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    SFXN1 sideroflexin 1 [ Homo sapiens ]

    Gene ID: 94081, updated on 11-May-2012
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    Summary

    Official Symbol
    SFXN1provided by HGNC
    Official Full Name
    sideroflexin 1provided by HGNC
    Primary source
    HGNC:16085
    See related
    Ensembl:ENSG00000164466; HPRD:18044; Vega:OTTHUMG00000130555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ12876
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    Genomic context

    Location :
    chromosome: 5
    Sequence :
    Chromosome: 5; NC_000005.9 (174905514..174955621)
    See SFXN1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene MKI67 (FHA domain) interacting nucleolar phosphoprotein pseudogene Neighboring gene dopamine receptor D1 Neighboring gene histamine receptor H2 Neighboring gene complexin 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Greco TM, et al. Mol Cell Proteomics, 2011 Feb. PMID 21081666.
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624.

    See all (26) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:125107 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125107 BioGRID:109622 ICT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125107 BioGRID:116068 PGRMC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125107 BioGRID:114374 TSC22D1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125107 BioGRID:122964 UBA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125107 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    sideroflexin-1
    Names
    sideroflexin-1
    TCC
    tricarboxylate carrier protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022754.5 → NP_073591.2  sideroflexin-1

      Status: VALIDATED

      Source sequence(s)
      AK022938, BC063241, BU689165, DA753705
      Consensus CDS
      CCDS4394.1
      UniProtKB/Swiss-Prot
      Q9H9B4
      Related
      ENSP00000316905, OTTHUMP00000161114, ENST00000321442, OTTHUMT00000252980
      Conserved Domains (1) summary
      cl04275
      Location:7 – 322
      Blast Score: 1244
      Mtc; Tricarboxylate carrier

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      174905514..174955621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      170004689..170054733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091393.3 (27443..77472) None
    genomic CH471062.2 EAW61370.1
      EAW61371.1
      EAW61372.1
      EAW61373.1
      EAW61374.1
      EAW61375.1
    mRNA AF327346.1 AAL56007.1
    mRNA AK022287.1 BAB14003.1
    mRNA AK022938.1 BAB14318.1
    mRNA AK025032.1 None
    mRNA AK056915.1 BAG51825.1
    mRNA BC020517.1 AAH20517.1
    mRNA BC063241.1 AAH63241.1
    mRNA BU689165.1 None
    mRNA BX648188.1 None
    mRNA DA753705.1 None
    other-genetic AM393845.1 CAL38720.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H9B4.4 GenPept UniProtKB/Swiss-Prot:Q9H9B4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

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