RHOA ras homolog family member A [ Homo sapiens ]

Gene ID: 387, updated on 19-May-2012

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Summary

Official Symbol: RHOAprovided by HGNC
Official Full Name: ras homolog family member Aprovided by HGNC
Primary source: HGNC:667
See related: Ensembl:ENSG00000067560; HPRD:01323; MIM:165390; Vega:OTTHUMG00000156838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARHA; ARH12; RHO12; RHOH12

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Genomic context

Location :: 3p21.3

Sequence :: Chromosome: 3; NC_000003.11 (49396578..49449526, complement)

See RHOA in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that LPS-induced NF-kappaB activation and IL-8 synthesis in endothelial cells are regulated by the MyD88 pathway and GEF-H1-RhoA pathway.
Title: GEF-H1-RhoA signaling pathway mediates LPS-induced NF-κB transactivation and IL-8 synthesis in endothelial cells.
there may be a fundamental alteration in the communication between the external mechanical environment (extracellular forces) and reorganization of the actin cytoskeleton mediated by RhoA in leiomyoma cells.
Title: Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma.
a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17.
Title: A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.
Data show that inhibitors of Stat3, IGF-IR and Rho GTPase were the most promising therapeutic agents for ovarian cancer.
Title: Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets.
Suggest that RhoA/ROCK, cytoskeletal organization, and FAK compose a "signaling network" that senses mechanical stretching and drives mechanical stretch-induced tenogenic differentiation of mesenchymal stem cells.
Title: RhoA/ROCK, cytoskeletal dynamics, and focal adhesion kinase are required for mechanical stretch-induced tenogenic differentiation of human mesenchymal stem cells.
Fasudil can reduce the secretion of downstream inflammatory factors and cytokines by inhibiting high glucose-activated HMCs Rho/ROCK signaling pathway in mesangial cells.
Title: [The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium].
signaling from integrin alpha6beta4 facilitates lysophosphatidic acid- stimulated chemotaxis through preferential activation of RhoA, which, in turn, facilitates activation of Rac1
Title: Integrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation.
Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins.
Title: Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins.
RhoA may serve as a potential biomarker and an attractive therapeutic target for hepatocellular carcinoma.
Title: Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma.
endocannabinoids, through their autocrine activation of CB1 and subsequent repression of RhoA activity, suppress migration in prostate carcinoma cells
Title: Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells.

Submit: New GeneRIF Correction See all (359)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src	PubMed
Vpr	vpr	HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of RhoA expression	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001655.1	NP_065875.2	ARHGAP21	BIND	PubMed	ARHGAP21 interacts with RhoA-GTP, and acts as a GAP to increase RhoA GTPase activity.
NP_001655.1	NP_851852.2	ARHGAP8	BIND	PubMed	BPGAP1 interacts with RhoA.
NP_001655.1	AAH11604.1	CNKSR1	BIND	PubMed	hCNK1 interacts with RhoA. This interaction was modelled on a demonstrated interaction between human CNK1 and RhoA from an unspecified species.
NP_001655.1	NP_071330.2	DEF6	BIND	PubMed	DEF6 interacts with RhoA. This interaction was modelled on a demonstrated interaction between human DEF6 and RhoA from an unspecified species.
NP_001655.1	NP_079255.2	MCF2L	BIND	PubMed	RhoA specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor Dbs. This interaction is modelled on a demonstrated interaction between mouse Dbs and human RhoA.
NP_001655.1	NP_004901.1	PITPNM1	BIND	PubMed	Nir2 interacts with RhoA.
NP_001655.1	NP_149035.1	RTKN	BIND	PubMed	Active, GTP-bound RhoA interacts with the RTKN (Rhotekin) Rho binding domain. This interaction was modelled on a demonstrated interaction between human RhoA and Rhotekin from an unspecified species.
NP_001655.1	NP_149035.1	RTKN	BIND	PubMed	RTKN (rhotekin) interacts with RhoA. This interaction was modeled on a demonstrated interaction between mouse RTKN and human RhoA.
NP_001655.1	NP_149035.1	RTKN	BIND	PubMed	Rhotekin interacts with RhoA-GTP. This interaction was modeled on a demonstrated interaction between Rhotekin from an unspecified species and human Rho-GTP.
NP_001655.1	NP_149035.1	RTKN	BIND	PubMed	RhoA interacts with RTKN (Rhotekin). This interaction was modeled on a demonstrated interaction between RhoA and RTKN from an unspecified species.
NP_001655.1		RTKN	BIND	PubMed	RhoA interacts with Rhotekin. This interaction was modeled on a demonstrated interaction between human RhoA and Rhotekin from an unspecified species.
NP_001655.1	NP_057864.1	tax	BIND	PubMed	Tax interacts with RhoA.
NP_001655.1	CAC39270.1		BIND	PubMed	YopT cleaves RhoA amino-terminal to prenylated Cys190. This interaction was modeled on a demonstrated interaction between Yersinia pseudotuberculosis YopT and RhoA from an unspecified species.
NP_001655.1			BIND	PubMed	RhoA interacts with GTP. This interaction was modelled on a demonstrated interaction between RhoA from an unspecified species and GTP.
P61586	Q12802	AKAP13	HPRD	PubMed
P61586	Q07960	ARHGAP1	HPRD	PubMed
P61586	Rho GTPase activating protein 10	ARHGAP21	HPRD	PubMed
P61586	P52565	ARHGDIA	HPRD	PubMed
P61586	P52566	ARHGDIB	HPRD	PubMed
P61586	Q99819	ARHGDIG	HPRD	PubMed
P61586	O15085	ARHGEF11	HPRD	PubMed
P61586	Q9NZN5	ARHGEF12	HPRD	PubMed
P61586	Rho specific guanine nucleotide exchange factor p114	ARHGEF18	HPRD	PubMed
P61586	Q92974	ARHGEF2	HPRD	PubMed
P61586	RAC/CDC42 exchange factor	ARHGEF25	HPRD	PubMed
P61586	Q9NR81	ARHGEF3	HPRD	PubMed
P61586	Q9NR80	ARHGEF4	HPRD	PubMed
P61586	Q03135	CAV1	HPRD	PubMed
P61586	O14578	CIT	HPRD	PubMed
P61586	Q969H4	CNKSR1	HPRD	PubMed
P61586	P78357	CNTNAP1	HPRD	PubMed
P61586	Q9Y4D1	DAAM1	HPRD	PubMed
P61586	DEF6	DEF6	HPRD	PubMed
P61586	P52824	DGKQ	HPRD	PubMed
P61586	O60610	DIAPH1	HPRD	PubMed
P61586	Q96N67	DOCK7	HPRD	PubMed
P61586	O14641	DVL2	HPRD	PubMed
P61586	P21333	FLNA	HPRD	PubMed
P61586	Q9P107	GMIP	HPRD	PubMed
P61586	Heat shock 70 KD protein 1A	HSPA1A	HPRD	PubMed
P61586	O60725	ICMT	HPRD	PubMed
P61586	Q14643	ITPR1	HPRD	PubMed
P61586	P16389	KCNA2	HPRD	PubMed
P61586	Q86UP2	KTN1	HPRD	PubMed
P61586	P10911	MCF2	HPRD	PubMed
P61586	O15068	MCF2L	HPRD	PubMed
P61586	Myosin phosphatase Rho interacting protein	MPRIP	HPRD	PubMed
P61586	O60890	OPHN1	HPRD	PubMed
P61586	O43924	PDE6D	HPRD	PubMed
P61586	O00562	PITPNM1	HPRD	PubMed
P61586	Q16512	PKN1	HPRD	PubMed
P61586	Q16513	PKN2	HPRD	PubMed
P61586	P19174	PLCG1	HPRD	PubMed
P61586	Q13393	PLD1	HPRD	PubMed
P61586	PLEKHG2	PLEKHG2	HPRD	PubMed
P61586	O14974	PPP1R12A	HPRD	PubMed
P61586	P17612	PRKACA	HPRD	PubMed
P61586	P17252	PRKCA	HPRD	PubMed
P61586	Q05513	PRKCZ	HPRD	PubMed
P61586	Q9UI14	RABAC1	HPRD	PubMed
P61586	P52306	RAP1GDS1	HPRD	PubMed
P61586	Q13972	RASGRF1	HPRD	PubMed
P61586	Rho guanine nucleotide exchange factor	RGNEF	HPRD	PubMed
P61586	P61586	RHOA	HPRD	PubMed
P61586	Q8TCX5	RHPN1	HPRD	PubMed
P61586	Q8IUC4	RHPN2	HPRD	PubMed
P61586	Q13464	ROCK1	HPRD	PubMed
P61586	Q9BST9	RTKN	HPRD	PubMed
P61586	Q9Y3L3	SH3BP1	HPRD	PubMed
P61586	Q9HCE7	SMURF1	HPRD	PubMed
P61586	Q7Z698	SPRED2	HPRD	PubMed
P61586	Q7Z6B7	SRGAP1	HPRD	PubMed
P61586	P36897	TGFBR1	HPRD	PubMed
P61586	P21980	TGM2	HPRD	PubMed
P61586	O75962	TRIO	HPRD	PubMed
P61586	P48995	TRPC1	HPRD	PubMed
P61586	P15498	VAV1	HPRD	PubMed
P61586	P52735	VAV2	HPRD	PubMed
P61586	Q9UKW4	VAV3	HPRD	PubMed
BioGRID:106880	BioGRID:116383	AKAP13	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:106885	ARHGAP1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:122784	ARHGAP10	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:116720	ARHGAP26	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:115091	ARHGAP32	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:109166	ARHGAP35	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:106887	ARHGAP5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:106889	ARHGDIA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-purification; Two-hybrid
BioGRID:106880	BioGRID:106891	ARHGDIG	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:114585	ARHGEF1	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:115164	ARHGEF11	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:116945	ARHGEF12	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:116950	ARHGEF18	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:114618	ARHGEF2	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:125438	ARHGEF25	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:119115	ARHGEF3	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:119114	ARHGEF4	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:107083	BCR	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:107106	BID	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:107293	CASP10	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:107291	CASP8	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:107305	CAV1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:116290	CIT	BioGRID	PubMed	Far Western; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:114078	CNTNAP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:107790	CRMP1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:106880	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:106880	BioGRID:119099	DEF6	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:107979	DGKQ	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:108073	DIAPH1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:108142	DPYSL2	BioGRID	PubMed	Phenotypic Suppression
BioGRID:106880	BioGRID:199221	Diap1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:207965	Diap3	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:113271	EZR	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:46157	F46F6.2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:114302	FADD	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:106851	FAS	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:106852	FASLG	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:109030	GNA12	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:109535	HSPA1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:117026	ICMT	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:109913	ITPR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:109940	KCNA2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:110092	KTN1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:200955	Kin	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:201049	Ktn1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:111585	MAPK8	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:110336	MCF2	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:116865	MCF2L	BioGRID	PubMed	Co-crystal Structure
BioGRID:106880	BioGRID:116776	MPRIP	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:110584	MSN	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:115565	NET1	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:207915	Net1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:111029	OPHN1	BioGRID	PubMed	Biochemical Activity
BioGRID:106880	BioGRID:120751	OTUB1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:106880	BioGRID:111173	PDE6D	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:111571	PKN1	BioGRID	PubMed	Far Western; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:111572	PKN2	BioGRID	PubMed	Far Western; Reconstituted Complex
BioGRID:106880	BioGRID:111351	PLCG1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:111353	PLD1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:122330	PLEKHG2	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:111377	PLXNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:111845	RAP1GDS1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:124521	RHPN2	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:119899	RIPK4	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:112020	ROCK1	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:114860	ROCK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:112156	RTKN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:198192	Rhoa	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106880	BioGRID:202950	Rock1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106880	BioGRID:36640	SKN7	BioGRID	PubMed	Two-hybrid
BioGRID:106880	BioGRID:121411	SMURF1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:106880	BioGRID:122265	SMURF2	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:121583	SRGAP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106880	BioGRID:112865	TEC	BioGRID	PubMed	Reconstituted Complex
BioGRID:106880	BioGRID:114323	TNFRSF10B	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:112986	TNFRSF1A	BioGRID	PubMed	Co-purification
BioGRID:106880	BioGRID:113055	TRIO	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:106880	BioGRID:113071	TRPC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:106880	BioGRID:115715	VAV3	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	TAS Traceable Author Statement more info	PubMed
myosin binding	IPI Inferred from Physical Interaction more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
GTP catabolic process	TAS Traceable Author Statement more info	PubMed
Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
apical junction assembly	IMP Inferred from Mutant Phenotype more info
axon guidance	TAS Traceable Author Statement more info
blood coagulation	TAS Traceable Author Statement more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cell morphogenesis	IEA Inferred from Electronic Annotation more info
cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
negative regulation of axonogenesis	TAS Traceable Author Statement more info
negative regulation of intracellular steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of neuron apoptosis	IEA Inferred from Electronic Annotation more info
nerve growth factor receptor signaling pathway	TAS Traceable Author Statement more info
ossification involved in bone maturation	ISS Inferred from Sequence or Structural Similarity more info
phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info
platelet activation	TAS Traceable Author Statement more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of NF-kappaB import into nucleus	NAS Non-traceable Author Statement more info	PubMed
positive regulation of axonogenesis	TAS Traceable Author Statement more info
positive regulation of cell cycle cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
regulation of axonogenesis	TAS Traceable Author Statement more info
regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info
spindle assembly involved in mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
trabecula morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
apical junction complex	IDA Inferred from Direct Assay more info
cell cortex	IDA Inferred from Direct Assay more info	PubMed
cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
intracellular	IEA Inferred from Electronic Annotation more info
midbody	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info
ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: transforming protein RhoA

Names: transforming protein RhoA; h12; oncogene RHO H12; rho cDNA clone 12; Aplysia ras-related homolog 12; small GTP binding protein RhoA; ras homolog gene family, member A

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001664.2 → NP_001655.1 transforming protein RhoA precursor

Status: VALIDATED

Source sequence(s)

AK130066, BC000946

Consensus CDS

CCDS2795.1

UniProtKB/Swiss-Prot

P61586

UniProtKB/TrEMBL

Q9BVT0

Related

ENSP00000400175, OTTHUMP00000210767, ENST00000418115, OTTHUMT00000346157

Conserved Domains (1) summary

cd01870
Location:5 – 179
Blast Score: 1011

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

49396578..49449526, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

49456057..49509248, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC104452.2 (155365..184553)	None
genomic	AC121247.2	None
genomic	AC137114.2 (1998..4000)	None
genomic	CH471055.1	EAW64978.1
		EAW64979.1
		EAW64980.1
genomic	CS401488.1	CAL40338.1
genomic	M83094.1	AAA67539.1
mRNA	AF498970.1	AAM21117.1
mRNA	AK130066.1	None
mRNA	AK130808.1	None
mRNA	AK222556.1	BAD96276.1
mRNA	AK296654.1	BAG59251.1
mRNA	AK307220.1	None
mRNA	BC000946.3	AAH00946.2
mRNA	BC001360.2	AAH01360.1
mRNA	BC005976.1	AAH05976.1
mRNA	BT019870.1	AAV38673.1
mRNA	BX647063.1	CAE46190.1
mRNA	L09159.1	AAA50612.1
mRNA	L25080.1	AAC33178.1
mRNA	X05026.1	CAA28690.1
other-genetic	EU831594.1	ACE87194.1
other-genetic	EU831679.1	ACE86513.1