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    ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) [ Homo sapiens ]

    Gene ID: 3684, updated on 19-May-2012
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    Summary

    Official Symbol
    ITGAMprovided by HGNC
    Official Full Name
    integrin, alpha M (complement component 3 receptor 3 subunit)provided by HGNC
    Primary source
    HGNC:6149
    See related
    Ensembl:ENSG00000169896; HPRD:00411; MIM:120980; Vega:OTTHUMG00000176612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; MGC117044
    Summary
    This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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    Genomic context

    Location :
    16p11.2
    Sequence :
    Chromosome: 16; NC_000016.9 (31271288..31344213)
    See ITGAM in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100652740 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif containing 72 Neighboring gene PYD (pyrin domain) containing 1 Neighboring gene integrin, alpha X (complement component 3 receptor 4 subunit) pseudogene Neighboring gene integrin, alpha X (complement component 3 receptor 4 subunit) Neighboring gene integrin, alpha D

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. IL-8 from local subcutaneous wounds regulates CD11b activation. Lundahl J, et al. Scand J Immunol, 2012 Apr. PMID 22229891.
    2. A cohesin-RAD21 interactome. Panigrahi AK, et al. Biochem J, 2012 Mar 15. PMID 22145905.
    3. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. Mahalingam B, et al. J Immunol, 2011 Dec 15. PMID 22095715.
    4. Effect of surgically-induced weight loss on inflammatory mediators and peripheral blood monocyte CD11b expression in morbid obesity. Sabri AA, et al. Egypt J Immunol, 2010. PMID 22053606.
    5. Structures and interaction analyses of integrin αMβ2 cytoplasmic tails. Chua GL, et al. J Biol Chem, 2011 Dec 23. PMID 22052909.

    See all (197) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. conclude that IL-8 is the major factor regulating the expression of CD11b activation epitope in neutrophils
      Title: IL-8 from local subcutaneous wounds regulates CD11b activation.
    2. structures and interaction analyses of integrin alphaMbeta2 cytoplasmic tails
      Title: Structures and interaction analyses of integrin αMβ2 cytoplasmic tails.
    3. Denticity of the Asp/Glu ligand of integrin CD11b/CD18 can modify divalent cation (calcium or magnesium) selectivity at the metal ion-dependent adhesion site in neutrophils, and hence integrin function.
      Title: Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.
    4. Data found that blocking CD11b, CD18, or CD54 on the endothelial progenitor cells (EPC) surface with monoclonal antibodies protected EPCs, enhancing its survival.
      Title: Trauma-activated polymorphonucleated leukocytes damage endothelial progenitor cells: probable role of CD11b/CD18-CD54 interaction and release of reactive oxygen species.
    5. a potential influence of ITGAM rs1143679 in vascular lesion as part of pathophysiology of systemic sclerosis
      Title: Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis.
    6. Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells
      Title: Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells.
    7. Morbidly obese individuals had significantly increased levels CD11b expression on monocytes as compared to controls.
      Title: Effect of surgically-induced weight loss on inflammatory mediators and peripheral blood monocyte CD11b expression in morbid obesity.
    8. low density lipoprotein receptor-related protein 1 (LRP1) interacts with integrin alphaMbeta2 at specific binding sites
      Title: Molecular basis for the interaction of low density lipoprotein receptor-related protein 1 (LRP1) with integrin alphaMbeta2: identification of binding sites within alphaMbeta2 for LRP1.
    9. PMN sialidase could be a physiologic source of the enzymatic activity that removes sialyl residues on beta2 integrin and ICAM-1, resulting in their enhanced interaction, and may be an important regulator of the recruitment of these cells to inflamed si...
      Title: Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1.
    10. Two large cohorts of systemic sclerosis (SSc) patients of European Caucasian ancestry do not support the implication of ITGAM, ITGAX, and CD58 genes in the genetic susceptibility of SSc, although they were identified as autoimmune disease risk genes.
      Title: Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts.
    Submit: New GeneRIF Correction See all (148)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

    Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

    Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

    Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.

    Systemic lupus erythematous, association with susceptibility to, 6

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1 PubMed
    Nef nef HIV-1 Nef interacts with complement receptor 3 (CR3) in a manner that allows CR3 redistribution toward bacterial-induced pseudopods in macrophages PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P11215 Q9Y679 AUP1    HPRD  PubMed  
    P11215 P01024 C3    HPRD  PubMed  
    P11215 Q9NNX6 CD209    HPRD  PubMed  
    P11215 P08603 CFH    HPRD  PubMed  
    P11215 Q9H2X3 CLEC4M    HPRD  PubMed  
    P11215 P08246 ELANE    HPRD  PubMed  
    P11215 P02679 FGG    HPRD  PubMed  
    P11215 P07359 GP1BA    HPRD  PubMed  
    P11215 P00738 HP    HPRD  PubMed  
    P11215 P05362 ICAM1    HPRD  PubMed  
    P11215 P13598 ICAM2    HPRD  PubMed  
    P11215 Q14773 ICAM4    HPRD  PubMed  
    P11215 P51617 IRAK1    HPRD  PubMed  
    P11215 P05107 ITGB2    HPRD  PubMed  
    P11215 Q9BX67 JAM3    HPRD  PubMed  
    P11215 Q03405 PLAUR    HPRD  PubMed  
    P11215 P04216 THY1    HPRD  PubMed  
    BioGRID:109890 BioGRID:107031 AUP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109890 BioGRID:109610 ICAM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109890 BioGRID:109863 IRAK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109890 BioGRID:123734 JAM3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109890 BioGRID:111345 PLAUR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109890 BioGRID:111638 PRTN3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109890 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glycoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    integrin alpha-M
    Names
    integrin alpha-M
    CR-3 alpha chain
    antigen CD11b (p170)
    leukocyte adhesion receptor MO1
    CD11 antigen-like family member B
    macrophage antigen alpha polypeptide
    cell surface glycoprotein MAC-1 subunit alpha
    neutrophil adherence receptor alpha-M subunit
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011719.1 RefSeqGene

      Range
      5001..77926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000632.3 → NP_000623.2  integrin alpha-M isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.
      Source sequence(s)
      AA436312, AC093520, AK057856, BC096348
      Consensus CDS
      CCDS45470.1
      UniProtKB/Swiss-Prot
      P11215
      Related
      ENSP00000287497, OTTHUMP00000254640, ENST00000287497, OTTHUMT00000432816
      Conserved Domains (4) summary
      cd01469
      Location:149 – 324
      Blast Score: 660
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1129 – 1143
      Blast Score: 92
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:614 – 1032
      Blast Score: 886
      Integrin_alpha2; Integrin alpha
      cl15299
      Location:516 – 562
      Blast Score: 139
      FG-GAP; FG-GAP repeat

    2. NM_001145808.1 → NP_001139280.1  integrin alpha-M isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC093520, BC096348, BM194233, J03925
      Consensus CDS
      CCDS54004.1
      UniProtKB/Swiss-Prot
      P11215
      Related
      ENSP00000441691, OTTHUMP00000254641, ENST00000544665, OTTHUMT00000432817
      Conserved Domains (4) summary
      cd01469
      Location:149 – 324
      Blast Score: 660
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1130 – 1144
      Blast Score: 92
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615 – 1033
      Blast Score: 886
      Integrin_alpha2; Integrin alpha
      cl15299
      Location:517 – 563
      Blast Score: 139
      FG-GAP; FG-GAP repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      31271288..31344213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      28832071..28904704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC093520.4 (77491..150394) None
    genomic CH471192.1 EAW52143.1
      EAW52144.1
    genomic JA738583.1 CCF76944.1
    genomic M76724.1 AAA58410.1
    genomic M84477.1 AAA51960.1
    genomic S52227.1 AAB24821.1
    mRNA AA436312.1 None
    mRNA AK057856.1 None
    mRNA AK127637.1 BAG54538.1
    mRNA AY187247.1 None
    mRNA AY187248.1 None
    mRNA BC096346.3 AAH96346.1
    mRNA BC096347.3 AAH96347.1
    mRNA BC096348.3 AAH96348.1
    mRNA BC099660.3 AAH99660.1
    mRNA BM194233.1 None
    mRNA J03925.1 AAA59544.1
    mRNA J04145.1 AAA59903.1
    mRNA M18044.1 AAA59491.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11215.2 GenPept UniProtKB/Swiss-Prot:P11215
    Q4VAK1 GenPept UniProtKB/TrEMBL:Q4VAK1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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