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    PTEN phosphatase and tensin homolog [ Homo sapiens (human) ]

    Gene ID: 5728, updated on 19-May-2013
    Official Symbol
    PTENprovided by HGNC
    Official Full Name
    phosphatase and tensin homologprovided by HGNC
    Primary source
    HGNC:9588
    See related
    HPRD:03431; MIM:601728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del
    Summary
    This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
    Location :
    10q23.3
    Sequence :
    Chromosome: 10; NC_000010.10 (89623195..89728532)
    See PTEN in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene cofilin 1 (non-muscle) pseudogene 1 Neighboring gene killin, p53-regulated DNA replication inhibitor Neighboring gene ribosomal protein L11 pseudogene 3 Neighboring gene mediator complex subunit 6 pseudogene 1 Neighboring gene vomeronasal 1 receptor 55 pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. Patel R, et al. J Clin Invest, 2013 Mar 1. PMID 23434594.
    2. Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior. Anastasio NC, et al. J Neurosci, 2013 Jan 23. PMID 23345234.
    3. Expression of PTEN and survivin in cervical cancer: promising biological markers for early diagnosis and prognostic evaluation. Lu D, et al. Br J Biomed Sci, 2012. PMID 23310986.
    4. Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency. Takeda H, et al. Exp Cell Res, 2013 Feb 15. PMID 23274758.
    5. PTEN protein expression in malignant pleural mesothelioma. Agarwal V, et al. Tumour Biol, 2013 Apr. PMID 23242608.

    See all (1055) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. SPRY2, PTEN, and PP2A status is an important determinant of prostate cancer progression.
      Title: Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.
    2. miR-23b-3p is an oncogenic miRNA and inhibits PTEN tumor suppressor gene in renal cell carcinoma.
      Title: Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer.
    3. The positive expression rates of survivin and PTEN in vocal cord polyps were obviously lower than in papilloma of larynx and laryngeal squamous cell carcinoma.
      Title: [Analysis on expression of survivin and PTEN in vocal cords polyps, papilloma of larynx and laryngeal squamous cell carcinoma].
    4. The tumorigenic role of miR-21 in non-small cell lung cancer development through modulation of the PTEN signaling pathway.
      Title: MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN.
    5. Ars2 is overexpressed in human cholangiocarcinoma and may be a diagnostic marker. Ars2 depletion increases PTEN and PDCD4 protein levels via the reduction of miR-21.
      Title: Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21.
    6. Loss of PTEN protein expression is associated with malignant pleural mesothelioma.
      Title: PTEN protein expression in malignant pleural mesothelioma.
    7. model of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression
      Title: Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression.
    8. in primary endometrial carcinoma, mutations in PIK3CA, TP53, PTEN and FBXW7 correlate with high tumor grade, endometrial cancer type and lymph node status
      Title: High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.
    9. PTEN (phosphatase and tensin homolog deleted from chromosome 10), a cytosolic enzyme, can be transferred between cells in exosomes to suppress signaling and proliferation in target cells.
      Title: PTEN: an intercellular peacekeeper?
    10. PTEN mRNA expression was significantly downregulated in brain metastases compared with primary breast tumors, and PTEN mutations were frequently found in brain metastases.
      Title: Relevance of PTEN loss in brain metastasis formation in breast cancer patients.
    Submit: New GeneRIF Correction See all (904)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Bannayan-Riley-Ruvalcaba syndrome

    Summary from GeneReviews: PTEN Hamartoma Tumor Syndrome Go to GeneReviews

    Disease Characteristics
    The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and Proteus-like syndrome. CS is a multiple hamartoma syndrome with a high risk for benign and malignant tumors of the thyroid, breast, and endometrium. Affected individuals usually have macrocephaly, trichilemmomas, and papillomatous papules and present by the late 20s. The lifetime risk of developing breast cancer is 25%-50%, with an average age of diagnosis between 38 and 46 years. The lifetime risk for thyroid cancer (usually follicular, rarely papillary, but never medullary thyroid cancer) is approximately 10%. The risk for endometrial cancer, although not well defined, may approach 5%-10%. BRRS is a congenital disorder characterized by macrocephaly, intestinal hamartomatous polyposis, lipomas, and pigmented macules of the glans penis. PS is a complex, highly variable disorder involving congenital malformations and hamartomatous overgrowth of multiple tissues, as well as connective tissue nevi, epidermal nevi, and hyperostoses. Proteus-like syndrome is undefined but refers to individuals with significant clinical features of PS who do not meet the diagnostic criteria for PS.
    Diagnosis Testing
    The diagnosis of PHTS is made only when a PTEN mutation is identified. Up to 85% of individuals who meet the diagnostic criteria for CS and 65% of individuals with a clinical diagnosis of BRRS have a detectable PTEN mutation. Preliminary data also suggest that up to 50% of individuals with a Proteus-like syndrome and up to 20% of individuals with Proteus syndrome have PTEN mutations. PTEN sequence analysis, deletion/duplication testing, and FISH testing are available on a clinical basis.
    Genetic Counseling
    PHTS is inherited in an autosomal dominant manner. Because CS is likely underdiagnosed, the actual proportion of simplex cases (defined as individuals with no obvious family history) and familial cases (defined as >/=2 related affected individuals) cannot be determined. The majority of CS cases are simplex. Perhaps 10%-50% of individuals with CS have an affected parent. Each child of an affected individual has a 50% chance of inheriting the mutation and developing PHTS. Prenatal testing for pregnancies at increased risk is possible if the disease-causing mutation in the family is known.
    References

    Cowden syndrome

    Summary from GeneReviews: PTEN Hamartoma Tumor Syndrome Go to GeneReviews

    Disease Characteristics
    The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and Proteus-like syndrome. CS is a multiple hamartoma syndrome with a high risk for benign and malignant tumors of the thyroid, breast, and endometrium. Affected individuals usually have macrocephaly, trichilemmomas, and papillomatous papules and present by the late 20s. The lifetime risk of developing breast cancer is 25%-50%, with an average age of diagnosis between 38 and 46 years. The lifetime risk for thyroid cancer (usually follicular, rarely papillary, but never medullary thyroid cancer) is approximately 10%. The risk for endometrial cancer, although not well defined, may approach 5%-10%. BRRS is a congenital disorder characterized by macrocephaly, intestinal hamartomatous polyposis, lipomas, and pigmented macules of the glans penis. PS is a complex, highly variable disorder involving congenital malformations and hamartomatous overgrowth of multiple tissues, as well as connective tissue nevi, epidermal nevi, and hyperostoses. Proteus-like syndrome is undefined but refers to individuals with significant clinical features of PS who do not meet the diagnostic criteria for PS.
    Diagnosis Testing
    The diagnosis of PHTS is made only when a PTEN mutation is identified. Up to 85% of individuals who meet the diagnostic criteria for CS and 65% of individuals with a clinical diagnosis of BRRS have a detectable PTEN mutation. Preliminary data also suggest that up to 50% of individuals with a Proteus-like syndrome and up to 20% of individuals with Proteus syndrome have PTEN mutations. PTEN sequence analysis, deletion/duplication testing, and FISH testing are available on a clinical basis.
    Genetic Counseling
    PHTS is inherited in an autosomal dominant manner. Because CS is likely underdiagnosed, the actual proportion of simplex cases (defined as individuals with no obvious family history) and familial cases (defined as >/=2 related affected individuals) cannot be determined. The majority of CS cases are simplex. Perhaps 10%-50% of individuals with CS have an affected parent. Each child of an affected individual has a 50% chance of inheriting the mutation and developing PHTS. Prenatal testing for pregnancies at increased risk is possible if the disease-causing mutation in the family is known.
    References

    PTEN hamartoma tumor syndrome

    Summary from GeneReviews: PTEN Hamartoma Tumor Syndrome Go to GeneReviews

    Disease Characteristics
    The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and Proteus-like syndrome. CS is a multiple hamartoma syndrome with a high risk for benign and malignant tumors of the thyroid, breast, and endometrium. Affected individuals usually have macrocephaly, trichilemmomas, and papillomatous papules and present by the late 20s. The lifetime risk of developing breast cancer is 25%-50%, with an average age of diagnosis between 38 and 46 years. The lifetime risk for thyroid cancer (usually follicular, rarely papillary, but never medullary thyroid cancer) is approximately 10%. The risk for endometrial cancer, although not well defined, may approach 5%-10%. BRRS is a congenital disorder characterized by macrocephaly, intestinal hamartomatous polyposis, lipomas, and pigmented macules of the glans penis. PS is a complex, highly variable disorder involving congenital malformations and hamartomatous overgrowth of multiple tissues, as well as connective tissue nevi, epidermal nevi, and hyperostoses. Proteus-like syndrome is undefined but refers to individuals with significant clinical features of PS who do not meet the diagnostic criteria for PS.
    Diagnosis Testing
    The diagnosis of PHTS is made only when a PTEN mutation is identified. Up to 85% of individuals who meet the diagnostic criteria for CS and 65% of individuals with a clinical diagnosis of BRRS have a detectable PTEN mutation. Preliminary data also suggest that up to 50% of individuals with a Proteus-like syndrome and up to 20% of individuals with Proteus syndrome have PTEN mutations. PTEN sequence analysis, deletion/duplication testing, and FISH testing are available on a clinical basis.
    Genetic Counseling
    PHTS is inherited in an autosomal dominant manner. Because CS is likely underdiagnosed, the actual proportion of simplex cases (defined as individuals with no obvious family history) and familial cases (defined as >/=2 related affected individuals) cannot be determined. The majority of CS cases are simplex. Perhaps 10%-50% of individuals with CS have an affected parent. Each child of an affected individual has a 50% chance of inheriting the mutation and developing PHTS. Prenatal testing for pregnancies at increased risk is possible if the disease-causing mutation in the family is known.
    References
    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Silencing PTEN gene by siRNA prevents HIV-1 gp120-mediated neurotoxic effects PubMed
    Tat, p14 tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
    tat HIV-1 Tat upregulates PTEN expression in Tat-infected Jurkat T cells PubMed
    tat Inhibiting phosphatidylinositol 3-kinase by overexpressing PTEN phosphatase enhances HIV-1 Tat transactivation of the viral LTR promoter PubMed
    matrix gag HIV-1 p17 and its C-terminal truncated form of p17 (p17delta36) differentially regulate Akt phosphorylation by reducing and increasing phosphorylation levels of PTEN, respectively PubMed
    gag HIV-1 p17-induced activation of PTEN is mediated by RhoA-associated kinase (ROCK) PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000305.2 NP_056525.1 GLTSCR2    BIND  PubMed PTEN interacts with PICT-1. 
    NP_000305.2 NP_066016.1 MAGI3    BIND  PubMed MAGI3 interacts with PTEN/MMAC. 
    NP_000305.2 NP_005397.1 ROCK1    BIND  PubMed PTEN interacts with Rock1. 
    P60484 P31749 AKT1    HPRD  PubMed  
    P60484 P03950 ANG    HPRD  PubMed  
    P60484 P10275 AR    HPRD  PubMed  
    P60484 NP_001744.2 CAV1    BIND  PubMed caveolin-1 interacts with PTEN. 
    P60484 Q03135 CAV1    HPRD  PubMed  
    P60484 P05060 CHGB    HPRD  PubMed  
    P60484 Q7L5N1 COPS6    HPRD  PubMed  
    P60484 P68400 CSNK2A1    HPRD  PubMed  
    P60484 P19784 CSNK2A2    HPRD  PubMed  
    P60484 Q12959 DLG1    HPRD  PubMed  
    P60484 P69905 HBA2    HPRD  PubMed  
    P60484 Q86UL8 MAGI2    HPRD  PubMed  
    P60484 MAGI-3 MAGI3    HPRD  PubMed  
    P60484 Q9Y2H9 MAST1    HPRD  PubMed  
    P60484 Q6P0Q8 MAST2    HPRD  PubMed  
    P60484 O60307 MAST3    HPRD  PubMed  
    P60484 Q14764 MVP    HPRD  PubMed  
    P60484 P62136 PPP1CA    HPRD  PubMed  
    P60484 P49023 PXN    HPRD  PubMed  
    P60484 O14745 SLC9A3R1    HPRD  PubMed  
    P60484 Q15599 SLC9A3R2    HPRD  PubMed  
    P60484 Q15831 STK11    HPRD  PubMed  
    P60484 P04637 TP53    HPRD  PubMed  
    P60484 P63279 UBE2I    HPRD  PubMed  
    P60484 P68036 UBE2L3    HPRD  PubMed  
    P60484 Q9BVJ6 UTP14A    HPRD  PubMed  
    BioGRID:111700 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:106766 AMHR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:118982 ANAPC4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111700 BioGRID:119537 ANAPC5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111700 BioGRID:119538 ANAPC7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111700 BioGRID:106780 ANG    BioGRID  PubMed Two-hybrid 
    BioGRID:111700 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111700 BioGRID:116720 ARHGAP26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:113911 BAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:107291 CASP8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111700 BioGRID:107305 CAV1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:114582 CCNE2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111700 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111700 BioGRID:107489 CENPC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:107539 CHGB    BioGRID  PubMed Two-hybrid 
    BioGRID:111700 BioGRID:116176 COPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:111700 BioGRID:107789 CRKL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:107841 CSNK2A1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity; Reconstituted Complex 
    BioGRID:111700 BioGRID:107842 CSNK2A2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:111700 BioGRID:123157 DBF4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:108238 EEF1A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:108278 EGR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:111700 BioGRID:108403 ESR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111700 BioGRID:108495 FBN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:108726 FRK    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111700 BioGRID:119489 FZR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111700 BioGRID:115237 G3BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:108943 GFRA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:127907 GPR113    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:109289 HBA1    BioGRID  PubMed Two-hybrid 
    BioGRID:111700 BioGRID:115106 HDAC4    BioGRID  PubMed Negative Genetic 
    BioGRID:111700 BioGRID:123742 INHBE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:114048 IRS4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111700 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:110059 KRT14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:115855 LEPREL4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:129277 MAGI3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111700 BioGRID:111594 MAP2K6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:115293 MED12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:115286 MVP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111700 BioGRID:123296 NDFIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:120074 NDFIP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111700 BioGRID:116446 PARK7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111700 BioGRID:111182 PDGFRA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:122376 PINK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:111572 PKN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:111522 PPP3CA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:108480 PTK2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:111748 PTPN14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:111787 PXN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:123897 QRFPR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:114507 RPL14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:123608 SHARPIN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:114769 SLC9A3R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111700 BioGRID:1172218 SLC9A3R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111700 BioGRID:112416 SMTN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111700 BioGRID:211376 Smurf2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:111700 BioGRID:127829 TCEB3C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:126962 TTBK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111700 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:113180 UBE2L3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111700 BioGRID:116026 UTP14A    BioGRID  PubMed Two-hybrid 
    BioGRID:111700 BioGRID:119939 WNT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111700 BioGRID:116243 WWP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111700 BioGRID:116244 WWP2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111700 BioGRID:106828 XIAP    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111700 BioGRID:125966 ZNF787    BioGRID  PubMed Affinity Capture-MS 
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      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Inositol phosphate metabolism, organism-specific biosystem (from KEGG)
      Inositol phosphate metabolism, organism-specific biosystem
      Inositol phosphate metabolism
    • Inositol phosphate metabolism, organism-specific biosystem (from REACTOME)
      Inositol phosphate metabolism, organism-specific biosystemInositol phosphates (IPs) are molecules involves in signalling processes in eukaryotes. myo-Inositol consists of a six-carbon cyclic alcohol with an axial 2-hydroxy and five equatorial hydroxyls. M...
    • Inositol phosphate metabolism, conserved biosystem (from KEGG)
      Inositol phosphate metabolism, conserved biosystem
      Inositol phosphate metabolism
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Cancer pathway, organism-specific biosystem (from WikiPathways)
      Integrated Cancer pathway, organism-specific biosystem
      Integrated Cancer pathway
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Negative regulation of the PI3K/AKT network, organism-specific biosystem (from REACTOME)
      Negative regulation of the PI3K/AKT network, organism-specific biosystemThe PI3K/AKT network is negatively regulated by phosphatases that dephosphorylate PIP3, thus hampering AKT activation.
    • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-beta signaling pathway, organism-specific biosystem
      PDGFR-beta signaling pathway
    • PI Metabolism, organism-specific biosystem (from REACTOME)
      PI Metabolism, organism-specific biosystemPhosphatidylinositol (PI), a membrane phospholipid, can be reversibly phosphorylated at the 3, 4, and 5 positions of the inositol ring to generate seven phosphoinositides: phosphatidylinositol 3-phos...
    • PI-3K cascade, organism-specific biosystem (from REACTOME)
      PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
      PI3K/AKT Signaling in Cancer, organism-specific biosystemThis pathway describes how normal signaling by PI3K/AKT, presented in the contained module 'PIP3 Activates AKT Signaling' and recently reviewed by Manning and Cantley in 2007, is perturbed in cancer,...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimula...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phosphatidylinositol signaling system, organism-specific biosystem (from KEGG)
      Phosphatidylinositol signaling system, organism-specific biosystem
      Phosphatidylinositol signaling system
    • Phosphatidylinositol signaling system, conserved biosystem (from KEGG)
      Phosphatidylinositol signaling system, conserved biosystem
      Phosphatidylinositol signaling system
    • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
      Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
    • Prostate Cancer, organism-specific biosystem (from WikiPathways)
      Prostate Cancer, organism-specific biosystem
      Prostate Cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of Microtubule Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Microtubule Cytoskeleton, organism-specific biosystem
      Regulation of Microtubule Cytoskeleton
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
      Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR in disease, organism-specific biosystemThe pathway 'Signaling by FGFR in disease' shows 'Signaling by FGFR mutants' in parallel with the wild-type pathway 'Signaling by FGFR', allowing users to compare disease and normal events. FGFR mut...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
      Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
      Signaling of Hepatocyte Growth Factor Receptor
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystem (from REACTOME)
      Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystemAn array of inositol trisphosphate (IP3) and tetrakisphosphate (IP4) molecules are synthesised by the action of various kinases and phosphatases in the cytosol (Irvine & Schell 2001, Bunney & Katan 2...
    • Synthesis of PIPs at the plasma membrane, organism-specific biosystem (from REACTOME)
      Synthesis of PIPs at the plasma membrane, organism-specific biosystemAt the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystem
      mTOR signaling pathway
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, organism-specific biosystem (from BIOCYC)
      superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, organism-specific biosystem
      superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
    • superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, conserved biosystem (from BIOCYC)
      superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, conserved biosystem|FRAME: INOSITOL-1-4-5-TRISPHOSPHATE| is a secondary messenger molecule used in signal transduction and lipid signaling in eukaryotic cells. It mediates the biological response of a large number of h...
    • superpathway of inositol phosphate compounds, organism-specific biosystem (from BIOCYC)
      superpathway of inositol phosphate compounds, organism-specific biosystem
      superpathway of inositol phosphate compounds

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC11227

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    anaphase-promoting complex binding IPI
    Inferred from Physical Interaction
    more info
    		  
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    phosphatidylinositol-3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    activation of mitotic anaphase-promoting complex activity IDA
    Inferred from Direct Assay
    more info
    		  
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    brain morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    canonical Wnt receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		  
    cardiac muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    central nervous system myelin maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    central nervous system neuron axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    dentate gyrus development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    forebrain morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    induction of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    inositol phosphate dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    learning or memory ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    locomotor rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    male mating behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    maternal behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of cell aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell size ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of excitatory postsynaptic membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of organ growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of phosphatidylinositol 3-kinase cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of protein kinase B signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of synaptic vesicle clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    neuron-neuron synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    peptidyl-tyrosine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphatidylinositol dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
    		  
    phospholipid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of excitatory postsynaptic membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    postsynaptic density assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    prepulse inhibition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    presynaptic membrane assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    prostate gland growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein kinase B signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cellular component size ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    rhythmic synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    social behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    Schmidt-Lanterman incisure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    internal side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    myelin sheath adaxonal region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Names
    phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    phosphatase and tensin-like protein
    mutated in multiple advanced cancers 1
    MMAC1 phosphatase and tensin homolog deleted on chromosome 10
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    NP_000305.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007466.2 RefSeqGene

      Range
      5001..110337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_311

    mRNA and Protein(s)

    1. NM_000314.4 → NP_000305.3  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

      Status: REVIEWED

      Source sequence(s)
      AC063965, AK024986, BG772190, U92436
      Consensus CDS
      CCDS31238.1
      UniProtKB/TrEMBL
      F6KD01
      UniProtKB/Swiss-Prot
      P60484
      Conserved Domains (2) summary
      pfam10409
      Location:188 – 349
      Blast Score: 274
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl00053
      Location:87 – 184
      Blast Score: 152
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p10 Primary Assembly

      Range
      89623195..89728532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      83258013..83363313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018921.1 Alternate CHM1_1.0

      Range
      89994859..90100197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01021960.1 (10751..116051) None
    genomic AC063965.8 (80772..82821) None
    genomic AF000734.1 AAC08699.1
    genomic AF067844.1 AAD13528.1
    genomic AF143315.1 AAD38372.1
    genomic AMYH01002932.1 (286136..391474) None
    genomic CH471066.2 EAW50172.1
      EAW50173.1
      EAW50174.1
      EAW50175.1
    genomic DQ073384.1 AAY57327.1
    genomic HM849628.1 ADM26753.1
    genomic HM849629.1 ADM26754.1
    genomic HM849630.1 ADM26755.1
    genomic HM849631.1 ADM26756.1
    genomic HM849634.1 ADM26759.1
    genomic JA692802.1 CCF23296.1
    genomic JA902567.1 CCV19970.1
    genomic JB074276.1 CCV66764.1
    mRNA AA017584.1 None
    mRNA AI825848.1 None
    mRNA AK021619.1 None
    mRNA AK024986.1 None
    mRNA AK124525.1 None
    mRNA AK130076.1 None
    mRNA AK313581.1 BAG36351.1
    mRNA BC005821.2 AAH05821.1
    mRNA BG772190.1 None
    mRNA CA944942.1 None
    mRNA CR450306.1 CAG29302.1
    mRNA JF268690.1 ADZ48535.1
    mRNA U92436.1 AAC51182.1
    mRNA U93051.1 AAC51183.1
    mRNA U96180.1 AAB66902.1
    other-genetic DQ892604.2 ABM83530.1
    other-genetic DQ895562.2 ABM86488.1
    other-genetic EU176713.1 ABW03514.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60484.1 GenPept UniProtKB/Swiss-Prot:P60484

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
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      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • GTR
        GTR associated with a gene
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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