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    JUN jun proto-oncogene [ Homo sapiens ]

    Gene ID: 3725, updated on 20-May-2012
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    Summary

    Official Symbol
    JUNprovided by HGNC
    Official Full Name
    jun proto-oncogeneprovided by HGNC
    Primary source
    HGNC:6204
    See related
    Ensembl:ENSG00000177606; HPRD:01302; MIM:165160; Vega:OTTHUMG00000008376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AP1; AP-1; c-Jun
    Summary
    This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p32-p31
    Sequence :
    Chromosome: 1; NC_000001.10 (59246463..59249785, complement)
    See JUN in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene adenylate kinase 2 pseudogene 1 Neighboring gene Myb-like, SWIRM and MPN domains 1 Neighboring gene uncharacterized LOC100131060 Neighboring gene prohibitin pseudogene 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. IκB kinase β is required for activation of NF-κB and AP-1 in CD3/CD28-stimulated primary CD4(+) T cells. Lupino E, et al. J Immunol, 2012 Mar 15. PMID 22331067.
    2. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. Taira N, et al. J Clin Invest, 2012 Mar 1. PMID 22307329.
    3. Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation. Reddy NM, et al. Am J Pathol, 2012 Feb. PMID 22265050.
    4. AP-1 transcription factors, mucin-type molecules and MMPs regulate the IL-11 mediated invasiveness of JEG-3 and HTR-8/SVneo trophoblastic cells. Suman P, et al. PLoS One, 2012. PMID 22235337.
    5. c-Jun expression in human neuropathies: a pilot study. Hutton EJ, et al. J Peripher Nerv Syst, 2011 Dec. PMID 22176144.

    See all (680) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. IL-11 mediated differential activation of signaling and expression of effector molecules
      Title: AP-1 transcription factors, mucin-type molecules and MMPs regulate the IL-11 mediated invasiveness of JEG-3 and HTR-8/SVneo trophoblastic cells.
    2. an intricate network of energetically-coupled residues within the basic regions of the Jun-Fos heterodimeric transcription factor accounts for its allosteric binding to DNA
      Title: Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA.
    3. DYRK2 regulates tumor progression through modulation of c-Jun and c-Myc
      Title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
    4. The results suggest that Egr-1 may promote prostate cancer development by modulating the activity of factors NF-kappaB and AP-1, which are involved in cell proliferation and apoptosis.
      Title: Inhibition of Egr-1 by siRNA in prostate carcinoma cell lines is associated with decreased expression of AP-1 and NF-κB.
    5. in human primary CD4+ T cells, IKKbeta is required for the activation of NF-kappaB and AP-1 transcription factors in response to engagement of CD3 and CD28 coreceptor
      Title: IκB kinase β is required for activation of NF-κB and AP-1 in CD3/CD28-stimulated primary CD4(+) T cells.
    6. Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma
      Title: Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma.
    7. These results suggest that the Nrf2/ARE/Jun/Akt/Erk pathway plays an important role in the regulation of icariside-mediated antioxidant effects in HepG2 cells.
      Title: Icariside II enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression coupled with the ERK, Akt and JNK signaling pathways.
    8. report a novel transcriptional cooperation between GATA factors and cJUN on the mouse Star and human STAR promoters in MA-10 Leydig cells. This cooperation was observed with different GATA members, whereas only cJUN could cooperate with GATA factors
      Title: Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells.
    9. c-Jun is rarely expressed in normal nerves, but it is expressed in Schwann cell nuclei of pathological nerves
      Title: c-Jun expression in human neuropathies: a pilot study.
    10. down-regulation of the Twist gene suppressed the proliferation of MKN45 gastric cancer cells by negatively regulating the AP-1 activity
      Title: Activator protein-1 involvement in proliferation inhibition by gene silencing of Twist in gastric cancer cells.
    Submit: New GeneRIF Correction See all (420)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway PubMed
    env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
    env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
    env HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites PubMed
    env Binding of heat-inactivated HIV-1 (iHIV-1) or HIV-1 gp120 to infected resting PBMCs is sufficient to activate NF-kappa B and AP-1, to induce cell surface expression of CD25, and to commit cells to produce virus PubMed
    env HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 induces activation of transcription factor, activated protein-1 (AP-1), comprised of Fos and Jun proteins, in CD4 positive T cell lines PubMed
    Nef nef HIV-1 Nef expression in human (THP-1) monocyte-macrophages induces both DNA binding and transcriptional activities of the activator protein-1 (AP-1) transcription factor, c-fos and c-jun; this induction requires the proline-rich PxxP motif of Nef PubMed
    nef HIV-1 Nef inhibits c-jun transcription in mitogen-stimulated human T cells PubMed
    Tat tat HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR PubMed
    tat HIV-1 Tat activates c-jun (Activator Protein-1; AP-1) through the activation of JNK, an effect mediated through the activation of p56lck PubMed
    tat Crosslinking experiments suggest a direct binding interaction between HIV-1 Tat and AP1 that is relatively inefficient and that correlates with the ability of AP1 to support Tat transactivation PubMed
    tat HIV-1 Tat-induced expression of MCP-1 is partially mediated through the activation of c-jun (Activator Protein-1; AP-1) binding to, and transactivation of the MCP-1 promoter by Tat PubMed
    tat HIV-1 Tat interacts with the cooperative rel/AP1 complex, downregulating its transactivation activity and leading to a decrease in IL-2 gene transcription PubMed
    Vpr vpr Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages. PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NM_002228.3 NP_003676.1 KHSRP    BIND  PubMed KSRP interacts with AREjun. This interaction was modeled on a demonstrated interaction between KSRP from human and AREjun from an unspecified species. 
    NP_002219.1 NP_009227.1 BRCA1    BIND  PubMed BRCA1 interacts with c-Jun. 
    NP_002219.1 NP_001722.1 BTG1    BIND  PubMed BTG1 interacts with JUN (c-Jun). This interaction was modeled on a demonstrated interaction between human BTG1 and quail c-Jun. 
    NP_002219.1 NC_000015.8 CYP19A1    BIND  PubMed JUN (cJUN) interacts with the CYP19A1 (aromatase PII) promoter. 
    NP_002219.1 NP_000116.1 ESR1    BIND  PubMed ER-alpha interacts with c-Jun. This interaction was modeled on a demonstrated interaction between human ER-alpha, and mouse c-Jun. 
    NP_002219.1 NP_001013433.1 FBXW7    BIND  PubMed Fbw7-gamma interacts with c-Jun. 
    NP_002219.1 NP_060785.2 FBXW7    BIND  PubMed Fbw7-beta interacts with c-Jun. 
    NP_002219.1 NP_361014.1 FBXW7    BIND  PubMed Fbw7-alpha interacts with c-Jun. 
    NP_002219.1 NP_005243.1 FOS    BIND  PubMed cFos interacts with cJun. 
    NP_002219.1 NP_005243.1 FOS    BIND  PubMed c-Jun interacts with c-Fos. This interaction was modelled on a demonstrated interaction between c-Jun from an unspecified species and c-Fos from an unspecified species. 
    NP_002219.1 NC_000011.8 FOSL1    BIND  PubMed c-Jun interacts with the region of the FRA-1 promoter containing the TRE, SRE and ATF sites. 
    NP_002219.1 AL035456.26 JAG1    BIND  PubMed c-Jun interacts with Jagged1 promoter. 
    NP_002219.1 NP_002219.1 JUN    BIND  PubMed c-Jun interacts with another molecule of c-Jun. 
    NP_002219.1 NP_002219.1 JUN    BIND  PubMed cJun interacts with a second cJun molecule. 
    NP_002219.1 NP_002219.1 JUN    BIND  PubMed c-Jun interacts with c-Jun. This interaction was modelled on a demonstrated interaction between c-Jun from an unspecified species and c-Jun from an unspecified species. 
    NP_002219.1 NP_002220.1 JUNB    BIND  PubMed c-Jun interacts with Jun B. 
    NP_002219.1 NP_002744.1 MAPK10    BIND  PubMed JNK3alpha1 interacts with c-Jun. 
    NP_002219.1 NP_620448.1 MAPK10    BIND  PubMed MAPK10 (JNK3) phosphorylates JUN (c-Jun) 
    NP_002219.1 NP_620448.1 MAPK10    BIND  PubMed JNK3alpha2 interacts with c-Jun. 
    NP_002219.1 NP_002742.3 MAPK11    BIND  PubMed p38-2 interacts with and very weakly phosphorylates c-Jun. 
    NP_002219.1 MAPK14    BIND  PubMed An unspecified isoform of p38 interacts with and phosphorylates c-Jun. 
    NP_002219.1 NP_002741.1 MAPK8    BIND  PubMed JNK1alpha2 interacts with c-Jun. 
    NP_002219.1 NP_620634.1 MAPK8    BIND  PubMed JNK1beta1 interacts with c-Jun. 
    NP_002219.1 NP_620635.1 MAPK8    BIND  PubMed JNK1beta2 interacts with c-Jun. 
    NP_002219.1 NP_620637.1 MAPK8    BIND  PubMed MAPK8 (JNK1) phosphorylates JUN (c-Jun) 
    NP_002219.1 NP_620637.1 MAPK8    BIND  PubMed JNK1alpha1 interacts with c-Jun. 
    NP_002219.1 MAPK8    BIND  PubMed c-Jun is phosphorylated by JNK-1. This interaction was modeled on a demonstrated interaction between c-Jun and JNK-1, both from an unspecified species. 
    NP_002219.1 MAPK8    BIND  PubMed JNK1 phosphorylates c-Jun. This interaction was modeled on a demonstrated interaction between bovine JNK1 or JNK1 from an unspecified species, and c-Jun from an unspecified species. 
    NP_002219.1 NP_002743.3 MAPK9    BIND  PubMed JNK2alpha1 interacts with c-Jun. 
    NP_002219.1 NP_620707.1 MAPK9    BIND  PubMed JNK2alpha2 interacts with c-Jun. 
    NP_002219.1 NP_620708.1 MAPK9    BIND  PubMed JNK2beta1 interacts with c-Jun. 
    NP_002219.1 NP_620709.1 MAPK9    BIND  PubMed JNK2beta2 interacts with c-Jun. 
    NP_002219.1 MAPK9    BIND  PubMed An unspecified isoform of JNK2 interacts with and phosphorylates c-Jun. 
    NP_002219.1 NP_057358.2 PLEKHO1    BIND  PubMed CKIP-1 interacts with c-Jun. 
    NP_002219.1 NP_000312.1 RB1    BIND  PubMed RB interacts with c-Jun. 
    NP_002219.1 NP_068810.2 RELA    BIND  PubMed NF-kappa-B interacts with c-Jun. 
    NP_002219.1 NP_071902.2 RFWD2    BIND  PubMed The carboxy-terminal WD-40 repeat region of hCOP1 interacts with c-jun. 
    NP_002219.1 NP_003396.1 YWHAH    BIND  PubMed JNK interacts with 14-3-3-eta. 
    P05412 P00519 ABL1    HPRD  PubMed  
    P05412 P10275 AR    HPRD  PubMed  
    P05412 P18846 ATF1    HPRD  PubMed  
    P05412 P15336 ATF2    HPRD  PubMed  
    P05412 P18847 ATF3    HPRD  PubMed  
    P05412 P18848 ATF4    HPRD  PubMed  
    P05412 Q16520 BATF    HPRD  PubMed  
    P05412 P20749 BCL3    HPRD  PubMed  
    P05412 P41182 BCL6    HPRD  PubMed  
    P05412 P38398 BRCA1    HPRD  PubMed  
    P05412 Q8WX92 COBRA1    HPRD  PubMed  
    P05412 Q92905 COPS5    HPRD  PubMed  
    P05412 Q02930 CREB5    HPRD  PubMed  
    P05412 Q92793 CREBBP    HPRD  PubMed  
    P05412 P68400 CSNK2A1    HPRD  PubMed  
    P05412 P35638 DDIT3    HPRD  PubMed  
    P05412 Q9NR30 DDX21    HPRD  PubMed  
    P05412 Q08211 DHX9    HPRD  PubMed  
    P05412 P18146 EGR1    HPRD  PubMed  
    P05412 E74 like factor 3 ELF3    HPRD  PubMed  
    P05412 P60002 ELOF1    HPRD  PubMed  
    P05412 Q05925 EN1    HPRD  PubMed  
    P05412 Q09472 EP300    HPRD  PubMed  
    P05412 P11308 ERG    HPRD  PubMed  
    P05412 P03372 ESR1    HPRD  PubMed  
    P05412 P14921 ETS1    HPRD  PubMed  
    P05412 P15036 ETS2    HPRD  PubMed  
    P05412 Q969H0 FBXW7    HPRD  PubMed  
    P05412 P01100 FOS    HPRD  PubMed  
    P05412 P15407 FOSL1    HPRD  PubMed  
    P05412 P15408 FOSL2    HPRD  PubMed  
    P05412 P23769 GATA2    HPRD  PubMed  
    P05412 Q00403 GTF2B    HPRD  PubMed  
    P05412 P13984 GTF2F2    HPRD  PubMed  
    P05412 P51610 HCFC1    HPRD  PubMed  
    P05412 O15379 HDAC3    HPRD  PubMed  
    P05412 Q03014 HHEX    HPRD  PubMed  
    P05412 Q16665 HIF1A    HPRD  PubMed  
    P05412 P17096 HMGA1    HPRD  PubMed  
    P05412 P52272 HNRNPM    HPRD  PubMed  
    P05412 P31269 HOXA9    HPRD  PubMed  
    P05412 P31273 HOXC8    HPRD  PubMed  
    P05412 P51617 IRAK1    HPRD  PubMed  
    P05412 Q96J02 ITCH    HPRD  PubMed  
    P05412 Jun dimerization protein 2 JDP2    HPRD  PubMed  
    P05412 P05412 JUN    HPRD  PubMed  
    P05412 O75444 MAF    HPRD  PubMed  
    P05412 Q9Y5Q3 MAFB    HPRD  PubMed  
    P05412 P53779 MAPK10    HPRD  PubMed  
    P05412 Q15759 MAPK11    HPRD  PubMed  
    P05412 P27361 MAPK3    HPRD  PubMed  
    P05412 P45983 MAPK8    HPRD  PubMed  
    P05412 P45984 MAPK9    HPRD  PubMed  
    P05412 Q8IW41 MAPKAPK5    HPRD  PubMed  
    P05412 Q9UQ07 MOK    HPRD  PubMed  
    P05412 Q9BQG0 MYBBP1A    HPRD  PubMed  
    P05412 P15172 MYOD1    HPRD  PubMed  
    P05412 Q13765 NACA    HPRD  PubMed  
    P05412 Q15788 NCOA1    HPRD  PubMed  
    P05412 Q15596 NCOA2    HPRD  PubMed  
    P05412 Q9Y6Q9 NCOA3    HPRD  PubMed  
    P05412 Q14494 NFE2L1    HPRD  PubMed  
    P05412 Q16236 NFE2L2    HPRD  PubMed  
    P05412 P23511 NFYA    HPRD  PubMed  
    P05412 P04150 NR3C1    HPRD  PubMed  
    P05412 Q13285 NR5A1    HPRD  PubMed  
    P05412 P48552 NRIP1    HPRD  PubMed  
    P05412 Q16288 NTRK3    HPRD  PubMed  
    P05412 Q6VY07 PACS1    HPRD  PubMed  
    P05412 O75925 PIAS1    HPRD  PubMed  
    P05412 Q13526 PIN1    HPRD  PubMed  
    P05412 P28069 POU1F1    HPRD  PubMed  
    P05412 Q15139 PRKD1    HPRD  PubMed  
    P05412 P78527 PRKDC    HPRD  PubMed  
    P05412 P06400 RB1    HPRD  PubMed  
    P05412 Q14498 RBM39    HPRD  PubMed  
    P05412 Q04206 RELA    HPRD  PubMed  
    P05412 Q8NHY2 RFWD2    HPRD  PubMed  
    P05412 Q02543 RPL18A    HPRD  PubMed  
    P05412 Q01196 RUNX1    HPRD  PubMed  
    P05412 Q13950 RUNX2    HPRD  PubMed  
    P05412 P12755 SKI    HPRD  PubMed  
    P05412 Q15796 SMAD2    HPRD  PubMed  
    P05412 P84022 SMAD3    HPRD  PubMed  
    P05412 Q13485 SMAD4    HPRD  PubMed  
    P05412 Q96GM5 SMARCD1    HPRD  PubMed  
    P05412 Q6STE5 SMARCD3    HPRD  PubMed  
    P05412 O75971 SNAPC5    HPRD  PubMed  
    P05412 Q9NRH2 SNRK    HPRD  PubMed  
    P05412 P56693 SOX10    HPRD  PubMed  
    P05412 P57073 SOX8    HPRD  PubMed  
    P05412 P08047 SP1    HPRD  PubMed  
    P05412 P17947 SPI1    HPRD  PubMed  
    P05412 Q01892 SPIB    HPRD  PubMed  
    P05412 P42224 STAT1    HPRD  PubMed  
    P05412 P40763 STAT3    HPRD  PubMed  
    P05412 Q14765 STAT4    HPRD  PubMed  
    P05412 P63165 SUMO1    HPRD  PubMed  
    P05412 P61956 SUMO2    HPRD  PubMed  
    P05412 P55854 SUMO3    HPRD  PubMed  
    P05412 Q6EEV6 SUMO4    HPRD  PubMed  
    P05412 P21675 TAF1    HPRD  PubMed  
    P05412 P20226 TBP    HPRD  PubMed  
    P05412 Q9UGU0 TCF20    HPRD  PubMed  
    P05412 P15884 TCF4    HPRD  PubMed  
    P05412 Q13569 TDG    HPRD  PubMed  
    P05412 Q15583 TGIF1    HPRD  PubMed  
    P05412 P11387 TOP1    HPRD  PubMed  
    P05412 P11388 TOP2A    HPRD  PubMed  
    P05412 P09493 TPM1    HPRD  PubMed  
    P05412 P07951 TPM2    HPRD  PubMed  
    P05412 Q15650 TRIP4    HPRD  PubMed  
    P05412 Q99576 TSC22D3    HPRD  PubMed  
    P05412 Ubiquitin B UBB    HPRD  PubMed  
    P05412 P63279 UBE2I    HPRD  PubMed  
    P05412 P11473 VDR    HPRD  PubMed  
    BioGRID:109928 BioGRID:106831 APLP2    BioGRID  PubMed Two-hybrid 
    BioGRID:109928 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:106901 ARRB1    BioGRID  PubMed Two-hybrid 
    BioGRID:109928 BioGRID:119215 ASCC1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:123921 ASCC2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:116170 ASCC3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:107776 ATF2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:106957 ATF3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:106958 ATF4    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:107074 BCL3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:107076 BCL6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:107479 CEBPA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:107532 CHD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:117421 COBRA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-Western; Co-localization; Two-hybrid 
    BioGRID:109928 BioGRID:107775 CREB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:114954 CREB5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:107832 CSK    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:109928 BioGRID:107841 CSNK2A1    BioGRID  PubMed Far Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:107842 CSNK2A2    BioGRID  PubMed Far Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:107972 DACH1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109928 BioGRID:108016 DDIT3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:114625 DDX21    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109928 BioGRID:114260 EDF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-fractionation; Reconstituted Complex 
    BioGRID:109928 BioGRID:108389 ERG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:108414 ETS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:108415 ETS2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:108636 FOS    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:113742 FOSL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:108638 FOSL2    BioGRID  PubMed Two-hybrid 
    BioGRID:109928 BioGRID:108894 GATA2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:109214 GTF2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:109216 GTF2E2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:109217 GTF2F1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:109218 GTF2F2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:115083 HDAC9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:109402 HMGA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:110751 HNRNPM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109928 BioGRID:109552 HSP90AA1    BioGRID  PubMed Two-hybrid 
    BioGRID:109928 BioGRID:109767 IKBKB    BioGRID  PubMed Biochemical Activity 
    BioGRID:109928 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:125807 JDP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:109928 JUN    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:116315 KAT7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:117048 MACF1    BioGRID  PubMed Two-hybrid 
    BioGRID:109928 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:109928 BioGRID:111581 MAPK3    BioGRID  PubMed Biochemical Activity 
    BioGRID:109928 BioGRID:111585 MAPK8    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:111587 MAPK9    BioGRID  PubMed Biochemical Activity 
    BioGRID:109928 BioGRID:110320 MAZ    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:109928 BioGRID:119788 MBD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:121835 MLL3    BioGRID  PubMed Two-hybrid 
    BioGRID:109928 BioGRID:114562 MTA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:121568 MTA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:110737 MYOD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:110748 NACA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:114200 NCOA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:116691 NCOA6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:114974 NCOR2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:110851 NFE2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:110852 NFE2L2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:110866 NFYA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:109165 NR3C1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:108792 NR5A1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:113843 NRIP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:106894 PHOX2A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:114124 PIAS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:114523 PIAS2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:111384 PML    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:111445 POU1F1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:120946 PPP2R2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109928 BioGRID:111524 PPP3CB    BioGRID  PubMed FRET; Reconstituted Complex 
    BioGRID:109928 BioGRID:111523 PPP4C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:111573 PRKD1    BioGRID  PubMed Biochemical Activity 
    BioGRID:109928 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:114952 RBM39    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:111902 RELA    BioGRID  PubMed Phenotypic Enhancement; Two-hybrid 
    BioGRID:109928 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:127223 RNF187    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:112110 RPS6KA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:109928 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:107308 RUNX2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:112208 SARS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109928 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:112566 SPI1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:112567 SPIB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:112652 STAT4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:112655 STAT6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; PCA; Reconstituted Complex 
    BioGRID:109928 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109928 BioGRID:112496 SUMO3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109928 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:217772 Senp2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:109928 BioGRID:211982 Smarca2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:203337 Smarcb1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109928 BioGRID:112735 TAF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:112802 TCF20    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:112908 TGIF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109928 BioGRID:113006 TOP2A    BioGRID  PubMed Far Western 
    BioGRID:109928 BioGRID:108165 TSC22D3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; PCA; Two-hybrid 
    BioGRID:109928 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:109928 BioGRID:113252 VAV1    BioGRID  PubMed Biochemical Activity 
    BioGRID:109928 BioGRID:113264 VDR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109928 BioGRID:1205541 tat    BioGRID  PubMed Affinity Capture-Western 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    RNA polymerase II activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IC
    Inferred by Curator
    more info
    		 PubMed 
    Rho GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cAMP response element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    MyD88-independent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    SMAD protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Toll signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    axon regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to potassium ion starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    leading edge cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
    		  
    microglial cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation by host of viral transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of neuron apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation by host of viral transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of Rho GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of monocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of neuron apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		  
    release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cAMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 1 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 2 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 3 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 4 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear chromosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nuclear euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcriptional repressor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    transcription factor AP-1
    Names
    transcription factor AP-1
    p39
    jun oncogene
    activator protein 1
    proto-oncogene c-Jun
    enhancer-binding protein AP1
    Jun activation domain binding protein
    v-jun sarcoma virus 17 oncogene homolog
    v-jun avian sarcoma virus 17 oncogene homolog
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002228.3 → NP_002219.1  transcription factor AP-1

      Status: REVIEWED

      Source sequence(s)
      BC002646, BC009874, BG831943, BI793062, BU782554, CD370800
      Consensus CDS
      CCDS610.1
      UniProtKB/Swiss-Prot
      P05412
      Related
      ENSP00000360266, OTTHUMP00000010036, ENST00000371222, OTTHUMT00000023042
      Conserved Domains (2) summary
      pfam03957
      Location:5 – 241
      Blast Score: 495
      Jun; Jun-like transcription factor
      cl02576
      Location:250 – 313
      Blast Score: 196
      bZIP_1; bZIP transcription factor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      59246463..59249785, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      57356787..57360109, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL136985.11 CAC10201.1
    genomic AY217548.1 AAO22993.1
    genomic CH471059.2 EAX06628.1
    genomic CS542415.1 CAM91157.1
    genomic J04111.1 AAA59197.1
    mRNA BC002646.2 None
    mRNA BC006175.1 AAH06175.1
    mRNA BC009874.2 AAH09874.2
    mRNA BC068522.1 AAH68522.1
    mRNA BG831943.1 None
    mRNA BI793062.1 None
    mRNA BT019759.1 AAV38564.1
    mRNA BU782554.1 None
    mRNA CD370800.1 None
    mRNA CR541724.1 CAG46525.1
    mRNA CR541752.1 CAG46552.1
    other-genetic DQ896432.2 ABM87431.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05412.2 GenPept UniProtKB/Swiss-Prot:P05412
    Q6FHK0 GenPept UniProtKB/TrEMBL:Q6FHK0
    Q6FHM7 GenPept UniProtKB/TrEMBL:Q6FHM7
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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