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    RB1 retinoblastoma 1 [ Homo sapiens (human) ]

    Gene ID: 5925, updated on 19-May-2013
    Official Symbol
    RB1provided by HGNC
    Official Full Name
    retinoblastoma 1provided by HGNC
    Primary source
    HGNC:9884
    Locus tag
    RP11-174I10.1
    See related
    Ensembl:ENSG00000139687; HPRD:01574; MIM:614041; Vega:OTTHUMG00000016900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RB; pRb; OSRC; pp110; p105-Rb
    Summary
    The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
    Location :
    13q14.2
    Sequence :
    Chromosome: 13; NC_000013.10 (48877883..49056026)
    See RB1 in Epigenomics, MapViewer

    Chromosome 13 - NC_000013.10Genomic Context describing neighboring genes Neighboring gene integral membrane protein 2B Neighboring gene long intergenic non-protein coding RNA 441 Neighboring gene protein phosphatase 1, regulatory subunit 26 pseudogene 1 Neighboring gene PEST containing nuclear protein pseudogene 5 Neighboring gene lysophosphatidic acid receptor 6 Neighboring gene uncharacterized LOC100996412 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 Neighboring gene uncharacterized LOC100996416 Neighboring gene long intergenic non-protein coding RNA 462

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Ubiquitin-independent proteasomal degradation of tumor suppressors by human cytomegalovirus pp71 requires the 19S regulatory particle. Winkler LL, et al. J Virol, 2013 Apr. PMID 23408605.
    2. miR-106a overexpression and pRB downregulation in sporadic colorectal cancer. Catela Ivkovic T, et al. Exp Mol Pathol, 2013 Feb. PMID 23178825.
    3. The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells. Collard TJ, et al. Cell Death Dis, 2012 Oct 11. PMID 23059827.
    4. Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: cancer cell expression of HLA-DR. Pillai S, et al. Gene, 2013 Jan 10. PMID 23041127.
    5. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Yatim A, et al. Mol Cell, 2012 Nov 9. PMID 23022380.

    See all (815) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Authors show that only the proteasome 19S regulatory particle that normally participates in ubiquitin-dependent protein degradation, is required for human herpesvirus 5 pp71-mediated degradation of Rb and Daxx.
      Title: Ubiquitin-independent proteasomal degradation of tumor suppressors by human cytomegalovirus pp71 requires the 19S regulatory particle.
    2. Studies indicate that retinoblastoma (RB) protein might possess many multifaceted and unique functions.
      Title: Twists in views on RB functions in cellular signaling, metabolism and stem cells.
    3. Studies indicate that the Ser/Thr phosphatases PP1 and PP2A are responsible for the dephosphorylation and activation of Rb proteins.
      Title: PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation.
    4. results suggest that miR-106a might have a regulatory role for Rb1 in sporadic colorectal cancer
      Title: miR-106a overexpression and pRB downregulation in sporadic colorectal cancer.
    5. RB1 deletions are associated with relapse in multiple myeloma.
      Title: Minor clone provides a reservoir for relapse in multiple myeloma.
    6. Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition.
      Title: Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition.
    7. the Rb gene regulatory network (GRN) subcircuit that regulates cell proliferation is linked to a GRN subcircuit regulating a tumor cell immune function.
      Title: Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: cancer cell expression of HLA-DR.
    8. Although the retinoblastoma protein (Rb) is known to regulate the growth of keratinocytes in a cell-autonomous manner, here we describe a function of Rb in the stromal compartment.
      Title: Regulation of epithelial differentiation and proliferation by the stroma: a role for the retinoblastoma protein.
    9. There are specific interactions among Rb, HDAC1 and E2F1 proteins in gallbladder carcinoma, indicating the existence of the direct Rb/E2F1/HDAC1 signal transduction pathway. p16 does not interact with any of these proteins.
      Title: Interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma.
    10. Rb1 germline mutations may contribute to genetic susceptibility for head and neck cancer.
      Title: Rb1/105 gene alterations and head and neck carcinogenesis.
    Submit: New GeneRIF Correction See all (433)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Retinoblastoma

    Summary from GeneReviews: Retinoblastoma Go to GeneReviews

    Disease Characteristics
    Retinoblastoma (Rb) is a malignant tumor of the developing retina that occurs in children, usually before age five years. Rb occurs in cells that have cancer-predisposing mutations in both copies of the gene RB1. Rb may be unifocal or multifocal. About 60% of affected individuals have unilateral Rb with a mean age of diagnosis of 24 months; about 40% have bilateral Rb with a mean age of diagnosis of 15 months. Individuals heterozygous for a cancer-predisposing mutation in one RB1 allele are said to have a germline mutation and thus have a heritable predisposition to Rb. They also have an increased risk of developing non-ocular tumors.
    Diagnosis Testing
    The clinical diagnosis of retinoblastoma is usually established by examination of the fundus of the eye using indirect ophthalmoscopy. Imaging studies can be used to support the diagnosis and stage the tumor. RB1 is the only gene in which mutations are known to cause heritable predisposition to retinoblastoma. Molecular genetic testing of RB1 in white blood cell DNA is available in clinical laboratories and can identify a germline mutation in more than 95% of individuals with a heritable predisposition to Rb. The probability that an RB1 gene mutation will be detected in white blood cell DNA of an index case depends on whether the tumor is bilateral or unilateral, whether the family history is positive or negative, and the sensitivity of the testing methodology.
    Genetic Counseling
    Heritable predisposition to retinoblastoma is caused by germline mutations in RB1 and is transmitted in an autosomal dominant manner. The risks to family members of a proband with Rb depend on whether or not the proband has a germline RB1 mutation. Molecular genetic testing of DNA from the proband's white blood cells (or other non-tumorous cells), as well as from the tumor, may detect the cancer-predisposing RB1 mutation. If a cancer-predisposing RB1 mutation is identified in the proband's white blood cells, mutation analysis can clarify the genetic status of at-risk sibs and offspring. If RB1 molecular genetic testing is not available or is uninformative, indirect testing using polymorphic loci linked to RB1 can be used in familial Rb to estimate the genetic status of at-risk family members. Empiric recurrence risk estimates can be used in families in which molecular genetic testing of RB1 and linkage analysis are unavailable or uninformative. Prenatal testing is possible if the heritable RB1 mutation in the parent is known or if RB1 linkage analysis is informative in the family.
    References
    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
    env The V3 loop of HIV-1 gp120 induces G1 arrest in IL-2-dependent cell cycle progression by reducing cyclin E expression and phosphorylation of retinoblastoma protein (pRb) PubMed
    Nef, p27 nef HIV-1 Nef is implicated in the upregulation of Cyclin D1, and subsequently phospho-pRb (Ser780), in infected podocytes and may be involved in the pathogenesis of HIV-associated nephropathy PubMed
    Tat, p14 tat Tat-expressing EBV-positive B cells show downregulation of Bcl-2, and in serum starvation conditions display the Retinoblastoma (Rb) hyper-phosphorylated form, progress throughout the cell cycle, and retain the ability to grow in small clumps PubMed
    tat HIV-1 Tat induces a G1 arrest in cells of glial origin, leading to a downregulation of cyclin E-Cdk2 kinase activity and phosphorylation of Rb PubMed
    tat Co-expression of the human retinoblastoma gene in HeLa cells with HIV-1 Tat inhibits the Tat mediated transactivation of the HIV-1 LTR promoter PubMed
    tat The under-phosphorylated form of Rb that is prevalent in HIV-1 Tat treated glial cells activates HIV-1 transcription by a mechanism involving the NFkappaB enhancer in the viral LTR promoter, likely through promoting the interaction of Rb with E2F-1 PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000312.1 AAD52016.1 AATF    BIND  PubMed Che-1 interacts with Rb. 
    NP_000312.1 NP_005148.1 ABL1    BIND  PubMed Rb interacts with c-Abl 
    NP_000312.1 NP_000035.2 AR    BIND  PubMed Rb interacts with AR. 
    NP_000312.1 NP_001871.2 ATF2    BIND  PubMed Rb interacts with ATF2. This interaction was modelled on a demonstrated interaction between Rb from an unspecified species and ATF2 from an unspecified species. 
    NP_000312.1 NP_060899.1 BDP1    BIND  PubMed Rb interacts with TFIIIB90 
    NP_000312.1 NC_000001.8 BGLAP    BIND  PubMed pRB interacts with OC promoter. 
    NP_000312.1 U75285.1 BIRC5    BIND  PubMed RB1 (pRB) interacts with the BIRC5 (survivin) promoter. 
    NP_000312.1 BAA90908.1 BNC2    BIND  PubMed pRB interacts with BAA90908. 
    NP_000312.1 NP_009227.1 BRCA1    BIND  PubMed BRCA1 interacts with Rb. 
    NP_000312.1 NC_000006.9 BRD2    BIND  PubMed pRB interacts with BRD2 promoter. 
    NP_000312.1 NC_000005.8 BRD8    BIND  PubMed pRB interacts with BRD8 promoter. 
    NP_000312.1 NP_001221.2 CASP10    BIND  PubMed CASP10 (caspase-10) cleaves RB-1 (hRB) at the DSID consensus site to produce the p68 form. 
    NP_000312.1 P42575 CASP2    BIND  PubMed CASP2 (caspase-2) cleaves RB-1 (hRB) at the DEAD consensus site into the p100 form. 
    NP_000312.1 NP_116786.1 CASP3    BIND  PubMed CASP3 (caspase-3) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p100, p68, p61 and p48 forms. 
    NP_000312.1 NP_001217.2 CASP6    BIND  PubMed CASP6 (caspase-6) cleaves RB-1 (hRB) at the DSID consensus site to produce the p68 form. 
    NP_000312.1 NP_203125.1 CASP7    BIND  PubMed CASP7 (caspase-7) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p68, p61 and p48 forms. 
    NP_000312.1 Q14790 CASP8    BIND  PubMed CASP8 (caspase-8) cleaves RB-1 (hRB) into the p68 form and to a lesser extent the p61 form. 
    NP_000312.1 NP_001220.2 CASP9    BIND  PubMed CASP9 (caspase-9) cleaves RB-1 (hRB) at the LEND consensus site to produce the p76 form. 
    NP_000312.1 NP_444284.1 CCND1    BIND  PubMed Rb interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between Cyclin D1 from mouse and Rb from human. 
    NP_000312.1 NP_001789.2 CDK2    BIND  PubMed CDK2 phosphorylates Rb carboxy-terminus. 
    NP_000312.1 NP_000066.1 CDK4    BIND  PubMed CDK4 phosphorylates Rb carboxy-terminus. This interaction was modelled on a demonstrated interaction between human Rb and mouse CDK4. 
    NP_000312.1 NP_001250.1 CDK6    BIND  PubMed Cdk6 phosphorylates Rb 
    NP_000312.1 NP_001250.1 CDK6    BIND  PubMed CDK6 phosphorylates Rb. This interaction was modeled on a demonstrated interaction between CDK6 and Rb, both from an unspecified species. 
    NP_000312.1 NC_000006.9 CDKN1A    BIND  PubMed Rb interacts with the p21 promoter. 
    NP_000312.1 NP_005186.2 CEBPD    BIND  PubMed C/EBP-delta interacts with Rb. 
    NP_000312.1 NP_001796.2 CEBPE    BIND  PubMed Rb interacts with C/EBPepsilon. 
    NP_000312.1 NP_001370.1 DNMT1    BIND  PubMed Rb interacts with hDnmt1. 
    NP_000312.1 E1A    BIND  PubMed RB1 (pRb) interacts with an unspecified isoform of the Adenovirus E1A protein. 
    NP_000312.1 NP_005216.1 E2F1    BIND  PubMed pRB interacts with E2F-1. 
    NP_000312.1 NP_005216.1 E2F1    BIND  PubMed pRb interacts with E2F1. 
    NP_000312.1 NP_005216.1 E2F1    BIND  PubMed pRB interacts with E2F1. 
    NP_000312.1 NP_005216.1 E2F1    BIND  PubMed Rb interacts with E2F 
    NP_000312.1 NP_005216.1 E2F1    BIND  PubMed E2F1 (RBP3) interacts with pRB. 
    NP_000312.1 NP_005216.1 E2F1    BIND  PubMed Rb interacts with E2F-1. 
    NP_000312.1 NP_004082.1 E2F2    BIND  PubMed pRB interacts with E2F-2. 
    NP_000312.1 NP_004082.1 E2F2    BIND  PubMed E2F-2 interacts with pRb. 
    NP_000312.1 NP_004082.1 E2F2    BIND  PubMed E2F1 interacts with pRb. 
    NP_000312.1 NP_055150.1 EID1    BIND  PubMed RB1 (pRb) interacts with CRI1 (EID-1). 
    NP_000312.1 NP_055150.1 EID1    BIND  PubMed pRB interacts with EID-1. 
    NP_000312.1 L16588.1 EPO    BIND  PubMed RB1 (pRB) interacts with the EPO gene 3(prime) enhancer. 
    NP_000312.1 NP_002022.1 FRK    BIND  PubMed pRB interacts with Rak. 
    NP_000312.1 NP_006089.1 GNB2L1    BIND  PubMed RACK1 interacts with Rb 
    NP_000312.1 NP_001512.1 GTF3C2    BIND  PubMed Rb interacts with TFIIIC2 
    NP_000312.1 NP_004955.2 HDAC1    BIND  PubMed RB interacts with HDAC1. 
    NP_000312.1 NP_004955.2 HDAC1    BIND  PubMed The Retinoblastoma protein interacts with Histone Deacetylase 1. 
    NP_000312.1 NP_001521.1 HIF1A    BIND  PubMed RB1 (pRB) interacts with HIF1A (HIF-1-alpha). 
    NP_000312.1 NP_002119.1 HMGB1    BIND  PubMed HMGB1 interacts with RB1 (pRB). This interaction was modelled on a demonstrated interaction between rat HMGB1 and human RB1 (pRB). 
    NP_000312.1 NP_002219.1 JUN    BIND  PubMed RB interacts with c-Jun. 
    NP_000312.1 NP_003875.3 KAT2B    BIND  PubMed pRb interacts with the acetyltransferase domain of P/CAF. 
    NP_000312.1 NP_005047.1 KDM5A    BIND  PubMed pRB interacts with RBP2. 
    NP_000312.1 NP_005047.1 KDM5A    BIND  PubMed Rbp2 interacts with Rb. This interaction was modeled on a demonstrated interaction between human Rbp2 and Rb from an unspecified species. 
    NP_000312.1 NP_061977.1 LIN37    BIND  PubMed pRb interacts with hMip40. 
    NP_000312.1 NP_919258.1 LIN54    BIND  PubMed pRb interacts with hMip120. 
    NP_000312.1 AAH65302.1 LIN9    BIND  PubMed pRb interacts with hMip130/TWIT. 
    NP_000312.1 NP_005563.1 LMNA    BIND  PubMed Rb interacts with lamin C 
    NP_000312.1 MAPK1    BIND  PubMed RB1 is phosphorylated by MAPK1. This interaction was modeled on a demonstrated interaction between human KIAA1536 and MAPK1 from an unspecified species. 
    NP_000312.1 NP_002743.3 MAPK9    BIND  PubMed Rb interacts with JNK2. This interaction was modelled on a demonstrated interaction between Rb from an unspecified species and JNK2 from an unspecified species. 
    NP_000312.1 BAA09534.1 MCM7    BIND  PubMed MCM7 interacts with Rb. 
    NP_000312.1 NP_002383.1 MDM2    BIND  PubMed Rb interacts with MDM2. 
    NP_000312.1 MDM2    BIND  PubMed Rb interacts with Mdm2. 
    NP_000312.1 NP_002384.1 MDM4    BIND  PubMed pRb interacts with MDMX. This interaction was modeled on a demonstrated interaction between mouse MDMX and human pRb. 
    NP_000312.1 MITF    BIND  PubMed An unspecified isoform of Mitf interacts with Rb. 
    NP_000312.1 J03910.1 MT1G    BIND  PubMed RB1 interacts with the MT1G promoter. 
    NP_000312.1 NP_054790.2 NCOA6    BIND  PubMed Rb interacts with ASC-2. 
    NP_000312.1 AAC17708.2 PELP1    BIND  PubMed PELP1 interacts with pRb. 
    NP_000312.1 NP_852556.2 PIK3R1    BIND  PubMed Rb interacts with p55alpha 
    NP_000312.1 NP_003620.1 PIK3R3    BIND  PubMed Rb interacts with PI3K regulatory subunit p55gamma 
    NP_000312.1 NP_066953.1 PPIA    BIND  PubMed Rb interacts with CypA. 
    NP_000312.1 NP_002871.1 RAF1    BIND  PubMed Raf-1 interacts with Rb. 
    NP_000312.1 NP_005601.1 RBBP4    BIND  PubMed The retinoblastoma protein 1 (Rb) interacts with RbAp48 
    NP_000312.1 NP_002884.1 RBBP7    BIND  PubMed The retinoblastoma protein, Rb, interacts with RbAp46. 
    NP_000312.1 NC_000011.8 RBL1    BIND  PubMed Rb interacts with the p107 promoter. 
    NP_000312.1 NP_004339.1 RUNX2    BIND  PubMed Runx2 interacts with pRb. 
    NP_000312.1 NP_002566.1 SERPINB2    BIND  PubMed Rb interacts with PAI-2. 
    NP_000312.1 SKP2    BIND  PubMed Skp2 interacts with Rb. 
    NP_000312.1 NP_003073.1 SNAPC1    BIND  PubMed Rb interacts with SNAP43 
    NP_000312.1 NP_003075.1 SNAPC3    BIND  PubMed Rb interacts with SNAP50 
    NP_000312.1 NP_043127.1 SV40gp6    BIND  PubMed pRB interacts with SV40 T antigen. 
    NP_000312.1 NP_620278.1 TAF1    BIND  PubMed TAFII250 interacts with Rb. 
    NP_000312.1 NP_003185.1 TBP    BIND  PubMed Rb interacts with TBP 
    NP_000312.1 NP_003267.1 TMPO    BIND  PubMed Rb interacts with LAP2alpha 
    NP_000312.1 NC_000011.8 TYR    BIND  PubMed Rb interacts with the TYR promoter. 
    NP_000312.1 UBE2I    BIND  PubMed RB1 (pRb) interacts with, and is sumoylated by, an unspecified isoform of UBE2I (Ubc9). 
    NP_000312.1 NP_783796.1 UL122    BIND  PubMed IE2 86 interacts with Rb. 
    NP_000312.1 AF095785.1 VEGFA    BIND  PubMed RB1 (pRB) interacts with the VEGF promoter. 
    NP_000312.1 NP_001018011.1 ZBTB16    BIND  PubMed pRB interacts with PLZF. 
    NP_000312.1     BIND  PubMed The Cyclin E-Cdk2 complex phosphorylates Rb 
    NP_000312.1     BIND  PubMed The Cyclin B1-Cdc2 complex phosphorylates Rb 
    NP_000312.1     BIND  PubMed The Cyclin A-Cdk2 complex phosphorylates Rb 
    NP_000312.1     BIND  PubMed Cyclin E-CDK2 complex interacts with and phosphorylates RB1 (Rb). 
    NP_000312.1     BIND  PubMed CCND1-CDK4 complex interacts with and phosphorylates RB1 (Rb). 
    NP_000312.1     BIND  PubMed A complex consiting of two subunits including cyclin C and cdk3 interacts with Rb. 
    P06400 Q9NY61 AATF    HPRD  PubMed  
    P06400 P00519 ABL1    HPRD  PubMed  
    P06400 P35869 AHR    HPRD  PubMed  
    P06400 P10275 AR    HPRD  PubMed  
    P06400 ARID3B ARID3B    HPRD  PubMed  
    P06400 P15336 ATF2    HPRD  PubMed  
    P06400 Q99933 BAG1    HPRD  PubMed  
    P06400 Transcription factor like nuclear regulator BDP1    HPRD  PubMed  
    P06400 Q6ZN30 BNC2    HPRD  PubMed  
    P06400 P38398 BRCA1    HPRD  PubMed  
    P06400 Q92994 BRF1    HPRD  PubMed  
    P06400 Q92851 CASP10    HPRD  PubMed  
    P06400 P42575 CASP2    HPRD  PubMed  
    P06400 P42574 CASP3    HPRD  PubMed  
    P06400 P55212 CASP6    HPRD  PubMed  
    P06400 P55210 CASP7    HPRD  PubMed  
    P06400 Q14790 CASP8    HPRD  PubMed  
    P06400 P55211 CASP9    HPRD  PubMed  
    P06400 O00257 CBX4    HPRD  PubMed  
    P06400 P78396 CCNA1    HPRD  PubMed  
    P06400 P24385 CCND1    HPRD  PubMed  
    P06400 P30279 CCND2    HPRD  PubMed  
    P06400 O60583 CCNT2    HPRD  PubMed  
    P06400 P30260 CDC27    HPRD  PubMed  
    P06400 P06493 CDK1    HPRD  PubMed  
    P06400 O94921 CDK14    HPRD  PubMed  
    P06400 P24941 CDK2    HPRD  PubMed  
    P06400 P11802 CDK4    HPRD  PubMed  
    P06400 Q00534 CDK6    HPRD  PubMed  
    P06400 P50750 CDK9    HPRD  PubMed  
    P06400 P38936 CDKN1A    HPRD  PubMed  
    P06400 P49715 CEBPA    HPRD  PubMed  
    P06400 P17676 CEBPB    HPRD  PubMed  
    P06400 P49716 CEBPD    HPRD  PubMed  
    P06400 Q15744 CEBPE    HPRD  PubMed  
    P06400 O75629 CREG1    HPRD  PubMed  
    P06400 Q13363 CTBP1    HPRD  PubMed  
    P06400 P39880 CUX1    HPRD  PubMed  
    P06400 Q13574 DGKZ    HPRD  PubMed  
    P06400 P26358 DNMT1    HPRD  PubMed  
    P06400 Q01094 E2F1    HPRD  PubMed  
    P06400 Q14209 E2F2    HPRD  PubMed  
    P06400 O00716 E2F3    HPRD  PubMed  
    P06400 Q16254 E2F4    HPRD  PubMed  
    P06400 E4F transcription factor 1 E4F1    HPRD  PubMed  
    P06400 EID1 EID1    HPRD  PubMed  
    P06400 P32519 ELF1    HPRD  PubMed  
    P06400 O14682 ENC1    HPRD  PubMed  
    P06400 Q09472 EP300    HPRD  PubMed  
    P06400 P01100 FOS    HPRD  PubMed  
    P06400 P42685 FRK    HPRD  PubMed  
    P06400 P63244 GNB2L1    HPRD  PubMed  
    P06400 Q8WUA4 GTF3C2    HPRD  PubMed  
    P06400 O60381 HBP1    HPRD  PubMed  
    P06400 Q13547 HDAC1    HPRD  PubMed  
    P06400 O15379 HDAC3    HPRD  PubMed  
    P06400 P09429 HMGB1    HPRD  PubMed  
    P06400 P11142 HSPA8    HPRD  PubMed  
    P06400 Q02363 ID2    HPRD  PubMed  
    P06400 P01308 INS    HPRD  PubMed  
    P06400 P05412 JUN    HPRD  PubMed  
    P06400 P29375 KDM5A    HPRD  PubMed  
    P06400 PLU 1 KDM5B    HPRD  PubMed  
    P06400 Q9Y468 L3MBTL1    HPRD  PubMed  
    P06400 Q5TKA1 LIN9    HPRD  PubMed  
    P06400 P02545 LMNA    HPRD  PubMed  
    P06400 P28482 MAPK1    HPRD  PubMed  
    P06400 P45984 MAPK9    HPRD  PubMed  
    P06400 P33993 MCM7    HPRD  PubMed  
    P06400 Q00987 MDM2    HPRD  PubMed  
    P06400 O15151 MDM4    HPRD  PubMed  
    P06400 P51948 MNAT1    HPRD  PubMed  
    P06400 P41218 MNDA    HPRD  PubMed  
    P06400 Q9UBU8 MORF4L1    HPRD  PubMed  
    P06400 Q15014 MORF4L2    HPRD  PubMed  
    P06400 P01106 MYC    HPRD  PubMed  
    P06400 P15172 MYOD1    HPRD  PubMed  
    P06400 Q14686 NCOA6    HPRD  PubMed  
    P06400 O14777 NDC80    HPRD  PubMed  
    P06400 Q9UQ80 PA2G4    HPRD  PubMed  
    P06400 Q02962 PAX2    HPRD  PubMed  
    P06400 Q02548 PAX5    HPRD  PubMed  
    P06400 Q8IZL8 PELP1    HPRD  PubMed  
    P06400 P35232 PHB    HPRD  PubMed  
    P06400 P27986 PIK3R1    HPRD  PubMed  
    P06400 Q92569 PIK3R3    HPRD  PubMed  
    P06400 P29590 PML    HPRD  PubMed  
    P06400 P09884 POLA1    HPRD  PubMed  
    P06400 P62937 PPIA    HPRD  PubMed  
    P06400 P62136 PPP1CA    HPRD  PubMed  
    P06400 P62140 PPP1CB    HPRD  PubMed  
    P06400 P36873 PPP1CC    HPRD  PubMed  
    P06400 Q13029 PRDM2    HPRD  PubMed  
    P06400 P05771 PRKCB    HPRD  PubMed  
    P06400 O75569 PRKRA    HPRD  PubMed  
    P06400 P55345 PRMT2    HPRD  PubMed  
    P06400 O75832 PSMD10    HPRD  PubMed  
    P06400 Q00577 PURA    HPRD  PubMed  
    P06400 P04049 RAF1    HPRD  PubMed  
    P06400 P06400 RB1    HPRD  PubMed  
    P06400 RB associated KRAB repressor RBAK    HPRD  PubMed  
    P06400 Q09028 RBBP4    HPRD  PubMed  
    P06400 Q15291 RBBP5    HPRD  PubMed  
    P06400 Q16576 RBBP7    HPRD  PubMed  
    P06400 Q99708 RBBP8    HPRD  PubMed  
    P06400 O75884 RBBP9    HPRD  PubMed  
    P06400 Q06587 RING1    HPRD  PubMed  
    P06400 O75150 RNF40    HPRD  PubMed  
    P06400 Q13950 RUNX2    HPRD  PubMed  
    P06400 P05120 SERPINB2    HPRD  PubMed  
    P06400 Q13309 SKP2    HPRD  PubMed  
    P06400 P51532 SMARCA4    HPRD  PubMed  
    P06400 Q12824 SMARCB1    HPRD  PubMed  
    P06400 Q16533 SNAPC1    HPRD  PubMed  
    P06400 Q92966 SNAPC3    HPRD  PubMed  
    P06400 Q13573 SNW1    HPRD  PubMed  
    P06400 P08047 SP1    HPRD  PubMed  
    P06400 Q02447 SP3    HPRD  PubMed  
    P06400 P17947 SPI1    HPRD  PubMed  
    P06400 Q01892 SPIB    HPRD  PubMed  
    P06400 O43463 SUV39H1    HPRD  PubMed  
    P06400 Q9BRZ6 SUV420H2    HPRD  PubMed  
    P06400 P21675 TAF1    HPRD  PubMed  
    P06400 P20226 TBP    HPRD  PubMed  
    P06400 P05549 TFAP2A    HPRD  PubMed  
    P06400 P21980 TGM2    HPRD  PubMed  
    P06400 Q96FV9 THOC1    HPRD  PubMed  
    P06400 P42166 TMPO    HPRD  PubMed  
    P06400 P11388 TOP2A    HPRD  PubMed  
    P06400 Q12931 TRAP1    HPRD  PubMed  
    P06400 P14373 TRIM27    HPRD  PubMed  
    P06400 Q15643 TRIP11    HPRD  PubMed  
    P06400 P17480 UBTF    HPRD  PubMed  
    P06400 Q13107 USP4    HPRD  PubMed  
    P06400 Q05516 ZBTB16    HPRD  PubMed  
    BioGRID:111860 BioGRID:117743 AATF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:106699 AHR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:118937 ANAPC2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:111860 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:115865 ARID3B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:111861 ARID4A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:106898 ARNT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:107776 ATF2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:114646 AURKB    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111860 BioGRID:107049 BAG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:107083 BCR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:111860 BioGRID:109227 BRF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:107293 CASP10    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107289 CASP6    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107290 CASP7    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107291 CASP8    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107292 CASP9    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:116151 CBX1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:114105 CBX4    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:111860 BioGRID:117030 CBX5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:114417 CCNA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:107331 CCNA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107332 CCNB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:111860 BioGRID:107334 CCND2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107336 CCND3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111860 BioGRID:107338 CCNE1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107344 CCNT2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:114400 CDC16    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:111860 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:107420 CDK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:111239 CDK14    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107453 CDK3    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107454 CDK4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111860 BioGRID:107455 CDK5    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107456 CDK6    BioGRID  PubMed Biochemical Activity 
    BioGRID:111860 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-fractionation; Reconstituted Complex 
    BioGRID:111860 BioGRID:107479 CEBPA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111860 BioGRID:107480 CEBPB    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:107481 CEBPD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:107536 CHEK1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:111860 BioGRID:116369 CHEK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111860 BioGRID:114332 CREG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:107903 CUX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:114095 DGKZ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:115582 DNAJA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:111860 BioGRID:108125 DNMT3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:108202 E2F2    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:111860 BioGRID:108203 E2F3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:108206 E2F4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111860 BioGRID:108209 E4F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:971805 EBNA-3B/EBNA-3C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:117243 EID1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:114079 ENC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:6954 FIE    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:108636 FOS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:108594 FOXM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:108726 FRK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:119489 FZR1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:111860 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:109220 GTF2H1    BioGRID  PubMed Co-fractionation 
    BioGRID:111860 BioGRID:109230 GTF3C1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:117927 HBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Negative Genetic; Reconstituted Complex 
    BioGRID:111860 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:125732 HIST4H4    BioGRID  PubMed Co-localization 
    BioGRID:111860 BioGRID:113763 HMGA2    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:109389 HMGB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:109624 ID2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:109842 INS    BioGRID  PubMed Co-purification 
    BioGRID:111860 BioGRID:109869 IRF3    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111860 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; Biochemical Activity 
    BioGRID:111860 BioGRID:116667 KDM1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:115035 KDM4A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111860 BioGRID:111862 KDM5A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:115984 KDM5B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:117486 L3MBTL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:123753 L3MBTL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:114384 LDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:126328 LIN54    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:130420 LIN9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:110186 LMNA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:110191 LMO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:107819 MAPK14    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111860 BioGRID:111585 MAPK8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:110344 MCM7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:110359 MDM4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:110474 MNAT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:111860 BioGRID:115001 MORF4L2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:125039 MRFAP1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:111860 BioGRID:110694 MYC    BioGRID  PubMed Two-hybrid 
    BioGRID:111860 BioGRID:110737 MYOD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:110818 NEFM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:110856 NFIX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111860 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111075 PA2G4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:111110 PAX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111114 PAX6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:117973 PELP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:111264 PHB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:114075 PIK3R3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:123539 PLA2G12A    BioGRID  PubMed Two-hybrid 
    BioGRID:111860 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:121232 PNO1    BioGRID  PubMed Co-fractionation 
    BioGRID:111860 BioGRID:111418 POLA1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:111860 BioGRID:111460 PPA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111464 PPARG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:111474 PPIA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:172796 PPP1CA    BioGRID  PubMed Two-hybrid 
    BioGRID:111860 BioGRID:113575 PRDM2    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:111860 BioGRID:114143 PRKRA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:109511 PRMT2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:111661 PSMA7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111688 PSMD10    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:111860 BioGRID:111772 PURA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:121759 RBAK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:111863 RBBP4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:111864 RBBP5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:111866 RBBP7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:111867 RBBP8    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111860 BioGRID:115964 RBBP9    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111860 BioGRID:111868 RBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111869 RBL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111882 RBP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111913 RFC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111947 RING1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:121942 RINT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:115149 RNF40    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:107308 RUNX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:111092 SERPINB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:116983 SIRT1    BioGRID  PubMed Negative Genetic 
    BioGRID:111860 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:112389 SKIL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Two-hybrid 
    BioGRID:111860 BioGRID:121274 SMYD2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111860 BioGRID:112501 SNAPC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:112503 SNAPC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:116597 SNW1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:112566 SPI1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:111860 BioGRID:112706 SUV39H1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:203256 Sin3a    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:203336 Smarca4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:112735 TAF1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:111860 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111860 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:112791 TCF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:112885 TFDP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:112887 TFDP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:112910 TGM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:115305 THOC1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:112967 TMPO    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:113006 TOP2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:115435 TRAP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:111919 TRIM27    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; Two-hybrid 
    BioGRID:111860 BioGRID:114732 TRIP11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111860 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111860 BioGRID:116934 UBR4    BioGRID  PubMed Affinity Capture-MS; Co-localization 
    BioGRID:111860 BioGRID:113190 UBTF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:118893 UHRF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:125434 UHRF2    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:111860 BioGRID:1678116 UL122    BioGRID  PubMed Two-hybrid 
    BioGRID:111860 BioGRID:113221 USP4    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:111860 BioGRID:113264 VDR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111860 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111860 BioGRID:119488 ZBTB7A    BioGRID  PubMed Affinity Capture-Western 
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA damage response, organism-specific biosystem (from WikiPathways)
      DNA damage response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
      E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regu...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • Inhibition of replication initiation of damaged DNA by RB1/E2F1, organism-specific biosystem (from REACTOME)
      Inhibition of replication initiation of damaged DNA by RB1/E2F1, organism-specific biosystem
      Inhibition of replication initiation of damaged DNA by RB1/E2F1
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Cancer pathway, organism-specific biosystem (from WikiPathways)
      Integrated Cancer pathway, organism-specific biosystem
      Integrated Cancer pathway
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
      Notch-mediated HES/HEY network, organism-specific biosystem
      Notch-mediated HES/HEY network
    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystem
      Orc1 removal from chromatin
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystem (from REACTOME)
      Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystemThe G1/S transition is facilitated by Cyclin E:Cdk2-mediated phoshorylation of proteins including Rb and Cyclin Kinase Inhibitors (CKIs).
    • Prostate Cancer, organism-specific biosystem (from WikiPathways)
      Prostate Cancer, organism-specific biosystem
      Prostate Cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues,...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
      Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TSH signaling pathway, organism-specific biosystem (from WikiPathways)
      TSH signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland (1). TSH plays an important physiological role in the regulation of the hypothalamic-pit...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    RNA polymerase II activating transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell morphogenesis involved in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    digestive tract development IEA
    Inferred from Electronic Annotation
    more info
    		  
    enucleate erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    maintenance of mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		 PubMed 
    myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein kinase activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription involved in G1/S phase of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein localization to chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of centromere complex assembly TAS
    Traceable Author Statement
    more info
    		  
    regulation of cohesin localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of lipid kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of transcription involved in G1/S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Rb-E2F complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    SWI/SNF complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chromatin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    retinoblastoma-associated protein
    Names
    retinoblastoma-associated protein
    retinoblastoma suspectibility protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009009.1 RefSeqGene

      Range
      5001..183144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000321.2 → NP_000312.2  retinoblastoma-associated protein

      Status: REVIEWED

      Source sequence(s)
      AL392048, BC040540, L41870
      Consensus CDS
      CCDS31973.1
      UniProtKB/Swiss-Prot
      P06400
      Related
      ENSP00000267163, OTTHUMP00000018397, ENST00000267163, OTTHUMT00000044884
      Conserved Domains (4) summary
      pfam08934
      Location:768 – 927
      Blast Score: 718
      Rb_C; Rb C-terminal domain
      pfam11934
      Location:115 – 228
      Blast Score: 292
      DUF3452; Domain of unknown function (DUF3452)
      pfam01857
      Location:645 – 766
      Blast Score: 478
      RB_B; Retinoblastoma-associated protein B domain
      pfam01858
      Location:373 – 573
      Blast Score: 753
      RB_A; Retinoblastoma-associated protein A domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000013.10 Reference GRCh37.p10 Primary Assembly

      Range
      48877883..49056026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000145.1 Alternate HuRef

      Range
      29670144..29848118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018924.1 Alternate CHM1_1.0

      Range
      29820961..29999081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01051004.1 (85800..96196) None
    genomic ABBA01051005.1 None
    genomic ABBA01051006.1 None
    genomic AF551763.1 AAN64133.1
    genomic AL136960.4 (100..56205) None
    genomic AL392048.9 (15304..137341) None
    genomic AMYH01005101.1 (70599..234481) None
    genomic AMYH01005102.1 None
    genomic AMYH01005103.1 None
    genomic AY124936.1 AAN41646.1
    genomic AY243567.1 AAO62758.1
    genomic AY260472.1 AAP39867.1
    genomic AY643840.1 AAT66036.2
    genomic CH471075.1 EAX08793.1
      EAX08794.1
    genomic L11910.1 AAA53483.1
    genomic L41890.1 AAA65735.1
    genomic L41891.1 AAA65736.1
    genomic L41893.1 AAA65737.1
    genomic L41894.1 AAA65738.1
    genomic L41895.1 AAA65739.1
    genomic L41896.1 AAA65740.1
    genomic L41897.1 AAA65741.1
    genomic L41898.1 AAB59471.1
    genomic L41899.1 AAB59473.1
    genomic L41904.1 AAB59580.1
    genomic L41908.1 AAA65744.1
    genomic L41909.1 AAA65745.1
    genomic L41910.1 AAA65746.1
    genomic L41912.1 AAA65747.1
    genomic L41913.1 AAA65748.1
    genomic L41914.1 AAA65749.1
    genomic L41997.1 AAB59482.1
    genomic L49225.1 AAA82563.1
    genomic L49231.1 AAA82557.1
    genomic L49232.1 AAA82558.1
    genomic M27866.1 AAA53484.1
    genomic X16439.1 CAA34462.1
    mRNA AB208788.1 BAD92025.1
    mRNA AF043224.1 AAC26845.1
    mRNA AK291258.1 BAF83947.1
    mRNA AK299179.1 BAG61225.1
    mRNA AK300284.1 BAG62042.1
    mRNA AK307125.1 None
    mRNA AK307730.1 None
    mRNA AY429568.1 None
    mRNA BC039060.1 AAH39060.1
    mRNA BC040540.1 AAH40540.1
    mRNA L41870.1 AAB59465.1
    mRNA M15400.1 AAA69807.1
    mRNA M19701.1 AAA60259.1
    mRNA M28419.1 AAA69808.1
    mRNA M33647.1 AAA69806.1
    other-genetic DQ891564.2 ABM82490.1
    other-genetic DQ894752.2 ABM85678.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06400.2 GenPept UniProtKB/Swiss-Prot:P06400

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • GTR
        GTR associated with a gene
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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