These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_001159969.1 → NP_001153441.1 epidermal growth factor receptor substrate 15 isoform B
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks multiple exons at the 5' end and has a distinct 5' UTR and start codon, compared to variant 1. These differences result in a protein (isoform B) with a shorter and distinct N-terminus, compared to isoform A. Isoform B localizes to early endosome membranes.
- Source sequence(s)
-
AA789139, AK294297, AW949896, BM681433, BX647676, DA801048, U07707
- UniProtKB/TrEMBL
-
B7Z240
- UniProtKB/Swiss-Prot
-
P42566
- Related
- ENSP00000379428, ENST00000396122
- Conserved Domains (2) summary
-
- TIGR02169
Location:33 – 184
Blast Score: 116
- SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
- pfam12325
Location:109 – 188
Blast Score: 112
- TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
-
NM_001981.2 → NP_001972.1 epidermal growth factor receptor substrate 15 isoform A
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Isoform A mainly localizes to clathrin-coated pits at the plasma membrane.
- Source sequence(s)
-
AL671986, CD657119, Z29064
- Consensus CDS
-
CCDS557.1
- UniProtKB/Swiss-Prot
-
P42566
- Related
- ENSP00000360798, OTTHUMP00000009896, ENST00000371733, OTTHUMT00000022422
- Conserved Domains (4) summary
-
- cd00052
Location:228 – 293
Blast Score: 232
- EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
- TIGR02168
Location:333 – 490
Blast Score: 134
- SMC_prok_B; chromosome segregation protein SMC, common bacterial type
- pfam12325
Location:423 – 502
Blast Score: 115
- TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
- smart00027
Location:121 – 215
Blast Score: 365
- EH; Eps15 homology domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000001.10 Reference GRCh37.p5 Primary Assembly
- Range
- 51819935..51984995, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000133.1 Alternate HuRef
- Range
- 49937536..50064736, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)