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    HLA-DRB5 major histocompatibility complex, class II, DR beta 5 [ Homo sapiens ]

    Gene ID: 3127, updated on 19-May-2012
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    Summary

    Official Symbol
    HLA-DRB5provided by HGNC
    Official Full Name
    major histocompatibility complex, class II, DR beta 5provided by HGNC
    Primary source
    HGNC:4953
    Locus tag
    hCG_1998957
    See related
    Ensembl:ENSG00000198502; HPRD:09209; MIM:604776; Vega:OTTHUMG00000031027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HLA-DRB; FLJ76359
    Summary
    HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (32485151..32498006, complement)
    See HLA-DRB5 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class II, DR alpha Neighboring gene major histocompatibility complex, class II, DR beta 9 (pseudogene) Neighboring gene major histocompatibility complex, class II, DR beta 6 (pseudogene) Neighboring gene major histocompatibility complex, class II, DR beta 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Bimodal distribution of RNA expression levels in human skeletal muscle tissue. Mason CC, et al. BMC Genomics, 2011 Feb 7. PMID 21299892.
    3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Anderson CA, et al. Nat Genet, 2011 Mar. PMID 21297633.
    4. Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. Slager SL, et al. Blood, 2011 Feb 10. PMID 21131588.
    5. A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Singer JB, et al. Nat Genet, 2010 Aug. PMID 20639878.

    See all (155) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. HLA-DRB5 was found to have bimodal expression in human skeletal muscle tissue.
      Title: Bimodal distribution of RNA expression levels in human skeletal muscle tissue.
    2. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.
    3. DNA methylation of CpG dinucleotides across HLA-DRB1*1501 and HLA-DRB5 does not determine whether patients manifest benign or malignant multiple sclerosis.
      Title: No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5.
    4. In our study, we found that the HLA-DR9 allele and HPV16E6 infection had a function of synergy in the process of malignant transformation of esophageal epithelial cells, and jointly promoting the occurrence and development of esophageal cancer.
      Title: [A 1:2 matched case-control study on the interaction of HPV16E6 and HLA-DR9 allele to esophageal cancer in Kazakh ethnicity, Xinjiang].
    5. the gene frequency of HLADR5 was significantly decreased in the total group of patients with autoimmune liver disease
      Title: HLA-DR allele frequencies in Mexican mestizos with autoimmune liver diseases including overlap syndromes.
    6. roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis
      Title: Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis.
    7. hMBP82-100-specific type B T cells escaped tolerance in HLA-DRB5*0101 Tg mice
      Title: Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice.
    8. Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
      Title: Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort.
    9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.
    10. Observational study of genotype prevalence. (HuGE Navigator)
      Title: Limited diversity of HLA-DRB1*02 alleles and DRB1-DRB5 haplotype associations in four United States population groups.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.

    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CD4+ T cells infected with CCR5-tropic HIV-1 have significantly higher levels of activation-marker expression (e.g. CD25, CD71 and HLA-DR) than CD4+ T lymphocytes infected with CXCR4-tropic HIV-1 PubMed
    env HIV envelope protein gp120 can specifically inhibit CD4-dependent class II MHC-restricted T cell response to Ag PubMed
    env Genetic variability in HIV-1 gp120 affects its interactions with HLA-DR molecules and T cell receptor PubMed
    env Amino acid residues 42-49 in the V1 region of CD4 are involved in the interaction between HIV-1 gp120 and class II major histocompatibility complex molecules PubMed
    Envelope surface glycoprotein gp160, precursor env Processing of HIV-1 gp160 to gp120 and gp41 is necessary for the association of HIV-1 envelope glycoproteins with class II MHC PubMed
    env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
    Envelope transmembrane glycoprotein gp41 env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
    env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
    env A 43-amino-acid sequence between amino acids 708 and 750 in the HIV-1 gp41(TM) cytoplasmic tail is required for efficient incorporation of HLA class II proteins into virions PubMed
    Pr55(Gag) gag Human Leukocyte Antigen DR (HLA-DR), Major Histocompatibility Complex class II molecules (MHC-II) induce a relocation of Gag to late endosomal/multivesicular bodies (LE/MVB) and increase the accumulation of viral particles assembling intracellularly PubMed
    gag HIV-1 Gag expression is able to induce HLA-DR cell-surface localization in H78-C10.0 cells PubMed
    gag In human macrophages, HIV-1 Gag proteins co-localize with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments PubMed
    Tat tat HIV-1 Tat downregulates expression of MHC class II genes in antigen-presenting cells (APC) by inhibiting the transactivator of MHC class II genes, CIITA PubMed
    tat HIV-1 Tat upregulates HLA-DR expression in monocyte-derived dendritic cells and T cells, thereby driving T cell-mediated immune responses and activation PubMed
    capsid gag HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:109372 BioGRID:106808 ANXA11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109372 BioGRID:106971 ATP1B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109372 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109372 BioGRID:109558 HSP90AB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109372 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109372 BioGRID:107369 MS4A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109372 BioGRID:111332 PKM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109372 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109372 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
      Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Asthma, organism-specific biosystem (from KEGG)
      Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Asthma, conserved biosystem (from KEGG)
      Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
      Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
      Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    major histocompatibility complex, class II, DR beta 5
    Names
    major histocompatibility complex, class II, DR beta 5
    DR9
    dw2
    DR-9
    DR beta-5
    DR2-beta-2
    MHC HLA-DR-beta chain
    MHC class II antigen DRB5
    leukocyte antigen class II
    MHC class II HLA beta chain
    MHC class II antigen DRB1*9
    human leucocyte antigen DRB5
    MHC HLA-DR-beta cell surface glycoprotein
    HLA class II histocompatibility antigen, DR beta 5 chain
    HLA class II histocompatibility antigen, DR-5 beta chain
    HLA class II histocompatibility antigen, DRB1-9 beta chain
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_002432.1 Reference

      Range
      64642..77497, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002125.3 → NP_002116.2  major histocompatibility complex, class II, DR beta 5 precursor

      Status: REVIEWED

      Source sequence(s)
      M20429
      Consensus CDS
      CCDS4751.1
      UniProtKB/Swiss-Prot
      Q30154
      Related
      ENSP00000364114, OTTHUMP00000029035, ENST00000374975, OTTHUMT00000076022
      Conserved Domains (2) summary
      cd05766
      Location:126 – 219
      Blast Score: 374
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      cl03042
      Location:42 – 116
      Blast Score: 404
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      32485151..32498006, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB010269.1 BAA36549.1
    genomic AB010270.1 BAA36550.1
    genomic AB106129.1 BAC66088.1
    genomic AB112913.1 BAD02944.1
    genomic AB176444.1 BAD15070.1
    genomic AF011786.1 AAB65751.1
    genomic AF029281.1 AAF65490.1
    genomic AF029282.1 AAF65491.1
    genomic AF029283.1 AAF65492.1
    genomic AF029285.1 AAF65494.1
    genomic AF029286.1 AAF65495.1
    genomic AF029291.1 AAF65500.1
    genomic AF029301.1 AAB88297.1
    genomic AF034858.1 AAC24013.1
    genomic AF047350.1 AAC05828.1
    genomic AF052574.1 AAC05839.1
    genomic AF081676.1 AAC32201.1
    genomic AF089719.1 AAC61746.1
    genomic AF093411.1 AAD10735.1
    genomic AF112877.1 AAD29582.1
    genomic AF112878.1 AAD29583.1
    genomic AF122887.1 AAD31766.1
    genomic AF142442.1 AAD31286.1
    genomic AF142445.1 AAD31289.1
    genomic AF142451.1 AAD31295.1
    genomic AF142465.1 AAD31309.1
    genomic AF142466.1 AAD31310.1
    genomic AF144080.1 AAD53053.1
    genomic AF164346.1 AAD47814.1
    genomic AF169239.1 AAD51315.1
    genomic AF186407.1 AAF06175.1
    genomic AF186408.1 AAF06176.1
    genomic AF201762.1 AAF35306.1
    genomic AF234175.1 AAG50193.1
    genomic AF234181.1 AAF64297.1
    genomic AF243537.1 AAG00414.1
    genomic AF247533.1 AAF99607.1
    genomic AF247534.1 AAF99608.1
    genomic AF267639.1 AAF78946.1
    genomic AF288212.1 AAG01005.1
    genomic AF306862.1 AAG42258.1
    genomic AF329281.1 AAK21117.1
    genomic AF335230.1 AAK20872.1
    genomic AF442519.1 AAN75784.1
    genomic AF450093.1 AAL47161.1
    genomic AJ243897.1 CAB51474.1
    genomic AJ243898.1 CAB51475.1
    genomic AJ245714.1 CAB53343.1
    genomic AJ245715.1 CAB53344.1
    genomic AJ245717.1 CAB53346.1
    genomic AJ249726.1 CAB56285.1
    genomic AJ251984.1 CAC19085.1
    genomic AJ252281.1 CAB65734.1
    genomic AJ271159.1 CAB71144.1
    genomic AJ289124.1 CAC19016.1
    genomic AJ297705.1 CAC10354.1
    genomic AJ306404.1 CAC29238.1
    genomic AJ401148.1 CAB94833.1
    genomic AJ404618.2 CAC06089.2
    genomic AJ491301.2 CAD36477.2
    genomic AJ506201.1 CAD44639.1
    genomic AJ506752.1 CAD44945.1
    genomic AJ507382.1 CAD45639.1
    genomic AJ507425.1 CAD45638.1
    genomic AJ507780.1 CAD47817.1
    genomic AJ512947.1 CAD55599.1
    genomic AJ534885.1 CAD59236.1
    genomic AJ539471.1 CAD62435.1
    genomic AJ783982.1 CAH04455.1
    genomic AJ854064.3 CAH69440.3
    genomic AJ854250.1 CAI05916.1
    genomic AJ867236.1 CAI29455.1
    genomic AJ871009.1 CAI38569.1
    genomic AJ878425.1 CAI47597.1
    genomic AL713966.7 (51313..64168) None
    genomic AM000036.1 CAJ01187.1
    genomic AM084908.1 CAJ29895.1
    genomic AM159646.1 CAJ43899.1
    genomic AM231063.1 CAJ76979.1
    genomic AY048687.1 AAL12226.1
    genomic AY141137.1 AAN28924.1
    genomic AY170862.1 AAO16556.1
    genomic AY172512.1 AAN86038.1
    genomic AY174184.1 AAO17056.1
    genomic AY179366.1 AAO23237.1
    genomic AY179367.1 AAO23238.1
    genomic AY179368.1 AAO23239.1
    genomic AY247411.1 AAO91660.1
    genomic AY257483.1 AAP13509.1
    genomic AY259126.1 AAP21612.1
    genomic AY259128.1 AAP21614.1
    genomic AY267906.1 AAP32697.1
    genomic AY277387.1 AAP34691.1
    genomic AY277391.1 AAP34695.1
    genomic AY277393.1 AAP34697.1
    genomic AY296120.1 AAP55804.1
    genomic AY296121.1 AAP55805.1
    genomic AY305859.1 AAP70485.1
    genomic AY307897.1 AAP74221.1
    genomic AY331806.1 AAP93590.1
    genomic AY379480.1 AAQ85128.1
    genomic AY396024.1 AAQ96776.1
    genomic AY429723.1 AAR10879.1
    genomic AY429728.1 AAR10882.1
    genomic AY457037.2 AAR20446.2
    genomic AY465115.1 AAR28667.1
    genomic AY502108.1 AAR89455.1
    genomic AY504812.1 AAR98643.1
    genomic AY504813.1 AAR98644.1
    genomic AY545466.1 AAS48869.1
    genomic AY641577.1 AAT64904.1
    genomic AY664400.1 AAT76040.1
    genomic AY664401.1 AAT76041.1
    genomic AY765349.1 AAV35213.1
    genomic AY877348.1 AAW66688.1
    genomic AY884215.1 AAW80834.1
    genomic AY899913.1 AAW82335.1
    genomic CH878642.1 EAW50813.1
      EAW50814.1
      EAW50815.1
      EAW50816.1
    genomic D13412.1 BAA02678.1
    genomic D14352.1 BAA03281.1
    genomic D29836.1 BAA06216.1
    genomic D49468.1 BAA08440.1
    genomic DQ135944.1 AAZ53370.1
    genomic DQ179034.1 ABA06592.1
    genomic DQ179042.1 ABA06600.1
    genomic DQ514604.1 ABF60567.1
    genomic DQ525634.1 ABF74599.1
    genomic DQ535034.1 ABF93212.1
    genomic DQ643390.1 ABG25965.1
    genomic DQ837166.1 ABH05946.1
    genomic EF078986.1 ABK56696.1
    genomic EF419344.1 ABN58745.1
    genomic EF495154.1 ABP38039.1
    genomic L21755.1 AAA58657.1
    genomic L26306.1 AAA67471.1
    genomic L41992.1 AAA65914.1
    genomic M15839.1 AAA58651.1
    genomic M35159.1 AAA59791.1
    genomic M57600.1 AAA36292.1
    genomic M63216.1 AAA52325.1
    genomic M74032.1 AAA63193.1
    genomic M81171.1 AAA91838.1
    genomic M81174.1 AAA91841.1
    genomic M81180.1 AAA91847.1
    genomic M98436.1 AAA59693.1
    genomic U08274.1 AAB87709.1
    genomic U25442.1 AAB50934.1
    genomic U25638.1 AAB02172.1
    genomic U26558.1 AAA67957.1
    genomic U34602.1 AAA75451.1
    genomic U37583.1 AAA79206.1
    genomic U41489.1 AAA86242.1
    genomic U41634.1 AAA84388.1
    genomic U59685.1 AAB52229.1
    genomic U66721.1 AAB52232.1
    genomic U68391.1 AAB08109.1
    genomic U72064.1 AAB17994.1
    genomic U72264.1 AAB17276.1
    genomic U79025.1 AAB52235.1
    genomic U79026.1 AAB52236.1
    genomic U79027.1 AAB52237.1
    genomic U95115.2 AAB58397.2
    genomic U96926.1 AAB71649.1
    genomic X64544.1 CAA45842.1
    genomic X64548.1 CAA45846.1
    genomic X64549.1 CAA45847.1
    genomic X65585.1 CAA46544.1
    genomic X86803.1 CAA60498.1
    genomic X95656.1 CAA64958.1
    genomic X97291.1 CAA65956.1
    genomic X99841.1 CAA68152.1
    genomic Y07590.1 CAA68865.1
    genomic Y09342.1 CAA70524.1
    genomic Y13727.1 CAA74055.1
    genomic Y17695.1 CAA76817.1
    genomic Y17819.1 CAA76871.1
    genomic Z83201.1 CAB05668.1
    genomic Z99006.1 CAB11742.1
    mRNA AB062112.2 BAB84521.2
    mRNA AF004817.1 AAB61608.1
    mRNA AF490771.1 AAO85467.1
    mRNA AJ297582.1 CAC08822.1
    mRNA AJ580838.1 CAE45568.1
    mRNA AK292140.1 BAF84829.1
    mRNA AK314834.1 BAG37353.1
    mRNA BC009234.2 AAH09234.1
    mRNA M15992.1 AAA59678.1
    mRNA M16086.1 AAA59679.1
    mRNA M16954.1 AAA36276.1
    mRNA M16955.1 AAA36277.1
    mRNA M16956.1 AAA36278.1
    mRNA M17377.1 AAA59818.1
    mRNA M17379.1 AAA59803.1
    mRNA M17382.1 AAA59819.1
    mRNA M17383.1 AAA36294.1
    mRNA M20429.1 AAA59822.1
    mRNA M20503.1 AAA59826.1
    mRNA M27689.1 AAA59829.1
    mRNA M30181.1 AAA59840.1
    mRNA M30182.1 AAA59715.1
    mRNA M32578.1 AAA59795.1
    mRNA M57648.1 AAA63218.1
    mRNA M59798.1 AAA64236.1
    mRNA S79786.1 AAD14315.1
    mRNA U17381.1 AAC50167.1
    mRNA U31770.1 AAB63983.1
    mRNA U66826.1 AAD43829.1
    mRNA U95818.1 AAD00818.1
    mRNA X99895.1 CAA68170.1
    other-genetic HQ447115.1 ADQ31602.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02969 GenPept UniProtKB/TrEMBL:O02969
    O19622 GenPept UniProtKB/TrEMBL:O19622
    O19728 GenPept UniProtKB/TrEMBL:O19728
    O19730 GenPept UniProtKB/TrEMBL:O19730
    O46698 GenPept UniProtKB/TrEMBL:O46698
    O78167 GenPept UniProtKB/TrEMBL:O78167
    Q000J6 GenPept UniProtKB/TrEMBL:Q000J6
    Q06654 GenPept UniProtKB/TrEMBL:Q06654
    Q06663 GenPept UniProtKB/TrEMBL:Q06663
    Q06664 GenPept UniProtKB/TrEMBL:Q06664
    Q07493 GenPept UniProtKB/TrEMBL:Q07493
    Q0R326 GenPept UniProtKB/TrEMBL:Q0R326
    Q29737 GenPept UniProtKB/TrEMBL:Q29737
    Q29789 GenPept UniProtKB/TrEMBL:Q29789
    Q29891 GenPept UniProtKB/TrEMBL:Q29891
    Q29903 GenPept UniProtKB/TrEMBL:Q29903
    Q29971 GenPept UniProtKB/TrEMBL:Q29971
    Q29972 GenPept UniProtKB/TrEMBL:Q29972
    Q29973 GenPept UniProtKB/TrEMBL:Q29973
    Q2YHL2 GenPept UniProtKB/TrEMBL:Q2YHL2
    Q30009 GenPept UniProtKB/TrEMBL:Q30009
    Q30109 GenPept UniProtKB/TrEMBL:Q30109
    Q30111 GenPept UniProtKB/TrEMBL:Q30111
    Q30136 GenPept UniProtKB/TrEMBL:Q30136
    Q30138 GenPept UniProtKB/TrEMBL:Q30138
    Q30140 GenPept UniProtKB/TrEMBL:Q30140
    Q30141 GenPept UniProtKB/TrEMBL:Q30141
    Q30148 GenPept UniProtKB/TrEMBL:Q30148
    Q30151 GenPept UniProtKB/TrEMBL:Q30151
    Q30154.1 GenPept UniProtKB/Swiss-Prot:Q30154
    Q30158 GenPept UniProtKB/TrEMBL:Q30158
    Q30178 GenPept UniProtKB/TrEMBL:Q30178
    Q31637 GenPept UniProtKB/TrEMBL:Q31637
    Q31641 GenPept UniProtKB/TrEMBL:Q31641
    Q31644 GenPept UniProtKB/TrEMBL:Q31644
    Q31645 GenPept UniProtKB/TrEMBL:Q31645
    Q3LTJ1 GenPept UniProtKB/TrEMBL:Q3LTJ1
    Q3LTJ2 GenPept UniProtKB/TrEMBL:Q3LTJ2
    Q5EEQ8 GenPept UniProtKB/TrEMBL:Q5EEQ8
    Q5EGD8 GenPept UniProtKB/TrEMBL:Q5EGD8
    Q5FY46 GenPept UniProtKB/TrEMBL:Q5FY46
    Q5GMP5 GenPept UniProtKB/TrEMBL:Q5GMP5
    Q5ND94 GenPept UniProtKB/TrEMBL:Q5ND94
    Q5QQ11 GenPept UniProtKB/TrEMBL:Q5QQ11
    Q5TJ21 GenPept UniProtKB/TrEMBL:Q5TJ21
    Q5W1E2 GenPept UniProtKB/TrEMBL:Q5W1E2
    Q5XKU0 GenPept UniProtKB/TrEMBL:Q5XKU0
    Q5Y7B6 GenPept UniProtKB/TrEMBL:Q5Y7B6
    Q5Y7E0 GenPept UniProtKB/TrEMBL:Q5Y7E0
    Q6BDC5 GenPept UniProtKB/TrEMBL:Q6BDC5
    Q6BDC8 GenPept UniProtKB/TrEMBL:Q6BDC8
    Q6DV47 GenPept UniProtKB/TrEMBL:Q6DV47
    Q6QE68 GenPept UniProtKB/TrEMBL:Q6QE68
    Q6RCP9 GenPept UniProtKB/TrEMBL:Q6RCP9
    Q6RCQ0 GenPept UniProtKB/TrEMBL:Q6RCQ0
    Q6S5H9 GenPept UniProtKB/TrEMBL:Q6S5H9
    Q6T714 GenPept UniProtKB/TrEMBL:Q6T714
    Q6T717 GenPept UniProtKB/TrEMBL:Q6T717
    Q6TKG7 GenPept UniProtKB/TrEMBL:Q6TKG7
    Q70I25 GenPept UniProtKB/TrEMBL:Q70I25
    Q75NJ5 GenPept UniProtKB/TrEMBL:Q75NJ5
    Q768U3 GenPept UniProtKB/TrEMBL:Q768U3
    Q7JFQ0 GenPept UniProtKB/TrEMBL:Q7JFQ0
    Q7JGS8 GenPept UniProtKB/TrEMBL:Q7JGS8
    Q7YP63 GenPept UniProtKB/TrEMBL:Q7YP63
    Q7YPZ8 GenPept UniProtKB/TrEMBL:Q7YPZ8
    Q7YPZ9 GenPept UniProtKB/TrEMBL:Q7YPZ9
    Q7YQ31 GenPept UniProtKB/TrEMBL:Q7YQ31
    Q7YQ32 GenPept UniProtKB/TrEMBL:Q7YQ32
    Q7YQ35 GenPept UniProtKB/TrEMBL:Q7YQ35
    Q7YQA2 GenPept UniProtKB/TrEMBL:Q7YQA2
    Q7YQA4 GenPept UniProtKB/TrEMBL:Q7YQA4
    Q7YQA8 GenPept UniProtKB/TrEMBL:Q7YQA8
    Q860B8 GenPept UniProtKB/TrEMBL:Q860B8
    Q860E3 GenPept UniProtKB/TrEMBL:Q860E3
    Q860I1 GenPept UniProtKB/TrEMBL:Q860I1
    Q860S1 GenPept UniProtKB/TrEMBL:Q860S1
    Q860S2 GenPept UniProtKB/TrEMBL:Q860S2
    Q860S7 GenPept UniProtKB/TrEMBL:Q860S7
    Q860Z2 GenPept UniProtKB/TrEMBL:Q860Z2
    Q861A5 GenPept UniProtKB/TrEMBL:Q861A5
    Q861B8 GenPept UniProtKB/TrEMBL:Q861B8
    Q861G4 GenPept UniProtKB/TrEMBL:Q861G4
    Q861G5 GenPept UniProtKB/TrEMBL:Q861G5
    Q861H2 GenPept UniProtKB/TrEMBL:Q861H2
    Q861H9 GenPept UniProtKB/TrEMBL:Q861H9
    Q8HWG3 GenPept UniProtKB/TrEMBL:Q8HWG3
    Q8HWG4 GenPept UniProtKB/TrEMBL:Q8HWG4
    Q8HWG5 GenPept UniProtKB/TrEMBL:Q8HWG5
    Q8HWH1 GenPept UniProtKB/TrEMBL:Q8HWH1
    Q8HWL8 GenPept UniProtKB/TrEMBL:Q8HWL8
    Q8HWN4 GenPept UniProtKB/TrEMBL:Q8HWN4
    Q8MGY3 GenPept UniProtKB/TrEMBL:Q8MGY3
    Q8MHQ0 GenPept UniProtKB/TrEMBL:Q8MHQ0
    Q8WLU1 GenPept UniProtKB/TrEMBL:Q8WLU1
    Q95385 GenPept UniProtKB/TrEMBL:Q95385
    Q95386 GenPept UniProtKB/TrEMBL:Q95386
    Q95388 GenPept UniProtKB/TrEMBL:Q95388
    Q95462 GenPept UniProtKB/TrEMBL:Q95462
    Q95HK3 GenPept UniProtKB/TrEMBL:Q95HK3
    Q95HK4 GenPept UniProtKB/TrEMBL:Q95HK4
    Q95HK5 GenPept UniProtKB/TrEMBL:Q95HK5
    Q95HK8 GenPept UniProtKB/TrEMBL:Q95HK8
    Q95HK9 GenPept UniProtKB/TrEMBL:Q95HK9
    Q95HN0 GenPept UniProtKB/TrEMBL:Q95HN0
    Q95IE2 GenPept UniProtKB/TrEMBL:Q95IE2
    Q99938 GenPept UniProtKB/TrEMBL:Q99938
    Q99948 GenPept UniProtKB/TrEMBL:Q99948
    Q9BCQ2 GenPept UniProtKB/TrEMBL:Q9BCQ2
    Q9BCS6 GenPept UniProtKB/TrEMBL:Q9BCS6
    Q9BCS8 GenPept UniProtKB/TrEMBL:Q9BCS8
    Q9BCT6 GenPept UniProtKB/TrEMBL:Q9BCT6
    Q9BD07 GenPept UniProtKB/TrEMBL:Q9BD07
    Q9BD35 GenPept UniProtKB/TrEMBL:Q9BD35
    Q9BD47 GenPept UniProtKB/TrEMBL:Q9BD47
    Q9GIL4 GenPept UniProtKB/TrEMBL:Q9GIL4
    Q9GIL7 GenPept UniProtKB/TrEMBL:Q9GIL7
    Q9GIX0 GenPept UniProtKB/TrEMBL:Q9GIX0
    Q9GIX7 GenPept UniProtKB/TrEMBL:Q9GIX7
    Q9GJF7 GenPept UniProtKB/TrEMBL:Q9GJF7
    Q9GJM1 GenPept UniProtKB/TrEMBL:Q9GJM1
    Q9MXZ2 GenPept UniProtKB/TrEMBL:Q9MXZ2
    Q9MXZ7 GenPept UniProtKB/TrEMBL:Q9MXZ7
    Q9MXZ8 GenPept UniProtKB/TrEMBL:Q9MXZ8
    Q9MY00 GenPept UniProtKB/TrEMBL:Q9MY00
    Q9MY01 GenPept UniProtKB/TrEMBL:Q9MY01
    Q9MY02 GenPept UniProtKB/TrEMBL:Q9MY02
    Q9MY07 GenPept UniProtKB/TrEMBL:Q9MY07
    Q9MY08 GenPept UniProtKB/TrEMBL:Q9MY08
    Q9MY09 GenPept UniProtKB/TrEMBL:Q9MY09
    Q9MY10 GenPept UniProtKB/TrEMBL:Q9MY10
    Q9MY12 GenPept UniProtKB/TrEMBL:Q9MY12
    Q9MY15 GenPept UniProtKB/TrEMBL:Q9MY15
    Q9MY22 GenPept UniProtKB/TrEMBL:Q9MY22
    Q9MY91 GenPept UniProtKB/TrEMBL:Q9MY91
    Q9MYH1 GenPept UniProtKB/TrEMBL:Q9MYH1
    Q9NPL1 GenPept UniProtKB/TrEMBL:Q9NPL1
    Q9TNV2 GenPept UniProtKB/TrEMBL:Q9TNV2
    Q9TNV3 GenPept UniProtKB/TrEMBL:Q9TNV3
    Q9TP67 GenPept UniProtKB/TrEMBL:Q9TP67
    Q9TP96 GenPept UniProtKB/TrEMBL:Q9TP96
    Q9TP97 GenPept UniProtKB/TrEMBL:Q9TP97
    Q9TPE2 GenPept UniProtKB/TrEMBL:Q9TPE2
    Q9TQ41 GenPept UniProtKB/TrEMBL:Q9TQ41
    Q9TQ42 GenPept UniProtKB/TrEMBL:Q9TQ42
    Q9TQ56 GenPept UniProtKB/TrEMBL:Q9TQ56
    Q9TQ60 GenPept UniProtKB/TrEMBL:Q9TQ60
    Q9TQ62 GenPept UniProtKB/TrEMBL:Q9TQ62
    Q9TQ64 GenPept UniProtKB/TrEMBL:Q9TQ64
    Q9TQ77 GenPept UniProtKB/TrEMBL:Q9TQ77
    Q9TQ78 GenPept UniProtKB/TrEMBL:Q9TQ78
    Q9TQD8 GenPept UniProtKB/TrEMBL:Q9TQD8
    Q9TQE0.1 GenPept UniProtKB/Swiss-Prot:Q9TQE0
    Q9UEX9 GenPept UniProtKB/TrEMBL:Q9UEX9
    Q9UIM7 GenPept UniProtKB/TrEMBL:Q9UIM7
    Q9UM35 GenPept UniProtKB/TrEMBL:Q9UM35
    Q9UM36 GenPept UniProtKB/TrEMBL:Q9UM36
    Q9UM38 GenPept UniProtKB/TrEMBL:Q9UM38
    Q9Y454 GenPept UniProtKB/TrEMBL:Q9Y454
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