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    HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 [ Homo sapiens (human) ]

    Gene ID: 3117, updated on 16-Jun-2013
    Official Symbol
    HLA-DQA1provided by HGNC
    Official Full Name
    major histocompatibility complex, class II, DQ alpha 1provided by HGNC
    Primary source
    HGNC:4942
    Locus tag
    DAQB-109B10.1
    See related
    Ensembl:ENSG00000196735; HPRD:06765; MIM:146880; Vega:OTTHUMG00000031106
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD; GSE; DQ-A1; CELIAC1; HLA-DQA
    Summary
    HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (32605183..32611429)
    See HLA-DQA1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class II, DR beta 6 (pseudogene) Neighboring gene major histocompatibility complex, class II, DR beta 1 Neighboring gene major histocompatibility complex, class II, DQ beta 1 Neighboring gene MT-CO3 pseudogene 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Mero IL, et al. PLoS One, 2013. PMID 23472185.
    2. Aspirin insensitive thrombophilia: transcript profiling of blood identifies platelet abnormalities and HLA restriction. Fallahi P, et al. Gene, 2013 May 15. PMID 23454623.
    3. Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women. Jiang J, et al. Gynecol Oncol, 2013 May. PMID 23428460.
    4. Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Vijai J, et al. PLoS Genet, 2013. PMID 23349640.
    5. Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. LeishGEN Consortium, et al. Nat Genet, 2013 Feb. PMID 23291585.

    See all (684) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. There were no significant associations for HLA-DQ rs2856718 and rs7453920 and cervical cancer in a Chinese population.
      Title: Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.
    2. HLA-DRB1/HLA-DQA1 rs9271366 may play a part in influencing the systemic lupus erythematosis susceptibility in Malays and Chinese in Malaysia.
      Title: HLA variants rs9271366 and rs9275328 are associated with systemic lupus erythematosus susceptibility in Malays and Chinese.
    3. There was a strong association of aspirin resistant thrombophilia with expression of HLA-DRB4 and HLA-DQA1.
      Title: Aspirin insensitive thrombophilia: transcript profiling of blood identifies platelet abnormalities and HLA restriction.
    4. in a genome wide association study, a common polymorphism (rs9272346) localizing to within 1 Kb of HLA-DQA1 (chromosome 6p21.3) was associated with asthma in adults with consistent evidence in the more heterogeneous group of adults and children
      Title: HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults.
    5. The HLA-DRB1-HLA-DQA1 HLA class II region contributes to visceral leishmaniasis susceptibility in India and Brazil.
      Title: Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.
    6. HLA-DQA1 gene copy number polymorphism is associated with gastric cancer susceptibility, and there is a multiplicative gene-environment interaction between this polymorphism and H.pylori infection in the development of gastric cancer.
      Title: [Association between HLA-DQA1 gene copy number polymorphisms and susceptibility to gastric cancer].
    7. The study found no statistically significant association between HLA-DQA1 haplotypes and H.pylori infection in the Lombok Indonesian population.
      Title: Association between HLA-DQ genotypes and haplotypes vs Helicobacter pylori infection in an Indonesian population.
    8. HLA-DQA1 *0401 allele might be predisposing gene of the anti-sperm antibody-positive immune infertility.
      Title: [Study of the correlation between 51 immune infertility patients of the Han nationality in Anhui and HLA-DQA1 gene and treatment of Mianbu III].
    9. Data show that the genotyping technique of single nucleotide polymorphisms (SNPs) rs2187668 and rs4664308 within HLA-DQA1 and PLA2R1 is valuable for assessing susceptibility to idiopathic membranous nephropathy (IMN).
      Title: Development of a high resolution melting method for genotyping of risk HLA-DQA1 and PLA2R1 alleles and ethnic distribution of these risk alleles.
    10. There were no significant differences in HLA-DQ allele frequencies in Lyme borreliosis Latvian patients.
      Title: Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients.
    Submit: New GeneRIF Correction See all (153)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Celiac disease

    Summary from GeneReviews: Celiac Disease Go to GeneReviews

    Disease Characteristics
    Celiac disease is a systemic immune disease that can be associated with gastrointestinal findings (diarrhea, weight loss, abdominal pain, anorexia, lactose intolerance, abdominal distention, and irritability) and/or highly variable non-gastrointestinal findings (iron-deficiency anemia, dermatitis herpetiformis, chronic fatigue, joint pain/inflammation, migraines, depression, attention-deficit disorder, epilepsy, osteoporosis/osteopenia, infertility and/or recurrent fetal loss, vitamin deficiencies, short stature, failure to thrive, delayed puberty, dental enamel defects, and autoimmune disorders). Classic celiac disease, characterized by mild to severe gastrointestinal symptoms, is less common than nonclassic celiac disease, characterized by absence of gastrointestinal symptoms.
    Diagnosis Testing
    The diagnosis of celiac disease relies on characteristic histologic findings on small-bowel biopsy and clinical and/or histologic improvement on a gluten-free diet. Most individuals with celiac disease have celiac disease-associated antibodies and specific pairs of allelic variants in two HLA genes, HLA-DQA1 and HLA-DQB1. Because 30% of the general population has one of the celiac disease-associated HLA alleles and only 3% of individuals with one or both of these alleles develop celiac disease, presence of celiac disease-associated HLA alleles is not diagnostic of celiac disease; however, their absence essentially excludes a diagnosis of celiac disease.
    Genetic Counseling
    Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 gene variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. Some empiric risk data are available for at-risk relatives.
    References

    NHGRI GWAS Catalog

    show more
    Protein Gene Interaction Pubs
    Env, gp160, envelope glycoprotein env Processing of HIV-1 gp160 to gp120 and gp41 is necessary for the association of HIV-1 envelope glycoproteins with class II MHC PubMed
    Envelope surface glycoprotein gp120 env HIV envelope protein gp120 can specifically inhibit CD4-dependent class II MHC-restricted T cell response to Ag PubMed
    env Amino acid residues 42-49 in the V1 region of CD4 are involved in the interaction between HIV-1 gp120 and class II major histocompatibility complex molecules PubMed
    Envelope transmembrane glycoprotein gp41 env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
    env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
    env A 43-amino-acid sequence between amino acids 708 and 750 in the HIV-1 gp41(TM) cytoplasmic tail is required for efficient incorporation of HLA class II proteins into virions PubMed
    Gag, Pr55 gag HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II PubMed
    gag Two peptides of the CA domain of HIV-1 Gag, VDRFYKTLRAEQASQ and DRFYKLTRAEQASQ, are presented on MHC II molecules of dendritic cells and have similar sensitivity for antigen-specific T cells PubMed
    gag HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54) PubMed
    Nef, p27 nef HIV-1 group N and group O Nef alleles only weakly downregulate CD4, CD28, and class I and II MHC molecules PubMed
    nef Expression of patient-derived HIV-1 nef alleles downregulates MHC-II cell surface expression in activated CD4+ T cells PubMed
    nef HIV-1 Nef expression inhibits MHC II presentation of viral antigens in infected antigen-presenting cells PubMed
    nef Nef-triggered MHCII endocytosis requires Rab5 activity and lyst function, whereas lysosomal trafficking of internalized MHCII molecules requires Rab7 activity PubMed
    Tat, p14 tat HIV-1 Tat downregulates expression of MHC class II genes in antigen-presenting cells (APC) by inhibiting the transactivator of MHC class II genes, CIITA PubMed
    Vpu, p16 vpu HIV-1 Vpu interacts with CD74 and modulates MHC II in HIV-1-infected cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P01909 P51693 APLP1    HPRD  PubMed  
    P01909 P04233 CD74    HPRD  PubMed  
    P01909 Q5T3J3 LRIF1    HPRD  PubMed  
    P01909 Q99962 SH3GL2    HPRD  PubMed  
    P01909 Q04724 TLE1    HPRD  PubMed  
    P01909 Q13432 UNC119    HPRD  PubMed  
    BioGRID:109362 BioGRID:106830 APLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109362 BioGRID:107457 CDK7    BioGRID  PubMed Two-hybrid 
    BioGRID:109362 BioGRID:114089 IKBKG    BioGRID  PubMed Two-hybrid 
    BioGRID:109362 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:109362 BioGRID:112353 SH3GL2    BioGRID  PubMed Two-hybrid 
    BioGRID:109362 BioGRID:112943 TLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:109362 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109362 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
      Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Asthma, organism-specific biosystem (from KEGG)
      Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Asthma, conserved biosystem (from KEGG)
      Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
      Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
      Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ27088, FLJ27328, MGC149527

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MHC class II receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    MHC class II receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
    Traceable Author Statement
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    lysosomal membrane TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
    		  
    transport vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    HLA class II histocompatibility antigen, DQ alpha 1 chain
    Names
    HLA class II histocompatibility antigen, DQ alpha 1 chain
    HLA-DCA
    DC-alpha
    DC-1 alpha chain
    MHC HLA-DQ alpha
    MHC class II DQA1
    MHC class II antigen
    leucocyte antigen DQA1
    MHC class II HLA-DQ-alpha-1
    leukocyte antigen alpha chain
    MHC class II surface glycoprotein
    MHC class II HLA-D alpha glycoprotein
    HLA class II histocompatibility antigen, DQ(W3) alpha chain

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032876.1 RefSeqGene

      Range
      5001..11247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002122.3 → NP_002113.2  HLA class II histocompatibility antigen, DQ alpha 1 chain precursor

      Status: REVIEWED

      Source sequence(s)
      AF533896, AK130811, BU617246, M20431
      Consensus CDS
      CCDS4752.1
      UniProtKB/Swiss-Prot
      P01909
      UniProtKB/TrEMBL
      Q8MH44
      Related
      ENSP00000339398, OTTHUMP00000029141, ENST00000343139, OTTHUMT00000076176
      Conserved Domains (2) summary
      cd05767
      Location:112 – 205
      Blast Score: 423
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:29 – 110
      Blast Score: 351
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p10 ALT_REF_LOCI_2

      Range
      4055571..4061859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p10 ALT_REF_LOCI_3

      Range
      3886910..3893071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p10 ALT_REF_LOCI_4

      Range
      4061343..4067504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1

      Range
      3944053..3950243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003846467.1 → XP_003846515.1  

      UniProtKB/TrEMBL
      Q5Y7H0
      Conserved Domains (2) summary
      cd05767
      Location:112 – 205
      Blast Score: 420
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:29 – 110
      Blast Score: 315
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    2. XM_003846468.1 → XP_003846516.1  

      UniProtKB/TrEMBL
      Q5Y7H0
      Conserved Domains (2) summary
      cd05767
      Location:112 – 205
      Blast Score: 420
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:29 – 110
      Blast Score: 315
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    3. XM_003846470.1 → XP_003846518.1  

      Conserved Domains (2) summary
      cd05767
      Location:112 – 204
      Blast Score: 416
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:29 – 110
      Blast Score: 311
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    4. XM_003846469.1 → XP_003846517.1  

      Conserved Domains (2) summary
      cd05767
      Location:107 – 200
      Blast Score: 419
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:24 – 105
      Blast Score: 316
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain

    Reference GRCh37.p10 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p10 ALT_REF_LOCI_6

      Range
      3842030..3848318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p10 ALT_REF_LOCI_7

      Range
      4038635..4044830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      32605183..32611429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      32346937..32353106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      32522941..32529187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AB006908.1 BAA22189.1
    genomic ABBA01038126.1 (2728..5541) None
    genomic ABBA01038127.1 None
    genomic AF109734.1 AAD56720.1
    genomic AF126253.2 AAD49219.2
    genomic AF322870.1 AAK11577.1
    genomic AF395700.1 AAM69677.1
    genomic AF515807.1 AAM74914.1
    genomic AF515808.1 AAM74915.1
    genomic AF515809.1 AAM74916.1
    genomic AF515810.1 AAM74917.1
    genomic AF515811.1 AAM74918.1
    genomic AF515812.1 AAM74919.1
    genomic AF515813.1 AAM74920.1
    genomic AJ296092.3 CAC88114.2
    genomic AL662789.11 (49299..55545) None
    genomic AL731683.12 (2001..7087) None
    genomic AL928759.1 (4703..5908) None
    genomic AL935026.4 (3481..9769) None
    genomic AM042559.1 CAJ14960.1
    genomic AM042560.1 CAJ14961.1
    genomic AM286275.1 CAL08011.1
    genomic AM286276.1 CAL08012.1
    genomic AM286277.1 CAL08013.1
    genomic AMYH01016239.1 (213900..220146) None
    genomic AY180974.1 AAO23559.1
    genomic AY197775.1 AAO45622.1
    genomic AY206406.1 AAO47362.1
    genomic AY375896.1 AAQ91390.1
    genomic AY375905.1 AAQ91391.1
    genomic AY375912.1 AAQ91392.1
    genomic AY375913.1 AAQ91393.1
    genomic AY375914.1 AAQ91394.1
    genomic AY375915.1 AAQ91395.1
    genomic AY375916.1 AAQ91396.1
    genomic AY375917.1 AAQ91397.1
    genomic AY375918.1 AAQ91398.1
    genomic AY375919.1 AAQ91399.1
    genomic AY375920.1 AAQ91400.1
    genomic AY375921.1 AAQ91401.1
    genomic AY375922.1 AAQ91402.1
    genomic AY375931.1 AAQ91411.1
    genomic AY375932.1 AAQ91412.1
    genomic AY375933.1 AAQ91413.1
    genomic AY375934.1 AAQ91414.1
    genomic AY375935.1 AAQ91415.1
    genomic AY375936.1 AAQ91416.1
    genomic AY375937.1 AAQ91417.1
    genomic AY375938.1 AAQ91418.1
    genomic AY375939.1 AAQ91419.1
    genomic AY375940.1 AAQ91420.1
    genomic AY375941.1 AAQ91421.1
    genomic AY375942.1 AAQ91422.1
    genomic AY375943.1 AAQ91423.1
    genomic AY375944.1 AAQ91424.1
    genomic AY375945.1 AAQ91425.1
    genomic AY375946.1 AAQ91426.1
    genomic AY375947.1 AAQ91427.1
    genomic AY375948.1 AAQ91428.1
    genomic AY375949.1 AAQ91429.1
    genomic AY375952.1 AAQ91430.1
    genomic AY375953.1 AAQ91431.1
    genomic AY375954.1 AAQ91432.1
    genomic AY375955.1 AAQ89959.1
    genomic AY375956.1 AAQ89960.1
    genomic AY375957.1 AAQ89961.1
    genomic AY375958.1 AAQ89962.1
    genomic AY375959.1 AAQ89963.1
    genomic AY375960.1 AAQ89964.1
    genomic AY375961.1 AAQ89965.1
    genomic AY375962.1 AAQ89966.1
    genomic AY375963.1 AAQ89967.1
    genomic AY375964.1 AAQ89968.1
    genomic AY375965.1 AAQ89969.1
    genomic AY375970.1 AAQ89974.1
    genomic AY375972.1 AAQ89976.1
    genomic AY375973.1 AAQ89977.1
    genomic AY375974.1 AAQ89978.1
    genomic AY375978.1 AAQ89982.1
    genomic AY375979.1 AAQ89983.1
    genomic AY375980.1 AAQ89984.1
    genomic AY375981.1 AAQ89985.1
    genomic AY375982.1 AAQ89986.1
    genomic AY375983.1 AAQ89987.1
    genomic AY375984.1 AAQ89988.1
    genomic AY375985.1 AAQ89989.1
    genomic AY375986.1 AAQ89990.1
    genomic AY375987.1 AAQ89991.1
    genomic AY547314.1 AAS49496.1
    genomic AY585236.1 AAT09985.1
    genomic AY663394.1 AAU87975.1
    genomic AY663395.1 AAU87978.1
    genomic AY663396.1 AAU87981.1
    genomic AY663397.1 AAU87984.1
    genomic AY663400.1 AAU87992.1
    genomic AY663405.1 AAU88004.1
    genomic AY663406.1 AAU88007.1
    genomic AY663408.1 AAU88013.1
    genomic AY663409.1 AAU88016.1
    genomic AY663411.1 AAU88022.1
    genomic AY663412.1 AAU88025.1
    genomic AY663413.1 AAU88028.1
    genomic AY663414.1 AAU88031.1
    genomic AY663415.1 AAU88034.1
    genomic BX248406.4 (18762..24957) None
    genomic BX927168.11 (2001..6669) None
    genomic CH471415.1 EAW50504.1
      EAW50505.1
    genomic CR753835.3 (99572..101064) None
    genomic CR753846.4 (2593..8754) None
    genomic CR933859.5 (14204..20394) None
    genomic DQ178403.1 ABA86855.1
    genomic DQ178407.1 ABA86856.1
    genomic DQ178411.1 ABA86857.1
    genomic DQ178415.1 ABA86858.1
    genomic M17236.1 AAA59756.1
    genomic M29613.1 AAA59759.1
    genomic M29616.1 AAA59759.1
    genomic M34999.1 AAA74633.1
    genomic M83887.1 AAA59757.1
    genomic S75685.1 AAB32621.1
    genomic U03675.1 AAB60341.1
    genomic U85035.1 AAB41891.1
    genomic U92032.1 AAB91990.1
    genomic U97555.1 AAB58310.1
    genomic Z84489.1 CAB06491.1
    mRNA AB209628.1 BAD92865.1
    mRNA AF012768.1 AAB70189.1
    mRNA AF522250.1 AAP80750.1
    mRNA AF533895.1 AAM94809.1
    mRNA AF533896.1 AAM94810.1
    mRNA AF533897.1 AAM94811.1
    mRNA AF533898.1 AAM94812.1
    mRNA AF533899.1 AAM94813.1
    mRNA AF533900.1 AAM94814.1
    mRNA AF533901.1 AAM94815.1
    mRNA AF533902.1 AAM94816.1
    mRNA AF533903.1 AAM94817.1
    mRNA AF533904.1 AAM94818.1
    mRNA AF533905.1 AAM94819.1
    mRNA AF533906.1 AAM94820.1
    mRNA AF533907.1 AAM94821.1
    mRNA AF533908.1 AAM94822.1
    mRNA AF533909.1 AAM94823.1
    mRNA AF533910.1 AAM94824.1
    mRNA AF533911.1 AAM94825.1
    mRNA AF533912.1 AAM94826.1
    mRNA AF533913.1 AAM94827.1
    mRNA AF533914.1 AAM94828.1
    mRNA AF533915.1 AAM94829.1
    mRNA AF533916.1 AAM94830.1
    mRNA AF533917.1 AAM94831.1
    mRNA AF533918.1 AAM94832.1
    mRNA AF533919.1 AAM94833.1
    mRNA AF533920.1 AAM94834.1
    mRNA AF533921.1 AAM94835.1
    mRNA AF533922.1 AAM94836.1
    mRNA AF533923.1 AAM94837.1
    mRNA AF533924.1 AAM94838.1
    mRNA AF533925.1 AAM94839.1
    mRNA AF533926.1 AAM94840.1
    mRNA AF533927.1 AAM94841.1
    mRNA AF533928.1 AAM94842.1
    mRNA AF533929.1 AAM94843.1
    mRNA AF533930.1 AAM94844.1
    mRNA AF533931.1 AAM94845.1
    mRNA AF533932.1 AAM94846.1
    mRNA AF533933.1 AAM94847.1
    mRNA AF533934.1 AAM94848.1
    mRNA AF533935.1 AAM94849.1
    mRNA AF533936.1 AAM94850.1
    mRNA AF533937.1 AAM94851.1
    mRNA AF533938.1 AAM94852.1
    mRNA AF533939.1 AAM94853.1
    mRNA AF533940.1 AAM94854.1
    mRNA AK130598.1 None
    mRNA AK130811.1 None
    mRNA AK130838.1 None
    mRNA AK297065.1 BAG59586.1
    mRNA AK313975.1 BAG36689.1
    mRNA BC008585.1 AAH08585.1
    mRNA BC051832.1 None
    mRNA BC073977.1 AAH73977.1
    mRNA BC125044.1 AAI25045.1
    mRNA BC125045.1 AAI25046.1
    mRNA BC171877.1 AAI71877.1
    mRNA BU617246.1 None
    mRNA CR450297.1 CAG29293.1
    mRNA DQ284436.1 ABC66202.1
    mRNA DQ284437.1 ABC66203.1
    mRNA DQ284438.1 ABC66204.1
    mRNA DQ284439.1 ABC66205.1
    mRNA DQ284440.1 ABC66206.1
    mRNA L34082.1 AAC41950.1
    mRNA L34083.1 AAC41951.1
    mRNA L34084.1 AAC41952.1
    mRNA L34085.1 AAC41953.1
    mRNA L34086.1 AAC41954.1
    mRNA L34087.1 AAC41955.1
    mRNA L34088.1 AAC41956.1
    mRNA L34090.1 AAC41958.1
    mRNA L34091.1 AAC41959.1
    mRNA L34092.1 AAC41960.1
    mRNA L34093.1 AAC41961.1
    mRNA L34094.1 AAC41962.1
    mRNA L42625.1 AAA85334.1
    mRNA L46875.1 None
    mRNA M16995.1 AAA59760.1
    mRNA M17846.1 AAA59707.1
    mRNA M17847.1 AAA59708.1
    mRNA M18935.1 AAA59784.1
    mRNA M20431.1 AAA59758.1
    mRNA M20506.1 AAA59774.1
    mRNA M26041.1 AAA36267.1
    mRNA M33906.1 AAA52671.1
    mRNA M34996.1 AAA35771.1
    mRNA M59802.1 AAA64233.1
    mRNA U77589.1 AAB51233.1
    mRNA X00033.1 CAA24917.1
    mRNA X00370.1 None
    mRNA X00452.1 CAA25141.1
    other-genetic DQ891535.2 ABM82461.1
    other-genetic DQ894724.2 ABM85650.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01909.1 GenPept UniProtKB/Swiss-Prot:P01909

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • GTR
        GTR associated with a gene
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
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        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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