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    IL2RA interleukin 2 receptor, alpha [ Homo sapiens ]

    Gene ID: 3559, updated on 19-May-2012
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    Summary

    Official Symbol
    IL2RAprovided by HGNC
    Official Full Name
    interleukin 2 receptor, alphaprovided by HGNC
    Primary source
    HGNC:6008
    Locus tag
    RP11-536K7.1
    See related
    Ensembl:ENSG00000134460; HPRD:00986; MIM:147730; Vega:OTTHUMG00000017616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD25; IL2R; TCGFR; IDDM10
    Summary
    The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
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    Genomic context

    Location :
    10p15-p14
    Sequence :
    Chromosome: 10; NC_000010.10 (6052657..6104333, complement)
    See IL2RA in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene F-box protein, helicase, 18 Neighboring gene interleukin 15 receptor, alpha Neighboring gene ribosomal protein L32 pseudogene 23 Neighboring gene RNA binding motif protein 17

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Interleukin 2 receptor α gene polymorphism and risk of multiple sclerosis: a meta-analysis. Wang LM, et al. J Int Med Res, 2011. PMID 22117963.
    2. Relationship between the anti-inflammatory properties of salmeterol/fluticasone and the expression of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in COPD. Yang L, et al. Respir Res, 2011 Oct 28. PMID 22032685.
    3. Tumor site immune markers associated with risk for subsequent basal cell carcinomas. Glaser R, et al. PLoS One, 2011. PMID 21980389.
    4. Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection. McSorley HJ, et al. PLoS One, 2011. PMID 21949691.
    5. Phenotype and function of CD25-expressing B lymphocytes isolated from human umbilical cord blood. Amu S, et al. Clin Dev Immunol, 2011. PMID 21941578.

    See all (295) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The levels of inflammatory factors are associated with the variation of Foxp3+Tregs in COPD.
      Title: Relationship between the anti-inflammatory properties of salmeterol/fluticasone and the expression of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in COPD.
    2. both of the IL2RA gene polymorphisms, rs2104286 and rs12722489, were associated with increased susceptibility to multiple sclerosis. [meta-analysis]
      Title: Interleukin 2 receptor α gene polymorphism and risk of multiple sclerosis: a meta-analysis.
    3. Interleukin-2 signaling pathway in human was analyzed by quantitative phosphoproteomics.
      Title: Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics.
    4. Results show that levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new basal cell carcinomas.
      Title: Tumor site immune markers associated with risk for subsequent basal cell carcinomas.
    5. Data show that production of IFN-gamma and IL-17A from duodenal biopsy culture was suppressed in hookworm-infected participants, and increased levels of CD4+CD25+Foxp3+ cells in the circulation and mucosa are associated with active celiac disease.
      Title: Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection.
    6. Increased CD4(+) CD69(+) CD25(-) T cells exert a critical role in hepatocellular carcinoma progression and might represent a clinically aggressive tumor phenotype.
      Title: Increased CD4(+) CD69(+) CD25(-) T cells in patients with hepatocellular carcinoma are associated with tumor progression.
    7. CD25 expression is a common denominator of a specific immunomodulatory B-cell subset ready to proliferate upon IL-2 stimulation.
      Title: Phenotype and function of CD25-expressing B lymphocytes isolated from human umbilical cord blood.
    8. Case Report: obtained good results in 2 high-titer ABO-incompatible living donor kidney transplantation using anti-CD20 and anti-CD25 antibodies without splenectomy, in conjunction with a calcineurin inhibitor plus mycophenolate mofetil or mizoribine.
      Title: The excellent outcomes of ABO-incompatible kidney transplantation with high titer (>×2048) using anti-CD20 and anti-CD25 antibody without splenectomy: two case reports.
    9. Demonstrate an increase in the proportion of CD4+CD25highIL-7Ralphahigh activated T cells in kidney transplant recipients, regardless of the immunosuppressive regimen.
      Title: Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients.
    10. These findings suggest an association of the rs2104286 IL2RA polymorphism with intermediate uveitis, but not with HLA-B27-associated acute anterior uveitis.
      Title: IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?
    Submit: New GeneRIF Correction See all (190)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Diabetes, mellitus, insulin-dependent, susceptibility to, 10

    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

    Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.

    Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.

    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

    Interleukin-2 receptor, alpha chain, deficiency of

    Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

    Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

    Risk alleles for multiple sclerosis identified by a genomewide study.

    Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CD4+ T cells infected with CCR5-tropic HIV-1 have significantly higher levels of activation-marker expression (e.g. CD25, CD71 and HLA-DR) than CD4+ T lymphocytes infected with CXCR4-tropic HIV-1 PubMed
    env The inhibition of IL-2R expression and proliferation induced by the interaction of CD4 with HIV-1 envelope glycoprotein gp120 is correlated with the inhibition of expression and activation of Janus kinase JAK3 PubMed
    env HIV-1 gp120 exerts a dose-dependent reduction of IL-2 mRNA expression, IL-2 production, and surface IL-2 receptor expression in CD4+ lymphocytes PubMed
    Envelope transmembrane glycoprotein gp41 env An HIV-1 gp41 peptide (amino acid residues 581-597) inhibits both protein kinase C (PKC)-dependent interleukin 2 (IL 2) production and the [Ca2+]i influx-dependent but PKC-independent induction of IL 2 receptor expression PubMed
    Nef nef HIV-1 Nef expression in the CD4+ T-cell line MT2 and in PHA-activated PBMCs downregulates the expression of IL-2R from the cell surface PubMed
    Tat tat HIV-1 Tat upregulates IL-2Ralpha (CD25) in PBMCs and purified T cells through integrins alpha-3 and alpha-5 PubMed
    tat HIV-1 Tat downregulates IL-2R in Jurkat and H9 T-cell lines, an effect that may contribute to the immunosuppressive effects of HIV-1 Tat PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000408.1 NP_000577.2 IL2    BIND  PubMed IL2 interacts with IL2RA. This interaction was modeled on a demonstrated interaction between radiolabeled IL2 from an unspecified species and IL2RA from human. 
    P01589 P01730 CD4    HPRD  PubMed  
    P01589 P05362 ICAM1    HPRD  PubMed  
    P01589 P60568 IL2    HPRD  PubMed  
    P01589 P01589 IL2RA    HPRD  PubMed  
    P01589 P14784 IL2RB    HPRD  PubMed  
    P01589 P19838 NFKB1    HPRD  PubMed  
    P01589 P40763 STAT3    HPRD  PubMed  
    P01589 P51692 STAT5B    HPRD  PubMed  
    BioGRID:109774 BioGRID:109610 ICAM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109774 BioGRID:109774 IL2RA    BioGRID  PubMed FRET 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 trafficking events, organism-specific biosystem
      Arf6 trafficking events
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
      Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem
      Calcium signaling in the CD4+ TCR pathway
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
      IL12 signaling mediated by STAT4, organism-specific biosystem
      IL12 signaling mediated by STAT4
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • IL2 signaling events mediated by STAT5, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by STAT5, organism-specific biosystem
      IL2 signaling events mediated by STAT5
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
      Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    drug binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    interleukin-2 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    interleukin-2 receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    activation-induced cell death of T cells IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of T cell homeostatic proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    interleukin-2 receptor subunit alpha
    Names
    interleukin-2 receptor subunit alpha
    p55
    IL2-RA
    IL-2-RA
    TAC antigen
    IL-2R subunit alpha
    IL-2 receptor subunit alpha
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007403.1 RefSeqGene

      Range
      4940..56616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_73

    mRNA and Protein(s)

    1. NM_000417.2 → NP_000408.1  interleukin-2 receptor subunit alpha precursor

      Status: REVIEWED

      Source sequence(s)
      AL137186, AL157395, X01057
      Consensus CDS
      CCDS7076.1
      UniProtKB/Swiss-Prot
      P01589
      Related
      ENSP00000369293, OTTHUMP00000019030, ENST00000379959, OTTHUMT00000046627
      Conserved Domains (2) summary
      cd00033
      Location:125 – 184
      Blast Score: 95
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:26 – 78
      Blast Score: 79
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      6052657..6104333, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      5979490..6030662, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL137186.18 CAI41069.1
      CAI41070.1
      CAI41085.1
    genomic AL137186.18 CAI41069.1
      CAI41070.1
      CAI41085.1
    genomic AL157395.17 CAH73595.1
      CAH73596.1
    genomic AY563103.1 AAS55572.1
    genomic BN000945.1 CAK26553.1
    genomic CH471072.2 EAW86412.1
      EAW86413.1
      EAW86414.1
    genomic HI573910.1 CBX47444.1
    genomic JA738831.1 CCF77061.1
    genomic M11066.1 AAA67527.1
    genomic M15864.1 AAA59162.1
    genomic X03131.1 CAA26906.1
    genomic X03138.1 None
    mRNA AF008556.1 AAB63458.1
    mRNA AK223313.1 BAD97033.1
    mRNA AK313847.1 BAG36576.1
    mRNA K03122.1 AAB59535.1
    mRNA M14098.1 AAA59142.1
    mRNA X01057.1 CAA25525.1
    other-genetic BC152889.1 AAI52890.1
    other-genetic BC156627.1 AAI56628.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15163 GenPept UniProtKB/TrEMBL:O15163
    P01589.1 GenPept UniProtKB/Swiss-Prot:P01589
    Q53FH4 GenPept UniProtKB/TrEMBL:Q53FH4
    Q5W006 GenPept UniProtKB/TrEMBL:Q5W006
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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