RHOF ras homolog family member F (in filopodia) [Homo sapiens] - Gene

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Summary

Official Symbol: RHOFprovided by HGNC
Official Full Name: ras homolog family member F (in filopodia)provided by HGNC
Primary source: HGNC:15703
See related: Ensembl:ENSG00000139725; HPRD:15246; Vega:OTTHUMG00000169077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RIF; ARHF; FLJ20247

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Genomic context

Location :: 12q24.31

Sequence :: Chromosome: 12; NC_000012.11 (122215660..122231594, complement)

See RHOF in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the present review, our aim is to summarize the current information about the Rif effectors and how Rif remodels actin cytoskeleton in many aspects. [Review]
Title: The small Rho GTPase Rif and actin cytoskeletal remodelling.
The authors show that enteropathogenic Escherichia coli translocates EspH, which inactivates mammalian RhoGEFs and triggers cytotoxicity.
Title: The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.
Rif GTPase is an alternative trigger of stress-fiber formation in epithelial cells.
Title: The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells.
deletion of genes RHOF in early-stage mycosis fungoides.
Title: Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF.
The protein encoded by this gene causes the formation of long, actin-rich filopodia. In combination with RAC1 and CDC42 it causes additional actin rearrangments, suggesting that this protein is intimately involved in regulation of the cytoskeleton.
Title: The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:120004	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	NAS Non-traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
GTP catabolic process	NAS Non-traceable Author Statement more info	PubMed
actin filament organization	IDA Inferred from Direct Assay more info	PubMed
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
intracellular	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: rho-related GTP-binding protein RhoF

Names: rho-related GTP-binding protein RhoF; rho in filopodia; rho family GTPase Rif; ras homolog gene family, member F (in filopodia)

NP_061907.2

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019034.2 → NP_061907.2 rho-related GTP-binding protein RhoF precursor

Status: VALIDATED

Source sequence(s)

AK000254, BG574506, BM830620, BQ053707, BQ422695, BU527972, CA426077

Consensus CDS

CCDS9222.1

UniProtKB/Swiss-Prot

Q9HBH0

Related

ENSP00000267205, OTTHUMP00000240047, ENST00000267205, OTTHUMT00000402165

Conserved Domains (1) summary

cd04132
Location:17 – 187
Blast Score: 826

Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

122215660..122231594, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

119227850..119243788, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC084018.28 (120922..136856)	None
genomic	CH471054.1	EAW98278.1
		EAW98279.1
genomic	CS026797.1	CAI61864.1
mRNA	AF239923.1	AAG24952.1
mRNA	AK000254.1	BAA91034.1
mRNA	AK130459.1	None
mRNA	AK289482.1	BAF82171.1
mRNA	BC018208.1	AAH18208.1
mRNA	BC018721.1	None
mRNA	BC032529.1	None
mRNA	BC043395.1	None
mRNA	BG574506.1	None
mRNA	BM830620.1	None
mRNA	BQ053707.1	None
mRNA	BQ422695.1	None
mRNA	BU527972.1	None
mRNA	CA426077.1	None