and AP-1 (c-Jun and c-Fos)	PubMed
	tat	HIV-1 Tat activates the AP-1 complex containing c-fos through a p56lck dependent mechanism	PubMed
Vpr	vpr	Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages.	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
K00650.1		EGFR	BIND	PubMed	An unspecified isoform of EGFR binds to c-fos promoter.
K00650.1		STAT3	BIND	PubMed	An unspecified isoform of STAT3 binds to c-fos promoter.
NC_000014.7	NP_001964.2	ELK4	BIND	PubMed	Sap-1a is interacts with the serum response element (SRE) of c-fos. This interaction was modeled on a demonstrated interaction between human Sap-1a and c-fos from an unspecified species.
NC_000014.7	NP_003122.1	SRF	BIND	PubMed	SRF interacts with the c-fos promoter CArG box. This interaction was modeled on a demonstrated interaction between human SRF and c-fos promoter CArG box from an unspecified species.
NM_005252.2	NP_003676.1	KHSRP	BIND	PubMed	KSRP interacts with AREfos. This interaction was modeled on a demonstrated interaction between KSRP from human and AREfos from an unspecified species.
NP_005243.1	AL035456.26	JAG1	BIND	PubMed	c-Fos interacts with Jagged1 promoter.
NP_005243.1	NP_002219.1	JUN	BIND	PubMed	cFos interacts with cJun.
NP_005243.1	NP_002219.1	JUN	BIND	PubMed	c-Jun interacts with c-Fos. This interaction was modelled on a demonstrated interaction between c-Jun from an unspecified species and c-Fos from an unspecified species.
NP_005243.1	NP_068810.2	RELA	BIND	PubMed	NF-kappa-B interacts with c-Fos.
P01100	P15336	ATF2	HPRD	PubMed
P01100	P17544	ATF7	HPRD	PubMed
P01100	Q16520	BATF	HPRD	PubMed
P01100	P20749	BCL3	HPRD	PubMed
P01100	P53567	CEBPG	HPRD	PubMed
P01100	Q8WX92	COBRA1	HPRD	PubMed
P01100	P68400	CSNK2A1	HPRD	PubMed
P01100	P19784	CSNK2A2	HPRD	PubMed
P01100	P35638	DDIT3	HPRD	PubMed
P01100	P29692	EEF1D	HPRD	PubMed
P01100	P19419	ELK1	HPRD	PubMed
P01100	P28324	ELK4	HPRD	PubMed
P01100	P29323	EPHB2	HPRD	PubMed
P01100	P14921	ETS1	HPRD	PubMed
P01100	P01100	FOS	HPRD	PubMed
P01100	P43694	GATA4	HPRD	PubMed
P01100	P13984	GTF2F2	HPRD	PubMed
P01100	P20823	HNF1A	HPRD	PubMed
P01100	P05412	JUN	HPRD	PubMed
P01100	P17275	JUNB	HPRD	PubMed
P01100	P17535	JUND	HPRD	PubMed
P01100	P02545	LMNA	HPRD	PubMed
P01100	O75444	MAF	HPRD	PubMed
P01100	O43318	MAP3K7	HPRD	PubMed
P01100	P28482	MAPK1	HPRD	PubMed
P01100	O75030	MITF	HPRD	PubMed
P01100	Q15788	NCOA1	HPRD	PubMed
P01100	Q9Y618	NCOR2	HPRD	PubMed
P01100	Q12968	NFATC3	HPRD	PubMed
P01100	P19838	NFKB1	HPRD	PubMed
P01100	Q96CV9	OPTN	HPRD	PubMed
P01100	P17612	PRKACA	HPRD	PubMed
P01100	P62195	PSMC5	HPRD	PubMed
P01100	P06400	RB1	HPRD	PubMed
P01100	Q04206	RELA	HPRD	PubMed
P01100	Q15418	RPS6KA1	HPRD	PubMed
P01100	O75676	RPS6KA4	HPRD	PubMed
P01100	Q01196	RUNX1	HPRD	PubMed
P01100	Q13950	RUNX2	HPRD	PubMed
P01100	Q8IY83	SCHIP1	HPRD	PubMed
P01100	P84022	SMAD3	HPRD	PubMed
P01100	Q96GM5	SMARCD1	HPRD	PubMed
P01100	P42224	STAT1	HPRD	PubMed
P01100	P63165	SUMO1	HPRD	PubMed
P01100	P61956	SUMO2	HPRD	PubMed
P01100	P55854	SUMO3	HPRD	PubMed
P01100	Q6EEV6	SUMO4	HPRD	PubMed
P01100	P21675	TAF1	HPRD	PubMed
P01100	P20226	TBP	HPRD	PubMed
P01100	Q12816	TRO	HPRD	PubMed
P01100	Q99576	TSC22D3	HPRD	PubMed
P01100	Q15853	USF2	HPRD	PubMed
P01100	Q96MR6	WDR65	HPRD	PubMed
P01100	P17861	XBP1	HPRD	PubMed
BioGRID:108636	BioGRID:107776	ATF2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:107074	BCL3	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:108636	BioGRID:115760	CARM1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108636	BioGRID:117421	COBRA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108636	BioGRID:107777	CREBBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:107841	CSNK2A1	BioGRID	PubMed	Far Western; Reconstituted Complex
BioGRID:108636	BioGRID:107842	CSNK2A2	BioGRID	PubMed	Far Western; Reconstituted Complex
BioGRID:108636	BioGRID:108016	DDIT3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108636	BioGRID:115776	DDX17	BioGRID	PubMed	Affinity Capture-Luminescence
BioGRID:108636	BioGRID:108347	EP300	BioGRID	PubMed	Biochemical Activity
BioGRID:108636	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108636	BioGRID:108415	ETS2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:109216	GTF2E2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:109217	GTF2F1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:109218	GTF2F2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:112789	HNF1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108636	BioGRID:109928	JUN	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BioGRID:108636	BioGRID:109930	JUND	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108636	BioGRID:116639	KDM2A	BioGRID	PubMed	Two-hybrid
BioGRID:108636	BioGRID:110269	MAF	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:108636	BioGRID:111580	MAPK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108636	BioGRID:111584	MAPK7	BioGRID	PubMed	Biochemical Activity
BioGRID:108636	BioGRID:110320	MAZ	BioGRID	PubMed	Affinity Capture-Western; Far Western
BioGRID:108636	BioGRID:110432	MITF	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108636	BioGRID:110748	NACA	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:114200	NCOA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:108636	BioGRID:115761	NCOA2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108636	BioGRID:113841	NCOA3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108636	BioGRID:116691	NCOA6	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:114974	NCOR2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:108636	BioGRID:111384	PML	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:111430	POLR2E	BioGRID	PubMed	Two-hybrid
BioGRID:108636	BioGRID:111902	RELA	BioGRID	PubMed	Phenotypic Enhancement; Two-hybrid
BioGRID:108636	BioGRID:112110	RPS6KA2	BioGRID	PubMed	Biochemical Activity
BioGRID:108636	BioGRID:114468	RPS6KA4	BioGRID	PubMed	Biochemical Activity
BioGRID:108636	BioGRID:107309	RUNX1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108636	BioGRID:107308	RUNX2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:108636	BioGRID:110263	SMAD3	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:108636	BioGRID:112566	SPI1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:113188	SUMO1	BioGRID	PubMed	Biochemical Activity
BioGRID:108636	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:108636	BioGRID:112496	SUMO3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108636	BioGRID:132223	SUMO4	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:108636	BioGRID:112735	TAF1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:112771	TBP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108636	BioGRID:108165	TSC22D3	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108636	BioGRID:128238	UBR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108636	BioGRID:113264	VDR	BioGRID	PubMed	Reconstituted Complex
BioGRID:108636	BioGRID:113331	XBP1	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
R-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
protein dimerization activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA methylation	TAS Traceable Author Statement more info	PubMed
MyD88-dependent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
MyD88-independent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
TRIF-dependent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
Toll signaling pathway	TAS Traceable Author Statement more info
aging	IEA Inferred from Electronic Annotation more info
cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
cellular response to extracellular stimulus	IEA Inferred from Electronic Annotation more info
cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
conditioned taste aversion	IEA Inferred from Electronic Annotation more info
female pregnancy	IEA Inferred from Electronic Annotation more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
innate immune response	TAS Traceable Author Statement more info
nervous system development	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info
regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
response to cAMP	IEA Inferred from Electronic Annotation more info
response to cold	IEA Inferred from Electronic Annotation more info
response to corticosterone stimulus	IEA Inferred from Electronic Annotation more info
response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to gravity	IEA Inferred from Electronic Annotation more info
response to light stimulus	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to progesterone stimulus	IEA Inferred from Electronic Annotation more info
response to toxin	IEA Inferred from Electronic Annotation more info
sleep	IEA Inferred from Electronic Annotation more info
stress-activated MAPK cascade	TAS Traceable Author Statement more info
toll-like receptor 1 signaling pathway	TAS Traceable Author Statement more info
toll-like receptor 2 signaling pathway	TAS Traceable Author Statement more info
toll-like receptor 3 signaling pathway	TAS Traceable Author Statement more info
toll-like receptor 4 signaling pathway	TAS Traceable Author Statement more info
toll-like receptor signaling pathway	TAS Traceable Author Statement more info
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
synaptosome	IEA Inferred from Electronic Annotation more info
transcription factor complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: proto-oncogene c-Fos

Names: proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029673.1 RefSeqGene

Range

5001..8457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005252.3 → NP_005243.1 proto-oncogene c-Fos

Status: REVIEWED

Source sequence(s)

AF111167, AK291326

Consensus CDS

CCDS9841.1

UniProtKB/Swiss-Prot

P01100

UniProtKB/TrEMBL

Q6FG41

Related

ENSP00000306245, OTTHUMP00000246818, ENST00000303562, OTTHUMT00000415044

Conserved Domains (1) summary

cl02576
Location:147 – 185
Blast Score: 133

bZIP_1; bZIP transcription factor

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

75745481..75748937

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

55913924..55917380

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB022275.1	BAA87920.1
genomic	AB022276.1	BAA87921.1
genomic	AF111167.2	AAC98315.1
genomic	AY212879.1	AAO21129.1
genomic	CH471061.1	EAW81227.1
		EAW81228.1
		EAW81229.1
genomic	HI574162.1	CBX47570.1
genomic	K00650.1	AAA52471.1
genomic	V01512.1	CAA24756.1
mRNA	AK097379.1	BAG53458.1
mRNA	AK290907.1	BAF83596.1
mRNA	AK291326.1	BAF84015.1
mRNA	AK298659.1	BAG60827.1
mRNA	BC004490.2	AAH04490.1
mRNA	BX647104.1	None
mRNA	CR541785.1	CAG46584.1
mRNA	CR542267.1	CAG47063.1
mRNA	S65138.1	AAB20306.1
other-genetic	DQ893444.2	ABM84370.1
other-genetic	DQ896750.2	ABM87749.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P01100.1	GenPept	UniProtKB/Swiss-Prot:P01100
Q6FG41	GenPept	UniProtKB/TrEMBL:Q6FG41
Q76MY9	GenPept	UniProtKB/TrEMBL:Q76MY9
Q76MZ0	GenPept	UniProtKB/TrEMBL:Q76MZ0