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    IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ]

    Gene ID: 3456, updated on 20-May-2012
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    Summary

    Official Symbol
    IFNB1provided by HGNC
    Official Full Name
    interferon, beta 1, fibroblastprovided by HGNC
    Primary source
    HGNC:5434
    Locus tag
    RP11-113D19.1
    See related
    Ensembl:ENSG00000171855; HPRD:00972; MIM:147640; Vega:OTTHUMG00000019652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFB; IFF; IFNB; MGC96956
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    Genomic context

    Location :
    9p21
    Sequence :
    Chromosome: 9; NC_000009.11 (21077104..21077943, complement)
    See IFNB1 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase-like A domain containing 2 Neighboring gene interferon, nu 1, pseudogene Neighboring gene interferon, omega 1 Neighboring gene interferon, alpha 21

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Alemtuzumab more effective than interferon β-1a at 5-year follow-up of CAMMS223 clinical trial. Coles AJ, et al. Neurology, 2012 Apr 3. PMID 22442431.
    2. The nucleocapsid protein of measles virus blocks host interferon response. Takayama I, et al. Virology, 2012 Mar 1. PMID 22226324.
    3. Immunomodulatory functions of type I interferons. González-Navajas JM, et al. Nat Rev Immunol, 2012 Jan 6. PMID 22222875.
    4. Interferons in autoimmune and inflammatory diseases: regulation and roles. Choubey D, et al. J Interferon Cytokine Res, 2011 Dec. PMID 22149411.
    5. IFN-β induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis. Chen M, et al. J Neuroimmunol, 2012 Jan 18. PMID 22112394.

    See all (209) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. IFN-beta-1b treatment effectiveness is evaluated by presence, number and severity of relapses, reduction in the relapse rate, disability progression, and response of multiple sclerosis patients to the treatment.
      Title: Human herpesvirus 6 and effectiveness of interferon β1b in multiple sclerosis patients.
    2. Studies indicate that IFN-alpha and beta (type I interferons) and IFN-signaling in the pathogenesis of certain autoimmune inflammatory diseases.
      Title: Interferons in autoimmune and inflammatory diseases: regulation and roles.
    3. Alemtuzumab is more effective than interferon beta-1a in reducing relapses and disability in patients with active relapsing-remitting multiple sclerosis in a long-term follow-up of a rater-blinded, randomized clinical trial.
      Title: Alemtuzumab more effective than interferon β-1a at 5-year follow-up of CAMMS223 clinical trial.
    4. IFN-beta-induced upregulation of glucocorticoid-induced tumor necrosis factor receptor ligand (GITRL) on dendritic cells and downregulation of CTLA-4 on regulatory T cells (Tregs) facilitates proliferation of anergic Tregs in treatment of multiple scle...
      Title: IFN-β induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis.
    5. Nucleocapsid protein of measles virus blocks host IFN-alpha/beta and gamma- responses.
      Title: The nucleocapsid protein of measles virus blocks host interferon response.
    6. Studies indicate that interferon-alpha (IFNalpha) and IFNbeta, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral and bacterial infections.
      Title: Immunomodulatory functions of type I interferons.
    7. Measles virus C protein interferes with Beta interferon transcription in the nucleus.
      Title: Measles virus C protein interferes with Beta interferon transcription in the nucleus.
    8. ligation of TLR-3 by poly(I:C) induces IDO expression in human first-trimester trophoblasts via an IFN-beta-dependent pathway
      Title: Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts.
    9. Specific biomarkers of IFNbeta bioactivity, were identified.
      Title: Search for specific biomarkers of IFNβ bioactivity in patients with multiple sclerosis.
    10. study presented the first evidence to show that activation of TLR3 is effective in blocking DENV2 replication via IFN-beta
      Title: Activation of Toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-β in cultured hepatoma cells.
    Submit: New GeneRIF Correction See all (146)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
    env Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN) PubMed
    env HIV-1 (possibly through the HIV-1 gp120 protein) induces low levels of IFN-beta in macrophages, and the IFN-beta plays an effective role in restriction of virus replication PubMed
    Envelope transmembrane glycoprotein gp41 env IFN-beta inhibits the binding of soluble gp41 to T, B and monocyte cell lines PubMed
    env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Nef nef HIV-1 Nef myristoylation is required for the activation of IRF-3, leading to the synthesis of IFNbeta in monocytes-derived-macrophages PubMed
    Tat tat IFN treatment significantly reduces HIV-1 mRNA levels from a Tat defective provirus, suggesting Tat can overcome the inhibitory effects of IFN on HIV-1 replication PubMed
    tat IFN beta is an effective inhibitor of HIV-1 Tat-stimulated growth, migration and morphogenesis of an endothelial cell line in vitro and of angiogenesis in vivo PubMed
    tat HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P01574 P17181 IFNAR1    HPRD  PubMed  
    P01574 P48551 IFNAR2    HPRD  PubMed  
    P01574 P01574 IFNB1    HPRD  PubMed  
    BioGRID:109678 BioGRID:109678 IFNB1    BioGRID  PubMed Co-crystal Structure 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
      Cytokines and Inflammatory Response, organism-specific biosystemInflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an imp...
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Osteoclast Signaling, organism-specific biosystem (from WikiPathways)
      Osteoclast Signaling, organism-specific biosystem
      Osteoclast Signaling
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • Regulation of IFNA signaling, organism-specific biosystem (from REACTOME)
      Regulation of IFNA signaling, organism-specific biosystemThere are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation...
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • TRAF3-dependent IRF activation pathway, organism-specific biosystem (from REACTOME)
      TRAF3-dependent IRF activation pathway, organism-specific biosystemIPS-1/MAVS/Cardif/VISA with its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the RIG-I/MDA5 signaling complex. TRAF3 acts as a scaffold for the assembly of a signa...
    • TRAF6 mediated IRF7 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation, organism-specific biosystemTRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    interferon-alpha/beta receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    B cell proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    humoral immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    natural killer cell activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of T-helper 2 cell cytokine production IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of cell proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of virion penetration into host cell NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of innate immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of MHC class I biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    response to virus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    extracellular region IC
    Inferred by Curator
    more info
    		 PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    interferon beta
    Names
    interferon beta
    IFN-beta
    fibroblast interferon
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002176.2 → NP_002167.1  interferon beta precursor

      Status: VALIDATED

      Source sequence(s)
      M28622
      Consensus CDS
      CCDS6495.1
      UniProtKB/Swiss-Prot
      P01574
      UniProtKB/TrEMBL
      Q5VWC9
      Related
      ENSP00000369581, OTTHUMP00000021131, ENST00000380232, OTTHUMT00000051881
      Conserved Domains (1) summary
      cd00095
      Location:27 – 178
      Blast Score: 472
      IFab; Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      21077104..21077943, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      21040313..21041152, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL390882.12 CAH70160.1
    genomic CH471071.2 EAW58625.1
    genomic EF064725.1 ABK41908.1
    genomic V00534.1 CAA23795.1
    genomic V00535.1 CAA23796.1
    mRNA AB451323.1 BAG70137.1
    mRNA AB451452.1 BAG70266.1
    mRNA BC069314.1 AAH69314.1
    mRNA BC096150.3 AAH96150.1
    mRNA BC096151.2 AAH96151.1
    mRNA BC096152.2 AAH96152.1
    mRNA BC096153.2 AAH96153.1
    mRNA M25460.1 AAC41702.1
    mRNA M28622.1 AAA36040.1
    mRNA V00546.1 CAA23807.1
    mRNA V00547.1 CAA23808.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01574.1 GenPept UniProtKB/Swiss-Prot:P01574
    Q15943 GenPept UniProtKB/TrEMBL:Q15943
    Q5VWC9 GenPept UniProtKB/TrEMBL:Q5VWC9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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