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PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma [ Homo sapiens (human) ]

Gene ID: 5288, updated on 17-Feb-2015
Official Symbol
PIK3C2Gprovided by HGNC
Official Full Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gammaprovided by HGNC
Primary source
HGNC:HGNC:8973
See related
Ensembl:ENSG00000139144; HPRD:16416; MIM:609001; Vega:OTTHUMG00000168841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI3K-C2GAMMA; PI3K-C2-gamma
Summary
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Orthologs
See PIK3C2G in MapViewer
Location:
12p12
Exon count:
35
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (18242978..18648418)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (18395912..18801352)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microRNA 3974 Neighboring gene RERG/RAS-like Neighboring gene Nedd4 family interacting protein 1 pseudogene 1 Neighboring gene zinc finger with KRAB and SCAN domains 7 pseudogene 1 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 1 pseudogene 9 Neighboring gene phospholipase C, zeta 1 Neighboring gene capping protein (actin filament) muscle Z-line, alpha 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
env HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity PubMed
env PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells PubMed
Nef nef Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K PubMed
nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
nef The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production PubMed
nef The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression PubMed
Tat tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis PubMed
tat Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex PubMed
tat HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase PubMed
tat Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase PubMed
tat HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K) PubMed

Go to the HIV-1, Human Interaction Database

Markers

Homology

Clone Names

  • MGC163149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phosphate kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3-phosphate biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PTDINS-3-kinase C2 gamma
phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide
phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma
phosphoinositide-3-kinase, class 2, gamma polypeptide
ptdIns-3-kinase C2 subunit gamma
NP_001275701.1
NP_001275703.1
NP_004561.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288772.1NP_001275701.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 1

    See proteins identical to NP_001275701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI478164, AJ000008, BC144134, BX092808
    Consensus CDS
    CCDS73452.1
    UniProtKB/TrEMBL
    B7ZLY6
    UniProtKB/TrEMBL
    F5H369
    UniProtKB/Swiss-Prot
    O75747
    Related
    ENSP00000445381, ENST00000538779
    Conserved Domains (6) summary
    cd06896
    Location:12481348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520678
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:13701482
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:692860
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cl02484
    Location:279369
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cd05177
    Location:8661219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
  2. NM_001288774.1NP_001275703.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, which results in the use of an alternate start codon and a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI478164, AJ000008, BC144133, BC144134, BX092808
    UniProtKB/TrEMBL
    B7ZLY6
    UniProtKB/Swiss-Prot
    O75747
    Conserved Domains (6) summary
    cd06896
    Location:10261126
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:298456
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:470638
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cl02484
    Location:57145
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cd05177
    Location:644997
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
    cl14603
    Location:11481260
    C2; C2 domain
  3. NM_004570.5NP_004561.3  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 3

    See proteins identical to NP_004561.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AI478164, AJ000008, BC144134, BX092808
    Consensus CDS
    CCDS44839.1
    UniProtKB/TrEMBL
    B7ZLY6
    UniProtKB/Swiss-Prot
    O75747
    Related
    ENSP00000404845, ENST00000433979
    Conserved Domains (6) summary
    cd06896
    Location:12071307
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd08381
    Location:13291441
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:651819
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    pfam00792
    Location:506629
    PI3K_C2; Phosphoinositide 3-kinase C2
    cl02484
    Location:279369
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cd05177
    Location:8251178
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38 Primary Assembly

    Range
    18242978..18648418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253393.1XP_005253450.1  

    See proteins identical to XP_005253450.1

    UniProtKB/TrEMBL
    F5H369
    Conserved Domains (6) summary
    cd06896
    Location:12481348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520678
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:13701482
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:692860
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cl02484
    Location:279369
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cd05177
    Location:8661219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma
  2. XM_006719088.1XP_006719151.1  

    See proteins identical to XP_006719151.1

    UniProtKB/TrEMBL
    F5H369
    Conserved Domains (6) summary
    cd06896
    Location:12481348
    PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:520678
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:13701482
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:692860
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cl02484
    Location:279369
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cd05177
    Location:8661219
    PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    18379684..18766393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 Alternate HuRef

    Range
    18182567..18569771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)