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    IRF2 interferon regulatory factor 2 [ Homo sapiens ]

    Gene ID: 3660, updated on 12-May-2012
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    Summary

    Official Symbol
    IRF2provided by HGNC
    Official Full Name
    interferon regulatory factor 2provided by HGNC
    Primary source
    HGNC:6117
    See related
    Ensembl:ENSG00000168310; HPRD:00962; MIM:147576; Vega:OTTHUMG00000160606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRF-2; DKFZp686F0244
    Summary
    IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4q34.1-q35.1
    Sequence :
    Chromosome: 4; NC_000004.11 (185308876..185395726, complement)
    See IRF2 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC391722 Neighboring gene uncharacterized LOC728175 Neighboring gene GAR1 ribonucleoprotein homolog (yeast) pseudogene Neighboring gene caspase 3, apoptosis-related cysteine peptidase

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells. Cui L, et al. Tumour Biol, 2012 Feb. PMID 22119988.
    2. Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. Gao PS, et al. J Invest Dermatol, 2012 Mar. PMID 22113474.
    3. Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription. Hayashi H, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 22042864.
    4. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    5. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.

    See all (52) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The results suggested that distinct markers in IRF2 may be associated with atopic dermatitis and eczema herpeticum (which may depend upon ethnic ancestry) and genetic variants in IRF2 may contribute to an abnormal immune response to herpes simplex virus.
      Title: Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum.
    2. these results suggest that IRF-2 plays an important role in the tumorigenesis of pancreatic cancer and down-regulation of IRF-2 would be a new treatment target for pancreatic cancer.
      Title: IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells.
    3. IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3
      Title: Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. IRF-2 activates the HPV-16 P97 promoter in vivo.
      Title: Interferon regulatory factor (IRF)-2 activates the HPV-16 E6-E7 promoter in keratinocytes.
    6. IRF-2 activates RIG-I promoter through ISRE-like site as well as IRF-1 and IFN-alpha stimulation.
      Title: Enhanced RIG-I expression is mediated by interferon regulatory factor-2 in peripheral blood B cells from hepatitis C virus-infected patients.
    7. PTB binding to multiple sites within IRF2 5'UTR leads to a conformational change in the RNA that facilitate binding of other trans-acting factors to mediate internal initiation of translation
      Title: Role of polypyrimidine tract binding protein in mediating internal initiation of translation of interferon regulatory factor 2 RNA.
    8. IRF2 interacts with the SUMO-E3 ligase PIASy and is sumoylated in vivo
      Title: Regulation of IRF2 transcriptional activity by its sumoylation.
    9. IRF-2 regulates NF-kappaB activity via the modulation of NF-kappaB subcellular localization.
      Title: IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway.
    Submit: New GeneRIF Correction See all (17)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef upregulates interferon regulatory factor 2 (IRF-2) in human T cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P14316 P68400 CSNK2A1    HPRD  PubMed  
    P14316 Q09472 EP300    HPRD  PubMed  
    P14316 P09429 HMGB1    HPRD  PubMed  
    P14316 P05114 HMGN1    HPRD  PubMed  
    P14316 Interferon regulatory factor 2 binding protein 1 IRF2BP1    HPRD  PubMed  
    P14316 Interferon regulatory factor 2 binding protein 2 IRF2BP2    HPRD  PubMed  
    P14316 Q02556 IRF8    HPRD  PubMed  
    P14316 Q92831 KAT2B    HPRD  PubMed  
    P14316 P19838 NFKB1    HPRD  PubMed  
    P14316 Q04206 RELA    HPRD  PubMed  
    P14316 P42224 STAT1    HPRD  PubMed  
    BioGRID:109868 BioGRID:115236 AP5Z1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109868 BioGRID:115787 ATG7    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109868 BioGRID:118883 BRD7    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109868 BioGRID:107841 CSNK2A1    BioGRID  PubMed Biochemical Activity 
    BioGRID:109868 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:109868 BioGRID:128769 FOXK1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109868 BioGRID:109820 FOXK2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109868 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109868 BioGRID:118959 HCFC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109868 BioGRID:117576 IRF2BP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109868 BioGRID:131797 IRF2BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109868 BioGRID:122101 IRF2BPL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109868 BioGRID:109621 IRF8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109868 BioGRID:108918 KAT2A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109868 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:109868 BioGRID:110857 NFKB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109868 BioGRID:111522 PPP3CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109868 BioGRID:111524 PPP3CB    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109868 BioGRID:111553 PRKACA    BioGRID  PubMed Biochemical Activity 
    BioGRID:109868 BioGRID:111902 RELA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109868 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • TRAF6 mediated IRF7 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation, organism-specific biosystemTRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    interferon regulatory factor 2
    Names
    interferon regulatory factor 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002199.3 → NP_002190.2  interferon regulatory factor 2

      Status: REVIEWED

      Source sequence(s)
      AA361545, BC015803, BP200998, BQ017798
      Consensus CDS
      CCDS3835.1
      UniProtKB/Swiss-Prot
      P14316
      UniProtKB/TrEMBL
      Q6IAS7
      Related
      ENSP00000377218, OTTHUMP00000218573, ENST00000393593, OTTHUMT00000361393
      Conserved Domains (1) summary
      cd00103
      Location:5 – 113
      Blast Score: 389
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      185308876..185395726, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      181063134..181150003, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC099343.3 (1991..88779) None
    genomic CH471056.2 EAX04677.1
      EAX04678.1
      EAX04679.1
      EAX04680.1
    genomic D14082.1 None
    mRNA AA361545.1 None
    mRNA AK312953.1 BAG35793.1
    mRNA BC015803.2 AAH15803.1
    mRNA BP200998.1 None
    mRNA BQ017798.1 None
    mRNA BT007264.1 AAP35928.1
    mRNA BX648934.1 None
    mRNA CR457077.1 CAG33358.1
    mRNA DQ409328.1 None
    mRNA X15949.1 CAA34073.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14316.2 GenPept UniProtKB/Swiss-Prot:P14316
    Q6IAS7 GenPept UniProtKB/TrEMBL:Q6IAS7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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      Supplemental Content

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