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    PRKDC protein kinase, DNA-activated, catalytic polypeptide [ Homo sapiens ]

    Gene ID: 5591, updated on 20-May-2012
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    Summary

    Official Symbol
    PRKDCprovided by HGNC
    Official Full Name
    protein kinase, DNA-activated, catalytic polypeptideprovided by HGNC
    Primary source
    HGNC:9413
    See related
    Ensembl:ENSG00000253729; HPRD:02941; MIM:600899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7; DNA-PKcs
    Summary
    This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
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    Genomic context

    Location :
    8q11
    Sequence :
    Chromosome: 8; NC_000008.10 (48685669..48872743, complement)
    See PRKDC in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene KIAA0146 Neighboring gene ubiquitin-conjugating enzyme E2N pseudogene Neighboring gene uncharacterized LOC100652845 Neighboring gene CCAAT/enhancer binding protein (C/EBP), delta Neighboring gene minichromosome maintenance complex component 4 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks. Pankotai T, et al. Nat Struct Mol Biol, 2012 Feb 12. PMID 22343725.
    2. A cohesin-RAD21 interactome. Panigrahi AK, et al. Biochem J, 2012 Mar 15. PMID 22145905.
    3. Sublethal doses of β-amyloid peptide abrogate DNA-dependent protein kinase activity. Cardinale A, et al. J Biol Chem, 2012 Jan 20. PMID 22139836.
    4. DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. Stronach EA, et al. Neoplasia, 2011 Nov. PMID 22131882.
    5. Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context. Gunn A, et al. J Biol Chem, 2011 Dec 9. PMID 22027841.

    See all (314) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data indicate that the function of DNA-PKcs on IR-induced Akt-S473 phosphorylation is cell line specific.
      Title: Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation.
    2. Our finding suggests that polymorphisms in DNA repair genes, POLN and PRKDC, were associated with increased melanoma risk in melanoma families with and without CDKN2A mutations.
      Title: Genetic variants in DNA repair genes and the risk of cutaneous malignant melanoma in melanoma-prone families with/without CDKN2A mutations.
    3. Immunohistochemical staining intensities of PARP-1 and DNA-PK were determined (score 0-3) and expression levels were correlated with /glioblastoma multiforme patients overall survival.
      Title: Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.
    4. results point to the pivotal role of DNAPK activity in the eviction of RNAPII from DNA upon encountering a DNA lesion
      Title: DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks.
    5. DNA-PK inhibition might prevent platinum-induced AKT activation without interfering with normal glucose homeostasis, an unwanted toxicity of direct AKT inhibitors.
      Title: DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
    6. Abeta mediates inhibition of the DNA-PK-dependent nonhomologous end joining pathway contributing to the accumulation of DSBs that, if not efficiently repaired, may lead to the neuronal loss observed in AD.
      Title: Sublethal doses of β-amyloid peptide abrogate DNA-dependent protein kinase activity.
    7. The DNA-PKcs not only did not protect cells from either telomere instability or celluar effects induced by 360A but was involved in th severe mitotic impairments induced by the G-quadrulpex ligand.
      Title: Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death.
    8. Lack of DNA-PKcs is accompanied by an increase in the protein level of one of the catalytic isozymes of protein kinase CK2, i.e., CK2alpha' and a concomitant increase in CK2 activity.
      Title: Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2α' levels.
    9. RAD50, DNA-PKcs kinase activity, and transcription context are each important to limit incorrect end use during EJ repair of multiple DSBs, but each has distinct roles during repair events requiring end processing
      Title: Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.
    10. analysis of gene expression associated with DNA-dependent protein kinase activity under normoxia, hypoxia, and reoxygenation
      Title: Gene expression associated with DNA-dependent protein kinase activity under normoxia, hypoxia, and reoxygenation.
    Submit: New GeneRIF Correction See all (143)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed
    tat Amino acids 56-101 of HIV-1 Tat mediate Tat binding to DNA-PK, an effect that augments DNA-PK-mediated phosphorylation of Sp1 during Tat transactivation of the HIV-1 LTR promoter PubMed
    integrase gag-pol DNA-PK is proposed to play a role in retroviral DNA integration and protects cells against toxicity induced by HIV-1 Integrase or integration PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_008835.5 NP_005154.1 AKT1    BIND  PubMed DNA-PKcs interacts with Akt1. 
    NP_008835.5 NP_002476.2 NBN    BIND  PubMed NBS1 interacts with PRKDC (DNA-PKc). 
    NP_008835.5 NP_002583.1 PCNA    BIND  PubMed PRKDC is a PCNA-binding protein 
    NP_008835.5 NP_002937.1 RPA2    BIND  PubMed DNA-PKcs interacts with RPA2. 
    NP_008835.5 NP_066964.1 XRCC5    BIND  PubMed XRCC5 (Ku80) interacts with PRKDC (DNA-PKc). 
    NP_008835.5     BIND  PubMed The LIG4-XRCC4 complex interacts with and is phosphorylated by DNA-PK. 
    NP_008835.5     BIND  PubMed Wortmannin interacts with PRKDC. 
    NP_008835.5     BIND  PubMed Ku antigen interacts with DNA-PKcs. 
    P78527 P00519 ABL1    HPRD  PubMed  
    P78527 P31749 AKT1    HPRD  PubMed  
    P78527 Q13315 ATM    HPRD  PubMed  
    P78527 Q8WXE1 ATRIP    HPRD  PubMed  
    P78527 Nuclear DNA binding protein C1D    HPRD  PubMed  
    P78527 P42574 CASP3    HPRD  PubMed  
    P78527 O15111 CHUK    HPRD  PubMed  
    P78527 Q99828 CIB1    HPRD  PubMed  
    P78527 Q96SD1 DCLRE1C    HPRD  PubMed  
    P78527 P20042 EIF2S2    HPRD  PubMed  
    P78527 P10144 GZMB    HPRD  PubMed  
    P78527 P09429 HMGB1    HPRD  PubMed  
    P78527 P26583 HMGB2    HPRD  PubMed  
    P78527 P09017 HOXC4    HPRD  PubMed  
    P78527 Q00613 HSF1    HPRD  PubMed  
    P78527 P07900 HSP90AA1    HPRD  PubMed  
    P78527 Q12905 ILF2    HPRD  PubMed  
    P78527 P05412 JUN    HPRD  PubMed  
    P78527 P49917 LIG4    HPRD  PubMed  
    P78527 P07948 LYN    HPRD  PubMed  
    P78527 P45983 MAPK8    HPRD  PubMed  
    P78527 O60934 NBN    HPRD  PubMed  
    P78527 Q14686 NCOA6    HPRD  PubMed  
    P78527 P04150 NR3C1    HPRD  PubMed  
    P78527 P09874 PARP1    HPRD  PubMed  
    P78527 P12004 PCNA    HPRD  PubMed  
    P78527 Q05655 PRKCD    HPRD  PubMed  
    P78527 P78527 PRKDC    HPRD  PubMed  
    P78527 P27694 RPA1    HPRD  PubMed  
    P78527 P15927 RPA2    HPRD  PubMed  
    P78527 Q5FBB7 SGOL1    HPRD  PubMed  
    P78527 P08047 SP1    HPRD  PubMed  
    P78527 P11831 SRF    HPRD  PubMed  
    P78527 P04637 TP53    HPRD  PubMed  
    P78527 Q14191 WRN    HPRD  PubMed  
    P78527 P23025 XPA    HPRD  PubMed  
    P78527 Q13426 XRCC4    HPRD  PubMed  
    P78527 P13010 XRCC5    HPRD  PubMed  
    P78527 P12956 XRCC6    HPRD  PubMed  
    P78527 P61981 YWHAG    HPRD  PubMed  
    BioGRID:111577 BioGRID:230161 4930572J05Rik    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:106543 ABL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111577 BioGRID:121497 AICDA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:106823 AIRE    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111577 BioGRID:106711 AKT2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:106671 AP1B1    BioGRID  PubMed Protein-peptide 
    BioGRID:111577 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:124372 ATG4C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:111577 BioGRID:313463 ATRIP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111577 BioGRID:114226 BECN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:106829 BIRC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:107140 BRCA1    BioGRID  PubMed Protein-peptide 
    BioGRID:111577 BioGRID:121948 C12orf44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:115705 C1D    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:111577 BioGRID:115889 CAMKK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:107424 CDC5L    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:111577 BioGRID:107487 CENPA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:115349 CHAF1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:114929 CHD1L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111577 BioGRID:107536 CHEK1    BioGRID  PubMed Protein-peptide; Reconstituted Complex 
    BioGRID:111577 BioGRID:107569 CHUK    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:111577 BioGRID:115774 CIB1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111577 BioGRID:107612 CLN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:114597 CTDP1    BioGRID  PubMed Biochemical Activity; Protein-peptide 
    BioGRID:111577 BioGRID:122170 DCLRE1C    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111577 BioGRID:122485 DDA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-fractionation 
    BioGRID:111577 BioGRID:108209 E4F1    BioGRID  PubMed Protein-peptide 
    BioGRID:111577 BioGRID:114411 EIF2S2    BioGRID  PubMed Co-purification 
    BioGRID:111577 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:108901 GBAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111577 BioGRID:109272 H3F3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:114368 HDAC3    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111577 BioGRID:109319 HDLBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:109275 HIST1H1A    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:545757 HIST1H1A    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:109261 HIST1H1C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:113949 HIST1H3E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:109457 HOXB7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:109530 HSF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111577 BioGRID:109767 IKBKB    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:109821 ILF2    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:111577 BioGRID:109822 ILF3    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:111577 BioGRID:108918 KAT2A    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:123914 KAT8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111577 BioGRID:110169 LIG4    BioGRID  PubMed Protein-peptide 
    BioGRID:111577 BioGRID:110186 LMNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:110245 LYN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111577 BioGRID:111585 MAPK8    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:111587 MAPK9    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:114138 MKNK1    BioGRID  PubMed Two-hybrid 
    BioGRID:111577 BioGRID:110438 MLH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:110501 MRE11A    BioGRID  PubMed Protein-peptide 
    BioGRID:111577 BioGRID:116143 MSL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:110763 NBN    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111577 BioGRID:575724 NCF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:110768 NCF2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:110769 NCF4    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:111577 BioGRID:115296 NR1H4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:109860 PDX1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:120645 PIDD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:111404 PMS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:111447 POU2F1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:111529 PPP6C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:116537 PPP6R1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:115053 PPP6R2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:120579 PPP6R3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:111552 PRKAB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:111577 PRKDC    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:111769 PTS    BioGRID  PubMed Protein-peptide 
    BioGRID:111577 BioGRID:111821 RAD17    BioGRID  PubMed Protein-peptide 
    BioGRID:111577 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:111867 RBBP8    BioGRID  PubMed Protein-peptide 
    BioGRID:111577 BioGRID:114797 RECQL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:112037 RPA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111577 BioGRID:112038 RPA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:941018 SAP25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:119603 SIRT6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization 
    BioGRID:111577 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:112550 SP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111577 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111577 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:115223 TELO2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111577 BioGRID:112923 THRA    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111577 BioGRID:112924 THRB    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111577 BioGRID:113010 TP53    BioGRID  PubMed Biochemical Activity; Protein-peptide 
    BioGRID:111577 BioGRID:115030 TTI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:123164 TTI2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:113237 USF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:113323 WRN    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Protein-peptide 
    BioGRID:111577 BioGRID:113352 XRCC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111577 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111577 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111577 BioGRID:113360 YY1    BioGRID  PubMed Co-purification 
    BioGRID:111577 BioGRID:1205541 tat    BioGRID  PubMed Biochemical Activity 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      BARD1 signaling events, organism-specific biosystem
      BARD1 signaling events
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Class I PI3K signaling events mediated by Akt, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events mediated by Akt, organism-specific biosystem
      Class I PI3K signaling events mediated by Akt
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
    • DNA-PK complex, organism-specific biosystem (from KEGG)
      DNA-PK complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • Non-homologous end-joining, organism-specific biosystem (from KEGG)
      Non-homologous end-joining, organism-specific biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
    • Non-homologous end-joining, conserved biosystem (from KEGG)
      Non-homologous end-joining, conserved biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
    • Nonhomologous End-joining (NHEJ), organism-specific biosystem (from REACTOME)
      Nonhomologous End-joining (NHEJ), organism-specific biosystemThe NHEJ pathway is initiated in response to the formation of a DNA double-strand break (DSB) induced by a DNA-damaging agent such as ionizing radiation. First, the Ku70/80 heterodimer binds to the ...
    • Processing of DNA ends prior to end rejoining, organism-specific biosystem (from REACTOME)
      Processing of DNA ends prior to end rejoining, organism-specific biosystemIonizing radiation induced DNA double strand breaks often contain end groups that must be processed before the DNA can be rejoined. Possible candidate proteins for the processing steps include Artem...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    B cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair TAS
    Traceable Author Statement
    more info
    		  
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell receptor V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    double-strand break repair TAS
    Traceable Author Statement
    more info
    		  
    double-strand break repair via nonhomologous end joining TAS
    Traceable Author Statement
    more info
    		  
    germ cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    immunoglobulin V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    lymphocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    pro-B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    DNA-dependent protein kinase-DNA ligase 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nonhomologous end joining complex IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    DNA-dependent protein kinase catalytic subunit
    Names
    DNA-dependent protein kinase catalytic subunit
    p460
    DNA-PK catalytic subunit
    hyper-radiosensitivity of murine scid mutation, complementing 1
    NP_001075109.1
    NP_008835.5
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023435.1 RefSeqGene

      Range
      5001..192076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_162

    mRNA and Protein(s)

    1. NM_001081640.1 → NP_001075109.1  DNA-dependent protein kinase catalytic subunit isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      U34994, U47077
      UniProtKB/Swiss-Prot
      P78527
      Related
      ENSP00000345182, ENST00000338368
      Conserved Domains (5) summary
      cd05172
      Location:3719 – 3984
      Blast Score: 1055
      PIKKc_DNA-PK; DNA-dependent protein kinase (DNA-PK), catalytic domain; The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
      smart00146
      Location:3750 – 3986
      Blast Score: 572
      PI3Kc; Phosphoinositide 3-kinase, catalytic domain
      pfam02259
      Location:3023 – 3470
      Blast Score: 538
      FAT; FAT domain
      pfam02260
      Location:4066 – 4097
      Blast Score: 116
      FATC; FATC domain
      pfam08163
      Location:1815 – 2210
      Blast Score: 1512
      NUC194; NUC194 domain

    2. NM_006904.6 → NP_008835.5  DNA-dependent protein kinase catalytic subunit isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      U47077
      UniProtKB/Swiss-Prot
      P78527
      Related
      ENSP00000313420, ENST00000314191
      Conserved Domains (5) summary
      cd05172
      Location:3719 – 4015
      Blast Score: 1062
      PIKKc_DNA-PK; DNA-dependent protein kinase (DNA-PK), catalytic domain; The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
      smart00146
      Location:3750 – 4017
      Blast Score: 621
      PI3Kc; Phosphoinositide 3-kinase, catalytic domain
      pfam02259
      Location:3023 – 3470
      Blast Score: 537
      FAT; FAT domain
      pfam02260
      Location:4097 – 4128
      Blast Score: 116
      FATC; FATC domain
      pfam08163
      Location:1815 – 2210
      Blast Score: 1512
      NUC194; NUC194 domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      48685669..48872743, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      44148581..44335706, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB052953.1 BAB79635.1
    genomic AC021236.10 (105195..132239) None
    genomic AC103686.4 (16554..176583) None
    genomic AY030284.1 AAK40350.1
    genomic AY316117.1 AAP69525.1
    genomic CH471068.1 EAW86680.1
      EAW86681.1
      EAW86682.1
      EAW86683.1
    genomic L27425.1 AAA79244.1
    genomic U63630.4 AAC52019.2
    genomic U90415.1 AAB51722.1
    mRNA AB208860.1 BAD92097.1
    mRNA AK296833.1 BAG59403.1
    mRNA BC017494.1 None
    mRNA BC024963.1 None
    mRNA BC037968.1 None
    mRNA U34994.3 AAC50210.3
    mRNA U35835.1 AAA79184.1
    mRNA U47077.5 AAB39925.5
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78527.3 GenPept UniProtKB/Swiss-Prot:P78527
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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