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    BMPR1B bone morphogenetic protein receptor, type IB [ Homo sapiens ]

    Gene ID: 658, updated on 11-May-2012
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    Summary

    Official Symbol
    BMPR1Bprovided by HGNC
    Official Full Name
    bone morphogenetic protein receptor, type IBprovided by HGNC
    Primary source
    HGNC:1077
    See related
    Ensembl:ENSG00000138696; HPRD:04457; MIM:603248; Vega:OTTHUMG00000130991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALK6; ALK-6; CDw293
    Summary
    This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
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    Genomic context

    Location :
    4q22-q24
    Sequence :
    Chromosome: 4; NC_000004.11 (95679128..96079601)
    See BMPR1B in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 5 Neighboring gene uncharacterized LOC100507012 Neighboring gene uncharacterized LOC100507031 Neighboring gene unc-5 homolog C (C. elegans) Neighboring gene ribosomal protein L30 pseudogene 6

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A covalently dimerized recombinant human bone morphogenetic protein-15 variant identifies bone morphogenetic protein receptor type 1B as a key cell surface receptor on ovarian granulosa cells. Pulkki MM, et al. Endocrinology, 2012 Mar. PMID 22294741.
    2. TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. Yan X, et al. Mol Cell Biol, 2011 Sep. PMID 21791611.
    3. A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China. Feng N, et al. Mol Biol Rep, 2012 Jan. PMID 21556765.
    4. Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. Haubold M, et al. Int J Biol Sci, 2010 Nov 24. PMID 21152263.
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. He C, et al. Hum Genet, 2010 Nov. PMID 20734064.

    See all (71) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. BMP15 uses preferentially BMPR1B as its type I receptor, suggesting an important role for the BMPR1B receptor in human female fertility
      Title: A covalently dimerized recombinant human bone morphogenetic protein-15 variant identifies bone morphogenetic protein receptor type 1B as a key cell surface receptor on ovarian granulosa cells.
    2. rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer and patients aged>70 years.
      Title: A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China.
    3. Data show that blocking both endogenous BMPR1A and BMPR1B almost offset the effect of BMP7 on the proliferation of NCI-H460 cell completely.
      Title: [BMP7 signaling via BMPR1A, BMPR1B inhibits the proliferation of lung large carcinoma NCI-H460 cell].
    4. BMPR1B were detected in the human retina and retinoblastoma cell lines.
      Title: Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells.
    5. Low BMP2 is associated with epithelial ovarian cancer.
      Title: Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients.
    6. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Human variation in alcohol response is influenced by variation in neuronal signaling genes.
    7. Results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk in breast cancer.
      Title: A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis.
    8. Decrease BMPR-1B expression led to decreased SMAD1 phosphorylation and correlated witht he malignant grade of human gliomas and a poor prognosis.
      Title: Expression and functional roles of Smad1 and BMPR-IB in glioma development.
    9. decreased expression of BMPR-IB correlates with poor prognosis in breast cancer patients and leads to increased cell proliferation of breast cancer cells in vitro
      Title: Reduced expression of BMPR-IB correlates with poor prognosis and increased proliferation of breast cancer cells.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.
    Submit: New GeneRIF Correction See all (26)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Brachydactyly, type A2

    Chrondrodysplasia, acromesomelic, with genital anomalies

    Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001194.1 NP_001193.1 BMP4    BIND  PubMed BMP4 interacts with BMPR1B (BR). This interaction was modeled on a demonstrated interaction between BMP4 from an unspecified species and BMPR1B from an unspecified species. 
    NP_001194.1 NP_006316.1 RAN    BIND  PubMed BMPR1B interacts with RAN. This interaction was modeled on a demonstrated interaction between human BMPR1B and mouse RAN. 
    O00238 Q16671 AMHR2    HPRD  PubMed  
    O00238 Q15052 ARHGEF6    HPRD  PubMed  
    O00238 O95972 BMP15    HPRD  PubMed  
    O00238 P12643 BMP2    HPRD  PubMed  
    O00238 P12644 BMP4    HPRD  PubMed  
    O00238 P22004 BMP6    HPRD  PubMed  
    O00238 P18075 BMP7    HPRD  PubMed  
    O00238 P36894 BMPR1A    HPRD  PubMed  
    O00238 O00238 BMPR1B    HPRD  PubMed  
    O00238 Q13873 BMPR2    HPRD  PubMed  
    O00238 O94921 CDK14    HPRD  PubMed  
    O00238 P11802 CDK4    HPRD  PubMed  
    O00238 P15882 CHN1    HPRD  PubMed  
    O00238 KIAA1892 DCAF12    HPRD  PubMed  
    O00238 IQ motif and WD repeats 1 DCAF6    HPRD  PubMed  
    O00238 P61962 DCAF7    HPRD  PubMed  
    O00238 Q9NW38 FANCL    HPRD  PubMed  
    O00238 P43026 GDF5    HPRD  PubMed  
    O00238 Q6KF10 GDF6    HPRD  PubMed  
    O00238 O60383 GDF9    HPRD  PubMed  
    O00238 Q9NR64 KLHL1    HPRD  PubMed  
    O00238 Q8N653 LZTR1    HPRD  PubMed  
    O00238 Q9NYS0 NKIRAS1    HPRD  PubMed  
    O00238 O95747 OXSR1    HPRD  PubMed  
    O00238 Q13153 PAK1    HPRD  PubMed  
    O00238 Q9UF11 PLEKHB1    HPRD  PubMed  
    O00238 Protein phosphatase 2A, catalytic subunit, alpha isoform PPP2CA    HPRD  PubMed  
    O00238 P48454 PPP3CC    HPRD  PubMed  
    O00238 P57735 RAB25    HPRD  PubMed  
    O00238 P57729 RAB38    HPRD  PubMed  
    O00238 Q9NRW1 RAB6B    HPRD  PubMed  
    O00238 P62826 RAN    HPRD  PubMed  
    O00238 P10114 RAP2A    HPRD  PubMed  
    O00238 Q96D21 RASD2    HPRD  PubMed  
    O00238 RAS like family 12 protein RASL12    HPRD  PubMed  
    O00238 Ras homolog enriched in brain like 1 RHEBL1    HPRD  PubMed  
    O00238 O00212 RHOD    HPRD  PubMed  
    O00238 Q9H4E5 RHOJ    HPRD  PubMed  
    O00238 P62979 RPS27A    HPRD  PubMed  
    O00238 P62070 RRAS2    HPRD  PubMed  
    O00238 O75995 SASH3    HPRD  PubMed  
    O00238 Hypothetical protein FLJ23356 SGK196    HPRD  PubMed  
    O00238 Q96B97 SH3KBP1    HPRD  PubMed  
    O00238 O43541 SMAD6    HPRD  PubMed  
    O00238 O15105 SMAD7    HPRD  PubMed  
    O00238 Q9UNH7 SNX6    HPRD  PubMed  
    O00238 O14544 SOCS6    HPRD  PubMed  
    O00238 Q13501 SQSTM1    HPRD  PubMed  
    O00238 Q7Z6B7 SRGAP1    HPRD  PubMed  
    O00238 O95630 STAMBP    HPRD  PubMed  
    O00238 Q8TDR2 STK35    HPRD  PubMed  
    O00238 Q9UNE7 STUB1    HPRD  PubMed  
    O00238 P36897 TGFBR1    HPRD  PubMed  
    O00238 P13805 TNNT1    HPRD  PubMed  
    O00238 Q96AE7 TTC17    HPRD  PubMed  
    O00238 Tetratricopeptide repeat domain 27 TTC27    HPRD  PubMed  
    O00238 P62987 UBA52    HPRD  PubMed  
    O00238 Q9H832 UBE2Z    HPRD  PubMed  
    O00238 SAPK substrate protein 1 UBXN1    HPRD  PubMed  
    O00238 Ubiquitin specific protease 45 USP45    HPRD  PubMed  
    O00238 Ventricular zone expressed PH domain homolog 1 VEPH1    HPRD  PubMed  
    BioGRID:107126 BioGRID:214954 1700006A11Rik    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:215941 Arhgef6    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:218476 Atg16l1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:107118 BMP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107126 BioGRID:107120 BMP4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107126 BioGRID:107123 BMP7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107126 BioGRID:107125 BMPR1A    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107126 BioGRID:107126 BMPR1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107126 BioGRID:107127 BMPR2    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107126 BioGRID:225455 Bcr    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:198373 Bmpr2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:202129 Cdk14    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:198645 Cdk4    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:224378 Chn1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:214962 Dcaf7    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:211887 Fancl    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:208300 Fbxo3    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:219722 Fbxo34    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:205976 Fbxw5    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:199682 Fkbp1a    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:199683 Fkbp1b    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:113839 GDF5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107126 BioGRID:134147 GDF6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107126 BioGRID:109763 IGSF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107126 BioGRID:212191 Ilkap    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:207563 Irf7    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:220238 Klhl1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:211770 Lztr1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:204951 Map2k3    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:201432 Mknk2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:212503 Naa20    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:247522 Nedd4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107126 BioGRID:213637 Nkiras1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:205156 Plekhb1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:202341 Ppp2ca    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:202346 Ppp3cc    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:215371 Rab38    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:234782 Rab6b    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:217966 Rap2a    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:217250 Rasd2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:213261 Rhebl1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:213337 Rhobtb1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:198198 Rhod    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:219817 Rhoj    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:219309 Rps27a    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:211811 Rras2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107126 BioGRID:121852 SNX6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107126 BioGRID:208383 Sh3kbp1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:201279 Smad6    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:201280 Smad7    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:201982 Sqstm1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:228239 Srgap1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:212113 Stk35    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:207969 Stub1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107126 BioGRID:114374 TSC22D1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107126 BioGRID:204163 Tgfbr1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107126 BioGRID:200956 Uhmk1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:218782 Usp45    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107126 BioGRID:106828 XIAP    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystemOvarian ???bottleneck??? genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertil...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by BMP, organism-specific biosystem (from REACTOME)
      Signaling by BMP, organism-specific biosystemThe TGF-beta/BMP (bone morphogenetic protein) pathway incorporates several signalling pathways that share most, but not all, components of a central signal transduction engine. The general signalling...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SMAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activin receptor activity, type II TAS
    Traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor signaling protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transforming growth factor beta-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane receptor protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transmembrane receptor protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transmembrane receptor protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    BMP signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    BMP signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    cartilage condensation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ovarian cumulus expansion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ovulation cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transmembrane receptor protein serine/threonine kinase signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    integral to plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    receptor complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    bone morphogenetic protein receptor type-1B
    Names
    bone morphogenetic protein receptor type-1B
    BMPR-1B
    BMP type-1B receptor
    activin receptor-like kinase 6
    serine/threonine receptor kinase
    NP_001194.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009245.1 RefSeqGene

      Range
      5001..405474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203.2 → NP_001194.1  bone morphogenetic protein receptor type-1B isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode isoform b.
      Source sequence(s)
      AC105395, AW299723, BC069796
      Consensus CDS
      CCDS3642.1
      UniProtKB/Swiss-Prot
      O00238
      Related
      ENSP00000426617, OTTHUMP00000161621, ENST00000515059, OTTHUMT00000253609
      Conserved Domains (5) summary
      cd00180
      Location:210 – 409
      Blast Score: 369
      PKc; Catalytic domain of Protein Kinases
      pfam01064
      Location:30 – 110
      Blast Score: 212
      Activin_recp; Activin types I and II receptor domain
      cl02621
      Location:174 – 202
      Blast Score: 84
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
      pfam00069
      Location:207 – 489
      Blast Score: 473
      Pkinase; Protein kinase domain
      cl09925
      Location:330 – 494
      Blast Score: 120
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001256792.1 → NP_001243721.1  bone morphogenetic protein receptor type-1B isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode isoform b.
      Source sequence(s)
      AC092609, AC105395, AK313642
      UniProtKB/Swiss-Prot
      O00238
      Conserved Domains (5) summary
      cd00180
      Location:210 – 409
      Blast Score: 369
      PKc; Catalytic domain of Protein Kinases
      pfam01064
      Location:30 – 110
      Blast Score: 212
      Activin_recp; Activin types I and II receptor domain
      cl02621
      Location:174 – 202
      Blast Score: 84
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
      pfam00069
      Location:207 – 489
      Blast Score: 473
      Pkinase; Protein kinase domain
      cl09925
      Location:330 – 494
      Blast Score: 120
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001256793.1 → NP_001243722.1  bone morphogenetic protein receptor type-1B isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC105395, AK299930
      UniProtKB/TrEMBL
      B4DSV1
      Conserved Domains (5) summary
      cd00180
      Location:240 – 439
      Blast Score: 366
      PKc; Catalytic domain of Protein Kinases
      pfam01064
      Location:60 – 140
      Blast Score: 215
      Activin_recp; Activin types I and II receptor domain
      cl02621
      Location:204 – 232
      Blast Score: 85
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
      pfam00069
      Location:237 – 519
      Blast Score: 471
      Pkinase; Protein kinase domain
      cl09925
      Location:360 – 524
      Blast Score: 120
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001256794.1 → NP_001243723.1  bone morphogenetic protein receptor type-1B isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode isoform b.
      Source sequence(s)
      AC105395, AK293008, AK299930
      UniProtKB/TrEMBL
      A8KAE3
      UniProtKB/TrEMBL
      B4DSV1
      UniProtKB/Swiss-Prot
      O00238
      Conserved Domains (5) summary
      cd00180
      Location:210 – 409
      Blast Score: 369
      PKc; Catalytic domain of Protein Kinases
      pfam01064
      Location:30 – 110
      Blast Score: 212
      Activin_recp; Activin types I and II receptor domain
      cl02621
      Location:174 – 202
      Blast Score: 84
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
      pfam00069
      Location:207 – 489
      Blast Score: 473
      Pkinase; Protein kinase domain
      cl09925
      Location:330 – 494
      Blast Score: 120
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      95679128..96079601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      91416328..91816286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004061.1 (1998..86396) None
    genomic AC092609.2 None
    genomic AC093634.3 (15405..82528) None
    genomic AC105395.1 None
    genomic CH471057.1 EAX06060.1
    mRNA AK293008.1 BAF85697.1
    mRNA AK299930.1 BAG61763.1
    mRNA AK313642.1 BAG36400.1
    mRNA AW299723.1 None
    mRNA BC047773.1 AAH47773.1
    mRNA BC069796.1 AAH69796.1
    mRNA BC069803.1 AAH69803.1
    mRNA D89675.1 BAA19765.1
    mRNA U89326.1 AAC28131.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00238.1 GenPept UniProtKB/Swiss-Prot:O00238
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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