ANXA2 annexin A2 [Homo sapiens] - Gene

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Summary

Official Symbol: ANXA2provided by HGNC
Official Full Name: annexin A2provided by HGNC
Primary source: HGNC:537
See related: Ensembl:ENSG00000182718; HPRD:01061; MIM:151740; Vega:OTTHUMG00000132763
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV
Summary: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 15q22.2

Sequence :: Chromosome: 15; NC_000015.9 (60639350..60690185, complement)

See ANXA2 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Levels of anti-A2 autoantibody are higher in antiphospholipid patients and systemic lupus erythematosus patients with thrombosis, which may be helpful in identifying potential cases of antiphospholipid syndrome.
Title: Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis.
Selective disruption of the fibrinolytic activity of ANX II may provide a novel strategy for specific inhibition of neoangiogenesis in human breast cancer.
Title: Antibody-directed neutralization of annexin II (ANX II) inhibits neoangiogenesis and human breast tumor growth in a xenograft model.
Aberrant expression of Annexin A2 and Cdc42 play a role in carcinogenesis, differentiation and metastasis of esophageal squamous cell carcinomas.
Title: Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
a novel interaction involving K17 and AnxA2 and identify AnxA2 as a potential regulator of keratin filaments.
Title: Identification of novel interaction between annexin A2 and keratin 17: evidence for reciprocal regulation.
Interferon-gamma stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis.
Title: Interferon-γ stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis.
This review retraces the current state of knowledge on Annexin A2 and A5 functions causing thrombophilia. [review]
Title: [Annexins as a new thrombotic factors].
this study identified a novel osteoporosis susceptibility gene ANXA2, and suggested a novel pathophysiological mechanism, mediated by ANXA2, for osteoporosis in humans
Title: Peripheral blood monocyte-expressed ANXA2 gene is involved in pathogenesis of osteoporosis in humans.
Results suggest that ANXA2 is a cellular RBP that can modulate the frameshifting efficiency of viral RNA, enabling it to act as an anti-viral cellular protein, and hinting at roles in RNA metabolism for other cellular mRNAs.
Title: Annexin A2 binds RNA and reduces the frameshifting efficiency of infectious bronchitis virus.
results suggest that the interaction of HAb18G/CD147 with annexin II is involved in the interconversion between mesenchymal and amoeboid movement of hepatocellular carcinoma cells.
Title: HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells.
Bcl-xL to Bax protein ratios, an index of survival activity in cells exposed to lethal stresses, were increased in the cells that had been precultured in rANX II for 24 h prior to UVC irradiation
Title: Extracellular recombinant annexin II confers UVC-radiation resistance and increases the Bcl-xL to Bax protein ratios in human UVC-radiation-sensitive cells.

Submit: New GeneRIF Correction See all (136)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Annexin 2 (Anx2) interacts with HIV-1 Gag by coimmunoprecipitation in transfected cells and in a cell-free system; Anx2 co-localizes with Gag and CD63 in intracellular vesicles of HIV-1 infected macrophages	PubMed
	gag	Anx2 depletion by siRNA is associated with decreased infectivity of HIV-1 and aberrant HIV-1 Gag processing, indicating an interaction of Anx2 with Gag	PubMed
Tat	tat	In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_004030.1	NP_002405.1	CD99	BIND	PubMed	CD99 interacts with ANXA2.
P07355	P02749	APOH	HPRD	PubMed
P07355	P14209	CD99	HPRD	PubMed
P07355	P60953	CDC42	HPRD	PubMed
P07355	P13688	CEACAM1	HPRD	PubMed
P07355	P07858	CTSB	HPRD	PubMed
P07355	O75923	DYSF	HPRD	PubMed
P07355	P62993	GRB2	HPRD	PubMed
P07355	Q9UHV8	LGALS13	HPRD	PubMed
P07355	O75608	LYPLA1	HPRD	PubMed
P07355	Q9Y6R4	MAP3K4	HPRD	PubMed
P07355	Q99972	MYOC	HPRD	PubMed
P07355	P35232	PHB	HPRD	PubMed
P07355	Q53H76	PLA1A	HPRD	PubMed
P07355	P00750	PLAT	HPRD	PubMed
P07355	P00747	PLG	HPRD	PubMed
P07355	P17252	PRKCA	HPRD	PubMed
P07355	P05771	PRKCB	HPRD	PubMed
P07355	P60903	S100A10	HPRD	PubMed
P07355	P26447	S100A4	HPRD	PubMed
P07355	P06703	S100A6	HPRD	PubMed
P07355	P12931	SRC	HPRD	PubMed
BioGRID:106799	BioGRID:106847	APOH	BioGRID	PubMed	Reconstituted Complex
BioGRID:106799	BioGRID:107358	CD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:107457	CDK7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106799	BioGRID:107103	CEACAM1	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:106799	BioGRID:107888	CTSB	BioGRID	PubMed	Reconstituted Complex
BioGRID:106799	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106799	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:201048	Ksr1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:110411	MGMT	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:113841	NCOA3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:111142	PCNA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:106799	BioGRID:111264	PHB	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106799	BioGRID:111343	PLAT	BioGRID	PubMed	Reconstituted Complex
BioGRID:106799	BioGRID:111490	PPM1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:112189	S100A10	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure
BioGRID:106799	BioGRID:112537	SOS1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106799	BioGRID:112655	STAT6	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:106799	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:121137	TRPV5	BioGRID	PubMed	Reconstituted Complex
BioGRID:106799	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:106799	BioGRID:113185	UBE3A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106799	BioGRID:1205537	gag	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
Rab GTPase binding	IEA Inferred from Electronic Annotation more info
calcium ion binding	IEA Inferred from Electronic Annotation more info
calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
phospholipase inhibitor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
body fluid secretion	IEA Inferred from Electronic Annotation more info
cellular response to acid	IEA Inferred from Electronic Annotation more info
collagen fibril organization	IEA Inferred from Electronic Annotation more info
fibrinolysis	IEA Inferred from Electronic Annotation more info
positive regulation of binding	IEA Inferred from Electronic Annotation more info
positive regulation of vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
skeletal system development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
Schmidt-Lanterman incisure	IEA Inferred from Electronic Annotation more info
basement membrane	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
early endosome	IEA Inferred from Electronic Annotation more info
colocalizes_with extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
extracellular region	IEA Inferred from Electronic Annotation more info
extrinsic to plasma membrane	IEA Inferred from Electronic Annotation more info
melanosome	IEA Inferred from Electronic Annotation more info
midbody	IDA Inferred from Direct Assay more info	PubMed
myelin sheath adaxonal region	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info	PubMed
protein complex	IEA Inferred from Electronic Annotation more info
sarcolemma	IEA Inferred from Electronic Annotation more info
soluble fraction	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: annexin A2

Names: annexin A2; annexin-2; protein I; annexin II; lipocortin II; chromobindin 8; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; calpactin I heavy polypeptide; placental anticoagulant protein IV

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002857.1 → NP_001002857.1 annexin A2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AW087150, BC015834, BC023990

Consensus CDS

CCDS10175.1

UniProtKB/Swiss-Prot

P07355

Related

ENSP00000411352, OTTHUMP00000247477, ENST00000421017, OTTHUMT00000416474

Conserved Domains (1) summary

cl02574
Location:109 – 174
Blast Score: 255

Annexin; Annexin
NM_001002858.2 → NP_001002858.1 annexin A2 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AA661718, AC087385, BC001388, BX640598

Consensus CDS

CCDS32256.1

UniProtKB/Swiss-Prot

P07355

Related

ENSP00000346032, OTTHUMP00000247475, ENST00000332680, OTTHUMT00000416470

Conserved Domains (1) summary

cl02574
Location:127 – 192
Blast Score: 256

Annexin; Annexin
NM_001136015.2 → NP_001129487.1 annexin A2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AA661718, BC093056

Consensus CDS

CCDS10175.1

UniProtKB/Swiss-Prot

P07355

Related

ENSP00000379342, OTTHUMP00000163650, ENST00000396024, OTTHUMT00000256135

Conserved Domains (1) summary

cl02574
Location:109 – 174
Blast Score: 255

Annexin; Annexin
NM_004039.2 → NP_004030.1 annexin A2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks a segment in the 5' region, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AW087150, BC015834, D00017

Consensus CDS

CCDS10175.1

UniProtKB/Swiss-Prot

P07355

Related

ENSP00000387545, OTTHUMP00000247474, ENST00000451270, OTTHUMT00000416469

Conserved Domains (1) summary

cl02574
Location:109 – 174
Blast Score: 255

Annexin; Annexin

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

60639350..60690185, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

37461790..37512581, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC087385.5 (121533..172369)	None
genomic	CH471082.1	EAW77582.1
		EAW77583.1
		EAW77584.1
		EAW77585.1
		EAW77586.1
		EAW77587.1
genomic	CQ878716.1	CAH59520.1
mRNA	AA661718.1	None
mRNA	AK092006.1	BAG52463.1
mRNA	AK124427.1	None
mRNA	AK222542.1	None
mRNA	AK297923.1	BAG60240.1
mRNA	AK309356.1	None
mRNA	AW087150.1	None
mRNA	BC001388.2	AAH01388.1
mRNA	BC001748.1	None
mRNA	BC009564.1	AAH09564.1
mRNA	BC013843.1	None
mRNA	BC015834.1	AAH15834.1
mRNA	BC016774.1	AAH16774.1
mRNA	BC021114.1	AAH21114.1
mRNA	BC023990.1	AAH23990.1
mRNA	BC052558.1	AAH52558.1
mRNA	BC052567.1	AAH52567.1
mRNA	BC066955.1	AAH66955.2
mRNA	BC068065.1	AAH68065.1
mRNA	BC093056.1	AAH93056.1
mRNA	BT007432.1	AAP36100.1
mRNA	BX640598.1	CAE45704.1
mRNA	D00017.1	BAA00013.1
mRNA	D28364.1	BAA05730.1
other-genetic	DQ891008.2	ABM81934.1
other-genetic	DQ894187.2	ABM85113.1