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    CFL1 cofilin 1 (non-muscle) [ Homo sapiens ]

    Gene ID: 1072, updated on 20-May-2012

    Summary

    Official Symbol
    CFL1provided by HGNC
    Official Full Name
    cofilin 1 (non-muscle)provided by HGNC
    Primary source
    HGNC:1874
    See related
    Ensembl:ENSG00000172757; HPRD:03261; MIM:601442; Vega:OTTHUMG00000166602
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CFL
    Summary
    The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

    Genomic context

    Location :
    11q13
    Sequence :
    Chromosome: 11; NC_000011.9 (65622282..65625804, complement)
    See CFL1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507675 Neighboring gene ovo-like 1(Drosophila) Neighboring gene sorting nexin 32 Neighboring gene MUS81 endonuclease homolog (S. cerevisiae) Neighboring gene EGF containing fibulin-like extracellular matrix protein 2 Neighboring gene cathepsin W Neighboring gene fibroblast growth factor (acidic) intracellular binding protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
    Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005498.1 NP_061857.2 SSH1    BIND  PubMed Unphosphorylated SSH-1L interacts with and dephosphorylates cofilin. 
    P23528 P68133 ACTA1    HPRD  PubMed  
    P23528 P62736 ACTA2    HPRD  PubMed  
    P23528 P60709 ACTB    HPRD  PubMed  
    P23528 P68032 ACTC1    HPRD  PubMed  
    P23528 P63261 ACTG1    HPRD  PubMed  
    P23528 P05023 ATP1A1    HPRD  PubMed  
    P23528 P54253 ATXN1    HPRD  PubMed  
    P23528 P51795 CLCN5    HPRD  PubMed  
    P23528 Q92598 HSPH1    HPRD  PubMed  
    P23528 P53667 LIMK1    HPRD  PubMed  
    P23528 P53671 LIMK2    HPRD  PubMed  
    P23528 Q99417 MYCBP    HPRD  PubMed  
    P23528 Q7Z2Y5 NRK    HPRD  PubMed  
    P23528 P14672 SLC2A4    HPRD  PubMed  
    P23528 Slingshot 1 SSH1    HPRD  PubMed  
    P23528 Q76I76 SSH2    HPRD  PubMed  
    P23528 Q8TE77 SSH3    HPRD  PubMed  
    P23528 Q15569 TESK1    HPRD  PubMed  
    P23528 Q96S53 TESK2    HPRD  PubMed  
    P23528 P60174 TPI1    HPRD  PubMed  
    P23528 O75083 WDR1    HPRD  PubMed  
    P23528 P61981 YWHAG    HPRD  PubMed  
    P23528 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:107499 BioGRID:106573 ACTA1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107499 BioGRID:106575 ACTB    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:106586 ACTG1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:115750 CAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:108276 EGFR    BioGRID  PubMed PCA 
    BioGRID:107499 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107499 BioGRID:116022 HSPH1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107499 BioGRID:110172 LIMK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107499 BioGRID:110173 LIMK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107499 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:117086 MAPK8IP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:117673 MYCBP    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:111822 RAD21    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:112020 ROCK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107499 BioGRID:112109 RPS6KA1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:112592 SRC    BioGRID  PubMed Biochemical Activity 
    BioGRID:107499 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:115717 TAB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107499 BioGRID:112739 TAGLN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:113020 TPI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107499 BioGRID:124277 TXNDC17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107499 BioGRID:119509 UCHL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107499 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RAC1 signaling pathway, organism-specific biosystem
      RAC1 signaling pathway
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
      Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
     
    platelet activation TAS
    Traceable Author Statement
    more info
     
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
     
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cofilin-1
    Names
    cofilin-1
    p18
    18 kDa phosphoprotein
    cofilin, non-muscle isoform

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005507.2NP_005498.1  cofilin-1

      Status: REVIEWED

      Source sequence(s)
      AK097690, BC018256, CB850882
      Consensus CDS
      CCDS8114.1
      UniProtKB/Swiss-Prot
      P23528
      Related
      ENSP00000309629, ENST00000308162
      Conserved Domains (1) summary
      cd11286
      Location:3153
      Blast Score: 396
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      65622282..65625804, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      61948799..61952321, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP001266.4 (154501..158023) None
    genomic CH471076.1 EAW74448.1
      EAW74449.1
      EAW74450.1
      EAW74451.1
      EAW74452.1
    mRNA AK097690.1 BAG53513.1
    mRNA BC011005.2 AAH11005.1
    mRNA BC012265.1 AAH12265.1
    mRNA BC012318.1 AAH12318.1
    mRNA BC018256.2 AAH18256.1
    mRNA BC024975.1 None
    mRNA BT006846.1 AAP35492.1
    mRNA CB850882.1 None
    mRNA D00682.1 BAA00589.1
    mRNA U21909.1 AAA64501.1
    mRNA X95404.1 CAA64685.1
    other-genetic DQ891769.2 ABM82695.1
    other-genetic EU176624.1 ABW03425.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23528.3 GenPept UniProtKB/Swiss-Prot:P23528

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