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CD83 CD83 molecule [ Homo sapiens (human) ]

Gene ID: 9308, updated on 24-Aug-2015
Official Symbol
CD83provided by HGNC
Official Full Name
CD83 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1703
See related
Ensembl:ENSG00000112149; HPRD:05170; MIM:604534; Vega:OTTHUMG00000014283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BL11; HB15
Summary
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Orthologs
See CD83 in Epigenomics, MapViewer
Location:
6p23
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (14117256..14136918)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (14117487..14137149)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 182 Neighboring gene mitochondrial ribosomal protein L35 pseudogene 1 Neighboring gene uncharacterized LOC105374939 Neighboring gene uncharacterized LOC105374940 Neighboring gene long intergenic non-protein coding RNA 1108

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of CD83 (BL11, HB15) in human B cells PubMed
env Inhibition of CpG-B-induced maturation of plasmacytoid dendritic cells by HIV-1 gp120 results in downregulation of CD40, CD83, CCR7, and HLA-DR expression PubMed
env HIV-1 gp120 inhibits TLR9-mediated upregulation of CD83 and the secretion of inflammatory cytokines TNF-alpha and IL-6, and chemokine IP10 in plasmacytoid dendritic cells (pDC) PubMed
env The presence of HIV-1 gp120 inhibits the oral mucosal pathogen Porphyromonas gingivalis-induced CD80, CD83, and CD86 upregulation PubMed
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD83 PubMed
nef HIV-1 Nef induces upregulation of CD80, CD83, and CD86 protein expression in a concentration dependent fashion in monocyte derived dendritic cells PubMed
Pr55(Gag) gag Expression of CD80, CD83, CD86, and HLA-DR molecules are significantly downregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs PubMed
Tat tat HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses PubMed
Vpr vpr HIV-1 Vpr inhibits the expression of co-stimulatory molecules including CD80, CD83, and CD86 at the transcriptional level without altering normal cellular transcription during dendritic cell maturation PubMed
vpr HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC) PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD83 PubMed

Go to the HIV-1, Human Interaction Database

  • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
defense response TAS
Traceable Author Statement
more info
PubMed 
humoral immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of CD4-positive, alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
CD83 antigen
Names
B-cell activation protein
CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)
cell surface protein HB15
cell-surface glycoprotein
hCD83

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030372.1 RefSeqGene

    Range
    5001..24663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040280.1NP_001035370.1  CD83 antigen isoform b precursor

    See identical proteins and their annotated locations for NP_001035370.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AK223315, AL133259, BC030830, DB178710
    UniProtKB/Swiss-Prot
    Q01151
    Conserved Domains (2) summary
    smart00410
    Location:21126
    IG_like; Immunoglobulin like
    cl11960
    Location:29129
    Ig; Immunoglobulin domain
  2. NM_001251901.1NP_001238830.1  CD83 antigen isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL133259, BC030830, DA532022
    Consensus CDS
    CCDS75403.1
    UniProtKB/TrEMBL
    A0A087WX61
    UniProtKB/Swiss-Prot
    Q01151
    Related
    ENSP00000480760, ENST00000612003
  3. NM_004233.3NP_004224.1  CD83 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_004224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL133259, BC030830, DB178710
    Consensus CDS
    CCDS4532.1
    UniProtKB/Swiss-Prot
    Q01151
    Related
    ENSP00000368450, OTTHUMP00000016057, ENST00000379153, OTTHUMT00000039916
    Conserved Domains (2) summary
    smart00410
    Location:21126
    IG_like; Immunoglobulin like
    cl11960
    Location:29129
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    14117256..14136918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    14119656..14139317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)