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    EEF1A1 eukaryotic translation elongation factor 1 alpha 1 [ Homo sapiens ]

    Gene ID: 1915, updated on 12-May-2012

    Summary

    Official Symbol
    EEF1A1provided by HGNC
    Official Full Name
    eukaryotic translation elongation factor 1 alpha 1provided by HGNC
    Primary source
    HGNC:3189
    Locus tag
    RP11-505P4.2
    See related
    Ensembl:ENSG00000156508; HPRD:00559; MIM:130590; Vega:OTTHUMG00000015031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCS3; EF1A; PTI1; CCS-3; EE1A1; EEF-1; EEF1A; EF-Tu; LENG7; eEF1A-1; GRAF-1EF; HNGC:16303; FLJ25721; MGC16224; MGC102687; MGC131894
    Summary
    This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    6q14.1
    Sequence :
    Chromosome: 6; NC_000006.11 (74225473..74230755, complement)
    See EEF1A1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene Mab-21 domain containing 1 Neighboring gene mitochondrial translation optimization 1 homolog (S. cerevisiae) Neighboring gene solute carrier family 17 (anion/sugar transporter), member 5 Neighboring gene ribosomal protein S27 pseudogene 15 Neighboring gene uncharacterized LOC100506740 Neighboring gene CD109 molecule

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat EF-1alpha stimulates the binding of RNA Polymerase II and TRP-185 to HIV-1 TAR RNA, suggesting an interaction between EF-1alpha and HIV-1 Tat PubMed
    integrase gag-pol Interaction of human EF1alpha with HIV-1 integrase is presumed based on a reported binding interaction between yeast TEF1alpha and integrase PubMed
    matrix gag The interaction between HIV-1 Matrix and elongation factor 1-alpha impairs translation in vitro, suggesting a role for this interaction in releasing viral RNA from polysomes, permitting the RNA to be packaged into virions PubMed
    gag The basic region of HIV-1 Matrix (amino acids 15-35) mediates binding to amino acids 1-74 of elongation factor 1-alpha PubMed
    gag Binding of elongation factor 1-alpha to HIV-1 Gag proteins (Matrix and Nucleocapsid) appears to be mediated by RNA PubMed
    gag Elongation factor 1-alpha binds to HIV-1 Matrix, as well as to HIV-1 Gag and Nucleocapsid and is incorporated into HIV-1 virion membranes PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001393.1 AAA61298.1 WARS    BIND  PubMed WRS interacts with EF-1-alpha. 
    NP_001393.1 NP_057850.1 gag    BIND  PubMed Gag polyprotein interacts with EF1-alpha. 
    NP_001393.1 NP_579876.2 gag    BIND  PubMed HIV-1 matrix protein interacts with EF1-alpha. 
    NP_001393.1 NP_705928.1 gag-pol    BIND  PubMed HIV-1 integrase interacts with EF1A. This interaction was modelled on a demonstrated interaction between HIV-1 integrase and TEF1-alpha from yeast. 
    P68104 P60709 ACTB    HPRD  PubMed  
    P68104 O95376 ARIH2    HPRD  PubMed  
    P68104 O15169 AXIN1    HPRD  PubMed  
    P68104 Q9HCU9 BRMS1    HPRD  PubMed  
    P68104 Q9BX70 BTBD2    HPRD  PubMed  
    P68104 P13994 CCDC130    HPRD  PubMed  
    P68104 P55774 CCL18    HPRD  PubMed  
    P68104 P33552 CKS2    HPRD  PubMed  
    P68104 Q14061 COX17    HPRD  PubMed  
    P68104 P78560 CRADD    HPRD  PubMed  
    P68104 Q9UGL9 CRCT1    HPRD  PubMed  
    P68104 Q16527 CSRP2    HPRD  PubMed  
    P68104 P14868 DARS    HPRD  PubMed  
    P68104 P63167 DYNLL1    HPRD  PubMed  
    P68104 P68104 EEF1A1    HPRD  PubMed  
    P68104 O00303 EIF3F    HPRD  PubMed  
    P68104 Q9NPD3 EXOSC4    HPRD  PubMed  
    P68104 P25445 FAS    HPRD  PubMed  
    P68104 O95257 GADD45G    HPRD  PubMed  
    P68104 Q15486 GUSBP1    HPRD  PubMed  
    P68104 O43504 HBXIP    HPRD  PubMed  
    P68104 P61604 HSPE1    HPRD  PubMed  
    P68104 Q15811 ITSN1    HPRD  PubMed  
    P68104 O60333 KIF1B    HPRD  PubMed  
    P68104 Q16363 LAMA4    HPRD  PubMed  
    P68104 Q6IAA8 LAMTOR1    HPRD  PubMed  
    P68104 P62310 LSM3    HPRD  PubMed  
    P68104 Q15013 MAD2L1BP    HPRD  PubMed  
    P68104 Q9UNF1 MAGED2    HPRD  PubMed  
    P68104 P42568 MLLT3    HPRD  PubMed  
    P68104 P51948 MNAT1    HPRD  PubMed  
    P68104 Q9Y6G3 MRPL42    HPRD  PubMed  
    P68104 Q99972 MYOC    HPRD  PubMed  
    P68104 Q99519 NEU1    HPRD  PubMed  
    P68104 Q8N138 ORMDL3    HPRD  PubMed  
    P68104 Q13310 PABPC4    HPRD  PubMed  
    P68104 P09466 PAEP    HPRD  PubMed  
    P68104 Q15102 PAFAH1B3    HPRD  PubMed  
    P68104 O43252 PAPSS1    HPRD  PubMed  
    P68104 Q9UN74 PCDHA4    HPRD  PubMed  
    P68104 P35080 PFN2    HPRD  PubMed  
    P68104 Q92561 PHYHIP    HPRD  PubMed  
    P68104 Q03405 PLAUR    HPRD  PubMed  
    P68104 P19174 PLCG1    HPRD  PubMed  
    P68104 P56282 POLE2    HPRD  PubMed  
    P68104 P19387 POLR2C    HPRD  PubMed  
    P68104 O60828 PQBP1    HPRD  PubMed  
    P68104 Q05655 PRKCD    HPRD  PubMed  
    P68104 Q00887 PSG9    HPRD  PubMed  
    P68104 O00231 PSMD11    HPRD  PubMed  
    P68104 P29074 PTPN4    HPRD  PubMed  
    P68104 Q14761 PTPRCAP    HPRD  PubMed  
    P68104 P51159 RAB27A    HPRD  PubMed  
    P68104 P40937 RFC5    HPRD  PubMed  
    P68104 O14924 RGS12    HPRD  PubMed  
    P68104 Q8N5U6 RNF10    HPRD  PubMed  
    P68104 P15927 RPA2    HPRD  PubMed  
    P68104 P05386 RPLP1    HPRD  PubMed  
    P68104 Q96IZ7 RSRC1    HPRD  PubMed  
    P68104 Q9NP81 SARS2    HPRD  PubMed  
    P68104 Q9NX18 SDHAF2    HPRD  PubMed  
    P68104 P50453 SERPINB9    HPRD  PubMed  
    P68104 P31947 SFN    HPRD  PubMed  
    P68104 P04278 SHBG    HPRD  PubMed  
    P68104 Q15796 SMAD2    HPRD  PubMed  
    P68104 Q13485 SMAD4    HPRD  PubMed  
    P68104 P43307 SSR1    HPRD  PubMed  
    P68104 Q93045 STMN2    HPRD  PubMed  
    P68104 P49888 SULT1E1    HPRD  PubMed  
    P68104 Q16594 TAF9    HPRD  PubMed  
    P68104 Q15583 TGIF1    HPRD  PubMed  
    P68104 P57727 TMPRSS3    HPRD  PubMed  
    P68104 Q13625 TP53BP2    HPRD  PubMed  
    P68104 P13693 TPT1    HPRD  PubMed  
    P68104 O14717 TRDMT1    HPRD  PubMed  
    P68104 P02766 TTR    HPRD  PubMed  
    P68104 Q9NRR5 UBQLN4    HPRD  PubMed  
    P68104 P23381 WARS    HPRD  PubMed  
    P68104 Q9HAV4 XPO5    HPRD  PubMed  
    P68104 Q9H0D6 XRN2    HPRD  PubMed  
    P68104 P61981 YWHAG    HPRD  PubMed  
    P68104 Q05516 ZBTB16    HPRD  PubMed  
    P68104 Q8TBK6 ZCCHC10    HPRD  PubMed  
    P68104 P17028 ZNF24    HPRD  PubMed  
    P68104 O75312 ZNF259    HPRD  PubMed  
    P68104 Complement component 4B     HPRD  PubMed  
    P68104 O43261     HPRD  PubMed  
    P68104 Q8IVG9     HPRD  PubMed  
    BioGRID:108237 BioGRID:117367 ABTB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108237 BioGRID:106764 AMFR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:128096 ANKRD24    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:115694 ARIH2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:113909 AXIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:117379 BRMS1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:120778 BTBD2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:107285 CASP2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:123536 CCDC130    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112265 CCL18    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:107583 CKS2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:115374 COX17    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114275 CRADD    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:120031 CRCT1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:107984 DARS    BioGRID  PubMed Biochemical Activity 
    BioGRID:108237 BioGRID:121157 DIABLO    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:115589 DLEU1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:108182 DUSP7    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114206 DYNLL1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:128177 EIF2C3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:114214 EIF3F    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:120007 EXOSC4    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:106851 FAS    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:108014 GADD45A    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:116117 GADD45G    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:115796 HBXIP    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:109568 HSPE1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114089 IKBKG    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:116185 IMMT    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114689 ITGB1BP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112351 ITSN1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:115326 KCNE3    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:116723 KIF1B    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:110043 KRAS    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:110104 LAMA4    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:120336 LAMTOR1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:118105 LSM3    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114955 MAD2L1BP    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114487 MAP3K14    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:107819 MAPK14    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:110446 MLLT3    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:110455 MME    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:110474 MNAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:122999 MRM1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:118800 MRPL42    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:125363 MYSM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:110831 NEU1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:115783 NOP56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:109407 NR4A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:110952 NRAS    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114727 NREP    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:125114 ORMDL3    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111084 PAEP    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111087 PAFAH1B3    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114522 PAPSS1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:121084 PCDHA4    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:111238 PFN2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:115139 PHYHIP    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111572 PKN2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111345 PLAUR    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111351 PLCG1    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108237 BioGRID:111423 POLE2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111428 POLR2C    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111456 POU5F1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:108237 BioGRID:111523 PPP4C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:115393 PQBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111652 PSG9    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:111689 PSMD11    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111741 PTPN4    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111754 PTPRCAP    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111811 RAB27A    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:108237 BioGRID:111846 RAP2A    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111917 RFC5    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:115249 RNF10    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112038 RPA2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112095 RPLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112151 RRAS    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:119470 RSRC1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:120288 SDHAF2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:111290 SERPINB9    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112490 SMN1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112506 SNCA    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:116597 SNW1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:112623 SSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:116258 STMN2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112660 SULT1E1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:124257 SUV420H2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:112743 TAF9    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112908 TGIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:122236 TMPRSS3    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114160 TNFSF11    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:113012 TP53BP2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:108124 TRDMT1    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:113127 TTR    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:202471 Tmsb4x    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108237 BioGRID:121223 UBQLN4    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:113250 VARS    BioGRID  PubMed Co-purification 
    BioGRID:108237 BioGRID:121574 XPO5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108237 BioGRID:116483 XRN2    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108237 BioGRID:120174 ZCCHC10    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:113403 ZNF24    BioGRID  PubMed Two-hybrid 
    BioGRID:108237 BioGRID:114401 ZNF259    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108237 BioGRID:204651 Zfp259    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108237 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Pathways from BioSystems

    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Elongation, organism-specific biosystemThe translation elongation cycle adds one amino acid at a time to a growing polypeptide according to the sequence of codons found in the mRNA. The next available codon on the mRNA is exposed in the a...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Peptide chain elongation, organism-specific biosystem (from REACTOME)
      Peptide chain elongation, organism-specific biosystemThe mechanism of a peptide bond requires the movement of three protons. First the deprotonation of the ammonium ion generates a reactive amine, allowing a nucleophilic attack on the carbonyl group. ...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Translation, organism-specific biosystem (from REACTOME)
      Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    translation elongation factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    translation TAS
    Traceable Author Statement
    more info
     
    translational elongation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    eukaryotic translation elongation factor 1 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    elongation factor 1-alpha 1
    Names
    elongation factor 1-alpha 1
    EF-1-alpha-1
    EF1a-like protein
    CTCL tumor antigen
    elongation factor Tu
    cervical cancer suppressor 3
    elongation factor 1 alpha subunit
    prostate tumor-inducing protein 1
    eukaryotic elongation factor 1 A-1
    leukocyte receptor cluster member 7
    leukocyte receptor cluster (LRC) member 7
    translation elongation factor 1 alpha 1-like 14
    glucocorticoid receptor AF-1 specific elongation factor
    eukaryotic translation elongation factor 1 alpha 1-like 14

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402.5NP_001393.1  elongation factor 1-alpha 1

      Status: REVIEWED

      Source sequence(s)
      AJ420488, AL603910, BC066893
      Consensus CDS
      CCDS4980.1
      UniProtKB/Swiss-Prot
      P68104
      UniProtKB/TrEMBL
      Q6IPS9
      Related
      ENSP00000339053, OTTHUMP00000063805, ENST00000309268, OTTHUMT00000128718
      Conserved Domains (4) summary
      cd03705
      Location:335432
      Blast Score: 456
      EF1_alpha_III; Domain III of EF-1. Eukaryotic elongation factor 1 (EF-1) is responsible for the GTP-dependent binding of aminoacyl-tRNAs to ribosomes. EF-1 is composed of four subunits: the alpha chain, which binds GTP and aminoacyl-tRNAs, the gamma chain that probably ...
      cd03693
      Location:242332
      Blast Score: 444
      EF1_alpha_II; EF1_alpha_II: this family represents the domain II of elongation factor 1-alpha (EF-1a) that is found in archaea and all eukaryotic lineages. EF-1A is very abundant in the cytosol, where it is involved in the GTP-dependent binding of aminoacyl-tRNAs to ...
      PTZ00141
      Location:1432
      Blast Score: 2201
      PTZ00141; elongation factor 1- alpha; Provisional
      cd01883
      Location:9238
      Blast Score: 1175
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      74225473..74230755, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      71425023..71430305, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001403.1: Suppressed sequence

      Description
      NM_001403.1: This RefSeq was permanently suppressed because it was based on a chimeric sequence and represented a partial CDS.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL603910.6 CAI14883.1
      CAI40951.1
    genomic CH471051.2 EAW48759.1
    genomic HC250971.1 CBJ05783.1
    genomic HC311160.1 CBJ21235.1
    genomic J04617.1 AAA52343.1
    mRNA AF174496.1 AAF36537.1
    mRNA AF211972.1 None
    mRNA AF328730.1 AAN09722.1
    mRNA AF397403.1 AAK93966.1
    mRNA AJ420488.1 None
    mRNA AK024888.1 None
    mRNA AK026650.1 None
    mRNA AK055058.1 BAG51457.1
    mRNA AK058051.1 None
    mRNA AK058082.1 None
    mRNA AK058163.1 None
    mRNA AK098510.1 None
    mRNA AK098518.1 None
    mRNA AK098587.1 None
    mRNA AK098623.1 None
    mRNA AK127384.1 BAG54498.1
    mRNA AK222515.1 BAD96235.1
    mRNA AK222519.1 BAD96239.1
    mRNA AK222523.1 BAD96243.1
    mRNA AK222551.1 BAD96271.1
    mRNA AK222982.1 BAD96702.1
    mRNA AK223030.1 BAD96750.1
    mRNA AK223042.1 BAD96762.1
    mRNA AK223046.1 BAD96766.1
    mRNA AK289374.1 BAF82063.1
    mRNA AK289442.1 BAF82131.1
    mRNA AK290691.1 BAF83380.1
    mRNA AK292639.1 BAF85328.1
    mRNA AK297878.1 BAG60202.1
    mRNA AK300922.1 BAG62554.1
    mRNA AK304214.1 BAG65087.1
    mRNA AK315827.1 BAF98718.1
    mRNA AY043301.1 AAK95378.1
    mRNA BC008587.1 AAH08587.1
    mRNA BC009733.1 AAH09733.1
    mRNA BC009875.2 AAH09875.1
    mRNA BC010735.1 AAH10735.1
    mRNA BC012509.1 AAH12509.1
    mRNA BC012891.1 AAH12891.1
    mRNA BC014224.2 AAH14224.1
    mRNA BC014377.1 AAH14377.1
    mRNA BC014892.1 AAH14892.1
    mRNA BC018150.1 AAH18150.1
    mRNA BC018641.2 AAH18641.1
    mRNA BC018850.2 None
    mRNA BC019050.2 None
    mRNA BC019669.1 None
    mRNA BC020477.2 None
    mRNA BC021686.1 AAH21686.1
    mRNA BC022412.1 AAH22412.1
    mRNA BC028674.1 AAH28674.1
    mRNA BC029337.1 None
    mRNA BC029343.1 None
    mRNA BC029997.1 None
    mRNA BC035877.1 None
    mRNA BC038339.1 AAH38339.1
    mRNA BC038897.1 None
    mRNA BC057391.1 AAH57391.1
    mRNA BC063511.1 AAH63511.1
    mRNA BC065761.1 AAH65761.1
    mRNA BC066893.1 AAH66893.1
    mRNA BC066894.1 None
    mRNA BC070131.1 AAH70131.1
    mRNA BC070500.1 AAH70500.1
    mRNA BC071619.1 AAH71619.1
    mRNA BC071727.1 AAH71727.1
    mRNA BC071741.1 AAH71741.1
    mRNA BC071841.1 AAH71841.1
    mRNA BC072385.1 AAH72385.1
    mRNA BC082268.1 AAH82268.1
    mRNA BC094687.1 AAH94687.1
    mRNA BC111051.1 AAI11052.1
    mRNA DQ185041.1 ABD14421.1
    mRNA DQ867534.1 ABI74620.1
    mRNA EF362804.1 ABO30531.1
    mRNA M27364.1 AAA52344.1
    mRNA M29548.1 AAA52367.1
    mRNA X03558.1 CAA27245.1
    mRNA X03689.1 CAA27325.1
    mRNA X16869.1 CAA34756.1
    mRNA EF219140.1 None
    other-genetic DQ891450.2 ABM82376.1
    other-genetic DQ894629.2 ABM85555.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68104.1 GenPept UniProtKB/Swiss-Prot:P68104
    Q14222 GenPept UniProtKB/TrEMBL:Q14222
    Q16577 GenPept UniProtKB/TrEMBL:Q16577
    Q2F837 GenPept UniProtKB/TrEMBL:Q2F837
    Q504Z0 GenPept UniProtKB/TrEMBL:Q504Z0
    Q53G85 GenPept UniProtKB/TrEMBL:Q53G85
    Q53G89 GenPept UniProtKB/TrEMBL:Q53G89
    Q53GA1 GenPept UniProtKB/TrEMBL:Q53GA1
    Q53GE9 GenPept UniProtKB/TrEMBL:Q53GE9
    Q53HM9 GenPept UniProtKB/TrEMBL:Q53HM9
    Q53HQ7 GenPept UniProtKB/TrEMBL:Q53HQ7
    Q53HR1 GenPept UniProtKB/TrEMBL:Q53HR1
    Q53HR5 GenPept UniProtKB/TrEMBL:Q53HR5
    Q5JR01 GenPept UniProtKB/TrEMBL:Q5JR01
    Q6IPN6 GenPept UniProtKB/TrEMBL:Q6IPN6
    Q6IPS9 GenPept UniProtKB/TrEMBL:Q6IPS9
    Q6IPT9 GenPept UniProtKB/TrEMBL:Q6IPT9
    Q6IQ15 GenPept UniProtKB/TrEMBL:Q6IQ15
    Q6NS35 GenPept UniProtKB/TrEMBL:Q6NS35
    Q6NSH7 GenPept UniProtKB/TrEMBL:Q6NSH7
    Q6P082 GenPept UniProtKB/TrEMBL:Q6P082
    Q6P4C9 GenPept UniProtKB/TrEMBL:Q6P4C9
    Q8IUB0 GenPept UniProtKB/TrEMBL:Q8IUB0
    Q8TBL1 GenPept UniProtKB/TrEMBL:Q8TBL1
    Q96C29 GenPept UniProtKB/TrEMBL:Q96C29
    Q96CD8 GenPept UniProtKB/TrEMBL:Q96CD8
    Q96EB3 GenPept UniProtKB/TrEMBL:Q96EB3
    Q96RE1 GenPept UniProtKB/TrEMBL:Q96RE1
    Q9H2I7 GenPept UniProtKB/TrEMBL:Q9H2I7
    Q9NZS6 GenPept UniProtKB/TrEMBL:Q9NZS6

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