We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

RHOA ras homolog family member A [ Homo sapiens (human) ]

Gene ID: 387, updated on 19-May-2013

Summary

Go to the top of the page Help

Official Symbol: RHOAprovided by HGNC
Official Full Name: ras homolog family member Aprovided by HGNC
Primary source: HGNC:667
See related: Ensembl:ENSG00000067560; HPRD:01323; MIM:165390; Vega:OTTHUMG00000156838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARHA; ARH12; RHO12; RHOH12

Genomic context

Go to the top of the page Help

Location :: 3p21.3

Sequence :: Chromosome: 3; NC_000003.11 (49396578..49449526, complement)

See RHOA in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an unbiased filter approach based on transcriptome-wide profiling identified RHOA as a gene contributing to variation in LDL-cholesterol response to statin
Title: RHOA is a modulator of the cholesterol-lowering effects of statin.
These findings indicate that the H1N1 virus NS1 protein induces G(0)/G(1) cell cycle arrest mainly through interfering with the RhoA/pRb signaling cascade, thus providing favorable conditions for viral protein accumulation and replication.
Title: Influenza A virus NS1 induces G0/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein.
Redox-dependent activation of RhoA/Rho-associated kinase and Src/vascular endothelial cadherin signaling pathways, together with Akt inactivation, contribute to endothelial dysfunction in diabetes.
Title: Diabetes causes bone marrow endothelial barrier dysfunction by activation of the RhoA-Rho-associated kinase signaling pathway.
Substitution of RhoA Val 43 with an Ile was found to significantly promote basal nucleotide exchange activity and enhance guanosine triphosphate-loading in cells.
Title: Divergence of Rho residue 43 impacts GEF activity.
Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein
Title: Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
in megakaryocytes, subcellular localization and regulation of MKL1 is dependent on RhoA activity and actin organization
Title: Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation.
these findings demonstrate that km23-1 regulates RhoA and motility-associated actin modulating proteins, suggesting that km23-1 may represent a novel target for anti-metastatic therapy.
Title: Role of km23-1 in RhoA/actin-based cell migration.
The positivity rate of RhoA in the bronchoalveolar lavage fluid is higher in asthma patients allergic to dust mites than in normal healthy subjects.
Title: [Expression levels of RhoA in bronchoalveolar lavage fluid of asthma patients allergic to dust mites].
Furthermore, pharmacological manipulations of cytoskeletal tension in conjunction with analysis of gene expression revealed that mechanical properties of the microenvironment signal through the small GTPase RhoA.
Title: Matrix compliance and RhoA direct the differentiation of mammary progenitor cells.
Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl
Title: Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.

Submit: New GeneRIF Correction See all (403)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

Go to the top of the page Help

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Inhibition of the RhoA/Rac1 signal cascade by guanine nucleotide dissociation inhibitors limits the HIV-1 gp120-dependent early phase of the viral life cycle	PubMed
	env	Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering	PubMed
Tat, p14	tat	HIV-1 Tat-mediated downregulation of occludin expression requires activities of the RhoA and p160-Rho-associated coiled kinase (ROCK) proteins in primary human brain micro vascular endothelial cells	PubMed
	tat	Disruption of lipid rafts by depletion of membrane cholesterol with methyl-beta-cyclodextrin abolishes Tat-mediated RhoA activation and P-glycoprotein (P-gp) upregulation	PubMed
	tat	Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain	PubMed
	tat	HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src	PubMed
	tat	Knocking down oxidase Nox4 completely suppresses Tat-dependent Ras and ERK activation downstream of Rac1 and RhoA and blocks Tat-dependent proliferation	PubMed
	tat	Tat activates both Ras and Rho GTPases in endothelial cells, leading to ERK phosphorylation	PubMed
Vpr, p15	vpr	HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of RhoA expression	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
NP_001655.1	NP_065875.2	ARHGAP21	BIND	PubMed	ARHGAP21 interacts with RhoA-GTP, and acts as a GAP to increase RhoA GTPase activity.
NP_001655.1	NP_851852.2	ARHGAP8	BIND	PubMed	BPGAP1 interacts with RhoA.
NP_001655.1	AAH11604.1	CNKSR1	BIND	PubMed	hCNK1 interacts with RhoA. This interaction was modelled on a demonstrated interaction between human CNK1 and RhoA from an unspecified species.
NP_001655.1	NP_071330.2	DEF6	BIND	PubMed	DEF6 interacts with RhoA. This interaction was modelled on a demonstrated interaction between human DEF6 and RhoA from an unspecified species.
NP_001655.1	NP_079255.2	MCF2L	BIND	PubMed	RhoA specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor Dbs. This interaction is modelled on a demonstrated interaction between mouse Dbs and human RhoA.
NP_001655.1	NP_004901.1	PITPNM1	BIND	PubMed	Nir2 interacts with RhoA.
NP_001655.1	NP_149035.1	RTKN	BIND	PubMed	Active, GTP-bound RhoA interacts with the RTKN (Rhotekin) Rho binding domain. This interaction was modelled on a demonstrated interaction between human RhoA and Rhotekin from an unspecified species.
NP_001655.1	NP_149035.1	RTKN	BIND	PubMed	RTKN (rhotekin) interacts with RhoA. This interaction was modeled on a demonstrated interaction between mouse RTKN and human RhoA.
NP_001655.1	NP_149035.1	RTKN	BIND	PubMed	Rhotekin interacts with RhoA-GTP. This interaction was modeled on a demonstrated interaction between Rhotekin from an unspecified species and human Rho-GTP.
NP_001655.1	NP_149035.1	RTKN	BIND	PubMed	RhoA interacts with RTKN (Rhotekin). This interaction was modeled on a demonstrated interaction between RhoA and RTKN from an unspecified species.
NP_001655.1		RTKN	BIND	PubMed	RhoA interacts with Rhotekin. This interaction was modeled on a demonstrated interaction between human RhoA and Rhotekin from an unspecified species.
NP_001655.1	NP_057864.1	tax	BIND	PubMed	Tax interacts with RhoA.
NP_001655.1	CAC39270.1		BIND	PubMed	YopT cleaves RhoA amino-terminal to prenylated Cys190. This interaction was modeled on a demonstrated interaction between Yersinia pseudotuberculosis YopT and RhoA from an unspecified species.
NP_001655.1			BIND	PubMed	RhoA interacts with GTP. This interaction was modelled on a demonstrated interaction between RhoA from an unspecified species and GTP.
P61586	Q12802	AKAP13	HPRD	PubMed
P61586	Q07960	ARHGAP1	HPRD	PubMed
P61586	Rho GTPase activating protein 10	ARHGAP21	HPRD	PubMed
P61586	P52565	ARHGDIA	HPRD	PubMed
P61586	P52566	ARHGDIB	HPRD	PubMed
P61586	Q99819	ARHGDIG	HPRD	PubMed
P61586	O15085	ARHGEF11	HPRD	PubMed
P61586	Q9NZN5	ARHGEF12	HPRD	PubMed
P61586	Rho specific guanine nucleotide exchange factor p114	ARHGEF18	HPRD	PubMed
P61586	Q92974	ARHGEF2	HPRD	PubMed
P61586	RAC/CDC42 exchange factor	ARHGEF25	HPRD	PubMed
P61586	Rho guanine nucleotide exchange factor	ARHGEF28	HPRD	PubMed
P61586	Q9NR81	ARHGEF3	HPRD	PubMed
P61586	Q9NR80	ARHGEF4	HPRD	PubMed
P61586	Q03135	CAV1	HPRD	PubMed
P61586	O14578	CIT	HPRD	PubMed
P61586	Q969H4	CNKSR1	HPRD	PubMed
P61586	P78357	CNTNAP1	HPRD	PubMed
P61586	Q9Y4D1	DAAM1	HPRD	PubMed
P61586	DEF6	DEF6	HPRD	PubMed
P61586	P52824	DGKQ	HPRD	PubMed
P61586	O60610	DIAPH1	HPRD	PubMed
P61586	Q96N67	DOCK7	HPRD	PubMed
P61586	O14641	DVL2	HPRD	PubMed
P61586	P21333	FLNA	HPRD	PubMed
P61586	Q9P107	GMIP	HPRD	PubMed
P61586	Heat shock 70 KD protein 1A	HSPA1A	HPRD	PubMed
P61586	O60725	ICMT	HPRD	PubMed
P61586	Q14643	ITPR1	HPRD	PubMed
P61586	P16389	KCNA2	HPRD	PubMed
P61586	Q86UP2	KTN1	HPRD	PubMed
P61586	P10911	MCF2	HPRD	PubMed
P61586	O15068	MCF2L	HPRD	PubMed
P61586	Myosin phosphatase Rho interacting protein	MPRIP	HPRD	PubMed
P61586	O60890	OPHN1	HPRD	PubMed
P61586	O43924	PDE6D	HPRD	PubMed
P61586	O00562	PITPNM1	HPRD	PubMed
P61586	Q16512	PKN1	HPRD	PubMed
P61586	Q16513	PKN2	HPRD	PubMed
P61586	P19174	PLCG1	HPRD	PubMed
P61586	Q13393	PLD1	HPRD	PubMed
P61586	PLEKHG2	PLEKHG2	HPRD	PubMed
P61586	O14974	PPP1R12A	HPRD	PubMed
P61586	P17612	PRKACA	HPRD	PubMed
P61586	P17252	PRKCA	HPRD	PubMed
P61586	Q05513	PRKCZ	HPRD	PubMed
P61586	Q9UI14	RABAC1	HPRD	PubMed
P61586	P52306	RAP1GDS1	HPRD	PubMed
P61586	Q13972	RASGRF1	HPRD	PubMed
P61586	P61586	RHOA	HPRD	PubMed
P61586	Q8TCX5	RHPN1	HPRD	PubMed
P61586	Q8IUC4	RHPN2	HPRD	PubMed
P61586	Q13464	ROCK1	HPRD	PubMed
P61586	Q9BST9	RTKN	HPRD	PubMed
P61586	Q9Y3L3	SH3BP1	HPRD	PubMed
P61586	Q9HCE7	SMURF1	HPRD	PubMed
P61586	Q7Z698	SPRED2	HPRD	PubMed
P61586	Q7Z6B7	SRGAP1	HPRD	PubMed
P61586	P36897	TGFBR1	HPRD	PubMed
P61586	P21980	TGM2	HPRD	PubMed
P61586	O75962	TRIO	HPRD	PubMed
P61586	P48995	TRPC1	HPRD	PubMed
P61586	P15498	VAV1	HPRD	PubMed
P61586	P52735	VAV2	HPRD	PubMed
P61586	Q9UKW4	VAV3	HPRD	PubMed
BioGRID:106880	BioGRID:116383	AKAP13	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:106885	ARHGAP1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:122784	ARHGAP10	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:116720	ARHGAP26	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:115091	ARHGAP32	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:109166	ARHGAP35	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:106887	ARHGAP5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:106889	ARHGDIA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-purification; Two-hybrid
BioGRID:106880	BioGRID:106891	ARHGDIG	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:114585	ARHGEF1	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:115164	ARHGEF11	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:116945	ARHGEF12	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:116950	ARHGEF18	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:114618	ARHGEF2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:106880	BioGRID:125438	ARHGEF25	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:119115	ARHGEF3	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:119114	ARHGEF4	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:115721	BAIAP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:107083	BCR	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:107106	BID	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:107293	CASP10	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:107291	CASP8	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:107305	CAV1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:107461	CDKN1B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:116290	CIT	BioGRID	PubMed	Far Western; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:107617	CLNS1A	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:114078	CNTNAP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:107765	CPT1A	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:107790	CRMP1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:106880	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:106880	BioGRID:246438	Cebpb	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:108019	DDX1	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:119099	DEF6	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:107979	DGKQ	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:108073	DIAPH1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:123559	DIAPH3	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:108142	DPYSL2	BioGRID	PubMed	Phenotypic Suppression
BioGRID:106880	BioGRID:199221	Diap1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:207965	Diap3	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:113271	EZR	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:114302	FADD	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:115098	FAM65B	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:106851	FAS	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:106852	FASLG	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:109030	GNA12	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:115671	GNB2L1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:109535	HSPA1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:109582	HTR1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:117026	ICMT	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:109913	ITPR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:109940	KCNA2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:110092	KTN1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:200955	Kin	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:201049	Ktn1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:125700	LRRK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:110378	MAP3K1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:106880	BioGRID:111585	MAPK8	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:108326	MARK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:110336	MCF2	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:116865	MCF2L	BioGRID	PubMed	Co-crystal Structure
BioGRID:106880	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:116776	MPRIP	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:110498	MPV17	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:110584	MSN	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:115565	NET1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:115408	NUBP2	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:207915	Net1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:111029	OPHN1	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:120751	OTUB1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:106880	BioGRID:111173	PDE6D	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:111571	PKN1	BioGRID	PubMed	Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:111572	PKN2	BioGRID	PubMed	Far Western; Reconstituted Complex
BioGRID:106880	BioGRID:111351	PLCG1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:111353	PLD1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:122330	PLEKHG2	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:115520	PLIN3	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:111377	PLXNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:111441	PON2	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:110742	PPP1R12A	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:114956	PRDX6	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:111688	PSMD10	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:111845	RAP1GDS1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:124521	RHPN2	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:119899	RIPK4	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:112020	ROCK1	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:114860	ROCK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:112061	RPL18	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:112100	RPN2	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:112147	RPS27A	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:112156	RTKN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:198192	Rhoa	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106880	BioGRID:202950	Rock1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:36640	SKN7	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:106789	SLC25A5	BioGRID	PubMed	Co-fractionation
BioGRID:106880	BioGRID:121411	SMURF1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:122265	SMURF2	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:121583	SRGAP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:112865	TEC	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:114323	TNFRSF10B	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:112986	TNFRSF1A	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:113055	TRIO	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:106880	BioGRID:113071	TRPC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:204360	Ttc3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:115715	VAV3	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:46157	pkn-1	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

Go to the top of the page Help

AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
Adherens junction, organism-specific biosystem (from KEGG)
Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Adherens junction, conserved biosystem (from KEGG)
Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
Arf6 downstream pathway, organism-specific biosystem
Arf6 downstream pathway
Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
Aurora B signaling, organism-specific biosystem
Aurora B signaling
Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
Axonal growth inhibition (RHOA activation), organism-specific biosystem (from REACTOME)
Axonal growth inhibition (RHOA activation), organism-specific biosystemp75NTR can also form a receptor complex with the Nogo receptor (NgR). Such complexes mediates axonal outgrowth inhibitory signals of MDGIs (myelin-derived growth-inhibitors), such as Nogo66, myelin-a...
Axonal growth stimulation, organism-specific biosystem (from REACTOME)
Axonal growth stimulation, organism-specific biosystemComplex formation between p75NTR and RHOA can leads to inhibition of RHOA activity and axonal growth.
B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
Class I PI3K signaling events, organism-specific biosystem
Class I PI3K signaling events
Colorectal cancer, organism-specific biosystem (from KEGG)
Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Colorectal cancer, conserved biosystem (from KEGG)
Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
E-cadherin signaling in keratinocytes, organism-specific biosystem (from Pathway Interaction Database)
E-cadherin signaling in keratinocytes, organism-specific biosystem
E-cadherin signaling in keratinocytes
E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
E-cadherin signaling in the nascent adherens junction
EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
EPHA forward signaling, organism-specific biosystem
EPHA forward signaling
EPHA2 forward signaling, organism-specific biosystem (from Pathway Interaction Database)
EPHA2 forward signaling, organism-specific biosystem
EPHA2 forward signaling
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endothelins, organism-specific biosystem (from Pathway Interaction Database)
Endothelins, organism-specific biosystem
Endothelins
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
G beta:gamma signalling through PI3Kgamma, organism-specific biosystem (from REACTOME)
G beta:gamma signalling through PI3Kgamma, organism-specific biosystemPI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predomi...
G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
G-protein beta:gamma signalling, organism-specific biosystemThe classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known tha...
G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL2-mediated signaling events, organism-specific biosystem
IL2-mediated signaling events
Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
Integrins in angiogenesis, organism-specific biosystem
Integrins in angiogenesis
LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
LPA receptor mediated events, organism-specific biosystem
LPA receptor mediated events
Leptin signaling pathway, organism-specific biosystem (from WikiPathways)
Leptin signaling pathway, organism-specific biosystemLeptin is a peptide hormone mainly synthesised and secreted from adipocytes. It is also expressed in other tissues including placenta, stomach and skeletal muscle. Leptin mediates its effects by bind...
Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Leukocyte transendothelial migration, conserved biosystem (from KEGG)
Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
Lissencephaly gene (LIS1) in neuronal migration and development
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
N-cadherin signaling events, organism-specific biosystem
N-cadherin signaling events
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
Neurotrophic factor-mediated Trk receptor signaling
Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Neurotrophin signaling pathway, conserved biosystem (from KEGG)
Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
Noncanonical Wnt signaling pathway, organism-specific biosystem
Noncanonical Wnt signaling pathway
Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
Osteopontin-mediated events, organism-specific biosystem
Osteopontin-mediated events
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
PLK1 signaling events, organism-specific biosystem
PLK1 signaling events
Pancreatic secretion, organism-specific biosystem (from KEGG)
Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pancreatic secretion, conserved biosystem (from KEGG)
Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
Paxillin-independent events mediated by a4b1 and a4b7
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Plasma membrane estrogen receptor signaling, organism-specific biosystem
Plasma membrane estrogen receptor signaling
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
Regulation of RhoA activity, organism-specific biosystem
Regulation of RhoA activity
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
Rho GTPase cycle, organism-specific biosystem (from REACTOME)
Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
RhoA signaling pathway, organism-specific biosystem
RhoA signaling pathway
S1P1 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P1 pathway, organism-specific biosystem
S1P1 pathway
S1P2 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P2 pathway, organism-specific biosystem
S1P2 pathway
S1P3 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P3 pathway, organism-specific biosystem
S1P3 pathway
S1P4 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P4 pathway, organism-specific biosystem
S1P4 pathway
S1P5 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P5 pathway, organism-specific biosystem
S1P5 pathway
Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystem (from REACTOME)
Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystemRepulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppressio...
Semaphorin interactions, organism-specific biosystem (from REACTOME)
Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PRL, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by PRL, organism-specific biosystem
Signaling events mediated by PRL
Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by PTP1B, organism-specific biosystem
Signaling events mediated by PTP1B
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by focal adhesion kinase, organism-specific biosystem
Signaling events mediated by focal adhesion kinase
Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem (from Pathway Interaction Database)
Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem
Signaling events regulated by Ret tyrosine kinase
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
Stabilization and expansion of the E-cadherin adherens junction
Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-2-mediated signaling events, organism-specific biosystem
Syndecan-2-mediated signaling events
Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-4-mediated signaling events, organism-specific biosystem
Syndecan-4-mediated signaling events
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
TGF-beta receptor signaling, organism-specific biosystem
TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemIn normal cells and in the early stages of cancer development, signaling by TGF-beta plays a tumor suppressive role, as SMAD2/3:SMAD4-mediated transcription inhibits cell division by downregulating M...
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Thromboxane A2 receptor signaling, organism-specific biosystem
Thromboxane A2 receptor signaling
Tight junction, organism-specific biosystem (from KEGG)
Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tight junction, conserved biosystem (from KEGG)
Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Vascular smooth muscle contraction, conserved biosystem (from KEGG)
Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
amb2 Integrin signaling, organism-specific biosystem
amb2 Integrin signaling
mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
mTOR signaling pathway, organism-specific biosystem
mTOR signaling pathway
p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
p75(NTR)-mediated signaling, organism-specific biosystem
p75(NTR)-mediated signaling
p75NTR regulates axonogenesis, organism-specific biosystem (from REACTOME)
p75NTR regulates axonogenesis, organism-specific biosystemp75NTR modulates axonal growth by regulating the activity of small GTPases like RHOA and RHOB, that control the state of actin polymerization. The best studied is RHOA. In its active, GTP-bound form,...

General gene information

Go to the top of the page Help

Markers

GDB:181197 (e-PCR)
- UniSTS:155171

A004G04 (e-PCR)
- UniSTS:31829

D3S1330E (e-PCR)
- UniSTS:147343

RH46190 (e-PCR)
- UniSTS:64932

A004T30 (e-PCR)
- UniSTS:72110

RH91501 (e-PCR)
- UniSTS:88496

WI-18922 (e-PCR)
- UniSTS:62388

G60181 (e-PCR)
- UniSTS:137440

D3S2384 (e-PCR), detects polymorphism
- UniSTS:55294

Homology

Homologs of the RHOA gene: The RHOA gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	TAS Traceable Author Statement more info	PubMed
myosin binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
apical junction assembly	IMP Inferred from Mutant Phenotype more info
axon guidance	TAS Traceable Author Statement more info
blood coagulation	TAS Traceable Author Statement more info
cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
cleavage furrow formation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB cascade	IEA Inferred from Electronic Annotation more info
negative regulation of axonogenesis	TAS Traceable Author Statement more info
negative regulation of intracellular steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
neurotrophin TRK receptor signaling pathway	TAS Traceable Author Statement more info
ossification involved in bone maturation	ISS Inferred from Sequence or Structural Similarity more info
phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info
platelet activation	TAS Traceable Author Statement more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of NF-kappaB import into nucleus	NAS Non-traceable Author Statement more info	PubMed
positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
positive regulation of axonogenesis	TAS Traceable Author Statement more info
positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of translation	IEA Inferred from Electronic Annotation more info
positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
regulation of axonogenesis	TAS Traceable Author Statement more info
regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of dendrite development	IEA Inferred from Electronic Annotation more info
regulation of osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
response to glucose stimulus	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info
spindle assembly involved in mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
stress fiber assembly	IEA Inferred from Electronic Annotation more info
stress-activated protein kinase signaling cascade	IEA Inferred from Electronic Annotation more info
trabecula morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info
virus-host interaction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
apical junction complex	IDA Inferred from Direct Assay more info
axon	IEA Inferred from Electronic Annotation more info
cell cortex	IDA Inferred from Direct Assay more info	PubMed
cell junction	TAS Traceable Author Statement more info
cleavage furrow	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
lamellipodium	IEA Inferred from Electronic Annotation more info
midbody	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info
ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: transforming protein RhoA

Names: transforming protein RhoA; h12; oncogene RHO H12; rho cDNA clone 12; Aplysia ras-related homolog 12; small GTP binding protein RhoA; ras homolog gene family, member A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001664.2 → NP_001655.1 transforming protein RhoA precursor

Status: VALIDATED

Source sequence(s)

AK130066, BC000946

Consensus CDS

CCDS2795.1

UniProtKB/Swiss-Prot

P61586

UniProtKB/TrEMBL

Q9BVT0

Related

ENSP00000400175, OTTHUMP00000210767, ENST00000418115, OTTHUMT00000346157

Conserved Domains (2) summary

cd01870
Location:5 – 179
Blast Score: 1011

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

PTZ00369
Location:1 – 193
Blast Score: 214

PTZ00369; Ras-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p10 Primary Assembly

Range

49396578..49449526, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

49456057..49509248, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018914.1 Alternate CHM1_1.0

Range

49328869..49381979, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01024587.1 (45845..46114)	None
genomic	ABBA01024588.1	None
genomic	ABBA01024589.1	None
genomic	ABBA01024590.1	None
genomic	ABBA01024591.1	None
genomic	ABBA01024592.1	None
genomic	ABBA01024593.1	None
genomic	ABBA01024594.1 (15144..16598)	None
genomic	AC104452.2 (155366..184554)	None
genomic	AC121247.2	None
genomic	AC137114.2 (1999..4001)	None
genomic	AMYH01013156.1 (99076..127048)	None
genomic	AMYH01013157.1	None
genomic	AMYH01013158.1	None
genomic	CH471055.1	EAW64978.1
		EAW64979.1
		EAW64980.1
genomic	CS401488.1	CAL40338.1
genomic	M83094.1	AAA67539.1
mRNA	AF498970.1	AAM21117.1
mRNA	AK130066.1	None
mRNA	AK130808.1	None
mRNA	AK222556.1	BAD96276.1
mRNA	AK296654.1	BAG59251.1
mRNA	AK307220.1	None
mRNA	BC000946.3	AAH00946.2
mRNA	BC001360.2	AAH01360.1
mRNA	BC005976.1	AAH05976.1
mRNA	BT019870.1	AAV38673.1
mRNA	BX647063.1	CAE46190.1
mRNA	L09159.1	AAA50612.1
mRNA	L25080.1	AAC33178.1
mRNA	X05026.1	CAA28690.1
other-genetic	EU831594.1	ACE87194.1
other-genetic	EU831679.1	ACE86513.1