IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: IL12Aprovided by HGNC
Official Full Name: interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)provided by HGNC
Primary source: HGNC:5969
See related: Ensembl:ENSG00000168811; HPRD:01193; MIM:161560; Vega:OTTHUMG00000158942
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P35; CLMF; NFSK; NKSF1; IL-12A
Summary: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 3q25.33

Sequence :: Chromosome: 3; NC_000003.11 (159706623..159713806)

See IL12A in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
Title: The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
Autoimmune diseases appear to cluster in two groups that either show strong associations with the Th1/Th17 pathway (IL12B and IL23R) or the Th1/IL-35 pathway ( polymorphisms in the IL12A gene region). Review
Title: Genetic variations in interleukin-12 related genes in immune-mediated diseases.
Genotyped IL12A and IL12B polymorphisms in four hundred-five patients with cervical cancer and four hundred fifty unrelated Showed that the IL12B polymorphism may be a genetic risk factor for cervical cancer.
Title: Contribution of IL12A and IL12B polymorphisms to the risk of cervical cancer.
This study investigates gene expression of interleukin (IL)-12-related (IL-12A, IL-12B, IL-23A) cytokine and IL-10 in stimulated monocytes from colorectal cancer (CRC) patients.
Title: Monocytes expression of IL-12 related and IL-10 genes in association with development of colorectal cancer.
These findings suggest that the IL-12A and IL-12B independently and jointly be involved in the susceptibility to intracranial aneurysm.
Title: Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm.
Data show that SNP of IL-12B gene was associated with significantly increased overall risk of cancers, however, the SNPs of IL-12A gene did not appear to have an influence on cancer susceptibility.
Title: Functional polymorphisms in the interleukin-12 gene contribute to cancer risk: evidence from a meta-analysis of 18 case-control studies.
variation in the IL12B gene, but not IL12A, partly explains inter-individual differences in disease susceptibility and severity
Title: Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity.
IL-12A rs2243115 polymorphism may contribute to genetic susceptibility to COPD in a Chinese population
Title: Association between single-nucleotide polymorphisms in interleukin-12A and risk of chronic obstructive pulmonary disease.
We found significant differences on the mean values of IL-12 between the panic disorder and control groups
Title: Decreased IFN-γ and IL-12 levels in panic disorder.
Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via STAT3 pathways.
Title: Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via STAT3 pathways.

Submit: New GeneRIF Correction See all (109)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

Multiple common variants for celiac disease influencing immune gene expression.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Env, gp160, envelope glycoprotein	env	Chimeric HIV-1 gp140 - CD40L trimers can target and activate dendritic cells to release IL-6, IL-10 and IL-12	PubMed
	env	IL-7 and IL-12 significantly augment proliferative responses to HIV-1 gp160	PubMed
Envelope surface glycoprotein gp120	env	HIV-1 gp120 inhibits early and late production of interleukin (IL)-12 by peripheral blood mononuclear cells (PBMC)	PubMed
	env	Secretion of IL-12 is found in macrophages primed with gamma interferon (IFN-gamma) and subsequently treated with gp120	PubMed
	env	Apoptosis of CD4+ lymphocytes induced by HIV-1 gp120 cross-linking to CD4 is inhibited by IL-12	PubMed
	env	HIV-gp120 induces a significant IL-10 synthesis, which in turn inhibits IL-12 subunits mRNA accumulation and protein secretion after Staphylococcus aureus strain cowan I (SAC)-activation	PubMed
Nef, p27	nef	IL-12 and GM-CSF increase the magnitude of the specific immune response with higher breadth by targeting HIV-1 Nef peptides (amino acids 9-23, 11-26, 140-155, 179-193, and 181-195)	PubMed
	nef	IL-1beta, IL-12, and IL-15 are factors involved in the upregulation of IFN-gamma expression in coculture between Nef-pulsed iDCs and NK cells	PubMed
	nef	HIV-1 Nef upregulates IL-12 release in immature human and macaque dendritic cells	PubMed
Tat, p14	tat	Wild-type Tat but not Cys-22 and oxidized Tat induces CD1A-expressing monocyte-derived dendritic cells (MDDC) maturation and increases the production of cytokines TNF-alpha, IL-12, MIP-1alpha, and MIP-1beta	PubMed
	tat	HIV-1 Tat upregulates IL-12 expression in Jurkat T-cells, Raji B-cells, and monocyte-derived dendritic cells	PubMed
	tat	HIV-1 Tat downregulates IL-12 production by human dendritic cells by blocking extracellular calcium influx	PubMed
	tat	HIV-1 Tat downregulates IL-12 production by human peripheral blood mononuclear cells (PBMCs)	PubMed
Vpr, p15	vpr	The C-terminal domain or the R90 residue of HIV-1 Vpr are important for Vpr-mediated IL-12 degradation via ubiquitin-dependent pathway	PubMed
	vpr	HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway	PubMed
	vpr	HIV-1 Vpr downregulates the production of interleukin 12 (IL-12) in dendritic cells	PubMed
	vpr	HIV-1 Vpr suppresses expression and secretion of IL-12 subunit p35 and IL-12 holo-protein, but not IL-12 subunit p40	PubMed
matrix	gag	HIV-1 Matrix upregulates levels of IL-2, IL-12 and IL-15 in natural killer cells and induces natural killer cell proliferation	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_000873.2	NP_000873.2	IL12A	BIND	PubMed	p35 interacts with p35 to form a homodimer.
P29459	P10747	CD28	HPRD	PubMed
P29459	Q14213	EBI3	HPRD	PubMed
P29459	P29459	IL12A	HPRD	PubMed
P29459	P29460	IL12B	HPRD	PubMed
P29459	P10145	IL8	HPRD	PubMed
P29459	Q92558	WASF1	HPRD	PubMed
BioGRID:109806	BioGRID:109807	IL12B	BioGRID	PubMed	Co-crystal Structure

Pathways from BioSystems

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African trypanosomiasis, organism-specific biosystem (from KEGG)
African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
African trypanosomiasis, conserved biosystem (from KEGG)
African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
Allograft rejection, organism-specific biosystem (from KEGG)
Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
Allograft rejection, conserved biosystem (from KEGG)
Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amoebiasis, conserved biosystem (from KEGG)
Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL12-mediated signaling events, organism-specific biosystem
IL12-mediated signaling events
IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL27-mediated signaling events, organism-specific biosystem
IL27-mediated signaling events
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Legionellosis, organism-specific biosystem (from KEGG)
Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Legionellosis, conserved biosystem (from KEGG)
Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Leishmaniasis, organism-specific biosystem (from KEGG)
Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Leishmaniasis, conserved biosystem (from KEGG)
Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Malaria, organism-specific biosystem (from KEGG)
Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Malaria, conserved biosystem (from KEGG)
Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Type I diabetes mellitus, organism-specific biosystem (from KEGG)
Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
Type I diabetes mellitus, conserved biosystem (from KEGG)
Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...

General gene information

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Markers

PMC105864P1 (e-PCR)
- UniSTS:270118

NoName (e-PCR)
- UniSTS:488050

GDB:252062 (e-PCR)
- UniSTS:156323

SHGC-12751 (e-PCR)
- UniSTS:32985

RH17729 (e-PCR)
- UniSTS:66784

Homology

Homologs of the IL12A gene: The IL12A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to cytokine activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cytokine activity	TAS Traceable Author Statement more info	PubMed
contributes_to growth factor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to growth factor activity	NAS Non-traceable Author Statement more info	PubMed
interleukin-12 beta subunit binding	IEA Inferred from Electronic Annotation more info
interleukin-12 receptor binding	NAS Non-traceable Author Statement more info	PubMed
interleukin-27 binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
cell migration	IDA Inferred from Direct Assay more info	PubMed
defense response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
defense response to protozoan	IEA Inferred from Electronic Annotation more info
immune response	TAS Traceable Author Statement more info	PubMed
negative regulation of interleukin-17 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NK T cell activation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interferon-gamma production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of lymphocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of natural killer cell activation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA Inferred from Direct Assay more info	PubMed
positive regulation of smooth muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tyrosine phosphorylation of Stat4 protein	IDA Inferred from Direct Assay more info	PubMed
response to UV-B	IDA Inferred from Direct Assay more info	PubMed
response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
response to virus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
interleukin-12 complex	IDA Inferred from Direct Assay more info	PubMed
interleukin-12 complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: interleukin-12 subunit alpha

Names: interleukin-12 subunit alpha; CLMF p35; IL35 subunit; IL-12 subunit p35; IL-12, subunit p35; interleukin 12, p35; interleukin-12 alpha chain; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; natural killer cell stimulatory factor 1, 35 kD subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033022.1 RefSeqGene

Range

5001..12184

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000882.3 → NP_000873.2 interleukin-12 subunit alpha precursor

Status: REVIEWED

Source sequence(s)

AC010370, AW472810, BC104982, M65291

Consensus CDS

CCDS3187.1

UniProtKB/TrEMBL

O60595

UniProtKB/Swiss-Prot

P29459

Related

ENSP00000303231, OTTHUMP00000213703, ENST00000305579, OTTHUMT00000352602

Conserved Domains (1) summary

pfam03039
Location:35 – 253
Blast Score: 858

IL12; Interleukin-12 alpha subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p10 Primary Assembly

Range

159706623..159713806

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

157102994..157110193

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018914.1 Alternate CHM1_1.0

Range

159687417..159694599

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01058801.1 (24736..31935)	None
genomic	AC010370.5 (107709..114891)	None
genomic	AF050083.1	AAC05211.1
		AAC05212.1
genomic	AF404773.1	AAK84425.1
genomic	AMYH01013613.1 (224837..232019)	None
genomic	CH471052.2	EAW78656.1
		EAW78657.1
		EAW78658.1
genomic	CS498405.1	CAM82732.1
genomic	HH821934.1	CBX32667.1
genomic	JA104599.1	CCA63969.1
mRNA	AF101062.1	AAD16432.1
mRNA	AF180562.1	AAD56385.1
mRNA	AW472810.1	None
mRNA	BC035571.1	None
mRNA	BC104982.1	AAI04983.1
mRNA	BC104984.1	AAI04985.1
mRNA	BG702253.1	None
mRNA	M65271.1	AAA35694.1
mRNA	M65291.1	AAA59937.1