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    RABEP1 rabaptin, RAB GTPase binding effector protein 1 [ Homo sapiens ]

    Gene ID: 9135, updated on 11-May-2012

    Summary

    Official Symbol
    RABEP1provided by HGNC
    Official Full Name
    rabaptin, RAB GTPase binding effector protein 1provided by HGNC
    Primary source
    HGNC:17677
    See related
    Ensembl:ENSG00000029725; HPRD:04684; MIM:603616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAB5EP; RABPT5

    Genomic context

    Location :
    17p13.2
    Sequence :
    Chromosome: 17; NC_000017.10 (5185558..5289132)
    See RABEP1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130950 Neighboring gene zinc finger protein 594 Neighboring gene SLP adaptor and CSK interacting membrane protein Neighboring gene nucleoporin 88kDa Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15276 O43747 AP1G1    HPRD  PubMed  
    Q15276 O75843 AP1G2    HPRD  PubMed  
    Q15276 P42574 CASP3    HPRD  PubMed  
    Q15276 P17677 GAP43    HPRD  PubMed  
    Q15276 Q9UJY5 GGA1    HPRD  PubMed  
    Q15276 Q9UJY4 GGA2    HPRD  PubMed  
    Q15276 Q9NZ52 GGA3    HPRD  PubMed  
    Q15276 P57058 HUNK    HPRD  PubMed  
    Q15276 Q9H082 RAB33B    HPRD  PubMed  
    Q15276 P20338 RAB4A    HPRD  PubMed  
    Q15276 P20339 RAB5A    HPRD  PubMed  
    Q15276 Q15276 RABEP1    HPRD  PubMed  
    Q15276 Q9UJ41 RABGEF1    HPRD  PubMed  
    Q15276 P49815 TSC2    HPRD  PubMed  
    Q15276 P61981 YWHAG    HPRD  PubMed  
    BioGRID:114583 BioGRID:106673 AP1G1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114583 BioGRID:112221 ATXN7    BioGRID  PubMed Two-hybrid 
    BioGRID:114583 BioGRID:113999 EEA1    BioGRID  PubMed Co-fractionation 
    BioGRID:114583 BioGRID:108867 GAP43    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114583 BioGRID:117540 GGA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114583 BioGRID:116697 GGA2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114583 BioGRID:116775 GGA3    BioGRID  PubMed Two-hybrid 
    BioGRID:114583 BioGRID:119035 HUNK    BioGRID  PubMed Two-hybrid 
    BioGRID:114583 BioGRID:111799 RAB1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114583 BioGRID:123654 RAB33B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114583 BioGRID:111805 RAB4A    BioGRID  PubMed Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:114583 BioGRID:111806 RAB5A    BioGRID  PubMed Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:114583 BioGRID:114583 RABEP1    BioGRID  PubMed Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:114583 BioGRID:159596 RABGEF1    BioGRID  PubMed Two-hybrid 
    BioGRID:114583 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:114583 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114583 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular membrane fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
     
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rab GTPase-binding effector protein 1
    Names
    rab GTPase-binding effector protein 1
    rabaptin-4
    rabaptin-5
    neurocrescin
    rabaptin-5alpha
    renal carcinoma antigen NY-REN-17

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083585.1NP_001077054.1  rab GTPase-binding effector protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AA873800, AF098638, AL157499, BC041700, DB169027, X91141
      Consensus CDS
      CCDS42243.1
      UniProtKB/Swiss-Prot
      Q15276
      Related
      ENSP00000339569, ENST00000341923
      Conserved Domains (3) summary
      pfam09311
      Location:612774
      Blast Score: 239
      Rab5-bind; Rabaptin-like protein
      pfam03528
      Location:89195
      Blast Score: 255
      Rabaptin; Rabaptin
      TIGR02168
      Location:14309
      Blast Score: 122
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. NM_004703.4NP_004694.2  rab GTPase-binding effector protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA873800, AL157499, BC041700, BX103338, DB169027, X91141
      Consensus CDS
      CCDS45592.1
      UniProtKB/Swiss-Prot
      Q15276
      Related
      ENSP00000437701, ENST00000546142
      Conserved Domains (3) summary
      pfam09311
      Location:612807
      Blast Score: 285
      Rab5-bind; Rabaptin-like protein
      pfam03528
      Location:89195
      Blast Score: 250
      Rabaptin; Rabaptin
      TIGR02168
      Location:14309
      Blast Score: 119
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      5185558..5289132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      5076120..5179776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004148.1 (12678..13349) None
    genomic AC015727.7 (55037..117541) None
    genomic AC087500.16 None
    genomic CH471108.2 EAW90343.1
      EAW90344.1
      EAW90345.1
    mRNA AA873800.1 None
    mRNA AF098638.1 AAC70781.1
    mRNA AK297535.1 BAG59936.1
    mRNA AK310932.1 None
    mRNA AK314183.1 BAG36864.1
    mRNA AL050211.1 None
    mRNA AL120839.1 None
    mRNA AL157499.1 None
    mRNA BC018742.1 None
    mRNA BC032435.1 AAH32435.1
    mRNA BC041700.1 AAH41700.1
    mRNA BC065242.1 None
    mRNA BI666786.1 None
    mRNA BX103338.1 None
    mRNA DB169027.1 None
    mRNA X77723.1 None
    mRNA X91141.1 CAA62580.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05BX6 GenPept UniProtKB/TrEMBL:Q05BX6
    Q15276.2 GenPept UniProtKB/Swiss-Prot:Q15276

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