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    CD80 CD80 molecule [ Homo sapiens ]

    Gene ID: 941, updated on 20-May-2012
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    Summary

    Official Symbol
    CD80provided by HGNC
    Official Full Name
    CD80 moleculeprovided by HGNC
    Primary source
    HGNC:1700
    See related
    Ensembl:ENSG00000121594; HPRD:00202; MIM:112203; Vega:OTTHUMG00000159419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
    Summary
    The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
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    Genomic context

    Location :
    3q13.3-q21
    Sequence :
    Chromosome: 3; NC_000003.11 (119243140..119278481, complement)
    See CD80 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene protein O-glucosyltransferase 1 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene cysteine and glycine-rich protein 2 pseudogene Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene phospholipase A1 member A

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CD80 and CD86 polymorphisms in populations of various ancestries: 5 new CD80 promoter alleles. Beltrame MH, et al. Hum Immunol, 2012 Jan. PMID 22074996.
    2. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. Yang J, et al. J Immunol, 2011 Aug 1. PMID 21697455.
    3. Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80. Haile ST, et al. J Immunol, 2011 Jun 15. PMID 21555531.
    4. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Qureshi OS, et al. Science, 2011 Apr 29. PMID 21474713.
    5. Expression and distribution of S-100, CD83, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma. Xu WC, et al. Cancer Invest, 2011 May. PMID 21469977.

    See all (140) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that CD80 promoter and CD86 exon 8 allele frequencies vary significantly among populations of different ancestries.
      Title: CD80 and CD86 polymorphisms in populations of various ancestries: 5 new CD80 promoter alleles.
    2. The interaction between PDL1 on antigen prresenting cells and B7.1 on T cells plays a dominant role in bidirectional interactions between these two molecules during alloimmune responses.
      Title: The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo.
    3. the expression of the co-stimulatory molecule CD80 was decreased in intestines of celiac disease children after gluten-free diet.
      Title: The effect of gluten-free diet on Th1-Th2-Th3-associated intestinal immune responses in celiac disease.
    4. the costimulatory molecule CD80 prevents PDL1-mediated immune suppression by tumor cells and restores T cell activation
      Title: Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80.
    5. Efficiency of GHA priming chemotherapy on refractory acute myeloid leukemia and myelodysplastic syndrome may be correlated with B7.1 expression.
      Title: [Efficiency of GHA priming chemotherapy on patients with refractory acute myeloid leukemia and myelodysplastic syndrome and its relationship with expression of costimulatory molecule B7.1].
    6. The low expression of CD80 and CD86 in thyroid papillary carcinoma may help them evade the immune system.
      Title: Expression and distribution of S-100, CD83, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma.
    7. study shows CTLA-4 can capture its ligands (CD80, CD86)from opposing cells by trans-endocytosis; data reveal mechanism of immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by cell-extrinsic depletion of ligands
      Title: Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
    8. These results suggest that the polymorphisms of the CD86 gene may be used as genetic markers for making the diagnosis and prognosis of Graves' ophthalmopathy.
      Title: The association between polymorphisms of B7 molecules (CD80 and CD86) and Graves' ophthalmopathy in a Taiwanese population.
    9. Thalidomide can up-regulate the expression of B7-1 molecules on myeloma cells.
      Title: [Regulatory effect of thalidomide on the expression of costimulatory molecules in patients with multiple myeloma].
    10. increased CD80 and CD86 expression with the progression of tubulointerstitial lesion might play an important role in the development of lupus nephropathy
      Title: [Expression and significance of CD80/CD86 in renal tissue of lupus nephritis].
    Submit: New GeneRIF Correction See all (83)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

    Multiple common variants for celiac disease influencing immune gene expression.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The binding of HIV-1 gp120 to CD4 molecules on T cells interrupts the sequential cascade of intercellular interactions involving antigen/MHC class II-TCR/CD4, CD40L-CD40, and B71-CD28 PubMed
    env Molecular interactions of CD2 with LFA-3 and CD28 with B7-1 in conjunction with TCR occupancy prevent T cells from programmed apoptosis mediated by binding of CD4 to HIV-1 gp120, resulting in increased levels of IL-2 and IL-4 secretion from the T cells PubMed
    Nef nef HIV-1 Nef-induced B-cell differentiation response is suppressed by monoclonal antibodies to cell surface molecule B7, indicating an interaction between Nef and B7 PubMed
    nef HIV-1 Nef downregulates the co-stimulatory molecule CD80 from the cell surface in the human monocytic U937 cell line as well as in mouse macrophages and dendritic cells PubMed
    nef HIV-1 Nef co-localizes with MHC class I (MHCI), CD80, and CD86 in intracellular compartments by staining assays, and binds to both human CD80 and CD86 using yeast two-hybrid assays PubMed
    Tat tat HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses PubMed
    Vpr vpr HIV-1 Vpr inhibits the expression of co-stimulatory molecules including CD80, CD83, and CD86 at the transcriptional level without altering normal cellular transcription during dendritic cell maturation PubMed
    vpr HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC) PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005182.1 NP_006130.1 CD28    BIND  PubMed CD80 interacts with CD28. 
    NP_005182.1 NP_005205.2 CTLA4    BIND  PubMed CD80 interacts with CTLA-4. 
    NP_005182.1     BIND  PubMed CD80 interacts with Compound 2. 
    NP_005182.1     BIND  PubMed Ad3 fiber protein homotrimer interacts with CD80. 
    P33681 P10747 CD28    HPRD  PubMed  
    P33681 P33681 CD80    HPRD  PubMed  
    P33681 P42081 CD86    HPRD  PubMed  
    P33681 P16410 CTLA4    HPRD  PubMed  
    BioGRID:107379 BioGRID:107378 CD28    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107379 BioGRID:107379 CD80    BioGRID  PubMed Co-crystal Structure 
    BioGRID:107379 BioGRID:107875 CTLA4    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
      Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
      CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
    • CD28 dependent PI3K/Akt signaling, organism-specific biosystem (from REACTOME)
      CD28 dependent PI3K/Akt signaling, organism-specific biosystemPI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors (CD28), cytokine receptors and chemokine receptors. However, the specific role...
    • CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
      CD28 dependent Vav1 pathway, organism-specific biosystemCD28 binds to several intracellular proteins including PI3 kinase, Grb-2, Gads and ITK. Grb-2 specifically co-operates with Vav-1 in the up-regulation of NFAT/AP-1 transcription. CD28 costimulation r...
    • CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
      CTLA4 inhibitory signaling, organism-specific biosystemCTLA4 is one of the best studied inhibitory receptors of the CD28 superfamily. CTLA4 inhibits Tcell activation by reducing IL2 production and IL2 expression, and by arresting T cells at the G1 phase ...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    coreceptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    T cell activation IC
    Inferred by Curator
    more info
    		 PubMed 
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    cell-cell signaling IC
    Inferred by Curator
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of T-helper 1 cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of interleukin-2 biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    T-lymphocyte activation antigen CD80
    Names
    T-lymphocyte activation antigen CD80
    activation B7-1 antigen
    costimulatory factor CD80
    CTLA-4 counter-receptor B7.1
    B-lymphocyte activation antigen B7
    costimulatory molecule variant IgV-CD80
    CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005191.3 → NP_005182.1  T-lymphocyte activation antigen CD80 precursor

      Status: REVIEWED

      Source sequence(s)
      AC073352, BC042665, BP225173
      Consensus CDS
      CCDS2989.1
      UniProtKB/TrEMBL
      A0N0P2
      UniProtKB/Swiss-Prot
      P33681
      Related
      ENSP00000264246, OTTHUMP00000215214, ENST00000264246, OTTHUMT00000355196
      Conserved Domains (3) summary
      cd00098
      Location:154 – 232
      Blast Score: 100
      IgC; Immunoglobulin Constant domain
      smart00406
      Location:46 – 118
      Blast Score: 83
      IGv; Immunoglobulin V-Type
      cl11960
      Location:37 – 138
      Blast Score: 104
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      119243140..119278481, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      116618830..116654199, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073352.22 (116808..116980) None
    genomic CH471052.2 EAW79564.1
      EAW79565.1
    genomic EF064750.1 ABK41933.1
    genomic M83077.1 AAA58390.1
    genomic U72535.1 AAC51754.1
    mRNA AK292129.1 BAF84818.1
    mRNA AY081815.1 AAL89819.1
    mRNA AY197777.1 AAO39208.1
    mRNA AY197778.1 AAO39209.1
    mRNA BC042665.1 AAH42665.1
    mRNA BP225173.1 None
    mRNA M27533.1 AAA36045.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33681.1 GenPept UniProtKB/Swiss-Prot:P33681
    Q5DTA9 GenPept UniProtKB/TrEMBL:Q5DTA9
    Q5DTB0 GenPept UniProtKB/TrEMBL:Q5DTB0
    Q6LCB7 GenPept UniProtKB/TrEMBL:Q6LCB7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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