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    HNRNPF heterogeneous nuclear ribonucleoprotein F [ Homo sapiens ]

    Gene ID: 3185, updated on 11-May-2012
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    Summary

    Official Symbol
    HNRNPFprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Fprovided by HGNC
    Primary source
    HGNC:5039
    See related
    Ensembl:ENSG00000169813; HPRD:03023; MIM:601037; Vega:OTTHUMG00000018029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPF; mcs94-1; OK/SW-cl.23; MGC110997
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    10q11.21
    Sequence :
    Chromosome: 10; NC_000010.10 (43881065..43904696, complement)
    See HNRNPF in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene RasGEF domain family, member 1A Neighboring gene FXYD domain containing ion transport regulator 4 Neighboring gene zinc finger protein 487, pseudogene Neighboring gene zinc finger protein 12 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene. Talukdar I, et al. PLoS One, 2011. PMID 22132154.
    3. Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. Fedorova OA, et al. Biochem Biophys Res Commun, 2011 Dec 16. PMID 22079093.
    4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    5. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These data point to a functional interaction between hnRNP F and SRSF1 as a mutant that eliminates SRSF1 binding to exon 11, or a SRSF1 knockdown, which prevents the stimulatory effect of hnRNP F over expression.
      Title: hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.
    2. this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2.
      Title: hnRNP F directs formation of an exon 4 minus variant of tumor-associated NADH oxidase (ENOX2).
    3. The study shows solution structures of the three quasi-RNA-recognition motifs of heterogeneous nuclear ribonucleoprotein F in complex with G-tract RNA.
      Title: Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.
    4. heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway
      Title: Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.
    5. Results suggest that hnRNP H and F are nuclear shuttling proteins whose posttranslational modifications may alter interaction with transportin 1, nuclear localization, and hence function.
      Title: A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1.
    6. The authors identified heterogeneous nuclear ribonucleoprotein F (hnRNP-F) as a cellular protein interacting with NS1 during influenza A virus infection.
      Title: Direct interaction of cellular hnRNP-F and NS1 of influenza A virus accelerates viral replication by modulation of viral transcriptional activity and host gene expression.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    8. hnRNPH and F regulate DM20 splicing by recruiting U1snRNP and hnRNPH plays a primary role in DM20 splice site selection in vivo
      Title: Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs.
    9. The solution structure of the three quasi RNA recognition motifs of hnRNP F and identification of the residues that are important for the interaction with the Bcl-x RNA.
      Title: NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
    10. high levels of hnRNP F are present in premalignant and malignant stages of colorectal cancer, reflecting a role for this protein early in colorectal tumorigenesis
      Title: Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.
    Submit: New GeneRIF Correction See all (11)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P52597 P31943 HNRNPH1    HPRD  PubMed  
    P52597 Q09161 NCBP1    HPRD  PubMed  
    P52597 P52298 NCBP2    HPRD  PubMed  
    P52597 Q92597 NDRG1    HPRD  PubMed  
    P52597 P24928 POLR2A    HPRD  PubMed  
    P52597 Ataxin 2 binding protein 1 RBFOX1    HPRD  PubMed  
    P52597 Q6EEV6 SUMO4    HPRD  PubMed  
    P52597 P83876 TXNL4A    HPRD  PubMed  
    P52597 Q96CS4 ZNF689    HPRD  PubMed  
    BioGRID:109426 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:109428 HNRNPH1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109426 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:211970 Mis12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:110766 NCBP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109426 BioGRID:116578 NCBP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109426 BioGRID:115669 NDRG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:203509 Nhp2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:120792 PRPF40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:116113 TXNL4A    BioGRID  PubMed Two-hybrid 
    BioGRID:109426 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:204613 Ybx1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:116303 ZWINT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109426 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    RNA splicing TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    nuclear mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    nuclear mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		  
    regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    heterogeneous nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein F
    Names
    heterogeneous nuclear ribonucleoprotein F
    HnRNP F protein
    nucleolin-like protein mcs94-1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098204.1 → NP_001091674.1  heterogeneous nuclear ribonucleoprotein F

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, AW069399, BC001432, BC015580, DB049909
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      Related
      ENSP00000444124, ENST00000540544
      Conserved Domains (2) summary
      cd00590
      Location:113 – 185
      Blast Score: 143
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08080
      Location:255 – 290
      Blast Score: 182
      zf-RNPHF; RNPHF zinc finger

    2. NM_001098205.1 → NP_001091675.1  heterogeneous nuclear ribonucleoprotein F

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, AK001364, AW069399, BC001432, DA535143
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      Related
      ENSP00000348345, OTTHUMP00000043414, ENST00000356053, OTTHUMT00000047706
      Conserved Domains (2) summary
      cd00590
      Location:113 – 185
      Blast Score: 143
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08080
      Location:255 – 290
      Blast Score: 182
      zf-RNPHF; RNPHF zinc finger

    3. NM_001098206.1 → NP_001091676.1  heterogeneous nuclear ribonucleoprotein F

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, AL542769, AW069399, BC001432, BC016736, DB011453
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      Related
      ENSP00000349573, OTTHUMP00000019482, ENST00000357065, OTTHUMT00000047702
      Conserved Domains (2) summary
      cd00590
      Location:113 – 185
      Blast Score: 143
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08080
      Location:255 – 290
      Blast Score: 182
      zf-RNPHF; RNPHF zinc finger

    4. NM_001098207.1 → NP_001091677.1  heterogeneous nuclear ribonucleoprotein F

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, AW069399, BC001432, BC106008, DA679417
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      Related
      ENSP00000438061, ENST00000544000
      Conserved Domains (2) summary
      cd00590
      Location:113 – 185
      Blast Score: 143
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08080
      Location:255 – 290
      Blast Score: 182
      zf-RNPHF; RNPHF zinc finger

    5. NM_001098208.1 → NP_001091678.1  heterogeneous nuclear ribonucleoprotein F

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, AW069399, BC001432, CR976524
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      Related
      ENSP00000400433, ENST00000443950
      Conserved Domains (2) summary
      cd00590
      Location:113 – 185
      Blast Score: 143
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08080
      Location:255 – 290
      Blast Score: 182
      zf-RNPHF; RNPHF zinc finger

    6. NM_004966.3 → NP_004957.1  heterogeneous nuclear ribonucleoprotein F

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, AW069399, BC001432, BC004254, DA594075
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      Related
      ENSP00000338477, OTTHUMP00000043413, ENST00000337970, OTTHUMT00000047705
      Conserved Domains (2) summary
      cd00590
      Location:113 – 185
      Blast Score: 143
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08080
      Location:255 – 290
      Blast Score: 182
      zf-RNPHF; RNPHF zinc finger

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      43881065..43904696, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      40407603..40431235, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL450326.30 (1999..6729) None
    genomic AL512654.9 CAI17066.1
    genomic CH471160.1 EAW86595.1
      EAW86596.1
      EAW86597.1
      EAW86598.1
      EAW86599.1
    mRNA AB062287.1 BAB93470.1
    mRNA AI133166.1 None
    mRNA AK001364.1 BAG50896.1
    mRNA AK296696.1 BAG59290.1
    mRNA AL542769.3 None
    mRNA AW069399.1 None
    mRNA BC001432.2 AAH01432.1
    mRNA BC004254.1 AAH04254.1
    mRNA BC015580.2 AAH15580.1
    mRNA BC016736.1 AAH16736.1
    mRNA BC106008.1 AAI06009.1
    mRNA CR976524.1 None
    mRNA DA535143.1 None
    mRNA DA594075.1 None
    mRNA DA679417.1 None
    mRNA DB011453.1 None
    mRNA DB049909.1 None
    mRNA L28010.1 AAC37584.1
    other-genetic DQ895381.2 ABM86307.1
    other-genetic EU176350.1 ABW03801.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52597.3 GenPept UniProtKB/Swiss-Prot:P52597
    Q8NI96 GenPept UniProtKB/TrEMBL:Q8NI96
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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