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PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 [ Homo sapiens (human) ]

Gene ID: 5058, updated on 18-May-2013

Summary

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Official Symbol: PAK1provided by HGNC
Official Full Name: p21 protein (Cdc42/Rac)-activated kinase 1provided by HGNC
Primary source: HGNC:8590
See related: Ensembl:ENSG00000149269; HPRD:03995; MIM:602590; Vega:OTTHUMG00000165138
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAKalpha
Summary: This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Genomic context

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Location :: 11q13-q14

Sequence :: Chromosome: 11; NC_000011.9 (77033060..77185108, complement)

See PAK1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that glucose-mediated activation of Cdc42 leads to activation of PAK1 and prompts activation of its downstream targets Raf-1, MEK1/2 and ERK1/2 to elicit F-actin remodeling and recruitment of insulin granules to the plasma membrane
Title: A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.
Gene array data revealed reduced expression of matrix metalloproteinase 9 with the ablation of either Pak1 or Pak6 gene expression in PC3 cells.
Title: P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion.
PI3K, Rac1 and PAK1 may play important roles in the pathogenesis of EMPD.
Title: PI3K, Rac1 and pPAK1 are overexpressed in extramammary Paget's disease.
Results show a strong positive correlation between advanced stage and grade and PAK1 expression in skin cnacer.
Title: p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.
PAK1 phosphorylates MCAK and regulates both its localization and function.
Title: Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization.
PAK1 negatively regulates the expression of TFPI and additionally contributes to increased TF activity.
Title: p21-activated kinase-1 signaling regulates transcription of tissue factor and tissue factor pathway inhibitor.
In the title.
Title: CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis.
the role of PAK1 in the promotion of cell motility, cell invasiveness and the down regulation of p120-catenin through CRK serine 41 phosphorylation in NSCLC cells
Title: PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells.
Pak-1 interacts with Wnt signaling to regulate tissue polarity and gene expression.
Title: p21-activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression.
Data suggest that targeting P21-activated protein kinase1 (PAK1) may represent a novel treatment strategy for developing novel chemotherapeutic agents.
Title: PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation.

Submit: New GeneRIF Correction See all (136)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface	PubMed
Nef, p27	nef	HIV-1 Nef mutants LLAA and delta12-39 significantly impairs downregulation of CD4. Nef LLAA mutant fails to interact with the endocytic machinery and Nef delta12-39 mutant lacks the interaction with the Nef-associated kinase complex	PubMed
	nef	The mutation of all four glutamates (amino acids 62-65) to alanine in HIV-1 Nef impairs the ability of Nef to regulate p21-activated protein kinase and enhance viral particle infectivity	PubMed
	nef	HIV-1 Nef-mediated p21-activated kinase (PAK) activation involves the binding of Nef and phosphatidylinositol 3-kinase (PI3K)	PubMed
	nef	HIV-1 Nef binding and activation of the PAK-related kinase and phosphorylation of its substrate (a complex composed of PIX and p95) are readily detected in both infected primary T lymphocytes and macrophages	PubMed
	nef	The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases	PubMed
	nef	HIV-1 Nef-mediated activation of a PAK-related kinase correlates with the induction of high virus loads and the development of AIDS in infected rhesus macaques	PubMed
	nef	The association of HIV-1 Nef with the cellular serine kinase PAK enhances efficient proviral DNA synthesis and virion infectivity	PubMed
	nef	A cellular serine kinase is found to specifically associate with HIV-1 Nef; proteins of 62 kDa and 72 kDa, which coimmunoprecipitated with Nef, are phosphorylated in in vitro kinase assays	PubMed
Tat, p14	tat	Uptake of the HIV-1 Tat protein is regulated by PAK1 activity in epithelial cells	PubMed
	tat	HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by introduction of mutations into the Tat cysteine-rich or basic domains	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
AAC24716.1		RAC1	BIND	PubMed	Active GTP-bound RAC1 interacts with PAK1B. This interaction was modelled on a demonstrated interaction between chicken RAC1 and human PAK1B.
NP_002567.3	NP_004300.1	ARHGDIA	BIND	PubMed	Pak1 interacts with and phosphorylates RhoGDI. This interaction was modeled on a demonstrated interaction between Pak1 from an unspecified species and human RhoGDI.
NP_002567.3		CDC42	BIND	PubMed	Cdc42 interacts with Pak1. This interaction was modelled on a demonstrated interaction between Cdc42 from an unspecified species and human Pak1.
NP_002567.3		CDC42	BIND	PubMed	PAK1 interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Cdc42.
NP_002567.3	NP_005219.2	EGFR	BIND	PubMed	Tyrosine-phosphorylated EGFR interacts with PAK1.
NP_002567.3	NP_002077.1	GRB2	BIND	PubMed	PAK1 interacts with Grb2.
NP_002567.3	NP_778224.1	HIST4H4	BIND	PubMed	PAK1 phosphorylates H4. This interaction was modeled on a demonstrated interaction between human PAK1 and H4 from an unspecified species.
NP_002567.3	NP_000256.1	NCF1C	BIND	PubMed	Pak1 interacts with and phosphorylates P47. This interaction was modeled on a demonstrated interaction between Pak1 and P47 from unspecified species.
NP_002567.3	NP_006144.1	NCK1	BIND	PubMed	Nck interacts with PAK1
NP_002567.3	NP_000259.1	NF2	BIND	PubMed	Merlin interacts with Pak1
NP_002567.3		RAC1	BIND	PubMed	PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between human PAK1 and Rac from Chinese hamster.
NP_002567.3		RAC1	BIND	PubMed	Rac1 interacts with Pak1. This interaction was modelled on a demonstrated interacton between Rac1 from an unspecified species and human Pak1.
NP_002567.3		RAC1	BIND	PubMed	PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Rac.
NP_002567.3		RAC1	BIND	PubMed	Rac1 interacts with Pak1. This interaction was modeled on a demonstrated interaction between Rac1 and Pak1 from an unspecified species.
NP_002567.3	NP_067028.1	RHOU	BIND	PubMed	Wrch-1 interacts with PAK. This interaction was modeled on a demonstrated interactions between human Wrch-1 and rat PAK.
NP_002567.3	NP_055816.2	SPEN	BIND	PubMed	Pak1 phosphorylates SHARP. This interaction was modeled on a demonstrated interaction between Pak1 and SHARP both from an unspecified species.
NP_002567.3	NP_003233.3	TGFBR2	BIND	PubMed	T-beta-RII interacts with PAK1. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse PAK1.
NP_002567.3			BIND	PubMed	PAK1 interacts with GTP-RAC1. This interaction was modeled on a demonstrated interaction between PAK1 and GTP-RAC from unspecified species.
NP_002567.3			BIND	PubMed	PAK1 interacts with GTP-RAC1.
NP_002567.3			BIND	PubMed	PAK1 interacts with GTP-RAC1 (GTP-RAC).
NP_002567.3			BIND	PubMed	PAK interacts with GTP-bound Rac.
NP_002567.3			BIND	PubMed	GTP-bound TCL interacts with PAK-1.
Q13153	Q9P2A4	ABI3	HPRD	PubMed
Q13153	P68133	ACTA1	HPRD	PubMed
Q13153	Q04771	ACVR1	HPRD	PubMed
Q13153	P31749	AKT1	HPRD	PubMed
Q13153	Q92974	ARHGEF2	HPRD	PubMed
Q13153	Q15052	ARHGEF6	HPRD	PubMed
Q13153	Q14155	ARHGEF7	HPRD	PubMed
Q13153	O15143	ARPC1B	HPRD	PubMed
Q13153	Q92934	BAD	HPRD	PubMed
Q13153	O00238	BMPR1B	HPRD	PubMed
Q13153	P51813	BMX	HPRD	PubMed
Q13153	P29466	CASP1	HPRD	PubMed
Q13153	P60953	CDC42	HPRD	PubMed
Q13153	Q9UQ88	CDK11A	HPRD	PubMed
Q13153	P21127	CDK11B	HPRD	PubMed
Q13153	Q00535	CDK5	HPRD	PubMed
Q13153	Q15078	CDK5R1	HPRD	PubMed
Q13153	P02452	COL1A1	HPRD	PubMed
Q13153	Cysteine-rich PAK1 inhibitor	CRIPAK	HPRD	PubMed
Q13153	P68400	CSNK2A1	HPRD	PubMed
Q13153	P19784	CSNK2A2	HPRD	PubMed
Q13153	O60469	DSCAM	HPRD	PubMed
Q13153	P63167	DYNLL1	HPRD	PubMed
Q13153	P00533	EGFR	HPRD	PubMed
Q13153	P04626	ERBB2	HPRD	PubMed
Q13153	P03372	ESR1	HPRD	PubMed
Q13153	P21333	FLNA	HPRD	PubMed
Q13153	P58012	FOXL2	HPRD	PubMed
Q13153	Q12778	FOXO1	HPRD	PubMed
Q13153	Q8WU20	FRS2	HPRD	PubMed
Q13153	Q14161	GIT2	HPRD	PubMed
Q13153	P62993	GRB2	HPRD	PubMed
Q13153	O14964	HGS	HPRD	PubMed
Q13153	H4 Histone family, member A	HIST1H4A	HPRD	PubMed
Q13153	P53667	LIMK1	HPRD	PubMed
Q13153	Q02750	MAP2K1	HPRD	PubMed
Q13153	P28482	MAPK1	HPRD	PubMed
Q13153	P02686	MBP	HPRD	PubMed
Q13153	Q15746	MYLK	HPRD	PubMed
Q13153	P14598	NCF1	HPRD	PubMed
Q13153	P16333	NCK1	HPRD	PubMed
Q13153	O43639	NCK2	HPRD	PubMed
Q13153	P35240	NF2	HPRD	PubMed
Q13153	O95747	OXSR1	HPRD	PubMed
Q13153	Q13153	PAK1	HPRD	PubMed
Q13153	Q9NWT1	PAK1IP1	HPRD	PubMed
Q13153	O15530	PDPK1	HPRD	PubMed
Q13153	P19174	PLCG1	HPRD	PubMed
Q13153	P49593	PPM1F	HPRD	PubMed
Q13153	Q05655	PRKCD	HPRD	PubMed
Q13153	P49023	PXN	HPRD	PubMed
Q13153	P63000	RAC1	HPRD	PubMed
Q13153	P04049	RAF1	HPRD	PubMed
Q13153	Q9H4E5	RHOJ	HPRD	PubMed
Q13153	Rho GTPase like protein ARHU	RHOU	HPRD	PubMed
Q13153	P29353	SHC1	HPRD	PubMed
Q13153	Q15797	SMAD1	HPRD	PubMed
Q13153	Q15796	SMAD2	HPRD	PubMed
Q13153	Q13485	SMAD4	HPRD	PubMed
Q13153	Q9HCE7	SMURF1	HPRD	PubMed
Q13153	Arg binding protein 2	SORBS2	HPRD	PubMed
Q13153	P17600	SYN1	HPRD	PubMed
Q13153	P36897	TGFBR1	HPRD	PubMed
Q13153	P37173	TGFBR2	HPRD	PubMed
Q13153	P61981	YWHAG	HPRD	PubMed
BioGRID:111095	BioGRID:119389	ABI3	BioGRID	PubMed	Reconstituted Complex
BioGRID:111095	BioGRID:106710	AKT1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111095	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:111095	BioGRID:114618	ARHGEF2	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:111095	BioGRID:114847	ARHGEF6	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:114393	ARHGEF7	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:111095	BioGRID:115402	ARPC1B	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111095	BioGRID:107048	BAD	BioGRID	PubMed	Biochemical Activity
BioGRID:111095	BioGRID:115721	BAIAP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:111095	BioGRID:107128	BMX	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111095	BioGRID:122413	C5orf42	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:31499	CDC42	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111095	BioGRID:107433	CDC42	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BioGRID:111095	BioGRID:609064	CDK11A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:111095	BioGRID:107455	CDK5	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:111095	BioGRID:117929	CHORDC1	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:130121	CRIPAK	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:111095	BioGRID:114206	DYNLL1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:111095	BioGRID:126680	DYNLL2	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:114596	DYRK1B	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:108314	ELF3	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:111095	BioGRID:108376	ERBB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111095	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111095	BioGRID:109044	GNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111095	BioGRID:109316	HDAC2	BioGRID	PubMed	Positive Genetic
BioGRID:111095	BioGRID:114593	HGS	BioGRID	PubMed	Reconstituted Complex
BioGRID:111095	BioGRID:113955	HIST1H4A	BioGRID	PubMed	Biochemical Activity
BioGRID:111095	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:110172	LIMK1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111095	BioGRID:110378	MAP3K1	BioGRID	PubMed	Biochemical Activity
BioGRID:111095	BioGRID:110722	MYLK	BioGRID	PubMed	Biochemical Activity
BioGRID:111095	BioGRID:120982	MYNN	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:110730	MYO6	BioGRID	PubMed	Biochemical Activity
BioGRID:111095	BioGRID:110770	NCK1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111095	BioGRID:114020	NCK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111095	BioGRID:111095	PAK1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-fractionation
BioGRID:111095	BioGRID:120335	PAK1IP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:111095	BioGRID:111330	PKLR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111095	BioGRID:111351	PLCG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111095	BioGRID:111817	RAC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:111095	BioGRID:111831	RAF1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:111095	BioGRID:121499	RHOJ	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:119029	SH3KBP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111095	BioGRID:112904	TGFBR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111095	BioGRID:112906	TGFBR2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111095	BioGRID:112910	TGM2	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111095	BioGRID:113364	YWHAG	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:113366	YWHAZ	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:115735	ZBTB18	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:118841	ZC3H7A	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:127074	ZNF418	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:120713	ZNF823	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:120886	ZNF83	BioGRID	PubMed	Two-hybrid
BioGRID:111095	BioGRID:1777041	nef	BioGRID	PubMed	Biochemical Activity

Pathways from BioSystems

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Activation of Rac, organism-specific biosystem (from REACTOME)
Activation of Rac, organism-specific biosystemA low level of Rac activity is essential to maintain axon outgrowth and Robo activation recruits Sos, a dual specificity GEF to the plasma membrane via Dock to activate Rac during midline repulsion.
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
Angiopoietin receptor Tie2-mediated signaling
Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
Aurora A signaling, organism-specific biosystem
Aurora A signaling
Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
CD28 co-stimulation, organism-specific biosystem (from REACTOME)
CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
CD28 dependent Vav1 pathway, organism-specific biosystemCD28 binds to several intracellular proteins including PI3 kinase, Grb-2, Gads and ITK. Grb-2 specifically co-operates with Vav-1 in the up-regulation of NFAT/AP-1 transcription. CD28 costimulation r...
CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
CDC42 signaling events, organism-specific biosystem
CDC42 signaling events
CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
CXCR4-mediated signaling events, organism-specific biosystem
CXCR4-mediated signaling events
Cell-Cell communication, organism-specific biosystem (from REACTOME)
Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
DSCAM interactions, organism-specific biosystem (from REACTOME)
DSCAM interactions, organism-specific biosystemDSCAM (Down syndrome cell adhesion molecule) is one of the members of the Ig superfamily CAMs with a domain architecture comprising 10 Ig domains, 6 fibronectin type III (FN) repeats, a single transm...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
EGF receptor (ErbB1) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
EGF receptor (ErbB1) signaling pathway, organism-specific biosystem
EGF receptor (ErbB1) signaling pathway
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
EPHA2 forward signaling, organism-specific biosystem (from Pathway Interaction Database)
EPHA2 forward signaling, organism-specific biosystem
EPHA2 forward signaling
EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
EPHB forward signaling, organism-specific biosystem
EPHB forward signaling
Endothelins, organism-specific biosystem (from Pathway Interaction Database)
Endothelins, organism-specific biosystem
Endothelins
Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
L1CAM interactions, organism-specific biosystem (from REACTOME)
L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
Neurotrophic factor-mediated Trk receptor signaling
Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
Osteopontin-mediated events, organism-specific biosystem
Osteopontin-mediated events
PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
PLK1 signaling events, organism-specific biosystem
PLK1 signaling events
Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
Prostate Cancer, organism-specific biosystem (from WikiPathways)
Prostate Cancer, organism-specific biosystem
Prostate Cancer
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
RAC1 signaling pathway, organism-specific biosystem
RAC1 signaling pathway
Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
Regulation of Microtubule Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Microtubule Cytoskeleton, organism-specific biosystem
Regulation of Microtubule Cytoskeleton
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
Regulation of p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
Regulation of p38-alpha and p38-beta, organism-specific biosystem
Regulation of p38-alpha and p38-beta
Renal cell carcinoma, organism-specific biosystem (from KEGG)
Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Renal cell carcinoma, conserved biosystem (from KEGG)
Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
S1P2 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P2 pathway, organism-specific biosystem
S1P2 pathway
Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
Semaphorin interactions, organism-specific biosystem (from REACTOME)
Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
Signal transduction by L1, organism-specific biosystem (from REACTOME)
Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by focal adhesion kinase, organism-specific biosystem
Signaling events mediated by focal adhesion kinase
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
Signaling of Hepatocyte Growth Factor Receptor
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
TCR signaling, organism-specific biosystem (from REACTOME)
TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...

General gene information

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Markers

PAK1_2112 (e-PCR)
- UniSTS:280885

D11S4697 (e-PCR)
- UniSTS:44363

D11S4079 (e-PCR), detects polymorphism
- UniSTS:25957

PMC140666P2 (e-PCR)
- UniSTS:270955

Pak1 (e-PCR), detects polymorphism
- UniSTS:527474

D11S1789 (e-PCR), detects polymorphism
- UniSTS:8857

SHGC-35393 (e-PCR)
- UniSTS:45214

WI-19865 (e-PCR)
- UniSTS:76724

AI072234 (e-PCR)
- UniSTS:244921

D11S4714 (e-PCR)
- UniSTS:1737

RH94191 (e-PCR)
- UniSTS:90573

D11S3332 (e-PCR)
- UniSTS:152574

Genotypes

See PAK1 SNP Geneview Report
See PAK1 SNP Genotype Report
See PAK1 SNP Variation Viewer Report

Homology

Homologs of the PAK1 gene: The PAK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, and N.crassa.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
collagen binding	IPI Inferred from Physical Interaction more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
NOT MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
T cell costimulation	TAS Traceable Author Statement more info
T cell receptor signaling pathway	TAS Traceable Author Statement more info
actin cytoskeleton reorganization	IDA Inferred from Direct Assay more info	PubMed
actin cytoskeleton reorganization	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
axon guidance	TAS Traceable Author Statement more info
branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info
cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
cellular response to stress	IEA Inferred from Electronic Annotation more info
dendrite development	IEA Inferred from Electronic Annotation more info
exocytosis	IEA Inferred from Electronic Annotation more info
innate immune response	TAS Traceable Author Statement more info
negative regulation of cell proliferation involved in contact inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
neuromuscular junction development	IEA Inferred from Electronic Annotation more info
neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of intracellular estrogen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
receptor clustering	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info
Z disc	ISS Inferred from Sequence or Structural Similarity more info
axon	ISS Inferred from Sequence or Structural Similarity more info
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
dendrite	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with filamentous actin	NAS Non-traceable Author Statement more info	PubMed
focal adhesion	IEA Inferred from Electronic Annotation more info
growth cone	IEA Inferred from Electronic Annotation more info
intercalated disc	ISS Inferred from Sequence or Structural Similarity more info
nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	IDA Inferred from Direct Assay more info
protein complex	IDA Inferred from Direct Assay more info	PubMed
ruffle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 1

Names: serine/threonine-protein kinase PAK 1; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)

NP_001122092.1

EC 2.7.11.1

NP_002567.3

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029900.1 RefSeqGene

Range

5001..157049

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001128620.1 → NP_001122092.1 serine/threonine-protein kinase PAK 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AF071884, BC050377, BC109299, BI793123, DA393732

Consensus CDS

CCDS44687.1

UniProtKB/Swiss-Prot

Q13153

Conserved Domains (3) summary

cd01093
Location:73 – 118
Blast Score: 204

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

smart00220
Location:270 – 517
Blast Score: 771

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:250 – 517
Blast Score: 1495

PKc_like; Protein Kinases, catalytic domain
NM_002576.4 → NP_002567.3 serine/threonine-protein kinase PAK 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

BC050377, BC109299, BI793123, DA393732

Consensus CDS

CCDS8250.1

UniProtKB/Swiss-Prot

Q13153

Related

ENSP00000348696, OTTHUMP00000228568, ENST00000356341, OTTHUMT00000382083

Conserved Domains (3) summary

cd01093
Location:73 – 118
Blast Score: 203

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cd06647
Location:250 – 542
Blast Score: 1607

STKc_PAK_I; Catalytic domain of the Protein Serine/Threonine Kinase, Group I p21-activated kinase

smart00220
Location:270 – 521
Blast Score: 790

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

77033060..77185108, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

73331052..73483383, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

76897807..77049866, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01017432.1 (8919..142696)	None
genomic	ABBA01017433.1	None
genomic	ABBA01017434.1	None
genomic	AMYH01003824.1 (7602..159661)	None
genomic	AP000486.6 (2276..150219)	None
genomic	AP003680.2	None
genomic	CH471076.1	EAW75026.1
		EAW75027.1
		EAW75028.1
		EAW75029.1
mRNA	AF071884.1	AAC24716.1
mRNA	AK055228.1	BAG51489.1
mRNA	AK293098.1	BAF85787.1
mRNA	AK295344.1	BAH12038.1
mRNA	AK296006.1	BAH12236.1
mRNA	BC050377.1	None
mRNA	BC109298.1	None
mRNA	BC109299.1	AAI09300.1
mRNA	BE501896.1	None
mRNA	BE502192.1	None
mRNA	BI793123.1	None
mRNA	BM451179.1	None
mRNA	DA393732.1	None
mRNA	U24152.1	AAA65441.1
mRNA	U51120.1	AAC50590.1
other-genetic	EU832767.1	ACE87778.1
other-genetic	GQ129310.1	ACT64444.1