HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 [ Homo sapiens ]

Gene ID: 3117, updated on 19-May-2012

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Summary

Official Symbol: HLA-DQA1provided by HGNC
Official Full Name: major histocompatibility complex, class II, DQ alpha 1provided by HGNC
Primary source: HGNC:4942
Locus tag: DAQB-109B10.1
See related: Ensembl:ENSG00000196735; HPRD:06765; MIM:146880; Vega:OTTHUMG00000031106
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD; GSE; DQ-A1; CELIAC1; HLA-DQA; FLJ27088; FLJ27328; MGC149527
Summary: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6p21.3

Sequence :: Chromosome: 6; NC_000006.11 (32605183..32611429)

See HLA-DQA1 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Patients with HLA-DQA1 genotype have higher alanine aminotransferase elevation, whereas the HLA-negative cases have a higher incidence of Gilbert's syndrome.
Title: Lapatinib-induced liver injury characterized by class II HLA and Gilbert's syndrome genotypes.
we found for the first time that HLA-DQA1*0102 was significantly increased in the controls (18.5% in controls, 9.1% in potential celiac disease (CD), 5.6% in uncomplicated CD, and 7.4% in complicated CD
Title: Influence of HLA-DQ2 and DQ8 on severity in celiac Disease.
We found a genomewide significant association of podoconiosis with the single-nucleotide polymorphism (SNP) rs17612858, located 5.8 kb from the HLA-DQA1 locus.
Title: HLA class II locus and susceptibility to podoconiosis.
HLA*DQA1-0103-DQB1*0601 could be protective with regard to the development of oral cancer.
Title: Association between HLA-DQA1, HLA-DQB1 and oral cancer.
DQA1*0601 was not statistically significant as risk predictors of DM type 1.
Title: HLA-DQ A1, -DQB1 and -DRB1 gene polymorphism--in Malay type 1 diabetes mellitus patients and their use for risk prediction.
DRB1*0301-DQA1*0501-DQB1*0201 was more frequent in type 1 diabetes patients with associated automimmune diseases
Title: Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.
Our findings elucidate the structural basis for reduced DQ2-DM interaction
Title: An insertion mutant in DQA1*0501 restores susceptibility to HLA-DM: implications for disease associations.
Polymorphisms in HLA-DQA1 gene is associated with lung squamous cell carcinoma.
Title: Contribution of the TP53, OGG1, CHRNA3, and HLA-DQA1 genes to the risk for lung squamous cell carcinoma.
Fifty-nine percent of childhood-onset patients with T1DM were identified with high genetic risk based on known HLA-DQA1/B1 associations
Title: HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetes.
the distribution of HLA-DQA1 alleles in Lebanon
Title: Human leukocyte antigen-DQA1 gene allelic distribution: experience of a major tertiary care center in Lebanon.

Submit: New GeneRIF Correction See all (129)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

Common variants on chromosome 6p22.1 are associated with schizophrenia.

Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.

Genome-wide association study identifies susceptibility loci for IgA nephropathy.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.

Gluten-sensitive enteropathy (celiac disease)

MIM: 212750

Celiac disease is a systemic immune disease that can be associated with gastrointestinal findings (diarrhea, weight loss, abdominal pain, anorexia, lactose intolerance, abdominal distention, and irritability) and/or highly variable non-gastrointestinal findings (iron-deficiency anemia, dermatitis herpetiformis, chronic fatigue, joint pain/inflammation, migraines, depression, attention-deficit disorder, epilepsy, osteoporosis/osteopenia, infertility and/or recurrent fetal loss, vitamin deficiencies, short stature, failure to thrive, delayed puberty, dental enamel defects, and autoimmune disorders). Classic celiac disease, characterized by mild to severe gastrointestinal symptoms, is less common than nonclassic celiac disease, characterized by absence of gastrointestinal symptoms.

Diagnosis Testing

The diagnosis of celiac disease relies on characteristic histologic findings on small-bowel biopsy and clinical and/or histologic improvement on a gluten-free diet. Most individuals with celiac disease have celiac disease-associated antibodies and specific pairs of allelic variants in two HLA genes, HLA-DQA1 and HLA-DQB1. Because 30% of the general population has one of the celiac disease-associated HLA alleles and only 3% of individuals with one or both of these alleles develop celiac disease, presence of celiac disease-associated HLA alleles is not diagnostic of celiac disease; however, their absence essentially excludes a diagnosis of celiac disease.

Genetic Counseling

Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 gene variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. Some empiric risk data are available for at-risk relatives.

References

PMID: 20301720

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

Multiple common variants for celiac disease influencing immune gene expression.

Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.

Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon- therapy in multiple sclerosis patients.

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV envelope protein gp120 can specifically inhibit CD4-dependent class II MHC-restricted T cell response to Ag	PubMed
	env	Amino acid residues 42-49 in the V1 region of CD4 are involved in the interaction between HIV-1 gp120 and class II major histocompatibility complex molecules	PubMed
Envelope surface glycoprotein gp160, precursor	env	Processing of HIV-1 gp160 to gp120 and gp41 is necessary for the association of HIV-1 envelope glycoproteins with class II MHC	PubMed
Envelope transmembrane glycoprotein gp41	env	Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1)	PubMed
	env	Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells	PubMed
	env	A 43-amino-acid sequence between amino acids 708 and 750 in the HIV-1 gp41(TM) cytoplasmic tail is required for efficient incorporation of HLA class II proteins into virions	PubMed
Tat	tat	HIV-1 Tat downregulates expression of MHC class II genes in antigen-presenting cells (APC) by inhibiting the transactivator of MHC class II genes, CIITA	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
P01909	P51693	APLP1	HPRD	PubMed
P01909	P04233	CD74	HPRD	PubMed
P01909	Q5T3J3	LRIF1	HPRD	PubMed
P01909	Q99962	SH3GL2	HPRD	PubMed
P01909	Q04724	TLE1	HPRD	PubMed
P01909	Q13432	UNC119	HPRD	PubMed
BioGRID:109362	BioGRID:106830	APLP1	BioGRID	PubMed	Two-hybrid
BioGRID:109362	BioGRID:120905	LRIF1	BioGRID	PubMed	Two-hybrid
BioGRID:109362	BioGRID:112353	SH3GL2	BioGRID	PubMed	Two-hybrid
BioGRID:109362	BioGRID:112943	TLE1	BioGRID	PubMed	Two-hybrid
BioGRID:109362	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:109362	BioGRID:114548	UNC119	BioGRID	PubMed	Two-hybrid

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General gene information

Markers

G43562 (e-PCR)
- UniSTS:95013

G28524 (e-PCR)
- UniSTS:6197

RH78929 (e-PCR)
- UniSTS:85056

PMC204479P1 (e-PCR)
- UniSTS:271940

RH76581 (e-PCR)
- UniSTS:93029

D5S498 (e-PCR), detects polymorphism
- UniSTS:35727

SHGC-152784 (e-PCR)
- UniSTS:177603

D6S2446 (e-PCR)
- UniSTS:256718

RH79899 (e-PCR)
- UniSTS:90069

D6S1666 (e-PCR)
- UniSTS:38121

D6S291 (e-PCR), detects polymorphism
- UniSTS:36598

D6S1666 (e-PCR)
- UniSTS:464376

Genotypes

Homology

Homologs of the HLA-DQA1 gene: The HLA-DQA1 gene is conserved in chimpanzee, , dog, cow, mouse, and rat.
Map Viewer (Mouse, Rat)

Pathways from BioSystems

Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Allograft rejection, organism-specific biosystem (from KEGG)
Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
Allograft rejection, conserved biosystem (from KEGG)
Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
Antigen processing and presentation, organism-specific biosystem (from KEGG)
Antigen processing and presentation, organism-specific biosystem
Antigen processing and presentation
Antigen processing and presentation, conserved biosystem (from KEGG)
Antigen processing and presentation, conserved biosystem
Antigen processing and presentation
Asthma, organism-specific biosystem (from KEGG)
Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
Asthma, conserved biosystem (from KEGG)
Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
Autoimmune thyroid disease, conserved biosystem (from KEGG)
Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Downstream TCR signaling, organism-specific biosystem (from REACTOME)
Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
Graft-versus-host disease, organism-specific biosystem (from KEGG)
Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
Graft-versus-host disease, conserved biosystem (from KEGG)
Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
Interferon gamma signaling, organism-specific biosystem (from REACTOME)
Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
Intestinal immune network for IgA production, conserved biosystem (from KEGG)
Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
Leishmaniasis, organism-specific biosystem (from KEGG)
Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Leishmaniasis, conserved biosystem (from KEGG)
Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
PD-1 signaling, organism-specific biosystem (from REACTOME)
PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
Staphylococcus aureus infection, conserved biosystem (from KEGG)
Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
Systemic lupus erythematosus, conserved biosystem (from KEGG)
Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
TCR signaling, organism-specific biosystem (from REACTOME)
TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Type I diabetes mellitus, organism-specific biosystem (from KEGG)
Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
Type I diabetes mellitus, conserved biosystem (from KEGG)
Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
MHC class II receptor activity	NAS Non-traceable Author Statement more info	PubMed
MHC class II receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
T cell costimulation	TAS Traceable Author Statement more info
T cell receptor signaling pathway	TAS Traceable Author Statement more info
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA Inferred from Electronic Annotation more info
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
immune response	IEA Inferred from Electronic Annotation more info
immune response	NAS Non-traceable Author Statement more info	PubMed
interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
MHC class II protein complex	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
endosome	IEA Inferred from Electronic Annotation more info
endosome membrane	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	NAS Non-traceable Author Statement more info	PubMed
lysosomal membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

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General protein information

Preferred Names: HLA class II histocompatibility antigen, DQ alpha 1 chain

Names: HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA-DCA; DC-alpha; DC-1 alpha chain; MHC HLA-DQ alpha; MHC class II DQA1; MHC class II antigen; leucocyte antigen DQA1; MHC class II HLA-DQ-alpha-1; leukocyte antigen alpha chain; MHC class II surface glycoprotein; MHC class II HLA-D alpha glycoprotein; HLA class II histocompatibility antigen, DQ(W3) alpha chain

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002122.3 → NP_002113.2 HLA class II histocompatibility antigen, DQ alpha 1 chain precursor

Status: REVIEWED

Source sequence(s)

AF533896, AK130811, BU617246, M20431

Consensus CDS

CCDS4752.1

UniProtKB/Swiss-Prot

P01909

UniProtKB/TrEMBL

Q8MH44

Related

ENSP00000339398, OTTHUMP00000029141, ENST00000343139, OTTHUMT00000076176

Conserved Domains (2) summary

cd05767
Location:112 – 205
Blast Score: 423

IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cl03058
Location:29 – 110
Blast Score: 351

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

32605183..32611429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p5 ALT_REF_LOCI_2

Genomic

NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

Range

4055571..4061859

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p5 ALT_REF_LOCI_3

Genomic

NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

Range

3886910..3893071

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p5 ALT_REF_LOCI_4

Genomic

NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

Range

4061343..4067504

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p5 ALT_REF_LOCI_6

Genomic

NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

Range

3842030..3848318

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p5 ALT_REF_LOCI_7

Genomic

NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

Range

4038635..4044830

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

32346937..32353106

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB006908.1	BAA22189.1
genomic	AF109734.1	AAD56720.1
genomic	AF126253.2	AAD49219.2
genomic	AF322870.1	AAK11577.1
genomic	AF395700.1	AAM69677.1
genomic	AF515807.1	AAM74914.1
genomic	AF515808.1	AAM74915.1
genomic	AF515809.1	AAM74916.1
genomic	AF515810.1	AAM74917.1
genomic	AF515811.1	AAM74918.1
genomic	AF515812.1	AAM74919.1
genomic	AF515813.1	AAM74920.1
genomic	AJ296092.3	CAC88114.2
genomic	AL662789.11 (49298..55544)	None
genomic	AL928759.1 (4702..5907)	None
genomic	AM042559.1	CAJ14960.1
genomic	AM042560.1	CAJ14961.1
genomic	AM286275.1	CAL08011.1
genomic	AM286276.1	CAL08012.1
genomic	AM286277.1	CAL08013.1
genomic	AY180974.1	AAO23559.1
genomic	AY197775.1	AAO45622.1
genomic	AY206406.1	AAO47362.1
genomic	AY375896.1	AAQ91390.1
genomic	AY375905.1	AAQ91391.1
genomic	AY375912.1	AAQ91392.1
genomic	AY375913.1	AAQ91393.1
genomic	AY375914.1	AAQ91394.1
genomic	AY375915.1	AAQ91395.1
genomic	AY375916.1	AAQ91396.1
genomic	AY375917.1	AAQ91397.1
genomic	AY375918.1	AAQ91398.1
genomic	AY375919.1	AAQ91399.1
genomic	AY375920.1	AAQ91400.1
genomic	AY375921.1	AAQ91401.1
genomic	AY375922.1	AAQ91402.1
genomic	AY375931.1	AAQ91411.1
genomic	AY375932.1	AAQ91412.1
genomic	AY375933.1	AAQ91413.1
genomic	AY375934.1	AAQ91414.1
genomic	AY375935.1	AAQ91415.1
genomic	AY375936.1	AAQ91416.1
genomic	AY375937.1	AAQ91417.1
genomic	AY375938.1	AAQ91418.1
genomic	AY375939.1	AAQ91419.1
genomic	AY375940.1	AAQ91420.1
genomic	AY375941.1	AAQ91421.1
genomic	AY375942.1	AAQ91422.1
genomic	AY375943.1	AAQ91423.1
genomic	AY375944.1	AAQ91424.1
genomic	AY375945.1	AAQ91425.1
genomic	AY375946.1	AAQ91426.1
genomic	AY375947.1	AAQ91427.1
genomic	AY375948.1	AAQ91428.1
genomic	AY375949.1	AAQ91429.1
genomic	AY375952.1	AAQ91430.1
genomic	AY375953.1	AAQ91431.1
genomic	AY375954.1	AAQ91432.1
genomic	AY375955.1	AAQ89959.1
genomic	AY375956.1	AAQ89960.1
genomic	AY375957.1	AAQ89961.1
genomic	AY375958.1	AAQ89962.1
genomic	AY375959.1	AAQ89963.1
genomic	AY375960.1	AAQ89964.1
genomic	AY375961.1	AAQ89965.1
genomic	AY375962.1	AAQ89966.1
genomic	AY375963.1	AAQ89967.1
genomic	AY375964.1	AAQ89968.1
genomic	AY375965.1	AAQ89969.1
genomic	AY375970.1	AAQ89974.1
genomic	AY375972.1	AAQ89976.1
genomic	AY375973.1	AAQ89977.1
genomic	AY375974.1	AAQ89978.1
genomic	AY375978.1	AAQ89982.1
genomic	AY375979.1	AAQ89983.1
genomic	AY375980.1	AAQ89984.1
genomic	AY375981.1	AAQ89985.1
genomic	AY375982.1	AAQ89986.1
genomic	AY375983.1	AAQ89987.1
genomic	AY375984.1	AAQ89988.1
genomic	AY375985.1	AAQ89989.1
genomic	AY375986.1	AAQ89990.1
genomic	AY375987.1	AAQ89991.1
genomic	AY547314.1	AAS49496.1
genomic	AY585236.1	AAT09985.1
genomic	AY663394.1	AAU87975.1
genomic	AY663395.1	AAU87978.1
genomic	AY663396.1	AAU87981.1
genomic	AY663397.1	AAU87984.1
genomic	AY663400.1	AAU87992.1
genomic	AY663405.1	AAU88004.1
genomic	AY663406.1	AAU88007.1
genomic	AY663408.1	AAU88013.1
genomic	AY663409.1	AAU88016.1
genomic	AY663411.1	AAU88022.1
genomic	AY663412.1	AAU88025.1
genomic	AY663413.1	AAU88028.1
genomic	AY663414.1	AAU88031.1
genomic	AY663415.1	AAU88034.1
genomic	CH471415.1	EAW50504.1
		EAW50505.1
genomic	DQ178403.1	ABA86855.1
genomic	DQ178407.1	ABA86856.1
genomic	DQ178411.1	ABA86857.1
genomic	DQ178415.1	ABA86858.1
genomic	M17236.1	AAA59756.1
genomic	M29613.1	AAA59759.1
genomic	M29616.1	AAA59759.1
genomic	M34999.1	AAA74633.1
genomic	M83887.1	AAA59757.1
genomic	S75685.1	AAB32621.1
genomic	U03675.1	AAB60341.1
genomic	U85035.1	AAB41891.1
genomic	U92032.1	AAB91990.1
genomic	U97555.1	AAB58310.1
genomic	Z84489.1	CAB06491.1
mRNA	AB209628.1	BAD92865.1
mRNA	AF012768.1	AAB70189.1
mRNA	AF522250.1	AAP80750.1
mRNA	AF533895.1	AAM94809.1
mRNA	AF533896.1	AAM94810.1
mRNA	AF533897.1	AAM94811.1
mRNA	AF533898.1	AAM94812.1
mRNA	AF533899.1	AAM94813.1
mRNA	AF533900.1	AAM94814.1
mRNA	AF533901.1	AAM94815.1
mRNA	AF533902.1	AAM94816.1
mRNA	AF533903.1	AAM94817.1
mRNA	AF533904.1	AAM94818.1
mRNA	AF533905.1	AAM94819.1
mRNA	AF533906.1	AAM94820.1
mRNA	AF533907.1	AAM94821.1
mRNA	AF533908.1	AAM94822.1
mRNA	AF533909.1	AAM94823.1
mRNA	AF533910.1	AAM94824.1
mRNA	AF533911.1	AAM94825.1
mRNA	AF533912.1	AAM94826.1
mRNA	AF533913.1	AAM94827.1
mRNA	AF533914.1	AAM94828.1
mRNA	AF533915.1	AAM94829.1
mRNA	AF533916.1	AAM94830.1
mRNA	AF533917.1	AAM94831.1
mRNA	AF533918.1	AAM94832.1
mRNA	AF533919.1	AAM94833.1
mRNA	AF533920.1	AAM94834.1
mRNA	AF533921.1	AAM94835.1
mRNA	AF533922.1	AAM94836.1
mRNA	AF533923.1	AAM94837.1
mRNA	AF533924.1	AAM94838.1
mRNA	AF533925.1	AAM94839.1
mRNA	AF533926.1	AAM94840.1
mRNA	AF533927.1	AAM94841.1
mRNA	AF533928.1	AAM94842.1
mRNA	AF533929.1	AAM94843.1
mRNA	AF533930.1	AAM94844.1
mRNA	AF533931.1	AAM94845.1
mRNA	AF533932.1	AAM94846.1
mRNA	AF533933.1	AAM94847.1
mRNA	AF533934.1	AAM94848.1
mRNA	AF533935.1	AAM94849.1
mRNA	AF533936.1	AAM94850.1
mRNA	AF533937.1	AAM94851.1
mRNA	AF533938.1	AAM94852.1
mRNA	AF533939.1	AAM94853.1
mRNA	AF533940.1	AAM94854.1
mRNA	AK130598.1	None
mRNA	AK130811.1	None
mRNA	AK130838.1	None
mRNA	AK297065.1	BAG59586.1
mRNA	AK313975.1	BAG36689.1
mRNA	BC008585.1	AAH08585.1
mRNA	BC051832.1	None
mRNA	BC073977.1	AAH73977.1
mRNA	BC125044.1	AAI25045.1
mRNA	BC125045.1	AAI25046.1
mRNA	BC171877.1	AAI71877.1
mRNA	BU617246.1	None
mRNA	CR450297.1	CAG29293.1
mRNA	DQ284436.1	ABC66202.1
mRNA	DQ284437.1	ABC66203.1
mRNA	DQ284438.1	ABC66204.1
mRNA	DQ284439.1	ABC66205.1
mRNA	DQ284440.1	ABC66206.1
mRNA	L34082.1	AAC41950.1
mRNA	L34083.1	AAC41951.1
mRNA	L34084.1	AAC41952.1
mRNA	L34085.1	AAC41953.1
mRNA	L34086.1	AAC41954.1
mRNA	L34087.1	AAC41955.1
mRNA	L34088.1	AAC41956.1
mRNA	L34090.1	AAC41958.1
mRNA	L34091.1	AAC41959.1
mRNA	L34092.1	AAC41960.1
mRNA	L34093.1	AAC41961.1
mRNA	L34094.1	AAC41962.1
mRNA	L42625.1	AAA85334.1
mRNA	L46875.1	None
mRNA	M16995.1	AAA59760.1
mRNA	M17846.1	AAA59707.1
mRNA	M17847.1	AAA59708.1
mRNA	M18935.1	AAA59784.1
mRNA	M20431.1	AAA59758.1
mRNA	M20506.1	AAA59774.1
mRNA	M26041.1	AAA36267.1
mRNA	M33906.1	AAA52671.1
mRNA	M34996.1	AAA35771.1
mRNA	M59802.1	AAA64233.1
mRNA	U77589.1	AAB51233.1
mRNA	X00033.1	CAA24917.1
mRNA	X00370.1	None
mRNA	X00452.1	CAA25141.1
other-genetic	DQ891535.2	ABM82461.1
other-genetic	DQ894724.2	ABM85650.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O19501	GenPept	UniProtKB/TrEMBL:O19501
O19522	GenPept	UniProtKB/TrEMBL:O19522
O19703	GenPept	UniProtKB/TrEMBL:O19703
O19704	GenPept	UniProtKB/TrEMBL:O19704
O19705	GenPept	UniProtKB/TrEMBL:O19705
O19760	GenPept	UniProtKB/TrEMBL:O19760
O19765	GenPept	UniProtKB/TrEMBL:O19765
P01909.1	GenPept	UniProtKB/Swiss-Prot:P01909
Q08AS3	GenPept	UniProtKB/TrEMBL:Q08AS3
Q08AS4	GenPept	UniProtKB/TrEMBL:Q08AS4
Q14K62	GenPept	UniProtKB/TrEMBL:Q14K62
Q14K63	GenPept	UniProtKB/TrEMBL:Q14K63
Q14K64	GenPept	UniProtKB/TrEMBL:Q14K64
Q29782	GenPept	UniProtKB/TrEMBL:Q29782
Q29882	GenPept	UniProtKB/TrEMBL:Q29882
Q29885	GenPept	UniProtKB/TrEMBL:Q29885
Q29995	GenPept	UniProtKB/TrEMBL:Q29995
Q2LIQ8	GenPept	UniProtKB/TrEMBL:Q2LIQ8
Q2LIR1	GenPept	UniProtKB/TrEMBL:Q2LIR1
Q30062	GenPept	UniProtKB/TrEMBL:Q30062
Q30063	GenPept	UniProtKB/TrEMBL:Q30063
Q30065	GenPept	UniProtKB/TrEMBL:Q30065
Q30066	GenPept	UniProtKB/TrEMBL:Q30066
Q30069	GenPept	UniProtKB/TrEMBL:Q30069
Q30085	GenPept	UniProtKB/TrEMBL:Q30085
Q30125	GenPept	UniProtKB/TrEMBL:Q30125
Q30216	GenPept	UniProtKB/TrEMBL:Q30216
Q59F33	GenPept	UniProtKB/TrEMBL:Q59F33
Q5Y7A8	GenPept	UniProtKB/TrEMBL:Q5Y7A8
Q5Y7C3	GenPept	UniProtKB/TrEMBL:Q5Y7C3
Q5Y7C6	GenPept	UniProtKB/TrEMBL:Q5Y7C6
Q5Y7C9	GenPept	UniProtKB/TrEMBL:Q5Y7C9
Q5Y7D2	GenPept	UniProtKB/TrEMBL:Q5Y7D2
Q5Y7F8	GenPept	UniProtKB/TrEMBL:Q5Y7F8
Q5Y7G1	GenPept	UniProtKB/TrEMBL:Q5Y7G1
Q5Y7H0	GenPept	UniProtKB/TrEMBL:Q5Y7H0
Q67A92	GenPept	UniProtKB/TrEMBL:Q67A92
Q67A93	GenPept	UniProtKB/TrEMBL:Q67A93
Q67A94	GenPept	UniProtKB/TrEMBL:Q67A94
Q67A95	GenPept	UniProtKB/TrEMBL:Q67A95
Q67A96	GenPept	UniProtKB/TrEMBL:Q67A96
Q67A97	GenPept	UniProtKB/TrEMBL:Q67A97
Q67A98	GenPept	UniProtKB/TrEMBL:Q67A98
Q67A99	GenPept	UniProtKB/TrEMBL:Q67A99
Q67AA0	GenPept	UniProtKB/TrEMBL:Q67AA0
Q67AA1	GenPept	UniProtKB/TrEMBL:Q67AA1
Q67AA2	GenPept	UniProtKB/TrEMBL:Q67AA2
Q67AA3	GenPept	UniProtKB/TrEMBL:Q67AA3
Q67AA4	GenPept	UniProtKB/TrEMBL:Q67AA4
Q67AA5	GenPept	UniProtKB/TrEMBL:Q67AA5
Q67AA6	GenPept	UniProtKB/TrEMBL:Q67AA6
Q67AA7	GenPept	UniProtKB/TrEMBL:Q67AA7
Q67AA8	GenPept	UniProtKB/TrEMBL:Q67AA8
Q67AA9	GenPept	UniProtKB/TrEMBL:Q67AA9
Q67AB0	GenPept	UniProtKB/TrEMBL:Q67AB0
Q67AB1	GenPept	UniProtKB/TrEMBL:Q67AB1
Q67AB2	GenPept	UniProtKB/TrEMBL:Q67AB2
Q67AB3	GenPept	UniProtKB/TrEMBL:Q67AB3
Q67AB4	GenPept	UniProtKB/TrEMBL:Q67AB4
Q67AB5	GenPept	UniProtKB/TrEMBL:Q67AB5
Q67AB6	GenPept	UniProtKB/TrEMBL:Q67AB6
Q67AB7	GenPept	UniProtKB/TrEMBL:Q67AB7
Q67AB8	GenPept	UniProtKB/TrEMBL:Q67AB8
Q67AB9	GenPept	UniProtKB/TrEMBL:Q67AB9
Q67AC0	GenPept	UniProtKB/TrEMBL:Q67AC0
Q67AC1	GenPept	UniProtKB/TrEMBL:Q67AC1
Q67AC2	GenPept	UniProtKB/TrEMBL:Q67AC2
Q67AC3	GenPept	UniProtKB/TrEMBL:Q67AC3
Q67AC4	GenPept	UniProtKB/TrEMBL:Q67AC4
Q67AC5	GenPept	UniProtKB/TrEMBL:Q67AC5
Q67AC6	GenPept	UniProtKB/TrEMBL:Q67AC6
Q67AC7	GenPept	UniProtKB/TrEMBL:Q67AC7
Q67AC8	GenPept	UniProtKB/TrEMBL:Q67AC8
Q67AC9	GenPept	UniProtKB/TrEMBL:Q67AC9
Q67AD0	GenPept	UniProtKB/TrEMBL:Q67AD0
Q67AD1	GenPept	UniProtKB/TrEMBL:Q67AD1
Q67AD2	GenPept	UniProtKB/TrEMBL:Q67AD2
Q67AD3	GenPept	UniProtKB/TrEMBL:Q67AD3
Q67AD4	GenPept	UniProtKB/TrEMBL:Q67AD4
Q67AD5	GenPept	UniProtKB/TrEMBL:Q67AD5
Q67AD6	GenPept	UniProtKB/TrEMBL:Q67AD6
Q67AD7	GenPept	UniProtKB/TrEMBL:Q67AD7
Q67AD8	GenPept	UniProtKB/TrEMBL:Q67AD8
Q67AD9	GenPept	UniProtKB/TrEMBL:Q67AD9
Q67AE0	GenPept	UniProtKB/TrEMBL:Q67AE0
Q67AE1	GenPept	UniProtKB/TrEMBL:Q67AE1
Q67AE2	GenPept	UniProtKB/TrEMBL:Q67AE2
Q67AE3	GenPept	UniProtKB/TrEMBL:Q67AE3
Q67AE4	GenPept	UniProtKB/TrEMBL:Q67AE4
Q67AE5	GenPept	UniProtKB/TrEMBL:Q67AE5
Q67AE6	GenPept	UniProtKB/TrEMBL:Q67AE6
Q67AE7	GenPept	UniProtKB/TrEMBL:Q67AE7
Q67AE8	GenPept	UniProtKB/TrEMBL:Q67AE8
Q67AE9	GenPept	UniProtKB/TrEMBL:Q67AE9
Q67AF0	GenPept	UniProtKB/TrEMBL:Q67AF0
Q67AF1	GenPept	UniProtKB/TrEMBL:Q67AF1
Q67AF2	GenPept	UniProtKB/TrEMBL:Q67AF2
Q67AF3	GenPept	UniProtKB/TrEMBL:Q67AF3
Q67AF4	GenPept	UniProtKB/TrEMBL:Q67AF4
Q67AF5	GenPept	UniProtKB/TrEMBL:Q67AF5
Q67AF6	GenPept	UniProtKB/TrEMBL:Q67AF6
Q67AF7	GenPept	UniProtKB/TrEMBL:Q67AF7
Q67AF8	GenPept	UniProtKB/TrEMBL:Q67AF8
Q67AF9	GenPept	UniProtKB/TrEMBL:Q67AF9
Q67AG0	GenPept	UniProtKB/TrEMBL:Q67AG0
Q67AG1	GenPept	UniProtKB/TrEMBL:Q67AG1
Q67AG2	GenPept	UniProtKB/TrEMBL:Q67AG2
Q67AG3	GenPept	UniProtKB/TrEMBL:Q67AG3
Q67AG4	GenPept	UniProtKB/TrEMBL:Q67AG4
Q67AG5	GenPept	UniProtKB/TrEMBL:Q67AG5
Q67AG6	GenPept	UniProtKB/TrEMBL:Q67AG6
Q67AG7	GenPept	UniProtKB/TrEMBL:Q67AG7
Q67AG8	GenPept	UniProtKB/TrEMBL:Q67AG8
Q67AG9	GenPept	UniProtKB/TrEMBL:Q67AG9
Q67AH0	GenPept	UniProtKB/TrEMBL:Q67AH0
Q67AH1	GenPept	UniProtKB/TrEMBL:Q67AH1
Q67AH2	GenPept	UniProtKB/TrEMBL:Q67AH2
Q67AH3	GenPept	UniProtKB/TrEMBL:Q67AH3
Q67AH4	GenPept	UniProtKB/TrEMBL:Q67AH4
Q67AH5	GenPept	UniProtKB/TrEMBL:Q67AH5
Q67AH6	GenPept	UniProtKB/TrEMBL:Q67AH6
Q67AH7	GenPept	UniProtKB/TrEMBL:Q67AH7
Q67AH8	GenPept	UniProtKB/TrEMBL:Q67AH8
Q67AH9	GenPept	UniProtKB/TrEMBL:Q67AH9
Q67AI0	GenPept	UniProtKB/TrEMBL:Q67AI0
Q67AI1	GenPept	UniProtKB/TrEMBL:Q67AI1
Q67AI2	GenPept	UniProtKB/TrEMBL:Q67AI2
Q67AI3	GenPept	UniProtKB/TrEMBL:Q67AI3
Q67AI4	GenPept	UniProtKB/TrEMBL:Q67AI4
Q67AI5	GenPept	UniProtKB/TrEMBL:Q67AI5
Q67AI6	GenPept	UniProtKB/TrEMBL:Q67AI6
Q6DKG8	GenPept	UniProtKB/TrEMBL:Q6DKG8
Q7YPT8	GenPept	UniProtKB/TrEMBL:Q7YPT8
Q861G0	GenPept	UniProtKB/TrEMBL:Q861G0
Q8MH00	GenPept	UniProtKB/TrEMBL:Q8MH00
Q8MH01	GenPept	UniProtKB/TrEMBL:Q8MH01
Q8MH02	GenPept	UniProtKB/TrEMBL:Q8MH02
Q8MH03	GenPept	UniProtKB/TrEMBL:Q8MH03
Q8MH04	GenPept	UniProtKB/TrEMBL:Q8MH04
Q8MH05	GenPept	UniProtKB/TrEMBL:Q8MH05
Q8MH06	GenPept	UniProtKB/TrEMBL:Q8MH06
Q8MH07	GenPept	UniProtKB/TrEMBL:Q8MH07
Q8MH08	GenPept	UniProtKB/TrEMBL:Q8MH08
Q8MH09	GenPept	UniProtKB/TrEMBL:Q8MH09
Q8MH10	GenPept	UniProtKB/TrEMBL:Q8MH10
Q8MH11	GenPept	UniProtKB/TrEMBL:Q8MH11
Q8MH12	GenPept	UniProtKB/TrEMBL:Q8MH12
Q8MH13	GenPept	UniProtKB/TrEMBL:Q8MH13
Q8MH14	GenPept	UniProtKB/TrEMBL:Q8MH14
Q8MH15	GenPept	UniProtKB/TrEMBL:Q8MH15
Q8MH16	GenPept	UniProtKB/TrEMBL:Q8MH16
Q8MH17	GenPept	UniProtKB/TrEMBL:Q8MH17
Q8MH18	GenPept	UniProtKB/TrEMBL:Q8MH18
Q8MH19	GenPept	UniProtKB/TrEMBL:Q8MH19
Q8MH20	GenPept	UniProtKB/TrEMBL:Q8MH20
Q8MH21	GenPept	UniProtKB/TrEMBL:Q8MH21
Q8MH22	GenPept	UniProtKB/TrEMBL:Q8MH22
Q8MH23	GenPept	UniProtKB/TrEMBL:Q8MH23
Q8MH24	GenPept	UniProtKB/TrEMBL:Q8MH24
Q8MH25	GenPept	UniProtKB/TrEMBL:Q8MH25
Q8MH26	GenPept	UniProtKB/TrEMBL:Q8MH26
Q8MH27	GenPept	UniProtKB/TrEMBL:Q8MH27
Q8MH28	GenPept	UniProtKB/TrEMBL:Q8MH28
Q8MH29	GenPept	UniProtKB/TrEMBL:Q8MH29
Q8MH30	GenPept	UniProtKB/TrEMBL:Q8MH30
Q8MH31	GenPept	UniProtKB/TrEMBL:Q8MH31
Q8MH32	GenPept	UniProtKB/TrEMBL:Q8MH32
Q8MH33	GenPept	UniProtKB/TrEMBL:Q8MH33
Q8MH34	GenPept	UniProtKB/TrEMBL:Q8MH34
Q8MH35	GenPept	UniProtKB/TrEMBL:Q8MH35
Q8MH36	GenPept	UniProtKB/TrEMBL:Q8MH36
Q8MH37	GenPept	UniProtKB/TrEMBL:Q8MH37
Q8MH38	GenPept	UniProtKB/TrEMBL:Q8MH38
Q8MH39	GenPept	UniProtKB/TrEMBL:Q8MH39
Q8MH40	GenPept	UniProtKB/TrEMBL:Q8MH40
Q8MH41	GenPept	UniProtKB/TrEMBL:Q8MH41
Q8MH42	GenPept	UniProtKB/TrEMBL:Q8MH42
Q8MH43	GenPept	UniProtKB/TrEMBL:Q8MH43
Q8MH44	GenPept	UniProtKB/TrEMBL:Q8MH44
Q8MH45	GenPept	UniProtKB/TrEMBL:Q8MH45
Q8MH50	GenPept	UniProtKB/TrEMBL:Q8MH50
Q8MH51	GenPept	UniProtKB/TrEMBL:Q8MH51
Q8MH52	GenPept	UniProtKB/TrEMBL:Q8MH52
Q8MH53	GenPept	UniProtKB/TrEMBL:Q8MH53
Q8MH54	GenPept	UniProtKB/TrEMBL:Q8MH54
Q8MH55	GenPept	UniProtKB/TrEMBL:Q8MH55
Q8MH56	GenPept	UniProtKB/TrEMBL:Q8MH56
Q9TQ69	GenPept	UniProtKB/TrEMBL:Q9TQ69
Q9UEF5	GenPept	UniProtKB/TrEMBL:Q9UEF5
Q9UM30	GenPept	UniProtKB/TrEMBL:Q9UM30