BST2 bone marrow stromal cell antigen 2 [Homo sapiens] - Gene

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Summary

Official Symbol: BST2provided by HGNC
Official Full Name: bone marrow stromal cell antigen 2provided by HGNC
Primary source: HGNC:1119
See related: Ensembl:ENSG00000130303; HPRD:02759; MIM:600534; Vega:OTTHUMG00000165993
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD317; TETHERIN
Summary: Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19p13.1

Sequence :: Chromosome: 19; NC_000019.9 (17513755..17516384, complement)

See BST2 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that human cytomegalovirus not only counteracts the function of BST2 as inhibitor of viral egress but also employs this anti-viral protein to gain entry into BST2-expressing hematopoietic cells
Title: BST2/Tetherin enhances entry of human cytomegalovirus.
key features of the helix-helix pairing that underlies interaction between Vpu protein of HIV-1 and BST-2
Title: HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions.
A precise model is provided which predicts the detailed interaction occurring between transmembrane domains of BST-2 and viral protein U (Vpu) of HIV-1; such a model should facilitate the design of anti-HIV agents that can disrupt this interaction.
Title: Characterization of the interface of the bone marrow stromal cell antigen 2-Vpu protein complex via computational chemistry.
VACV infection did not diminish THN surface levels or impair its function on retroviral release. This suggests that THN is unable to restrict VACV replication
Title: The cellular antiviral restriction factor tetherin does not inhibit poxviral replication.
APOBEC3G/3F and BST-2 mRNA expression was significantly elevated during IFN-alpha/riba treatment in patient-derived CD4+ T cells (P < 0.04 and P < 0.008, paired Wilcoxon), and extent of BST-2 induction was correlated with reduction in HIV-1 viral...
Title: Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo.
[review] Tetherin inhibits viral infection via a novel mechanism by blocking the release of nascent enveloped viral particles from the cell surface.
Title: Tetherin and its viral antagonists.
HIV-1 Vpu's lipid raft association is essential for counteraction of the particle release restriction imposed by CD317.
Title: HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin.
The BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of HIV-1 particle release.
Title: The tetherin/BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of particle release.
Tetherin is a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian virus. [review]
Title: Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.
Alanine-18 is important for HIV-1 group M Vpu localization and tetherin-Vpu interactions.
Title: Lack of adaptation to human tetherin in HIV-1 group O and P.

Submit: New GeneRIF Correction See all (80)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:107149	BioGRID:114457	BTRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107149	BioGRID:112895	TFRC	BioGRID	PubMed	Co-localization
BioGRID:107149	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107149	BioGRID:1205543	vpu	BioGRID	PubMed	Affinity Capture-Western; FRET

Function	Evidence Code	Pubs
protein homodimerization activity	IPI Inferred from Physical Interaction more info
signal transducer activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
B cell activation	IEA Inferred from Electronic Annotation more info
cell proliferation	TAS Traceable Author Statement more info	PubMed
cell-cell signaling	TAS Traceable Author Statement more info	PubMed
defense response to virus	IDA Inferred from Direct Assay more info
humoral immune response	TAS Traceable Author Statement more info	PubMed
innate immune response	IEA Inferred from Electronic Annotation more info
multicellular organismal development	TAS Traceable Author Statement more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
anchored to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
late endosome	IEA Inferred from Electronic Annotation more info
plasma membrane part	IDA Inferred from Direct Assay more info

General protein information

Preferred Names: bone marrow stromal antigen 2

Names: bone marrow stromal antigen 2; BST-2; NPC-A-7; HM1.24 antigen

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004335.2 → NP_004326.1 bone marrow stromal antigen 2

Status: REVIEWED

Source sequence(s)

D28137

Consensus CDS

CCDS12358.1

UniProtKB/Swiss-Prot

Q10589

Related

ENSP00000252593, OTTHUMP00000231653, ENST00000252593, OTTHUMT00000387346

Conserved Domains (1) summary

TIGR02168
Location:70 – 149
Blast Score: 81

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

17513755..17516384, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

17079843..17082475, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC010319.10 (86013..88642)	None
genomic	CH471106.1	EAW84602.1
		EAW84603.1
mRNA	AK223124.1	BAD96844.1
mRNA	AK291099.1	BAF83788.1
mRNA	AK303593.1	BAG64608.1
mRNA	AY320402.1	AAP73804.1
mRNA	BC033873.1	AAH33873.1
mRNA	D28137.1	BAA05679.1