Format

Send to:

Choose Destination

CD59 CD59 molecule [ Homo sapiens (human) ]

Gene ID: 966, updated on 8-May-2016
Official Symbol
CD59provided by HGNC
Official Full Name
CD59 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1689
See related
Ensembl:ENSG00000085063 HPRD:00117; MIM:107271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
Summary
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11p13
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (33703010..33736479, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33724556..33758025, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KIAA1549-like Neighboring gene uncharacterized LOC105376617 Neighboring gene chromosome 11 open reading frame 91 Neighboring gene F-box protein 3 Neighboring gene FBXO3 antisense RNA 1 (head to head)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 co-localizes with human CD59 in lipid rafts on the surface of ACH-2 cells upon provirus activation PubMed
env The complement regulatory proteins CD55 (DAF) and CD59 (HRF20) exist on HIV-1 virions, along with HIV-1 gp120 molecules, suggesting an interaction between these proteins and gp120 PubMed
env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
Envelope transmembrane glycoprotein gp41 env A peptide corresponding to the amino acids 598-613 of HIV-1 gp41, as well as recombinant gp41 protein, markedly reduce CD59 levels in a dose dependent manner in human neuronal and glial cells PubMed
Pr55(Gag) gag HIV-1 Gag P99A mutation reduces its co-localization with tetraspanin-enriched microdomain marker CD81 and lipid raft marker CD59 PubMed
gag HIV Gag proteins adopt a ring-like supramolecular organization at sites of intercellular contacts and co-localize with CD63 tetraspanin and raft components GM1, Thy-1, and CD59 PubMed
gag The highly basic region (HBR) of HIV-1 MA promotes Gag association with specific UDMs containing PSGL-1, CD43, and CD59 PubMed
gag The Matrix protein of HIV-1 Gag colocalizes with CD59 in lipid rafts, the site of virus particle budding from cells, and CD59 is incorporated into virus particles as a result of this process PubMed
matrix gag The highly basic region (HBR) of HIV-1 MA promotes Gag association with specific UDMs containing PSGL-1, CD43, and CD59 PubMed
gag HIV-1 Matrix co-localizes with CD59 in lipid rafts, the site of virus particle budding from cells, and CD59 is incorporated into virus particles as a result of this process PubMed

Go to the HIV-1, Human Interaction Database

  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystem (from REACTOME)
    COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystemCOPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles wer...
  • Cargo concentration in the ER, organism-specific biosystem (from REACTOME)
    Cargo concentration in the ER, organism-specific biosystemComputational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, wh...
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement cascade, organism-specific biosystem (from REACTOME)
    Complement cascade, organism-specific biosystemIn the complement cascade, a panel of soluble molecules rapidly and effectively senses a danger or damage and triggers reactions to provide a response that discriminates among foreign intruders, cell...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Regulation of Complement cascade, organism-specific biosystem (from REACTOME)
    Regulation of Complement cascade, organism-specific biosystemTwo inherent features of complement activation make its regulation very important: 1. There is an inherent positive feedback loop because the product of C3 activation forms part of an enzyme that cau...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC2354, FLJ38134, FLJ92039

Gene Ontology Provided by GOA

Function Evidence Code Pubs
complement binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
blood coagulation TAS
Traceable Author Statement
more info
PubMed 
cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of activation of membrane attack complex IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of complement activation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of complement activation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
anchored component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
compact myelin IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CD59 glycoprotein
Names
1F5 antigen
20 kDa homologous restriction factor
CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
CD59 molecule, complement regulatory protein
Ly-6-like protein
MEM43 antigen
T cell-activating protein
human leukocyte antigen MIC11
lymphocytic antigen CD59/MEM43
membrane attack complex (MAC) inhibition factor
membrane attack complex inhibition factor
membrane inhibitor of reactive lysis
protectin
surface anitgen recognized by monoclonal antibody 16.3A5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008057.1 RefSeqGene

    Range
    5000..38469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_41

mRNA and Protein(s)

  1. NM_000611.5NP_000602.1  CD59 glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_000602.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-8) encode the same protein.
    Source sequence(s)
    AL049629, AU136899, BC001506, BM680161
    Consensus CDS
    CCDS7886.1
    UniProtKB/Swiss-Prot
    P13987
    UniProtKB/TrEMBL
    Q6FHM9
    Related
    ENSP00000379191, OTTHUMP00000232408, ENST00000395850, OTTHUMT00000388809
    Conserved Domains (1) summary
    cd00117
    Location:2697
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. NM_001127223.1NP_001120695.1  CD59 glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_001120695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1-8) encode the same protein.
    Source sequence(s)
    AK309894, AL049629, BM680161
    Consensus CDS
    CCDS7886.1
    UniProtKB/Swiss-Prot
    P13987
    UniProtKB/TrEMBL
    Q6FHM9
    Related
    ENSP00000404822, OTTHUMP00000232411, ENST00000415002, OTTHUMT00000388813
    Conserved Domains (1) summary
    cd00117
    Location:2697
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. NM_001127225.1NP_001120697.1  CD59 glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_001120697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All variants (1-8) encode the same protein.
    Source sequence(s)
    AL049629, AU139541, BM680161, DA840870
    Consensus CDS
    CCDS7886.1
    UniProtKB/Swiss-Prot
    P13987
    UniProtKB/TrEMBL
    Q6FHM9
    Related
    ENSP00000410182, OTTHUMP00000232414, ENST00000437761, OTTHUMT00000388816
    Conserved Domains (1) summary
    cd00117
    Location:2697
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  4. NM_001127226.1NP_001120698.1  CD59 glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_001120698.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All variants (1-8) encode the same protein.
    Source sequence(s)
    AL049629, AU139541, BM680161
    Consensus CDS
    CCDS7886.1
    UniProtKB/Swiss-Prot
    P13987
    UniProtKB/TrEMBL
    Q6FHM9
    Related
    ENSP00000403511, OTTHUMP00000232412, ENST00000445143, OTTHUMT00000388814
    Conserved Domains (1) summary
    cd00117
    Location:2697
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  5. NM_001127227.1NP_001120699.1  CD59 glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_001120699.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. All variants (1-8) encode the same protein.
    Source sequence(s)
    AL049629, AU139009, BM680161
    Consensus CDS
    CCDS7886.1
    UniProtKB/Swiss-Prot
    P13987
    UniProtKB/TrEMBL
    Q6FHM9
    Related
    ENSP00000402425, OTTHUMP00000232413, ENST00000426650, OTTHUMT00000388815
    Conserved Domains (1) summary
    cd00117
    Location:2697
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  6. NM_203329.2NP_976074.1  CD59 glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_976074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-8) encode the same protein.
    Source sequence(s)
    AL049629, AU136899, BM680161, DA578905
    Consensus CDS
    CCDS7886.1
    UniProtKB/Swiss-Prot
    P13987
    UniProtKB/TrEMBL
    Q6FHM9
    Related
    ENSP00000432942, OTTHUMP00000232415, ENST00000527577, OTTHUMT00000388817
    Conserved Domains (1) summary
    cd00117
    Location:2697
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  7. NM_203330.2NP_976075.1  CD59 glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_976075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2-8.
    Source sequence(s)
    AL049629, AU136899, BM680161, DA250543
    Consensus CDS
    CCDS7886.1
    UniProtKB/Swiss-Prot
    P13987
    UniProtKB/TrEMBL
    Q6FHM9
    Related
    ENSP00000434617, OTTHUMP00000232416, ENST00000528700, OTTHUMT00000388818
    Conserved Domains (1) summary
    cd00117
    Location:2697
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  8. NM_203331.2NP_976076.1  CD59 glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_976076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-8) encode the same protein.
    Source sequence(s)
    AL049629, AU136899, BM680161, DA917093
    Consensus CDS
    CCDS7886.1
    UniProtKB/Swiss-Prot
    P13987
    UniProtKB/TrEMBL
    Q6FHM9
    Related
    ENSP00000340210, OTTHUMP00000232410, ENST00000351554, OTTHUMT00000388811
    Conserved Domains (1) summary
    cd00117
    Location:2697
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    33703010..33736479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    33724069..33757538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)