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    CFL1 cofilin 1 (non-muscle) [ Homo sapiens (human) ]

    Gene ID: 1072, updated on 18-May-2013
    Official Symbol
    CFL1provided by HGNC
    Official Full Name
    cofilin 1 (non-muscle)provided by HGNC
    Primary source
    HGNC:1874
    See related
    Ensembl:ENSG00000172757; HPRD:03261; MIM:601442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CFL
    Summary
    The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
    Location :
    11q13
    Sequence :
    Chromosome: 11; NC_000011.9 (65622282..65625804, complement)
    See CFL1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene ovo-like 1(Drosophila) Neighboring gene sorting nexin 32 Neighboring gene MUS81 structure-specific endonuclease Neighboring gene EGF containing fibulin-like extracellular matrix protein 2 Neighboring gene cathepsin W Neighboring gene fibroblast growth factor (acidic) intracellular binding protein

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering PubMed
    env HIV-1 gp120-CXCR4 signaling triggers cofilin activation and actin reorganization, which are important for a post entry process leading to viral nuclear localization PubMed
    Gag, Pr55 gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
    Nef, p27 nef HIV-1 Nef-induced LIMK1 activation and CFL1 phosphorylation are required for Nef-mediated inhibition of retinoid receptor function PubMed
    nef The HIV-1 Nef highly conserved valine-glycine-phenylalanine amino acid triplet (VGF) motif is important for Nef-PAK2 association and cofillin hyper-phosphorylation PubMed
    nef HIV-1 Nef inactivates cofilin by inducing its hyperphosphorylation via association with PAK2 activity PubMed
    Tat, p14 tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005498.1 NP_061857.2 SSH1    BIND  PubMed Unphosphorylated SSH-1L interacts with and dephosphorylates cofilin. 
    P23528 P68133 ACTA1    HPRD  PubMed  
    P23528 P62736 ACTA2    HPRD  PubMed  
    P23528 P60709 ACTB    HPRD  PubMed  
    P23528 P68032 ACTC1    HPRD  PubMed  
    P23528 P63261 ACTG1    HPRD  PubMed  
    P23528 P05023 ATP1A1    HPRD  PubMed  
    P23528 P54253 ATXN1    HPRD  PubMed  
    P23528 P51795 CLCN5    HPRD  PubMed  
    P23528 Q92598 HSPH1    HPRD  PubMed  
    P23528 P53667 LIMK1    HPRD  PubMed  
    P23528 P53671 LIMK2    HPRD  PubMed  
    P23528 Q99417 MYCBP    HPRD  PubMed  
    P23528 Q7Z2Y5 NRK    HPRD  PubMed  
    P23528 P14672 SLC2A4    HPRD  PubMed  
    P23528 Slingshot 1 SSH1    HPRD  PubMed  
    P23528 Q76I76 SSH2    HPRD  PubMed  
    P23528 Q8TE77 SSH3    HPRD  PubMed  
    P23528 Q15569 TESK1    HPRD  PubMed  
    P23528 Q96S53 TESK2    HPRD  PubMed  
    P23528 P60174 TPI1    HPRD  PubMed  
    P23528 O75083 WDR1    HPRD  PubMed  
    P23528 P61981 YWHAG    HPRD  PubMed  
    P23528 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:107499 BioGRID:106573 ACTA1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107499 BioGRID:106575 ACTB    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:106586 ACTG1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:106848 APP    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:106901 ARRB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:106902 ARRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:107776 ATF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:112217 ATXN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107499 BioGRID:115750 CAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:108223 ECT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:108276 EGFR    BioGRID  PubMed PCA 
    BioGRID:107499 BioGRID:109898 EIF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:117646 FBXO25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:108964 GJA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:109127 GRK5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107499 BioGRID:116022 HSPH1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107499 BioGRID:114995 ISG15    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107499 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:110172 LIMK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107499 BioGRID:110173 LIMK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107499 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:117086 MAPK8IP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:110611 MTAP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:117673 MYCBP    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:114909 POLR1C    BioGRID  PubMed Co-fractionation 
    BioGRID:107499 BioGRID:117417 POT1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:111642 PSEN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:111822 RAD21    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:112020 ROCK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107499 BioGRID:112109 RPS6KA1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:112592 SRC    BioGRID  PubMed Biochemical Activity 
    BioGRID:107499 BioGRID:116115 SUGT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:115717 TAB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:112739 TAGLN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:112872 TERF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:113020 TPI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107499 BioGRID:124277 TXNDC17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:113159 UBA52    BioGRID  PubMed Co-fractionation 
    BioGRID:107499 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:119509 UCHL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107499 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
      BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RAC1 signaling pathway, organism-specific biosystem
      RAC1 signaling pathway
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
      Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance TAS
    Traceable Author Statement
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
     
    establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
     
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    neural fold formation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet activation TAS
    Traceable Author Statement
    more info
     
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
     
    response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cofilin-1
    Names
    cofilin-1
    p18
    18 kDa phosphoprotein
    cofilin, non-muscle isoform

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005507.2NP_005498.1  cofilin-1

      Status: REVIEWED

      Source sequence(s)
      AK097690, BC018256, CB850882
      Consensus CDS
      CCDS8114.1
      UniProtKB/Swiss-Prot
      P23528
      Related
      ENSP00000309629, ENST00000308162
      Conserved Domains (1) summary
      cd11286
      Location:3153
      Blast Score: 396
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p10 Primary Assembly

      Range
      65622282..65625804, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      61948799..61952321, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018922.1 Alternate CHM1_1.0

      Range
      65543031..65546552, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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